Fexofast
Fexofast: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Fexofast
ATX code: R06AX26
Active ingredient: fexofenadine (fexofenadine)
Manufacturer: Micro Labs (India)
Description and photo updated: 22.11.2018
Prices in pharmacies: from 212 rubles.
Buy
Fexofast is a drug with antiallergic effect.
Release form and composition
The dosage form of Fexofast is film-coated tablets: 120 mg - white, round, biconvex; 180 mg - orange, oblong (in a cardboard box 1-3 or 10 blisters of 10 tablets).
Composition of 1 tablet:
- active substance: fexofenadine - 120 or 180 mg (fexofenadine hydrochloride - 126 or 189 mg);
- auxiliary components (120/180 mg): microcrystalline cellulose - 3.9 / 43.5 mg; starch - 2/60 mg; lactose - 2/159 mg; croscarmellose sodium - 13.75 / 36.5 mg; povidone - 0.75 / 3 mg; colloidal silicon dioxide - 0.6 / 1 mg; magnesium stearate - 1/3 mg;
- shell (120/180 mg): hydroxypropyl methylcellulose - 3.69 / 10.36 mg; propylene glycol - 0.69 / 2.144 mg; purified talc - 0.933 / 2.5 mg; titanium dioxide - 0.937 / 2.812 mg; dye sunset yellow varnish - 0 / 0.936 mg.
Pharmacological properties
Pharmacodynamics
Fexofenadine hydrochloride is a non-sedative histamine H 1 receptor blocker and is a pharmacologically active metabolite of terfenadine.
The antihistamine effect of Fexofast develops 60 minutes after ingestion, it reaches its maximum after 6 hours, its duration is 24 hours.
The emergence of tolerance with repeated use is not noted.
It has no sedative, cholino- and adrenolytic effects.
It does not lead to a change in the function of calcium / potassium channels, the QT interval when used in therapeutic doses.
Pharmacokinetics
After oral administration, fexofenadine hydrochloride is rapidly absorbed from the gastrointestinal tract, reaching Cmax (maximum concentration) in 1-3 hours. The average Cmax after taking 120 and 180 mg is approximately 427 and 494 ng / ml, respectively.
Plasma protein binding ranges from 60 to 70% (mainly with albumin and alpha1-glycoprotein). It does not penetrate the blood-brain barrier.
T1 / 2 (half-life) after repeated administration of fexofenadine - 14.4 hours. In moderate and severe renal failure (creatinine clearance 41–80 and 11–40 ml / min), T1 / 2 increases by 59 and 72%, respectively; in patients on hemodialysis - by 31%.
Fexofenadine hydrochloride undergoes partial extrahepatic metabolism (5% of the dose). It is excreted mainly in the bile (80%), 11% of the substance is excreted unchanged by the kidneys.
Indications for use
- seasonal allergic rhinitis;
- chronic urticaria.
Contraindications
- pregnancy and the period of breastfeeding;
- age up to 12 years;
- individual intolerance to the components of the drug.
A relative contraindication is chronic renal failure (Fexofast is used under medical supervision).
Instructions for the use of Fexofast: method and dosage
Fexofast is taken orally.
Frequency rate of application - 1 time per day.
Recommended single dose:
- seasonal allergic rhinitis: 120 mg;
- chronic urticaria: 180 mg.
In chronic renal failure, Fexofast is prescribed in a daily dose of 60 mg once.
Side effects
Possible side reactions: dizziness, headache, nausea, drowsiness: rarely (less than 1 case out of 1000 appointments) - insomnia, fatigue, sleep disturbance, nervousness; in some cases - urticaria, skin rash, pruritus, other hypersensitivity reactions (including angioedema, shortness of breath).
Overdose
The main symptoms are dizziness, dry mouth and drowsiness.
Therapy: standard measures aimed at removing the unabsorbed drug from the gastrointestinal tract; symptomatic / supportive treatment. Hemodialysis is not effective.
special instructions
Influence on the ability to drive vehicles and complex mechanisms
The question of the possibility of driving vehicles during therapy with Fexofast is decided individually based on the reaction to taking the drug, which is associated with the possibility of developing adverse reactions.
Application during pregnancy and lactation
According to the instructions, Fexofast is not prescribed during pregnancy / lactation.
Pediatric use
Fexofast therapy is contraindicated in patients under 12 years of age.
With impaired renal function
Chronic renal failure: Fexofast is prescribed under medical supervision.
Drug interactions
Possible interactions:
- erythromycin, ketoconazole: the plasma concentration of fexofenadine increases significantly;
- aluminum or magnesium-containing antacids (taken 15 minutes before taking Fexofast): the bioavailability of fexofenadine decreases, the recommended interval is at least 120 minutes.
Analogs
Feksofast's analogues are Feksadin, Dinox, Beksist-Sanovel, Telfadin, Allerfex, Telfast, Allegra, Gifast.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Fexofast
According to reviews, Fexofast effectively relieves the symptoms of allergic reactions. It is noted that the drug has a long-term effect and does not cause drowsiness. In some cases, they indicate the high cost and lack of therapeutic action.
The price of Fexofast in pharmacies
The approximate price of Fexofast (10 tablets of 120 or 180 mg) is 201-236 or 238-252 rubles.
Fexofast: prices in online pharmacies
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Drug name Price Pharmacy |
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Fexofast 120 mg film-coated tablets 10 pcs. 212 r Buy |
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Fexofast tablets p.o 120mg 10pcs 238 r Buy |
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Fexofast tablets p.p. 120mg 10 pcs. 246 r Buy |
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Fexofast 180 mg film-coated tablets 10 pcs. 273 r Buy |
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Fexofast tablets p.p. 180mg 10 pcs. 275 RUB Buy |
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Fexofast tablets p / o 180mg 10 pcs. 279 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
