Isoprinosine From Human Papillomavirus: Doctor Reviews, Instructions

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2024-01-15 19:51

Isoprinosine for human papillomavirus

The content of the article:

Therapeutic tactics for HPV infection
Release form and composition
Characteristics of the drug
Prescribing regimens for Isoprinosine for HPV
Possible side effects of the drug
Features of use
Contraindications
Special recommendations
Benefits of the drug
Analogs
Video

Human papillomavirus (HPV) causes not only papillomas, or warts, but also dysplasia, cancer of the cervix, vagina, anus in women, and cancer of the penis and anus in men. At this stage, there are no effective methods of therapy that can completely destroy HPV, therefore, treatment combines local and systemic methods aimed at removing areas of altered epithelium and transferring HPV to an inactive state. Isoprinosine from human papillomavirus successfully copes with the second task, providing a complex antiviral and immunomodulatory effect on the body.

Isoprinosine is used to stimulate immunity

Therapeutic tactics for HPV infection

The direction and scope of therapy largely depend on the activity of HPV in the body. The human papillomavirus in epithelial cells can exist in two forms.

Option of existence	Processes in the body
Benign	HPV, having entered the cells of the epithelium of the skin or mucous membranes, through sexual or household contact, is not activated. It is in a dormant state: it does not integrate into the chromosomal apparatus of the cell, does not cause the appearance of clinical symptoms. This form of existence, called episomal, is possible with good immunity.
Malignant	The virus integrates into the genome of the infected cell, which results in the active production of specific HPV-encoded proteins, as well as the implementation of one of two options for action on the epithelium: productive and unproductive. In the first variant, papillomas of various localization, genital warts appear in the genital and oral cavity, in the second - changes inside the epithelium: dysplasias of varying severity and cancer. Different types of exposure are determined by the type of virus, of which there are more than 100, and the state of the human immune system. The active form of HPV existence, also known as introsomal, becomes possible with a decrease in the general resistance of the body.

Only the destruction of papillomatous formations does not guarantee a lasting effect. The absence of relapses of the disease can be achieved by the use of medications that enhance the local and general immune response, converting the virus into an inactive form. These drugs include Isoprinosine, registered in more than 70 countries around the world and receiving numerous positive reviews from practicing specialists. However, it should be noted that there was no evidence of its effectiveness in studies.

Release form and composition

Isoprinosine is available in the form of white or almost white tablets with a slight characteristic amine odor. The active substance of the drug, inosine pranobex, has a therapeutic effect, the content of which in one tablet is 500 mg. The auxiliary components included in the composition include: mannitol (E 421), povidone, magnesium stearate and wheat starch.

Characteristics of the drug

The main properties of Isoprinosine are presented in the table.

Characteristic	Description
Pharmacological group	The drug belongs to the direct-acting antiviral drugs included in the Anatomical-therapeutic classification in the section "Antiviral drugs for systemic use".
Pharmacological properties	Possesses antiviral and immunomodulatory effects. The first is realized through the suppression of HPV synthesis by inhibition of the reproduction of DNA and mRNA of viral particles in the ribosomes of infected cells. Correction of the immune response is carried out due to several mechanisms: activation of T-lymphocytes, in relation to which it even blocks the inhibitory effect of glucocorticoids; stimulation of the activity of phagocytic cells by strengthening their biochemical processes; increasing the production of antiviral proteins - interferons.
Pharmacokinetics	After taking the drug, the peak concentration of the ingredients in the blood is observed in 1-2 hours due to good absorption from the gastrointestinal tract. The active substance is a purine derivative, therefore, its metabolism in the body occurs according to the cycle inherent in purine nucleotides, and is accompanied by the formation of uric acid. The latter is excreted by the kidneys within 2 days.

Prescribing regimens for Isoprinosine for HPV

Isoprinosine from papillomas is taken after a meal, washed down with a small amount of water, in the next dosage.

