Papaverine Hydrochloride - Instructions For Use, Price, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Papaverine hydrochloride

Papaverine hydrochloride: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Use in the elderly
14. 14. Drug interactions
15. 15. Analogs
16. 16. Terms and conditions of storage
17. 17. Terms of dispensing from pharmacies
18. 18. Reviews
19. 19. Price in pharmacies

Latin name: Papaverine hydrochloride

ATX code: A03AD01

Active ingredient: papaverine (papaverine)

Manufacturer: JSC "Moskhimfarmpreparaty" named after N. A. Semashko "(Russia), JSC" Dalkhimpharm "(Russia), FKP" Armavir Biofabrika "(Russia), JSC" Biosintez "(Russia), JSC" Pharmstandard "(Russia), JSC" Medisorb "(Russia)

Description and photo update: 2018-23-10

Prices in pharmacies: from 24 rubles.

Buy

Papaverine hydrochloride is a drug with antispasmodic and hypotensive effects.

Release form and composition

Dosage forms of papaverine hydrochloride release:

• solution for injections: transparent, slightly colored (in ampoules of 2, 5 or 10 ml, 5 ampoules in blisters, in a cardboard box 1 or 2 packs or 10 ampoules);
• rectal suppositories: torpedo-shaped, from white with a creamy / yellowish tint to white (in blister strip packs of 5 pcs., in a cardboard box 2 packs);
• tablets: white, with a line (10 pcs. in blister and non-blister packs, in a cardboard box 1-3 packs).

Composition of 1 ml injection solution:

• active substance: papaverine hydrochloride - 20 mg;
• additional components: methionine - 0.1 mg; edetate disodium - 0.05 mg; water for injection - up to 1 ml.

Composition of 1 suppository:

• active substance: papaverine hydrochloride - 20 mg;
• additional components: base for suppositories (emulsifier No. 1, hard fat, cosmetic stearin) - in an amount sufficient to obtain a suppository weighing 1250 mg.

Composition of 1 tablet:

• active substance: papaverine hydrochloride - 40 mg;
• additional components: sucrose - 236.5 mg; calcium stearate - 3.5 mg; starch - 70 mg.

Pharmacological properties

Pharmacodynamics

Papaverine hydrochloride is one of the antispasmodic drugs that have an antihypertensive effect.

Main effects:

• inhibition of phosphodiesterase;
• a decrease in the content of calcium in the cell and the accumulation of cyclic adenosine monophosphate;
• decreased tone and relaxation of smooth muscles of internal organs (genitourinary system / gastrointestinal tract) and blood vessels;
• a decrease in the excitability of the heart muscle and a slowdown in intracardiac conduction (when used in large doses).

It has a mild effect on the central nervous system (it has a sedative effect in large doses).

Pharmacokinetics

The absorption of a substance is determined by the dosage form. On average, the bioavailability of the substance is 54%. The connection with plasma proteins is 90%.

Penetrates through histohematogenous barriers, being distributed in the body.

Metabolized in the liver. The half-life is 0.5–2 hours (it can be extended up to 24 hours). It is excreted by the kidneys in the form of metabolites. In hemodialysis, it is completely removed from the blood.

Indications for use

According to the instructions, Papaverine hydrochloride is prescribed in the following cases:

• spasms of smooth muscles of the abdominal organs (pylorospasm, cholecystitis, renal colic, spastic colitis);
• angina pectoris (simultaneously with other drugs);
• spasms of blood vessels of the brain and heart;
• bronchospasm;
• spasm of peripheral vessels (endarteritis).

The drug in the form of tablets and injectable solution is also used for premedication as an adjunct drug.

Contraindications

Absolute:

• atrioventricular block;
• severe liver failure;
• glaucoma;
• age up to 6 months / 10 years / 18 years (injection solution / tablets / suppositories);
• elderly age;
• individual intolerance to the components of the drug.

Relative (Papaverine hydrochloride is prescribed under medical supervision):

• shock conditions;
• conditions after traumatic brain injury;
• hyperplasia of the prostate;
• chronic renal failure;
• hypothyroidism;
• insufficiency of adrenal function;
• supraventricular tachycardia;
• pregnancy and lactation.

Instructions for the use of papaverine hydrochloride: method and dosage

Injection solution

Methods of administration of papaverine hydrochloride - intravenous, intramuscular, subcutaneous.

Recommended dosage regimen:

• intramuscularly, subcutaneously: 2–4 times a day, 20–40 mg;
• intravenously slowly: 2-4 times a day, 20 mg (after preliminary dilution in 0.9% sodium chloride solution of 10-20 ml).

