Propazin - Instructions For Use, Reviews, Price, Tablet Analogs

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Propazin - Instructions For Use, Reviews, Price, Tablet Analogs
Propazin - Instructions For Use, Reviews, Price, Tablet Analogs

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Propazin

Propazin: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  11. 11. In case of impaired renal function
  12. 12. For violations of liver function
  13. 13. Use in the elderly
  14. 14. Drug interactions
  15. 15. Analogs
  16. 16. Terms and conditions of storage
  17. 17. Terms of dispensing from pharmacies
  18. 18. Reviews
  19. 19. Price in pharmacies

Latin name: Propazinum

ATX code: N05AA03

Active ingredient: promazin (Promazine)

Manufacturer: Tatkhimfarmpreparaty, JSC (Russia)

Description and photo update: 2019-26-08

Prices in pharmacies: from 695 rubles.

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Film-coated tablets, Propazin
Film-coated tablets, Propazin

Propazine is an antipsychotic drug (neuroleptic).

Release form and composition

Dosage form Propazin - coated tablets: blue with marbling and blotches, non-uniformity of surface staining is possible; the cross section shows 2 layers (in blister strip packs of 10 pcs., 5 packs in a cardboard box; in cans of 50 pcs., in a cardboard box 1 can).

Active ingredient: promazine, in 1 tablet - 25 or 50 mg.

Auxiliary components: potato starch, dextrose (glucose) monohydrate, stearic acid, lactose (milk sugar), talc, sucrose (sugar), indigo carmine dye.

Pharmacological properties

Pharmacodynamics

The active component of Propazin - promazine is included in the group of aliphatic phenothiazine derivatives. Its spectrum of action and chemical structure are similar to chlorpromazine (aminazine), but promazine is less toxic and less active.

The mechanism of antipsychotic action is due to the blocking of postsynaptic mesolimbic dopaminergic receptors in the brain.

Promazin has sedative and antipsychotic efficacy, inferior in strength to chlorpromazine, reduces physical activity, has a hypothermic, antiemetic and hypotensive effect. Its peripheral adrenergic and anticholinergic action is similar to chlorpromazine; on antihistaminic properties the drug is superior to chlorpromazine. Propazine has less pronounced side effects than chlorpromazine (in the form of akathisia, lethargy, depression, lethargy, apathy, somatovegetative and extrapyramidal disorders).

With combined use, it increases the intensity and duration of the action of antihypertensive, hypnotic, narcotic, analgesic, antihistamines and alcohol.

Pharmacokinetics

Promazin is well absorbed after oral administration. The maximum concentration of the substance is reached in 2–4 hours.

Binds to proteins at 90%. Metabolism occurs in the liver with the formation of inactive metabolites. The excretion of promazin is carried out mainly by the kidneys.

Indications for use

  • Psychotic disorders of any etiology;
  • Acute and chronic psychoses, accompanied by delusional disorders, hallucinations, psychomotor agitation;
  • Agitated depression;
  • Manic states;
  • Other mental illnesses (neuroses, reactive states, psychopathies) accompanied by fear, tension, insomnia, impulsive attacks, agitation;
  • Withdrawal syndrome (in drug addiction practice);
  • Vomiting of various etiologies (as an antiemetic).

Depending on the indications, Propazin can be used as a monopreparation or in combination with other psychotropic drugs.

Contraindications

Absolute:

  • Myxedema;
  • Progressive systemic diseases of the brain and spinal cord;
  • Brain trauma;
  • Depression of the function of the central nervous system and coma of any etiology;
  • Closed-angle glaucoma;
  • Bronchiectasis in the stage of decompensation;
  • Severe arterial hypotension;
  • Diseases of the heart in the stage of decompensation (rheumatic heart disease, myocardial dystrophy, heart defects, etc.);
  • Diseases accompanied by the risk of thromboembolic complications;
  • Hyperplasia of the prostate;
  • Peptic ulcer and 12 duodenal ulcer in the period of exacerbation;
  • Diseases of the kidneys, liver and hematopoietic organs with dysfunction;
  • Lactase deficiency, galactose intolerance, glucose-galactose malabsorption;
  • Children under 12 years of age;
  • Pregnancy;
  • Breast-feeding;
  • Increased individual sensitivity to the components of Propazin.