Age group	Dosage
Children aged 3 to 12 years (body weight from 15-20 kg and above)	The average dose is 50 mg per kilogram of body weight (50 mg / kg) per day, divided into 3-4 doses. The maximum amount of the drug taken during the day should not exceed the dose determined at the rate of 50 mg / kg of the child's weight. The average course of treatment is 14 days, the maximum is 28 days.
Children over 12 years old and adults	Standard dose: 50 mg / kg of patient weight (6 to 8 tablets per day) during the day for 3-4 doses. The maximum amount of funds taken per day should not exceed 4 g. Duration of admission is from 14 to 28 days.

The duration of treatment for genital warts and cervical dysplasia is determined by the nature of the course of the disease, the severity of clinical manifestations, and the patient's immune status.

Variant of the course of infection	Isoprinosine regimen
Genital and perianal genital warts	Combined method: removal of formations (surgical or radio wave excision, cryodestruction, laser vaporization, chemical cauterization) in combination with systemic antiviral treatment with Isoprinosine. Prescribing regimen: 50 mg / kg body weight, divided into 3-4 doses (6-8 tablets), for 2-4 weeks.
Prevention of relapse after removal of genital warts and a course of systemic therapy	Patients at high risk of disease recurrence (hormonal disorders, smoking, alcohol abuse, concomitant viral, bacterial, fungal infections, overwork, etc.): 50 mg / kg per day for 3-4 doses for 5 days a week, take 1– 2 weeks a month for 3 months. Patients with a low risk of relapse: 2 months after combined treatment - taking the drug at 50 mg / kg body weight per day for 3-4 doses for 14 days.
Reappearance of genital warts after combined treatment (destruction and systemic treatment)	In the acute phase: 5 days, 50 mg / kg of body weight (no more than 4 g per day) for 3-4 doses, starting from the 6th day, 500 mg (1 tablet) twice a day (daily dose 1000 mg) from 3 to 6 months. The second option: 50 mg / kg (6–8 tablets) per day for 3–4 doses for 10–14 days, only 3 courses with a 1 month break between courses.
Cervical intraepithelial neoplasias (CIN Ӏ – degrees)	As part of a combination treatment (drug therapy and destruction): before the onset of destruction, 1000 mg (2 tablets) 3-4 times a day for 10 days, then 10 days after the destructive treatment, repeat the course, only 1 to 3 courses, depending on the results control examination.

Possible side effects of the drug

Isoprinosine, according to numerous patient reviews and expert observations, is well tolerated. One of the side effects of taking the drug, due to the peculiarities of its metabolism in the body, is a transient increase in the level of uric acid in urine and blood serum.

The instruction for Isoprinosine contains a list of side effects that may occur in patients while taking the medication.

Organs and systems	Symptoms
Gastrointestinal tract	Pain in the epigastric region, nausea, vomiting, rarely loose stools, constipation.
Liver and biliary tract	Transient increase in the activity of transaminases (ALT, AST), alkaline phosphatase in the blood serum.
Skin	Itching, rash, hyperemia.
Nervous system	Dizziness, headache, weakness, drowsiness, difficulty falling asleep.
urinary system	Polyuria (increased urine production).
Locomotor apparatus	Arthralgia (joint pain).

Features of use

Isoprinosine treat diseases caused by the human papillomavirus, taking into account certain conditions of the body, some of the characteristics of the drug itself, its interaction with other drugs.

Features of use	Interaction, possibility of receiving
Joint reception with other drugs	The effectiveness of the drug decreases when used simultaneously with immunosuppressants. Xanthine oxidase inhibitors, which prevent the formation of uric acid, and uricosuric agents, which increase the excretion of uric acid, can increase its level in blood plasma when taken simultaneously with Isoprinosine.
Pregnancy	The lack of research on the safety of the drug during gestation does not allow recommending it for treatment during pregnancy.
Lactation	It is not recommended to be taken by breastfeeding women, as there is no reliable data on the possibility of penetration of the active substance into breast milk.
Influence on the ability to drive mechanisms and vehicles	There are no special prohibiting recommendations, but it should be borne in mind that taking the drug can provoke dizziness and headache.

