Holityline

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Holityline: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. Drug interactions
12. Analogs
13. Terms and conditions of storage
14. Terms of dispensing from pharmacies
15. Reviews
16. Price in pharmacies

Latin name: Cholitilin

ATX code: N07AX02

Active ingredient: choline alfoscerate (choline alfoscerate)

Producer: LLC "Company" DEKO "(Russia), Artlife (Russia), Minskinterkaps (Republic of Belarus)

Description and photo update: 2018-21-11

Prices in pharmacies: from 249 rubles.

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Solution for intravenous and intramuscular administration of Cholytilin

Cholytilin is a nootropic agent.

Release form and composition

Dosage forms of Cholytilin:

solution for intravenous and intramuscular administration: clear, colorless or slightly colored liquid (4 ml in ampoules, in a blister strip packaging 3, 5 or 10 ampoules, in a cardboard box 1-2 packs);
capsules: soft gelatinous, brown, oval; content - oily, colorless or slightly colored transparent liquid (10 or 14 pcs. in blisters, in a cardboard box 1, 2, 3 or 4 packages).

The composition of one ampoule of solution:

active substance: choline alfoscerate polyhydrate (Lipoid GPC 85F) - 1000 mg in terms of choline alfoscerate;
auxiliary components: water for injection, povidone.

Composition of one capsule:

active substance: choline alfoscerate hydrate (L-α-glycerophosphorylcholine) - 400 mg in terms of choline alfoscerate;
auxiliary components: macrogol (polyethylene glycol 400), povidone (plasdon S-15 or kollidon 17 PF), purified water;
shell: gelatin, sorbitol, methyl parahydroxybenzoate, propyl parahydroxybenzoate, glycerol (glycerin), titanium dioxide, purified water, dyes of iron oxide black, iron oxide red and iron oxide yellow.

Pharmacological properties

Pharmacodynamics

Choline alfoscerate is a central anticholinergic stimulant containing 40.5% of metabolically protected choline.

The drug activates the reticular formation, provides synthesis of phosphatidylcholine and acetylcholine in neuronal membranes, enhances metabolic processes, improves blood flow in the central nervous system and increases its linear velocity. It normalizes the spatio-temporal characteristics of spontaneous bioelectrical activity of the brain, restores consciousness, and eliminates focal neurological symptoms. It has a beneficial effect on the behavioral and cognitive reactions of patients with cerebrovascular diseases (for example, discirculatory encephalopathy or residual cerebral circulation disorders).

Cholytilin reduces cholinergic activity, prevents and corrects pathogenetic factors of involutional psychoorganic syndrome. By participating in the synthesis of phosphatidylcholine, it improves the plasticity of neuronal membranes and synoptic transmission. Stimulates the dose-dependent release of acetylcholine under physiological conditions.

Cholytilin has no mutagenic and teratogenic effects, does not affect the reproductive cycle.

Pharmacokinetics

The drug is rapidly distributed in various tissues and organs, including the brain. Easily penetrates the blood-brain barrier.

It is excreted to a greater extent by the lungs (85%) in the form of carbon dioxide, to a lesser extent (15%) through the intestines and by the kidneys.

Indications for use

According to the instructions, Cholytilin is used as part of the complex therapy of the following diseases / conditions:

psychoorganic syndrome against the background of degenerative diseases and involutional processes of the brain;
cerebrovascular insufficiency;
multi-infarction dementia;
craniocerebral trauma with a predominantly stem level of the lesion (acute period).

Contraindications

acute stage of hemorrhagic stroke;
age up to 18 years;
pregnancy;
lactation period;
the presence of hypersensitivity to any component of the drug.

Instructions for the use of Cholytilin: method and dosage

Cholytilin in the form of a solution is injected slowly intravenously (IV) or intramuscularly (IM). The recommended daily dose is 1000 mg (1 ampoule), the duration of treatment is 15–20 days. If it is necessary to continue therapy, then the patient is transferred to the oral form of the drug.

Cholytilin in capsule form should be taken orally. Usually it is prescribed 400 mg 3 times a day for 3-6 months. In the subacute period of traumatic brain injury, it is recommended to take 800 mg in the morning and 400 mg in the afternoon for a course of 6 months.

Side effects

from the nervous system: anxiety, dizziness, headache, insomnia, drowsiness, nervousness, aggressiveness;
from the digestive system: pharyngitis, dryness of the oral mucosa, constipation or diarrhea;
on the part of the skin: skin rashes, urticaria;
others: increased urination; with intravenous or intramuscular injection - pain at the injection site.

Overdose

No information available.

special instructions

Influence on the ability to drive vehicles and complex mechanisms

During therapy, care should be taken when driving and performing work that requires increased attention, speed of motor and mental reactions.

Application during pregnancy and lactation

During pregnancy and lactation, Cholytilin is contraindicated for use.

Pediatric use

The drug is not used in pediatrics (for the treatment of children and adolescents under 18 years of age).

Drug interactions

Interactions, which would be of clinical significance, with the simultaneous use of Cholytilin with other drugs have not been established.

Analogs

Analogues of Cholytilin are: Gleacer, Delecit, Choline alfoscerat, Cerepro, Nookholin Rompharm, Cereton, Gliatilin.

Terms and conditions of storage

Store at temperatures up to 25 ° C in a dry place protected from light, out of reach of children.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Holityline

Few reviews of Cholytilin indicate its effective and mild nootropic effect, as well as good tolerance.

Price for Holityline in pharmacies

The average price for Holitilin in capsule form is 827 rubles. (14 pcs per pack). A solution for intramuscular and intravenous administration can be purchased for about 415 rubles. (3 ampoules per pack).

Holityline: prices in online pharmacies

Drug name

Price

Pharmacy

Cholytilin 250 mg / ml solution for intravenous and intramuscular administration 4 ml 3 pcs.

249 r

Buy

Cholytilin 400 mg capsules 14 pcs.

359 r

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Cholytilin capsules 400mg 14 pcs.

397 r

Buy

Cholytilin 400 mg capsules 28 pcs.

455 RUB

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Cholytilin capsules 400mg 28 pcs.

827 RUB

Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!