Ethoxidol
Ethoxidol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Ethoxidol
ATX code: C01EB, N07XX
Active ingredient: Ethylmethylhydroxypyridine malate (Ethlvlmethylhydroxypyridine malate)
Producer: Sintez, JSC (Russia), Medimex, JSC (Russia)
Description and photo update: 2018-17-05
Prices in pharmacies: from 475 rubles.
Buy
Etoxidol is a drug with anxiolytic, anticonvulsant, antitoxic, membrane-protective, nootropic action.
Release form and composition
Dosage forms of Ethoxidol release:
- chewable tablets: flat-cylindrical, scored and chamfered, white or white with a creamy shade, marbling, inclusions and slight surface roughness are acceptable (10 pcs. in blisters, in a cardboard box 1, 2 or 5 packs; in polymer jars 10, 20 or 50 pcs., In a cardboard box 1 jar);
- solution for intravenous (intravenous) and intramuscular (intramuscular) administration: yellowish-brown or colorless (in glass ampoules of 2 or 5 ml, in a cardboard box of 10 ampoules or 2 blister packs of 5 ampoules each).
Composition of 1 tablet Ethoxidol:
- active substance: ethylmethylhydroxypyridine malate - 100 mg;
- auxiliary components: acetylglutamic acid - 68 mg; deanol - 32 mg; glycine - 20 mg; microcrystalline cellulose - 260.1 mg; povidone - 1.6 mg; lactose monohydrate - 36 mg; pregelatinized starch 30 mg; colloidal silicon dioxide - 9.5 mg; magnesium stearate - 6 mg; croscarmellose sodium - 12.8 mg; sodium cyclamate - 18 mg; orange flavor 6 mg
Composition of 1 ml of Ethoxidol solution:
- active substance: ethylmethylhydroxypyridine malate - 50 mg;
- auxiliary components: acetylglutamic acid - 34 mg; deanol - 16 mg; glycine - 0.1 mg; edetate disodium - 0.5 mg; water for injection - up to 1 ml.
Pharmacological properties
Pharmacodynamics
Ethoxidol is one of the inhibitors of free radical processes; has anxiolytic, anticonvulsant, antitoxic, membrane-protective, nootropic effect, increases the body's resistance to stress. Improves blood flow in the ischemic zone, has anti-ischemic properties, exhibits a hypolipidemic effect, limits the zone of ischemic damage, reduces the content of low density lipoproteins and total cholesterol.
Etoxidol increases the body's resistance to the effects of various damaging factors, to oxygen-dependent pathological conditions (ischemia and hypoxia, shock, cerebral circulation disorders, intoxication with antipsychotic drugs and alcohol).
Due to the use of the drug, cerebral metabolism, blood supply to the brain, rheological properties of blood and microcirculation are improved, platelet aggregation decreases, and membrane structures of blood cells (platelets and erythrocytes) are stabilized during hemolysis.
The mechanism of action of Ethoxidol is due to its antioxidant, membrane-protective and antihypoxant effects. It reduces membrane viscosity, inhibits lipid peroxidation, increases membrane fluidity, superoxide oxidase activity and lipid-protein ratio. It modulates the activity of membrane-bound enzymes (adenylate cyclase, calcium-independent phosphodiesterase, acetylcholinesterase), receptor complexes, which leads to an increase in their ability to bind to ligands, improves synoptic transmission, transport of neurotransmitters, and preserves the structural and functional organization of biomembranes.
Pharmacokinetics
After oral administration, ethylmethylhydroxypyridine malate is completely and rapidly absorbed from the gastrointestinal tract, the average rate is 0.569 ± 0.086 hours. After taking 100 mg of Ethoxidol, C max (maximum concentration of the substance) in blood plasma is reached after 0.28 ± 0.08 hours and is 487 ± 72.4 ng / ml, after which the substance is rapidly excreted. T 1/2 (half-life) is 1.46 ± 0.13 hours.
Ethoxidol is rapidly distributed throughout the organs and tissues of the body. It is determined in blood plasma for 7-10 hours.
The drug undergoes intensive metabolism in the liver with the formation of phosphate-3-hydroxypyridine, glucuronoconjugated products.
After i / m administration, Etoxidol is determined in blood plasma for 4 hours. C max with the introduction of 100 mg is in the range of 0.3–1.06 μg / ml, the time to reach it is 0.25 hours.
Ethylmethylhydroxypyridine malate from the bloodstream quickly passes into tissues and organs and is quickly eliminated from the body. The retention time of Ethoxidol is from 1.84 to 2.38 hours.
T 1/2 - 1.15-1.75 hours. The substance is excreted from the body by the kidneys, mainly in the form of glucuronides, unchanged - in a small amount.
Indications for use
Chewable tablets
- coronary heart disease (along with other drugs);
- ischemic stroke (along with other drugs);
- mild to moderate cognitive disorders;
- encephalopathy.
Injection solution
- cerebral circulation disorders in acute course;
- encephalopathy;
- vegetative dystonia syndrome;
- anxiety disorders in neurosis-like / neurotic states;
- cognitive disorders of atherosclerotic genesis in mild course;
- intoxication with antipsychotic drugs in acute course;
- withdrawal syndrome in alcoholism with a predominance of vegetative-vascular and neurosis-like disorders (relief).
Contraindications
Absolute:
- pregnancy and the period of breastfeeding;
- age up to 18 years;
- individual intolerance to any component of the drug.
Additionally for chewable tablets Ethoxidol:
- acute renal / hepatic impairment;
- lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
Ethoxidol injection solution in patients with a history of allergic diseases / reactions should be used under medical supervision.
