Papaverine hydrochloride
Papaverine hydrochloride: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Papaverine hydrochloride
ATX code: A03AD01
Active ingredient: papaverine (papaverine)
Manufacturer: JSC "Moskhimfarmpreparaty" named after N. A. Semashko "(Russia), JSC" Dalkhimpharm "(Russia), FKP" Armavir Biofabrika "(Russia), JSC" Biosintez "(Russia), JSC" Pharmstandard "(Russia), JSC" Medisorb "(Russia)
Description and photo update: 2018-23-10
Prices in pharmacies: from 24 rubles.
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Papaverine hydrochloride is a drug with antispasmodic and hypotensive effects.
Release form and composition
Dosage forms of papaverine hydrochloride release:
- solution for injections: transparent, slightly colored (in ampoules of 2, 5 or 10 ml, 5 ampoules in blisters, in a cardboard box 1 or 2 packs or 10 ampoules);
- rectal suppositories: torpedo-shaped, from white with a creamy / yellowish tint to white (in blister strip packs of 5 pcs., in a cardboard box 2 packs);
- tablets: white, with a line (10 pcs. in blister and non-blister packs, in a cardboard box 1-3 packs).
Composition of 1 ml injection solution:
- active substance: papaverine hydrochloride - 20 mg;
- additional components: methionine - 0.1 mg; edetate disodium - 0.05 mg; water for injection - up to 1 ml.
Composition of 1 suppository:
- active substance: papaverine hydrochloride - 20 mg;
- additional components: base for suppositories (emulsifier No. 1, hard fat, cosmetic stearin) - in an amount sufficient to obtain a suppository weighing 1250 mg.
Composition of 1 tablet:
- active substance: papaverine hydrochloride - 40 mg;
- additional components: sucrose - 236.5 mg; calcium stearate - 3.5 mg; starch - 70 mg.
Pharmacological properties
Pharmacodynamics
Papaverine hydrochloride is one of the antispasmodic drugs that have an antihypertensive effect.
Main effects:
- inhibition of phosphodiesterase;
- a decrease in the content of calcium in the cell and the accumulation of cyclic adenosine monophosphate;
- decreased tone and relaxation of smooth muscles of internal organs (genitourinary system / gastrointestinal tract) and blood vessels;
- a decrease in the excitability of the heart muscle and a slowdown in intracardiac conduction (when used in large doses).
It has a mild effect on the central nervous system (it has a sedative effect in large doses).
Pharmacokinetics
The absorption of a substance is determined by the dosage form. On average, the bioavailability of the substance is 54%. The connection with plasma proteins is 90%.
Penetrates through histohematogenous barriers, being distributed in the body.
Metabolized in the liver. The half-life is 0.5–2 hours (it can be extended up to 24 hours). It is excreted by the kidneys in the form of metabolites. In hemodialysis, it is completely removed from the blood.
Indications for use
According to the instructions, Papaverine hydrochloride is prescribed in the following cases:
- spasms of smooth muscles of the abdominal organs (pylorospasm, cholecystitis, renal colic, spastic colitis);
- angina pectoris (simultaneously with other drugs);
- spasms of blood vessels of the brain and heart;
- bronchospasm;
- spasm of peripheral vessels (endarteritis).
The drug in the form of tablets and injectable solution is also used for premedication as an adjunct drug.
Contraindications
Absolute:
- atrioventricular block;
- severe liver failure;
- glaucoma;
- age up to 6 months / 10 years / 18 years (injection solution / tablets / suppositories);
- elderly age;
- individual intolerance to the components of the drug.
Relative (Papaverine hydrochloride is prescribed under medical supervision):
- shock conditions;
- conditions after traumatic brain injury;
- hyperplasia of the prostate;
- chronic renal failure;
- hypothyroidism;
- insufficiency of adrenal function;
- supraventricular tachycardia;
- pregnancy and lactation.
Instructions for the use of papaverine hydrochloride: method and dosage
Injection solution
Methods of administration of papaverine hydrochloride - intravenous, intramuscular, subcutaneous.
Recommended dosage regimen:
- intramuscularly, subcutaneously: 2–4 times a day, 20–40 mg;
- intravenously slowly: 2-4 times a day, 20 mg (after preliminary dilution in 0.9% sodium chloride solution of 10-20 ml).
