Oxacillin
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Oxacillin is an antibiotic drug of the penicillin group.
Release form and composition
Dosage forms of Oxacillin release:
- Powder for solution preparation for intramuscular and intravenous administration: hygroscopic, white or almost white (in vials, 1, 5, 10 or 50 vials in a cardboard box);
- Powder for preparing a solution for intramuscular administration: hygroscopic, white or almost white (in vials, 1, 5 or 10 vials in a cardboard box);
- Tablets (10 pcs. In blisters, 2 packages in a cardboard box; 20 pcs. In dark glass jars, 1 can in a cardboard box).
The composition of 1 bottle of powder for the preparation of a solution for i / m and i / v administration includes the active substance: oxacillin - 0.25, 0.5 or 1 g (in the form of sodium salt).
The composition of 1 bottle of powder for the preparation of a solution for intramuscular administration includes an active substance: oxacillin - 0.25 or 0.5 g (in the form of sodium salt).
The active ingredient is a part of 1 tablet: sodium oxacillin - 0.25 g.
Indications for use
Oxacillin is prescribed for the treatment of infectious diseases caused by gram-positive microorganisms that produce and do not produce penicillinase, namely postoperative and wound infections, sepsis, meningitis, pyelitis, abscess, cholecystitis, phlegmon, cystitis, osteomyelitis, infected bacterial endocarditis, sinusitis.
Contraindications
A contraindication to the use of Oxacillin is the presence of hypersensitivity to the components of the drug, as well as to other beta-lactam antibiotic agents.
Caution is required by the appointment of Oxacillin in patients with diseases / conditions such as:
- Bronchial asthma and / or allergic reactions (anamnestic data);
- Renal failure in chronic course;
- Enterocolitis in the presence of antibiotics (anamnestic data).
For women during pregnancy and breastfeeding, Oxacillin can be prescribed only for health reasons after the ratio of the expected benefits to the health of the mother with the potential risk to the fetus / child. During lactation, breastfeeding should be interrupted during therapy.
Method of administration and dosage
Oxacillin injection solution is used intramuscularly or intravenously.
Recommended dosing regimen (daily dose):
- Adults and children from 6 years old: 2-4 g;
- Children 2-6 years old: 2 g;
- Children from 3 months to 2 years: 1 g;
- Children under 3 months - 0.06-0.08 g / kg;
- Premature and newborn babies: 0.02-0.04 g / kg.
Oxacillin solution should be injected every 4-6 hours (4 times a day).
The average duration of the course is 7-10 days; in the treatment of severe forms of the disease (sepsis, septic endocarditis), it may increase to 2-3 weeks and longer.
Method of preparation and administration of solutions:
- Intramuscularly: 0.25 g powder / 1.5 ml water for injection, 0.5 g powder / 3 ml water for injection;
- Intravenous jet: 0.25 or 0.5 g of powder / 5 ml of water for injection or 0.9% sodium chloride solution; the drug must be injected slowly (over 5-10 minutes);
- Intravenous drip: dilution to a concentration of 0.0005-0.002 g / ml with 0.9% sodium chloride solution or 5% dextrose solution; Oxacillin is administered at a rate of 60-100 drops per minute for 1-2 hours.
Oxacillin tablets are taken orally.
The doctor sets the dosage regimen individually.
Recommended dosage regimen (single dose):
- Adults and children weighing more than 40 kg: 0.5-1 g 4-6 times a day (every 4-6 hours);
- Children weighing up to 40 kg: 0.0125-0.025 g / kg 4 times a day (every 6 hours).
Side effects
- Digestive system: dyspepsia in the form of nausea, diarrhea, vomiting, oral candidiasis, pseudomembranous enterocolitis, hepatotoxic effect in the form of hyperthermia, nausea, vomiting, jaundice of the skin or sclera, increased activity of hepatic transaminases (more often develops when high doses are prescribed - from 6 g to day);
- Genitourinary system: vaginal candidiasis, hematuria, interstitial nephritis, proteinuria;
- Allergic reactions: urticaria, pruritus; less often - bronchospasm, angioedema; in rare cases - eosinophilia, anaphylactic shock.
special instructions
It is inappropriate to use Oxacillin in the treatment of infections caused by microorganisms sensitive to the action of benzylpenicillin.
Drug interactions
During therapy, an increase in doses of calcium folinate (which is an antidote to folic acid antagonists) and its longer use may be required.
The combination of Oxacillin with ampicillin or benzylpenicillin is rational, since the spectrum of action increases.
Combined use with other drugs that have a hepatotoxic effect should be avoided.
With the combined use of Oxacillin with some drugs, the following effects may be observed:
- Laxative medicines and antacids: decreasing the absorption of Oxacillin;
- Methotrexate: increasing its toxicity;
- Bacteriostatic antibiotics: decreased effectiveness (combined use is not recommended);
- Drugs that block tubular secretion: an increase in the concentration of oxacillin in the blood.
Analogs
Oxacillin analogs are: Oxamp, Oxamp-Sodium, Ampiox, Oxacillin-Akos, Oxacillin-Ferein, Oxacillin sodium salt, Oxamsar.
Terms and conditions of storage
Store in a dry place out of reach of children at temperatures up to 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