Instructions for use of Ethoxidol: method and dosage
Chewable tablets
Ethoxidol is taken orally. The tablets must be chewed and then washed down with water.
Recommended dosage regimen:
- complex therapy of ischemic heart disease, therapy of ischemic stroke: 3 times a day, 1 tablet with a further increase in the dose to an effective one. The maximum single dose is 2 tablets, the daily dose is 8 tablets. The duration of the course is at least 2 months, the doctor may prescribe a second course;
- complex therapy of cognitive disorders: 3-4 times a day, 1 tablet, the duration of use has no restrictions.
Injection solution
Ethoxidol can be administered intramuscularly and intravenously (drip or jet).
The dose is determined individually. Therapy begins with 50-100 mg 1-3 times a day, gradually increasing the dose to an effective one.
Before infusion, the drug is diluted in 0.9% sodium chloride solution.
Intravenous stream Ethoxidol is injected slowly over 5-7 minutes, the drip rate is 40-60 drops / min.
The maximum daily dose is 800 mg.
Recommended dosage regimen:
- acute disorders of cerebral circulation: in the first 2-4 days i.v. (drip) 200-300 mg, then i / m 3 times a day, 100 mg. Duration of use - from 10 to 14 days;
- discirculatory encephalopathy in the decompensation phase: IV (drip or jet) 2-3 times a day, 100 mg for 14 days, then 100 mg / m 2 times a day in the same course;
- course prevention of discirculatory encephalopathy: intramuscularly 2 times a day, 100 mg. Duration of use - from 10 to 14 days;
- mild cognitive impairment in elderly patients and with anxiety disorders: i / m, 100-300 mg per day. Duration of use - from 14 to 30 days;
- alcohol withdrawal syndrome: i / m 2-3 times a day, 100-200 mg, or i / v drip 1-2 times a day for a course of 5 to 7 days;
- acute intoxication with antipsychotic drugs: intravenous injection of 50–300 mg per day for a course of 7 to 14 days.
Side effects
Chewable tablets
Ethoxidol is generally well tolerated. In rare cases, the following disorders may occur: allergic reactions, dyspepsia, nausea and xerostomia, diarrhea (as a rule, they quickly pass on their own or after drug withdrawal).
During a long course, sleep disturbances (in the form of drowsiness or sleep disturbance) and flatulence may occur.
Injection solution
Possible disorders: metallic taste / dry mouth, unpleasant odor, feeling of spreading warmth throughout the body, feeling short of breath, discomfort in the chest, sore throat (as a rule, these side reactions are of a short-term nature and are associated with an excessively high injection rate) …
During a long course, sleep disturbances (in the form of drowsiness or sleep disturbance), nausea and flatulence may occur.
Overdose
Chewable tablets
The development of an overdose is unlikely, due to the low toxicity of Ethoxidol.
The main symptoms: sleep disturbances (in the form of drowsiness, insomnia).
Conducting symptomatic therapy is shown.
Injection solution
The main symptoms are: sleep disturbances (in the form of insomnia, sometimes drowsiness); with the on / in the introduction - a short (no more than 1.5-2 hours) and a slight increase in blood pressure.
Overdose symptoms usually disappear on their own within 24 hours and do not require therapy. In severe cases of insomnia, 10 mg nitrazepam, 10 mg oxazepam, or 5 mg diazepam are prescribed. With an excessive increase in blood pressure, drugs with an antihypertensive effect under the control of blood pressure are indicated.
special instructions
Influence on the ability to drive vehicles and complex mechanisms
Patients during the period of therapy when driving vehicles should be careful.
Application during pregnancy and lactation
According to the instructions, Ethoxidol is not prescribed to women during pregnancy / lactation.
Pediatric use
For patients under the age of 18, therapy is contraindicated.
With impaired renal function
Chewable tablets are not prescribed for patients with acute renal failure.
For violations of liver function
Chewable tablets are not prescribed for patients with acute liver failure.
Drug interactions
Possible interactions:
- antiparkinsonian drugs (levodopa), drugs with antiepileptic action (carbamazepine), benzodiazepine anxiolytics: increasing their action;
- nitro drugs: increasing their antianginal activity;
- angiotensin-converting enzyme inhibitors, beta-blockers: increasing their antihypertensive action;
- ethyl alcohol: reducing its toxic effects.
Analogs
There is no information on Ethoxidol analogues.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life:
- chewable tablets - 3 years;
- injection solution - 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Ethoxidol
According to a few reviews, Ethoxidol is an effective drug. It is noted that the agent reduces intoxication in case of alcohol poisoning. The development of adverse reactions is rarely reported.
Price for Ethoxidol in pharmacies
The approximate price for Ethoxidol is:
- chewable tablets (20 or 50 pcs. per pack): 615–662 or 1480–1547 rubles;
- injection solution (10 ampoules of 2 ml per pack): 635-750 rubles.
Etoxidol: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Ethoxidol 100 mg chewable tablets 20 pcs. 475 RUB Buy |
|
Ethoxidol 50 mg / ml solution for intravenous and intramuscular administration 2 ml 10 pcs. 585 RUB Buy |
|
Ethoxidol solution for intravenous and intramuscular injection. 50mg / ml 2ml 10 pcs. 683 r Buy |
|
Ethoxidol tab. chewing 100mg n20 684 r Buy |
|
Ethoxidol 50 mg / ml solution for intravenous and intramuscular administration 5 ml 10 pcs. 1387 RUB Buy |
|
Ethoxidol 100 mg chewable tablets 50 pcs. 1479 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