Carefully:

  • Active alcoholism;
  • Epilepsy;
  • Cachexia;
  • Reye's syndrome;
  • Parkinson's disease;
  • Chronic diseases accompanied by respiratory failure (especially in adolescents over 12 years old);
  • Mammary cancer;
  • Elderly age.

Instructions for use of Propazin: method and dosage

Propazin tablets should be taken orally after meals.

Depending on the clinical situation, appoint 25-100 mg 2-4 times a day. If the severity of the antipsychotic action is not enough, the daily dose is gradually increased to 500-1000 mg.

The maintenance dose of Propazine is 50-150 mg 1-2 times a day.

Teenagers over 12 years old are prescribed 25 mg every 4-6 hours, if necessary, the dose is adjusted.

Weak and malnourished patients, as well as the elderly, usually require a lower starting dose. Further, if the need arises, it is gradually increased.

Side effects

Compared with the frequently used chlorpromazine, promazine is better tolerated and causes fewer side effects.

At the beginning of treatment, there may be: dizziness, drowsiness, accommodation disturbances (blurred vision), sleep disturbances, dry mouth, anorexia, gastralgia, nausea, vomiting, constipation, tachycardia, moderate orthostatic hypotension, nasal congestion, difficulty urinating.

In rare cases, the following side effects of Propazin are noted: allergic reactions, angioedema, cholestatic jaundice, retinopathy pigmentosa, impaired thermoregulation (heat stroke), heart rhythm disturbances, photosensitivity of the skin, weight gain, galactorrhea, decreased sexual potency, priapism, menstrual irregularities, melanosis, agranulocytosis, leukopenia, as well as the phenomenon of delayed reaction to external stimuli, the phenomenon of mental indifference and other changes in the psyche.

With prolonged use, extrapyramidal disorders (akinetic phenomena, autonomic disturbances, hyperkinesia, akathisia, tremor, dyskinesias) are possible, in some cases - convulsions. Antiparkinsonian drugs are used as correctors for these phenomena. Caffeine sodium (subcutaneously 2 ml of a 20% solution) and atropine (subcutaneously 1 ml of a 0.1% solution) help to relieve dyskinesia.

In extremely rare cases, it is possible to develop neuroleptic malignant syndrome.

Overdose

The main symptoms: hyperreflexia or areflexia, blurred vision, cardiotoxic effect (in the form of ventricular fibrillation, tachycardia, changes in the QRS wave, arrhythmia, heart failure, shock, lowering blood pressure, cardiac arrest), neurotoxic effect (including agitation, confusion, convulsions, disorientation, drowsiness, mydriasis, xerostomia, hypothermia or hyperpyrexia, vomiting, stupor or coma, muscle rigidity, respiratory depression, or pulmonary edema).

Therapy: gastric lavage, intake of activated charcoal. Induction of vomiting should be avoided, since in case of overdose disturbances of consciousness and dystonic reactions from the muscles of the neck and head, aspiration of vomit is possible.

Symptomatic therapy:

  • arrhythmia: phenytoin (intravenously at a dose of 9-11 mg / kg);
  • convulsions: diazepam;
  • heart failure: cardiac glycosides;
  • marked decrease in blood pressure: intravenous fluid or vasopressor drugs (phenylephrine, norepinephrine). The use of alpha and beta adrenergic agonists such as epinephrine should be avoided;
  • parkinsonism: diphenhydramine, diphenyltropine.

Also, in case of an overdose for at least 5 days, control of the function of the cardiovascular and central nervous systems, respiration, measurement of body temperature is shown. Consultation of a psychiatrist is recommended.

