Pentalgin-N
Pentalgin-N: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Pentalginum-N
ATX code: N02BB72
Active ingredient: codeine + caffeine + metamizole sodium + naproxen + phenobarbital (codeine + caffeine + metamizole sodium + naproxen + phenobarbital)
Producer: Pharmstandard-Tomskkhimfarm, JSC (Russia)
Description and photo updated: 22.11.2018
Pentalgin-N is a combined preparation with analgesic, antipyretic and anti-inflammatory effects.
Release form and composition
Dosage form Pentalgin-N - tablets: flat-cylindrical, from white to white with a cream or yellowish tinge, with the abbreviated name of the drug "PENT-N" printed on one side (in a cell or non-cell contour packaging 10 pcs., In a cardboard box 1 or 2 packs).
Composition of one tablet:
- active substances: analgin (metamizole sodium) - 300 mg, naproxen - 100 mg, caffeine - 50 mg, phenobarbital - 10 mg, codeine (in the form of codeine or codeine phosphate) - 8 mg;
- auxiliary components: potato starch, low molecular weight povidone (medical low molecular weight polyvinylpyrrolidone), sodium citrate, magnesium stearate.
Pharmacological properties
Pharmacodynamics
Pentalgin-N contains active substances with analgesic, antispasmodic, antipyretic, anti-inflammatory and sedative effects.
Metamizole sodium is a pyrazolone derivative. It has analgesic and antipyretic effects.
Naproxen, being a non-steroidal anti-inflammatory agent, has anti-inflammatory, analgesic and antipyretic properties, which are due to non-selective inhibition of the activity of the cyclooxygenase enzyme, which is responsible for the production of prostaglandins from arachidonic acid.
Caffeine helps to dilate the blood vessels of skeletal muscle tissue, heart, brain, kidneys, increase physical and mental performance, reduce fatigue and sleepiness. By increasing the permeability of histohematogenous barriers and increasing the bioavailability of non-narcotic analgesics, caffeine enhances their therapeutic effect.
Codeine has the property of stimulating opioid receptors in various parts of the central nervous system, leading to the activation of the antinociceptive system and an improvement in pain perception at the emotional level.
Phenobarbital and codeine increase the analgesic effect of sodium metamizole and naproxen.
Pharmacokinetics
The active substances of the drug are well absorbed in the gastrointestinal tract.
Some pharmacokinetic characteristics of the active ingredients of Pentalgin-N:
- metamizole sodium: hydrolyzes in the intestinal wall, forming an active metabolite 4-methyl-amino-antipyrine, which is metabolized, in turn, into 4-formyl-amino-antipyrine and other metabolites. 50-60% of the active metabolite binds to blood plasma proteins. The substance can pass into breast milk. Excreted metabolites in the urine;
- naproxen: bioavailability is 95%, binds to blood plasma proteins. The half-life (T1 / 2) is 12 to 15 hours. It is excreted mainly by the kidneys in the form of a metabolite (dimethylnaproxen), with bile - in small quantities;
- caffeine: well absorbed in the intestines. T1 / 2 is 5 hours (in some cases - up to 10 hours). It is excreted mainly in the urine in the form of metabolites, unchanged - approximately 10%;
- phenobarbital: bioavailability is about 80%, about 50% binds to blood plasma proteins. It has the ability to penetrate well through the placental barrier. Metabolism occurs in the liver with the formation of metabolites, the main of which has no pharmacological activity. It is excreted in the urine, including unchanged form - 20-25%;
- codeine: it binds slightly to blood plasma proteins. Metabolized in the liver. By demethylation, 10% of the substance is converted to morphine. It is excreted mainly by the kidneys, unchanged - 5-15%.
Indications for use
- pain syndrome of various origins of mild and moderate severity (including headache, neuralgia, migraine, pain in muscles, joints, sciatica, toothache, algodismenorrhea);
- colds and other illnesses accompanied by fever, inflammation and pain.
Contraindications
Absolute:
- severe renal and / or liver dysfunction;
- anemia, leukopenia;
- bronchial asthma, bronchospasm;
- respiratory depression;
- stomach and / or duodenal ulcer in the acute stage;
- severe arterial hypertension;
- acute myocardial infarction;
- arrhythmias;
- traumatic brain injury;
- glaucoma;
- deficiency of glucose-6-phosphate dehydrogenase;
- state of alcoholic intoxication;
- children under 12 years old;
- pregnancy, lactation period;
- increased individual sensitivity to any component that is part of Pentalgin-N.
