Texared
Texared: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. In case of impaired renal function
- 11. For violations of liver function
- 12. Use in the elderly
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Texared
ATX code: M01AC02
Active ingredient: tenoxicam (Tenoxicam)
Manufacturer: Mustafa Nevzat Ilach Sanai A. Sh. (Mustafa Nevzat Ilac Sanayii, AS) (Turkey)
Description and photo update: 2020-28-01
Prices in pharmacies: from 150 rubles.
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Texared is a non-steroidal anti-inflammatory drug (NSAID).
Release form and composition
Dosage forms:
- film-coated tablets, 20 mg: oval, biconvex, dividing risk on one side; the film shell is yellow with a brown tint, the core at the break is bright yellow [10 pcs. in blisters made of a combined material (polyvinyl chloride with aluminum foil), in a cardboard box 1 blister];
- lyophilisate for preparation of solution for injection: yellow with a greenish tinge lyophilized powder (includes 1 bottle of colorless glass containing 20 mg of lyophilisate, and 1 ampoule with 2 ml of solvent; 1 set in a cardboard box or 1 set in a polyvinyl chloride cassette, 1 cassette in a pack cardboard).
Each pack also contains instructions for the use of Texared.
Composition for 1 Texared tablet:
- active ingredient: tenoxicam - 20 mg;
- auxiliary components: lactose monohydrate - 90 mg; corn starch - 70 mg; pregelatinized starch - 16 mg; magnesium stearate - 1 mg; talc - 3 mg;
- film shell: Opadray OY-S22989 Yellow [hypromellose - 2.9 mg; titanium dioxide - 1.8 mg; polyethylene glycol 400 (PEG 400) - 0.3 mg; iron oxide yellow - 0.6 mg] - 5.6 mg.
Composition for 1 bottle of Texared lyophilisate:
- active ingredient: tenoxicam - 20 mg;
- auxiliary components: mannitol - 57.33 mg; trometamol - 3 mg; sodium hydroxide - 3.28 mg; sodium metabisulfite - 2 mg; edetate disodium - 0.2 mg.
Solvent: water for injection - 2 ml.
Pharmacological properties
Pharmacodynamics
The active component of Texared, a non-steroidal anti-inflammatory drug (NSAID) tenoxicam, is a thienothiazine derivative of oxicam. It has anti-inflammatory, analgesic and antipyretic activity, and also has an antiplatelet effect, preventing platelet aggregation.
The anti-inflammatory effect of tenoxicam is based on its ability to inhibit the activity of cyclooxygenase isoenzymes (COX) involved in the metabolism of arachidonic acid, thus suppressing the synthesis of prostaglandins. The substance does not affect the activity of lipoxygenases. At the same time, it inhibits some functions of leukocytes, including the release of histamine and phagocytosis, and also reduces the concentration of active radicals in the focus of inflammation.
Pharmacokinetics
Tenoxicam is rapidly and completely absorbed from the gastrointestinal tract (GIT) unchanged. Bioavailability is 100%. The maximum concentration (C max) in plasma is reached 2 hours after oral administration. Taking pills after meals or simultaneously with antacids reduces the rate of absorption, but not its degree.
Tenoxicam binds to blood proteins at a level of 99%. Penetrates well into synovial fluid. The systemic clearance of the substance is low, and the half-life (T 1/2) is long. This allows you to take Texared 1 time per day.
Middle T 1/2 -. About 70 h urine excreted C 2 / 3 of the dose, faeces - 1 / 3. The content of tenoxicam in serum with prolonged use is 10-15 mcg / ml, the cumulation of the substance is not observed.
Indications for use
Texared is recommended for use in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, articular syndrome with exacerbation of gout, bursitis, tendovaginitis, as well as painful inflammation and degenerative diseases of the musculoskeletal system, such as lumbago, sciatica, epicondylitis.
The drug is effective in relieving pain syndrome of weak and moderate intensity of various etiologies: with arthralgia, myalgia, neuralgia, migraine, toothache and headache, algodismenorrhea, pain as a result of injury and burns.
NSAIDs have only a symptomatic effect, they do not affect the course of Texared's disease. It is unable to prevent development, stop progression and cause remission of the underlying disease.
Contraindications
Absolute:
- full / partial aspirin triad: a combination of asthma attacks (bronchial asthma), recurrent polypous rhinosinusitis and intolerance to NSAIDs, including acetylsalicylic acid (including history);
- pathologies of the digestive tract: erosive and ulcerative ulceration of the gastrointestinal tract, gastrointestinal bleeding (including anamnesis), inflammatory diseases of the gastrointestinal tract, severe gastritis;
- hypocoagulation, hemophilia, other blood diseases;
- liver failure, liver disease in the active phase;
- severe renal failure, GFR (glomerular filtration rate) less than 30 ml / min; progressive kidney disease;
- the recovery period after coronary artery bypass grafting;
- hearing loss;
- diagnosed hyperkalemia;
- pathology of the vestibular apparatus;
- deficiency of G6PD (glucose-6-phosphate dehydrogenase);
- pregnancy, lactation period;
- hypersensitivity to the active and / or auxiliary components of Texared tablets and injections.
