Frinosol
Frinosol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Frinozol
ATX code: R01AB01
Active ingredient: phenylephrine (Phenylephrine) + cetirizine (Cetirizine)
Manufacturer: JSC "Vertex" (Russia)
Description and photo update: 2020-25-03
Prices in pharmacies: from 192 rubles.
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Frinosol is a combined antiallergic drug (α-adrenergic agonist + H1-histamine receptor blocker).
Release form and composition
The dosage form of the drug is a nasal spray: a clear solution, light yellow or colorless (15 ml in plastic bottles with a spray for nasal use, each bottle is packed in an individual carton box together with instructions for the use of Frinosol).
Composition of 1 ml nasal spray:
- active ingredients: phenylephrine hydrochloride - 2.5 mg; cetirizine dihydrochloride - 2.5 mg;
- additional components: sodium hydrogen phosphate (anhydrous), 50% solution of benzalkonium chloride, glycerol, potassium dihydrogen phosphate, disodium edetate, purified water.
Pharmacological properties
Pharmacodynamics
Frinosol is a combined agent for local intranasal use, used for pathogenetic and symptomatic therapy.
Phenylephrine is an α1-adrenergic receptor agonist (sympathomimetic), under its influence there is a narrowing of the blood vessels of the nasal mucosa, tissue hyperemia and edema of the mucous membranes decrease, as well as congestion in the nasal mucosa. Thanks to its action, air permeability of the nasopharynx is restored, which helps to improve the patient's well-being and reduce the risk of developing possible complications that can be caused by stagnation of mucous secretions.
Cetirizine is a histamine H1 receptor blocker. It has anti-allergic properties, reduces capillary permeability, prevents the development of edema of the mucous membrane of the nasal cavity and its paranasal sinuses.
As an auxiliary component, the composition of Frinosol contains a moisturizing substance glycerol, which retains moisture and thereby provides hydration of the nasal mucosa in case of dryness and irritation.
Pharmacokinetics
The action of Frinosol does not depend on the content of its active components in the blood plasma, which is due to the local intranasal method of its application.
Indications for use
The use of Frinosol is indicated for the following diseases / conditions:
- chronic rhinitis;
- acute rhinitis (including with colds);
- vasomotor rhinitis;
- allergic rhinitis (including hay fever);
- chronic and acute sinusitis;
- acute otitis media (as an adjuvant).
In addition, a nasal spray is used in preparation for surgical interventions in the nasal area in order to eliminate edema of the nasal mucosa and paranasal sinuses after surgical interventions in this area.
Contraindications
Absolute:
- atrophic rhinitis;
- angle-closure glaucoma;
- gestation period;
- lactation (breastfeeding);
- the combined use of monoamine oxidase inhibitors, including taking in the previous 2 weeks;
- children and adolescents up to 18 years old (due to the lack of information on the safety and effectiveness of this nasal spray in pediatrics);
- hypersensitivity to phenylephrine, cetirizine or other substances in the combination drug.
Relative (Frinosol nasal spray must be used, observing precautions):
- chronic renal failure (CRF);
- obstruction of the bladder neck (for example, due to prostatic hypertrophy);
- prostate adenoma;
- cardiovascular diseases, including arrhythmias, arterial hypertension, generalized atherosclerosis;
- angina pectoris;
- increased seizure activity;
- epilepsy;
- hyperthyroidism;
- diabetes;
- elderly age.
In addition, Frinosol, like any local vasoconstrictor, is prescribed with caution to patients with severe reactions (tremor, dizziness, insomnia, increased blood pressure or cardiac arrhythmia) to sympathomimetics.
Frinosol, instructions for use: method and dosage
Spray Frinosol is used intranasally.
Recommended daily dose for adult patients: 1-2 injections into each nasal passage 2-3 times a day. The duration of continuous therapy should not exceed 7 days.
How to use the nasal spray:
- The bottle is held vertically, with the spray upwards.
- After thoroughly cleaning the nasal passages, they begin to administer the drug.
- Before injection, tilt the head and, after inserting the tip of the bottle into the nasal passage, press the spray bottle once with a short, sharp movement.
- During the injection, inhale lightly through the nose.
Side effects
The combination of phenylephrine with cetirizine in the form of a nasal spray in therapeutic doses is well tolerated, in some cases the following undesirable effects from systems and organs are possible (classified according to the recommendations of the World Health Organization: very often - from 1/10; often - from 1/100 to 1 / 10; infrequently - from 1/1000 to 1/100; rarely - from 1/10 000 to 1/1000; extremely rare - less than 1/10 000, including individual messages; with an unknown frequency - based on available data it is not possible to determine the incidence of side effects):
- nervous system: infrequently - paresthesia; rarely - convulsions; extremely rare - fainting, dyskinesia, taste perversion, tremor, dystonia; with an unknown frequency - dizziness, headache, deafness, memory impairment (including amnesia);
- mental disorders: infrequently - agitation; rarely - depression, confusion, hallucinations, aggression; extremely rare - tick; with an unknown frequency - sleep disorders (including nightmares), suicidal ideas;
- heart and blood vessels: rarely - tachycardia; with an unknown frequency - increased blood pressure, arrhythmia;
- blood and lymphatic system: extremely rare - thrombocytopenia;
- skin and subcutaneous tissues: infrequently - itching, rash; rarely - urticaria; extremely rare - persistent drug erythema, angioedema;
- muscle, skeletal and connective tissue: with an unknown frequency - arthralgia;
- immune system: rarely - hypersensitivity reactions; extremely rare - anaphylactic shock;
- digestive system: infrequently - diarrhea;
- metabolism and nutrition: with an unknown frequency - increased appetite;
- liver and biliary tract: rarely - liver failure with a change in liver function tests (an increase in the activity of gamma-glutamyl transferase, alkaline phosphatase, transaminases and bilirubin);
- kidneys and urinary tract: extremely rare - dysuria; with an unknown frequency - urinary retention;
- hearing organ and labyrinthine disorders: with unknown frequency - vertigo;
- organ of vision: extremely rarely - blurred visual perception, violation of accommodation, nystagmus; with an unknown frequency - vasculitis;
- general disorders and reactions at the injection site: infrequently - malaise, asthenia; rarely - irritation of the nasal mucosa (due to benzalkonium chloride, which is part of the drug), tingling, burning / dryness in the nose, discomfort in the nose, sneezing, nosebleeds; with an unknown frequency - difficulty in nasal breathing, mucous and watery nasal discharge, hyperemia and edema of the nasal mucosa.