Contraindications

Treatment of HPV infection with a drug is contraindicated if the patient has:

individual intolerance to the constituent components;
kidney pathology (urolithiasis, chronic renal failure);
heart rhythm disturbances;
gout;
body weight less than 15–20 kg (theoretically, it is possible to prescribe the drug to children from 1 year old, but taking into account weight restrictions, in practice, taking the drug is possible after 3 years).

Special recommendations

Taking into account the possibility of long-term administration of Isoprinosine, it is necessary to monitor the functioning of the kidneys and liver while taking it. Laboratory studies help to cancel the drug in time when indicators go beyond the permissible deviations.

Features of use	Recommended research
Taking the drug for more than 14 days	Determination of the concentration of uric acid in blood plasma and urine. Repeated laboratory tests are performed every 2 weeks of further admission.
Taking the drug for more than 28 days	Control of liver function: determination of the level of activity of endogenous enzymes from the group of transferases (AST, ALT) and a component of cell membranes - alkaline phosphatase. It is necessary to carry out such laboratory studies once a month if the treatment regimens involve the long-term administration of Isoprinosine.
Simultaneous administration of the drug with xanthine oxidase inhibitors (Zilorik, Milurit, Purinol, Remid, Sanfipurol, Allozim, Allopurinol, etc.) or uricosuric agents (Etamid, Urodan, Blemaren, Colchicine, etc.).	Monitoring the level of uric acid in the blood serum should be carried out not 2 weeks after the start of admission, but much earlier. The frequency of laboratory tests and the timing of their conduct is determined by the attending physician, taking into account the patient's condition. If the concentration of uric acid exceeds the permissible limits, then Isoprinosine is immediately canceled.

Benefits of the drug

The spectrum of action of Isoprinosine gives it a number of advantages in the treatment of not only various manifestations of human papillomavirus infection (PVI), but also its combination with other pathologies of the urogenital tract.

Features of pathology	Benefits of the tool
PVI and diseases of the urogenital sphere	PVI (warts, genital warts, cervical dysplasia) is often combined with other pathologies: chlamydia, bacterial vaginosis, ureaplasmosis, mycoplasmosis, herpes, fungal infections. The appointment of Isoprinosine helps to fight not only HPV, but also contributes to the successful treatment of these infections, since along with a pronounced antiviral effect (herpes, cytomegalovirus), it has proven immunomodulatory properties, and the final result of any treatment largely depends on the state of the immune system.
Early stages of CIN and chronic inflammatory diseases of the genital organs	Mild cervical dysplasia is often combined with chronic cervicitis (inflammation of the cervical mucosa) and vaginitis (inflammation of the vaginal mucosa) caused by opportunistic pathogens (staphylococcus, streptococcus, etc.). It is possible to successfully treat such patients without using destructive methods, but by conducting both antiviral and immunostimulating treatment. Isoprinosine provides both of these effects; therefore, its administration in combination with anti-inflammatory therapy often allows a positive result to be achieved without destruction of the foci.
Multiple genital and perianal genital warts	The presence of concomitant diseases (vaginal dysbiosis, herpetic, chlamydial, mycoplasma infections, etc.) lengthens the treatment period for PVI and contributes to the occurrence of relapses. Therefore, this combination is treated with a combined method: destruction of genital warts and systemic antiviral therapy. The use of Isoprinosine allows you to increase the effectiveness of treatment, especially with multiple small growths. This is due to the effect of the agent on HPV, not only in the places of localization of warts, which are difficult to reach for surgical or laser exposure, but also in the nerve nodes, or ganglia.

Analogs

Preparations with an active ingredient similar to the active ingredient of Isoprinosine (inosine pranobex) are produced under the following trade names:

Groprinosine;
Modimunal;
Normomed;
Metizoprinol;
Groprinosin-Richter.

Groprinosine is an analogue of Isoprinosine

The use of Isoprinosine from the human papillomavirus, both as monotherapy and in combination with other drugs and destructive therapeutic methods, allows you to successfully cope with the manifestations of PVI. But in order to achieve a lasting result, the appointment of the agent and control of its use must be carried out by a specialist.