Dialysis is ineffective.

special instructions

During treatment, it is necessary to carefully monitor blood pressure and pulse, constantly examine the functions of the kidneys and liver, the picture of peripheral blood, and conduct ophthalmological examinations.

It should be borne in mind that Propazine, used as an antiemetic, can mask vomiting caused by an overdose of other drugs.

Due to the risk of developing photosensitivity during treatment, one should not be exposed to ultraviolet radiation.

During treatment it is forbidden to consume alcoholic beverages

Influence on the ability to drive vehicles and complex mechanisms

During the period of therapy, you can not drive vehicles and perform potentially dangerous types of work that require high attention and speed of reactions.

Application during pregnancy and lactation

According to the instructions, Propazin is not prescribed during pregnancy / lactation.

Pediatric use

Propazin therapy is contraindicated in patients under 12 years of age.

In children over 12 years of age with chronic diseases accompanied by respiratory failure, care must be taken during the period of drug use.

With impaired renal function

Propazin is contraindicated in kidney diseases accompanied by impaired function.

For violations of liver function

Propazin is contraindicated in liver diseases, accompanied by a violation of their function.

Use in the elderly

In elderly patients, therapy should be carried out with caution.

Drug interactions

Possible interaction reactions in case of the simultaneous use of Propazin with other drugs:

  • Other substances that have a depressing effect on the central nervous system (alcohol and ethanol-containing drugs, narcotic analgesics, barbiturates, anesthetics, tranquilizers, etc.): increased depression of the central nervous system and respiratory depression;
  • Other drugs that cause extrapyramidal reactions: the frequency and severity of extrapyramidal disorders increases;
  • Epinephrine (adrenaline): the effect of epinephrine may be perverted, which can lead to a drop in blood pressure (this combination should be avoided);
  • Tricyclic antidepressants, monoamine oxidase inhibitors, maprotiline: the risk of neuroleptic malignant syndrome increases;
  • Anticonvulsants: the seizure threshold is lowered;
  • Drugs for the treatment of hyperthyroidism: the risk of agranulocytosis increases;
  • Antihypertensive drugs: there is a likelihood of severe orthostatic hypotension;
  • Ephedrine: its vasoconstrictor effect is weakened;
  • Apomorphine: its emetic effect decreases, the inhibitory effect on the central nervous system increases;
  • Means that reduce appetite (with the exception of fenfluramine): their effectiveness decreases;
  • Amphetamine, clonidine, guanethidine: their effect may be suppressed;
  • Bromocriptine: an increase in the concentration in the blood plasma of prolactin and a decrease in its action is possible;
  • Levodopa: its antiparkinsonian effect decreases;
  • Antiparkinsonian drugs, antacids, lithium preparations: absorption of promazine is disturbed;
  • Prochlorperazine: Prolonged loss of consciousness may occur.

It is necessary to avoid the simultaneous use of antidiarrheal and adsorbing agents.

Propazine enhances the anticholinergic effects of other concomitantly used drugs, while its antipsychotic effect may decrease.

Analogs

Analogs of Propazin are: Aminazin, Promazin, Mazheptil, Tizercin, Frenolone, Triftazin, Eperazin.

Terms and conditions of storage

Store in a dry, dark place at temperatures up to 25 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Propazin

There are few reviews about Propazin. In some of them, patients believe that the drug has the claimed therapeutic effect. It quickly relieves psychosis, hysteria, and other mental illnesses, is effective in withdrawal symptoms, but you need to carefully follow the doctor's prescription to avoid overdose.

Other users are dissatisfied with the effectiveness of Propazine, and also indicate the development of pronounced side reactions, manifested mainly as drowsiness and lethargy.

The price of Propazin in pharmacies

The approximate price of Propazin for a package of 50 tablets of 25 mg is 576-711 rubles.

Propazin: prices in online pharmacies

Drug name

Price

Pharmacy

Propazin 25 mg film-coated tablets 50 pcs.

695 RUB

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Propazin tablets p.p. 25mg 50 pcs.

728 RUB

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Anna Kozlova
Anna Kozlova

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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