Etatsizin
Instructions for use:
- 1. Composition and form of release
- 2. Pharmacological action
- 3. Indications for use
- 4. Instructions for use
- 5. Contraindications to use
- 6. Side effects
- 7. Interaction
- 8. Terms and conditions of storage
Prices in online pharmacies:
from 1297 rub.
Buy
Etacizin is a class 1C antiarrhythmic drug. Most reviews of Etacizin mention high pharmacotherapeutic efficacy and clinical safety of the drug.
Amiocordin, Amiodarone, Asparkam, Arrhythmil, Cordaron, Multak, Panangin, Ritmokard, Propanorm, Thiodarone are Etacizin analogues, included with it in the same pharmacological group.
Composition and form of release
According to the instructions, Etatsizin is available in the form of round tablets (0.05 g each), as well as in the form of a 2.5% solution for injection (2 ml ampoules).
Each tablet contains 0.05 g of carboethoxyaminodiethylaminopropionyl phenothiazine hydrochloride, as well as auxiliary components (methylcellulose, potato starch, sucrose, calcium stearate).
Pharmacological action of Etacizin
Etacizin slightly reduces the frequency of sinus rhythm, slows down atrioventricular, atrial, synotrial and intraventricular conduction. The drug has a moderate coronary dilatory, antispasmodic, anticholinergic and pronounced antiarrhythmic effect.
The action of Etacizin and Etacizin analogues helps to improve the functional state of the heart region with insufficient blood circulation. Etacizin slows down the rate of rise of the action potential front, limiting the conductivity of sodium channels on the outer and inner sides of the cardiomyocyte membrane. In addition, the drug inhibits calcium channels, providing a moderate vagolytic effect. All this slows down the process of conduction of excitation and contributes to the suppression of foci of ectopic automatism in the myocardium of the ventricles and atria.
Etatsizin is found in the blood 30-60 minutes after administration. The maximum plasma concentration is reached after two to three hours. The bioavailability of Etacizin is 40%. The drug is metabolized in the liver and excreted by the kidneys in the form of metabolites. According to the instructions Etatsizin freely penetrates into breast milk, as well as through the placental barrier.
Indications for the use of Etacizin
According to the instructions, the use of Etacizin or Etacizin analogues is indicated for the following diseases:
- Extrasystole (supraventricular and ventricular);
- Paroxysms of atrial flutter and atrial fibrillation;
- Supraventricular and ventricular tachycardia.
Instructions for use
According to the instructions, Etacizin in tablet form should be taken at an initial dose of 50 mg three times a day. If necessary, the dose is increased (under the control of an electrocardiogram) to 50 mg four times a day (0.2 g per day) or 0.1 g three times a day (0.3 g per day). When the effect is achieved, they switch to maintenance treatment in individually selected doses.
Intravenous Etatsizin is administered at a dose of 0.25-1 mg / kg. The contents of the ampoule of the drug are diluted with isotonic sodium chloride solution. The time of intravenous administration of Etatsizin is at least five minutes. Drip administration is considered more effective with less pronounced side effects.
Contraindications to the use of Etacizin
- Synotrial blockade;
- IHD in acute form;
- Pregnancy;
- Heart failure;
- Cardiogenic shock;
- Atrioventricular block (II and III degrees);
- A pronounced decrease in blood pressure;
- Dysfunction of the liver and kidneys;
- Lactation period;
- Children under the age of eighteen.
Judging by the reviews, Etacizin should be used with caution in angle-closure glaucoma, benign prostatic hyperplasia, cardiomegaly, electrolyte imbalance (hyperkalemia, hypokalemia, hypomagnesemia).
Side effect
Some reviews of Etatsizin say that during treatment with this drug, tinnitus, slight drowsiness, impaired vision and coordination of movements, dizziness, staggering while walking may occur.
Judging by the reviews to Etatsizin, when using the drug in maximum doses, the risk of the appearance and development of cardiac side effects - intraventricular, atrioventricular and sinoatrial blockade, proarrhythmic effect, signs of heart failure increases.
Interaction
The use of Etacizin with other antiarrhythmic drugs 1C (propafenone, allapinin) and class IA (aymalin, procainamide, quinidine, disopyramide) is contraindicated.
According to the instructions, the combined use of Etacizin with MAO inhibitors is not recommended.
The simultaneous use of Etacizin and beta-blockers can enhance the antiarrhythmic effect.
Storage conditions and periods
Etacizin is stored in a dry place, protected from sunlight.
The shelf life of ampoules is 1.5 years, tablets - 2 years.
Etatsizin: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Etatsizin 50 mg film-coated tablets 50 pcs. 1297 RUB Buy |
|
Etacizin tablets p.o. 50mg 50 pcs. RUB 1588 Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
