Enduracin
Enduracin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Enduracin
ATX code: C10AD02
Active ingredient: nicotinic acid (Nicotinic acid)
Manufacturer: Endurance Products Co. (Endurance Products Co.) (USA)
Description and photo update: 2020-16-04
Enduracin is a vitamin and lipid-lowering agent.
Release form and composition
Dosage form - prolonged-release tablets: oval, white with yellowish blotches, have a specific smell (in a cardboard box, instructions for the use of Enduracin and 1 opaque polymer bottle containing 30 or 100 pcs.).
Composition of 1 tablet:
- active substance: nicotinic acid - 500 mg;
- auxiliary components: magnesium stearate, purified monoglyceride, carnauba wax.
Pharmacological properties
Pharmacodynamics
Enduracin is a tablet form of nicotinic acid on a wax matrix, due to which the active substance is evenly released and absorbed within 6-8 hours. As a result of this prolonged release, the effectiveness of the drug increases and the number of side effects decreases.
Nicotinic acid is a biologically active substance that participates in many metabolic processes in the human body. In small doses it has a vitamin effect, in large doses it is anti-sclerotic. The drug promotes the expansion of blood vessels, especially small ones, enhances blood microcirculation, has a small anticoagulant effect.
Pharmacokinetics
After oral administration, nicotinic acid is absorbed in the gastrointestinal tract within 6-8 hours. During the first hour, about half of the drug is absorbed, by the eighth hour after administration, about 96%.
In the human body, the drug is metabolized and excreted by the kidneys.
Indications for use
Enduracin is used in the complex therapy of the following diseases:
- cerebrovascular insufficiency;
- chronic ischemic heart disease (stable angina pectoris, atherosclerotic cardiosclerosis, a condition after unstable angina pectoris or myocardial infarction);
- lipid metabolism disorders: hypoalphacholesterolemia with high density lipoprotein cholesterol less than 35 mg / dl (less than 0.9 mmol / l)
- hypercholesterolemia with a total cholesterol concentration of 200–300 mg / dL (5.2–7.8 mmol / L), hypertriglyceridemia with a blood triglyceride concentration of 200–400 mg / dL (2.3–4.6 mmol / L).
Contraindications
Absolute:
- severe arterial hypertension;
- type I and II diabetes mellitus;
- gout;
- nephrolithiasis;
- hyperuricemia;
- chronic hepatitis or cirrhosis of the liver of any genesis;
- peptic ulcer of the stomach and duodenum, including in the phase of remission;
- age up to 18 years;
- period of pregnancy and lactation;
- hypersensitivity to any component of the drug.
Relative (Enduracin should be used with caution): hyperacid gastritis, hemorrhages.
Enduracin, instructions for use: method and dosage
Enduracin should be taken with or after a meal, swallowing the tablets whole without chewing or breaking, with sufficient amount of non-hot water.
With cerebrovascular insufficiency and coronary heart disease, the recommended initial dose is 500 mg (1 tablet) once a day. After one week, the dose is increased to 1000 mg per day (1 tablet in the morning and in the evening). From the third week, 1500 mg per day is prescribed (3 tablets). After 3 months of regular intake of Enduracin, a biochemical blood test (uric acid, glucose, alkaline phosphatase, lipids, transaminases) is required. In case of insufficient severity of the therapeutic effect, treatment is continued in a daily dose of 2000–3000 mg (4–6 tablets) for 1–2 months. After the therapeutic effect is achieved, a break in treatment is allowed for 1 month, after which a second course is carried out for 2.5–3 months.
Recommended dose for lipid metabolism disorders:
- moderate dyslipidemia in the presence of risk factors - 500–1000 mg per day;
- isolated hypoalphacholesterolemia - 1000 mg per day.
Side effects
Adverse drug reactions that occur when taking Enduracin in therapeutic doses:
- from the skin and subcutaneous tissues: dry skin, redness of the facial skin, burning sensation, itching, allergic reactions;
- from the digestive system: exacerbation of gastric ulcer and duodenal ulcer, diarrhea, nausea, vomiting;
- from the central nervous system: headache, dizziness, paresthesia;
- on the part of the cardiovascular system: orthostatic hypotension, arrhythmia;
- from the musculoskeletal system: myalgia;
- laboratory data: increased activity of transaminases, uric acid and glucose in blood plasma.
With prolonged use of Enduracin, the following disorders are possible: asthenia, fatty degeneration of the liver, increased concentration of alkaline phosphatase and lactate dehydrogenase in the blood, decreased glucose tolerance.
Overdose
No information available.
special instructions
Drug therapy should always be started with a small dose and gradually increased.
Periodically during treatment (every 2 months), a medical examination is required. Cholesterol levels should be monitored at least every 3–6 months.
In the event of side effects, it is required to reduce the dose of Enduracin or take a break in treatment for 3-7 days, and then resume taking the drug at a lower dose.
If you experience severe itching or headache, it is recommended to pre-take 125 mg of acetylsalicylic acid.
Influence on the ability to drive vehicles and complex mechanisms
Enduracin causes dizziness in some patients, this should be taken into account when driving a car and performing potentially dangerous types of work.
Application during pregnancy and lactation
Enduracin tablets are contraindicated during pregnancy and lactation.
Pediatric use
The drug is not used to treat children and adolescents under 18 years of age.
With impaired renal function
Enduracin is contraindicated for nephrolithiasis.
For violations of liver function
Enduracin tablets are contraindicated for chronic hepatitis and liver cirrhosis of any genesis.
Use in the elderly
There is no need to change the dose of the drug depending on the age of the patient.
Drug interactions
Enduracin should be used with caution in conjunction with anticoagulants, acetylsalicylic acid and antihypertensive drugs, since nicotinic acid can enhance their effect.
Lipid-lowering drugs of other groups, when used together, can enhance the toxic effects of Enduracin.
Analogs
Analogues of Enduracin are Nicotinic acid, Nicotinic acid - SOLOpharm, Nicotinic acid-Vial, Nicotinic acid bufus.
Terms and conditions of storage
Store at temperatures up to 25 ° C in a dry, dark place. Keep out of the reach of children.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Enduracin
On specialized medical sites and forums, there are no reviews about Enduracin, which would lead to a conclusion about the effectiveness and tolerability of the drug.
Enduracin price in pharmacies
At the moment, the price of Enduracin is unknown, since the drug is not available in pharmacies. Latest online pharmacy price for 500 mg tablets, 100 pcs. in the package - 336 rubles.
The cost of an analogue preparation: Nicotinic acid, tablets 50 mg, 50 pcs. in the package - 21–39 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