The maximum single dose for children 6–12 months old is 1 mg, 1–12 years old - 0.2 mg / kg.
Suppositories
Papaverine hydrochloride is administered rectally.
The recommended dosage regimen: 2-3 times a day, 20-40 mg.
Pills
Papaverine hydrochloride is taken orally.
Recommended dosage regimen:
- adolescents over 14 years old and adults: 3-4 times a day, 40-60 mg; the maximum single dose is 200 mg, the daily dose is 600 mg;
- children 10-14 years old: 3-4 times a day, 20 mg.
Side effects
- hematopoietic system: eosinophilia;
- digestive system: constipation;
- cardiovascular system: lowering blood pressure, atrioventricular block, ventricular premature beats;
- central nervous system: drowsiness;
- liver: increased activity of hepatic transaminases;
- allergic reactions: skin rash, pruritus, urticaria.
Overdose
The main symptoms are: decreased blood pressure, drowsiness, weakness, diplopia.
In case of an overdose, symptomatic therapy is performed (in order to maintain blood pressure).
special instructions
When smoking, there is a decrease in the vasodilating effect of papaverine hydrochloride.
The intake of ethanol during the treatment period should be excluded.
Intravenous injection solution should be injected slowly, under medical supervision.
Influence on the ability to drive vehicles and complex mechanisms
When driving motor vehicles, patients should take into account the possibility of developing drowsiness.
Application during pregnancy and lactation
The safety of papaverine hydrochloride during pregnancy and during breastfeeding has not been established.
Pediatric use
The drug is not prescribed:
- injection solution: up to 6 months;
- tablets: up to 10 years;
- suppositories: up to 18 years old.
With impaired renal function
Patients with chronic renal failure should be treated with caution.
For violations of liver function
In severe hepatic impairment, Papaverine hydrochloride is not used.
Use in the elderly
Due to the risk of developing hyperthermia, Papaverine hydrochloride is not prescribed for elderly patients.
Drug interactions
- methyldopa: reducing the hypotensive effect of methyldopa;
- levodopa: reduced antiparkinsonian effect of levodopa;
- tricyclic antidepressants, procainamide, reserpine, quinidine: increased hypotensive effect of papaverine;
- barbiturates: increased antispasmodic action of papaverine.
Analogs
The analogues of Papaverine hydrochloride are: Papaverine, Papaverine hydrochloride MS.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 15/25 ° C (suppositories / injection solution and tablets). Keep out of the reach of children.
Shelf life:
- solution, suppositories - 2 years;
- tablets - 5 years.
Terms of dispensing from pharmacies
Released:
- solution - by prescription;
- suppositories, tablets - without a prescription.
Reviews of Papaverine hydrochloride
According to reviews, papaverine hydrochloride is a safe, affordable and effective drug. Suppositories are used for symptomatic conservative treatment for hemorrhoids, thereby facilitating the act of defecation, partially relieving pain and bleeding from enlarged hemorrhoids.
Also, suppositories are widely used by pregnant women with increased uterine tone. It should be borne in mind that the safety of the drug in this group of patients has not been studied. Of the shortcomings, most often indicate a decrease in blood pressure.
The price of papaverine hydrochloride in pharmacies
The approximate price for Papaverine hydrochloride is:
- tablets (20 pcs. in a package) - 27 rubles;
- suppositories (10 pcs. per package) - 21–39 rubles;
- injection solution (10 ampoules, 2 ml each) - 14–48 rubles.
Papaverine hydrochloride: prices in online pharmacies
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Drug name Price Pharmacy |
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Papaverine hydrochloride MS 40 mg tablets 20 pcs. RUB 24 Buy |
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Papaverine hydrochloride 20 mg rectal suppositories 10 pcs. RUB 25 Buy |
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Papaverine hydrochloride 0.04 g tablets 20 pcs. RUB 26 Buy |
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Papaverine hydrochloride 2% solution for injection 2 ml 10 pcs. 34 rbl. Buy |
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Papaverine hydrochloride 2% solution for injection 2 ml 10 pcs. RUB 36 Buy |
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Papaverine hydrochloride 20 mg rectal suppositories 10 pcs. RUB 47 Buy |
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Papaverine hydrochloride suppositories rectal. 20mg 10 pcs. RUB 65 Buy |
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Papaverine hydrochloride suppositories rectal. 20mg 10 pcs. RUB 67 Buy |
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Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