The maximum single dose for children 6–12 months old is 1 mg, 1–12 years old - 0.2 mg / kg.

Suppositories

Papaverine hydrochloride is administered rectally.

The recommended dosage regimen: 2-3 times a day, 20-40 mg.

Pills

Papaverine hydrochloride is taken orally.

Recommended dosage regimen:

• adolescents over 14 years old and adults: 3-4 times a day, 40-60 mg; the maximum single dose is 200 mg, the daily dose is 600 mg;
• children 10-14 years old: 3-4 times a day, 20 mg.

Side effects

• hematopoietic system: eosinophilia;
• digestive system: constipation;
• cardiovascular system: lowering blood pressure, atrioventricular block, ventricular premature beats;
• central nervous system: drowsiness;
• liver: increased activity of hepatic transaminases;
• allergic reactions: skin rash, pruritus, urticaria.

Overdose

The main symptoms are: decreased blood pressure, drowsiness, weakness, diplopia.

In case of an overdose, symptomatic therapy is performed (in order to maintain blood pressure).

special instructions

When smoking, there is a decrease in the vasodilating effect of papaverine hydrochloride.

The intake of ethanol during the treatment period should be excluded.

Intravenous injection solution should be injected slowly, under medical supervision.

Influence on the ability to drive vehicles and complex mechanisms

When driving motor vehicles, patients should take into account the possibility of developing drowsiness.

Application during pregnancy and lactation

The safety of papaverine hydrochloride during pregnancy and during breastfeeding has not been established.

Pediatric use

The drug is not prescribed:

• injection solution: up to 6 months;
• tablets: up to 10 years;
• suppositories: up to 18 years old.

With impaired renal function

Patients with chronic renal failure should be treated with caution.

For violations of liver function

In severe hepatic impairment, Papaverine hydrochloride is not used.

Use in the elderly

Due to the risk of developing hyperthermia, Papaverine hydrochloride is not prescribed for elderly patients.

Drug interactions

• methyldopa: reducing the hypotensive effect of methyldopa;
• levodopa: reduced antiparkinsonian effect of levodopa;
• tricyclic antidepressants, procainamide, reserpine, quinidine: increased hypotensive effect of papaverine;
• barbiturates: increased antispasmodic action of papaverine.

Analogs

The analogues of Papaverine hydrochloride are: Papaverine, Papaverine hydrochloride MS.

Terms and conditions of storage

Store in a place protected from light and moisture at temperatures up to 15/25 ° C (suppositories / injection solution and tablets). Keep out of the reach of children.

Shelf life:

• solution, suppositories - 2 years;
• tablets - 5 years.

Terms of dispensing from pharmacies

Released:

• solution - by prescription;
• suppositories, tablets - without a prescription.

Reviews of Papaverine hydrochloride

According to reviews, papaverine hydrochloride is a safe, affordable and effective drug. Suppositories are used for symptomatic conservative treatment for hemorrhoids, thereby facilitating the act of defecation, partially relieving pain and bleeding from enlarged hemorrhoids.

Also, suppositories are widely used by pregnant women with increased uterine tone. It should be borne in mind that the safety of the drug in this group of patients has not been studied. Of the shortcomings, most often indicate a decrease in blood pressure.

The price of papaverine hydrochloride in pharmacies

The approximate price for Papaverine hydrochloride is:

• tablets (20 pcs. in a package) - 27 rubles;
• suppositories (10 pcs. per package) - 21–39 rubles;
• injection solution (10 ampoules, 2 ml each) - 14–48 rubles.

Papaverine hydrochloride: prices in online pharmacies

Drug name Price Pharmacy

Papaverine hydrochloride MS 40 mg tablets 20 pcs. RUB 24 Buy

Papaverine hydrochloride 20 mg rectal suppositories 10 pcs. RUB 25 Buy

Papaverine hydrochloride 0.04 g tablets 20 pcs. RUB 26 Buy

Papaverine hydrochloride 2% solution for injection 2 ml 10 pcs. 34 rbl. Buy

Papaverine hydrochloride 2% solution for injection 2 ml 10 pcs. RUB 36 Buy

Papaverine hydrochloride 20 mg rectal suppositories 10 pcs. RUB 47 Buy

Papaverine hydrochloride suppositories rectal. 20mg 10 pcs. RUB 65 Buy

Papaverine hydrochloride suppositories rectal. 20mg 10 pcs. RUB 67 Buy

See all offers from pharmacies

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!