Overdose
Since the systemic absorption of Frinosol when applied topically is very low, overdose is almost impossible.
Overdose symptoms registered with excessive intake of the active components of the drug separately:
- phenylephrine: possible increased blood pressure, heart rhythm disturbances, agitation;
- cetirizine: dizziness, headache, confusion, anxiety, increased fatigue, weakness, malaise, diarrhea, itching, sedation, drowsiness, stupor, mydriasis, tremor, tachycardia, urinary retention were observed with a single oral dose of 50 mg.
Treatment: stimulation of vomiting or gastric lavage, administration of activated charcoal, intake of large amounts of liquid; further - supportive and symptomatic therapy. There is no specific antidote. Hemodialysis is ineffective. In case of symptoms of an overdose, you should urgently seek medical help.
special instructions
Continuous use of a nasal spray should not exceed 7 days. With excessive or prolonged use of Frinosol, tachyphylaxis and the rebound phenomenon may occur, due to the re-development of nasal congestion (rhinitis medicamentosa), the development of a systemic vasoconstrictor effect is possible.
When using Frinosol, as with the use of similar vasoconstrictor agents, the dose of the drug recommended in the instructions must not be exceeded. Otherwise, manifestations of the systemic action of the drug may occur, especially in elderly patients.
Patients taking monoamine oxidase inhibitors are not recommended to use phenylephrine for 2 weeks after their cancellation, as this can cause an increase in the severity of the adrenergic effects of sympathomimetic drugs and increase the risk of adverse reactions from the cardiovascular system.
Frinosol is intended exclusively for local intranasal use.
Influence on the ability to drive vehicles and complex mechanisms
Patients who drive vehicles and complex mechanisms, as well as engage in other activities that require the speed of psychomotor reactions and concentration of attention, must be careful during Frinosol therapy. What is associated with the likelihood of developing undesirable reactions from the nervous system when using a nasal spray, manifested in the form of dizziness.
Application during pregnancy and lactation
The use of Frinosol is contraindicated in women during gestation and breastfeeding, since there are no data on the safety and efficacy of using the drug during these periods of a woman's life.
Pediatric use
It is contraindicated for patients under 18 years of age to use the Frinosol nasal spray, since there is no data on the effectiveness and safety of the drug in this age category.
With impaired renal function
Patients with chronic renal failure should use Frinosol, taking precautions.
For violations of liver function
For persons with impaired hepatic function, there are no special indications for the use of Frinosol.
Use in the elderly
Elderly patients should use Frinosol, taking precautions.
Drug interactions
Against the background of Frinosol treatment, the use of tetra- and tricyclic antidepressants, β-blockers, monoamine oxidase inhibitors (selegiline, procarbazine), guanadrel, maprotiline, guanethidine is not recommended.
With systemic absorption of phenylephrine, thyroid hormones mutually increase the associated risk of developing coronary insufficiency, especially in coronary atherosclerosis.
Analogs
Frinosol analogues are Allergodil, Nazivin Sensitiv, Vibrocil, Dimetinden + Phenylephrine, Cromohexal, etc.
Terms and conditions of storage
Store at a temperature not exceeding 25 ° С in a place protected from sunlight. Keep out of the reach of children.
Shelf life is 2 years. At the end of the expiration date indicated on the package, the drug must not be used.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Frinosol
On the Internet, you can find mixed reviews about Frinosol. Most users speak out positively, pointing out such advantages of the drug as speed of action, long decongestant effect, absence of dryness of the nasal mucosa, relieving congestion in case of allergies, convenient packaging and low cost of the product. Patients note that the spray eliminates the manifestations of a cold in a few minutes, stops sneezing, removes irritation and itching in the nasopharynx.
However, there are also negative reviews about Frinosol, which report that the action of the spray lasts no more than 15 minutes, after which the congestion returns.
Price for Frinosol in pharmacies
The price of Frinosol, a nasal spray 2.5 mg / ml + 2.5 mg / ml, varies between 208-276 rubles. (1 bottle of 15 ml in the package).
Frinosol: prices in online pharmacies
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Drug name Price Pharmacy |
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Frinosol 2.5 mg + 2.5 mg nasal spray 15 ml 1 pc. 192 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