Relative (use of the drug requires caution):
- arterial hypertension of mild to moderate severity;
- peptic ulcer and / or duodenal ulcer in remission;
- elderly age.
Instructions for the use of Pentalgin-N: method and dosage
Pentalgin-N tablets are taken orally.
It is recommended to take 1 tablet 1-3 times a day. The maximum daily dose is 4 tablets.
Without a doctor's recommendation, you should not take the drug for more than 5 days as an analgesic and for more than 3 days as an antipyretic agent.
Side effects
- from the central nervous system: dizziness, drowsiness;
- from the digestive system: nausea, vomiting, pain in the epigastric region, constipation; with prolonged intake of high doses - liver dysfunction;
- on the part of the cardiovascular system: palpitations;
- from the hematopoietic system: rarely - hematopoietic disorders (granulocytopenia, leukopenia, agranulocytosis);
- from the urinary system: with prolonged use in high doses - impaired renal function;
- allergic reactions: itching, skin rash, urticaria.
Overdose
In case of an overdose of Pentalgin-N, the following symptoms may develop: nausea, vomiting, drowsiness, weakness, gastralgia, cardiac arrhythmias, tachycardia, delirium, respiratory depression.
Treatment in case of an overdose consists in the induction of vomiting, gastric lavage through a tube, the use of adsorbents (for example, activated carbon), symptomatic therapy aimed at maintaining the functioning of vital organs.
special instructions
While taking Pentalgin-N, it may be difficult to establish a diagnosis in case of acute abdominal pain syndrome.
In patients with hay fever and atopic bronchial asthma, the risk of hypersensitivity reactions increases with the use of the drug.
In the case of long-term (more than five days) administration of Pentalgin-N, it is necessary to monitor liver function indicators and a picture of peripheral blood.
During the period of use of the drug, the results of doping control in athletes may change.
Influence on the ability to drive vehicles and complex mechanisms
Since Pentalgin-N can cause such adverse reactions as dizziness and drowsiness, while taking the tablets, you should refrain from driving vehicles and performing potentially hazardous activities that require increased concentration of attention and a quick psychomotor reaction.
Application during pregnancy and lactation
According to the instructions, Pentalgin-N is contraindicated for use by pregnant and breastfeeding women.
If it is necessary to use the drug during the lactation period, breastfeeding should be discontinued.
Pediatric use
It is prohibited to prescribe Pentalgin-N to children under 12 years of age.
With impaired renal function
It is contraindicated to take the drug in patients with severe renal impairment.
For violations of liver function
In case of severe violations of liver function, it is not recommended to prescribe Pentalgin-N.
Use in the elderly
Elderly patients should be careful when taking the drug.
Drug interactions
The use of Pentalgin-N simultaneously with certain drugs can lead to the development of the following effects:
- non-opioid analgesics: increased toxic effects;
- allopurinol, tricyclic antidepressants, oral contraceptives: increased toxicity of metamizole sodium;
- phenylbutazone, barbiturates and other drugs causing the induction (increase in the rate of synthesis) of microsomal liver enzymes: weakening the action of metamizole sodium;
- cyclosporine: decrease in its level in the blood;
- tranquilizers and sedatives: enhancing the analgesic effect of the drug.
Analogs
Pentalgin-N analogs are Piralgin, Pentalgin, Baralgin M, Maksigan, Spazmalin, Sedalgin plus, Tetralgin, Banalgin, etc.
Terms and conditions of storage
Store in a dark, dry place at a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Pentalgin-N
There are a lot of reviews about Pentalgin-N, and they are mostly positive. The drug helped almost all who wrote a review to get rid of pain of various origins. Pills have also proven themselves as an antipyretic agent for colds. Users note that the drug acts quickly, the analgesic effect lasts for a fairly long time. Many people prefer to have Pentalgin-N in their home medicine cabinet.
Price for Pentalgin-N in pharmacies
The price of Pentalgin-N for a pack of 10 tablets is approximately 210 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