The drug is prescribed with caution to patients with diabetes mellitus, edema, chronic heart failure, arterial hypertension, ischemic heart disease, peripheral arterial disease, cerebrovascular disease, dyslipidemia / hyperlipidemia, chronic renal failure (GFR from 30 to 60 ml / min), Helicobacter infection pylori, severe somatic diseases, alcoholism; while taking oral glucocorticosteroids (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid and clopidogrel), selective serotonin reuptake inhibitors (including citalopram, paroxetine, sertraline, fluoxetine and NSAIDs in elderly patients) sick.
Texared, instructions for use: method and dosage
- orally: Texared tablets are taken after meals (preferably at the same time), once a day. Dosage for short-term admission - 1 tablet (20 mg) per day, with long-term treatment - ½ tablet (10 mg) per day. For the treatment of acute attacks of gout - 2 tablets (40 mg) per day for the first 2 days, for the next 5 days - 1 tablet (20 mg) per day. For elderly patients, the maximum dose is 20 mg / day;
- parenteral: Texared injections are intended for intramuscular or intravenous administration. The dosage for short-term administration is 20 mg / day, for long-term treatment - 10 mg / day. In the treatment of gouty arthritis in the initial period (1-2 days) - 40 mg / day, the next 3-5 days - 20 mg / day. The daily dose is administered at a time.
Side effects
- Gastrointestinal tract (11.4%): nausea, vomiting, pain / burning sensation in the stomach, constipation, diarrhea, flatulence, abdominal pain, NSAID gastropathy, stomatitis, anorexia; prolonged use of high doses can cause ulceration of the gastrointestinal tract mucosa, perforation of the intestinal walls, bleeding - gastrointestinal, uterine, gingival, hemorrhoidal;
- liver and bile ducts (1-2%): impaired hepatic function; increased activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) and serum bilirubin concentration;
- skin and subcutaneous tissue (2.5%): itching, rash, erythema, urticaria; extremely rare - photodermatitis, Stevens-Johnson syndrome, Lyell's syndrome;
- cardiovascular system: tachycardia, heart failure, increased blood pressure;
- nervous system (2.6%): dizziness, headache, drowsiness, agitation, depression, tinnitus, hearing loss, eye irritation, visual impairment;
- urinary system (1–2%): increased blood concentration of urea nitrogen and creatinine;
- hematopoietic system (1-2%): leukopenia, agranulocytosis; rarely - thrombocytopenia, anemia; extremely rare - granulocytopenia, decreased hemoglobin levels;
- laboratory data: hyperbilirubinemia, hypercreatininemia, increased activity of hepatic transaminases, prolonged bleeding time.
Against the background of parenteral use of Texared, mental disorders (1.7%) and metabolic disorders (1%) were also observed.
Overdose
In case of an overdose of tenoxicam, symptomatic treatment is performed.
special instructions
During therapy, it is required to monitor liver and kidney function, peripheral blood patterns. With the simultaneous use of Texared with indirect anticoagulants, it is necessary to control the prothrombin index, with oral hypoglycemic agents - the level of glucose in the blood.
When determining 17-ketosteroids, tenoxicam is discontinued 48 hours before the study.
In the case of planning a surgical intervention, Texared is canceled a few days before the operation.
When prescribing the drug simultaneously with diuretics for the treatment of patients with arterial hypertension and chronic heart failure, it is important to consider the possibility of water and sodium retention in the body.
In order to reduce the risk of developing unwanted adverse reactions from the digestive tract, Texared should be used in the minimum effective dose for the least possible short course.
Influence on the ability to drive vehicles and complex mechanisms
One of the undesirable side reactions when using Texared is dizziness. This should be borne in mind by patients engaged in potentially hazardous work requiring a high concentration of attention and speed of psychomotor reactions. They must be careful when driving complex machinery and vehicles.
Application during pregnancy and lactation
Pregnant and breastfeeding women should not use Texared.
With impaired renal function
- severe renal failure (GFR less than 30 ml / min) and progressive kidney disease - the use of Texared is contraindicated;
- chronic renal failure (GFR from 30 to 60 ml / min) - the drug is used with caution.
For violations of liver function
Liver failure and active liver disease are contraindications to the use of Texared.
Use in the elderly
Elderly patients Texared should be used with caution.
Drug interactions
When tenoxicam is used together with other substances / drugs, the following pharmacological interactions are possible:
- uricosuric drugs: tenoxicam reduces their effectiveness;
- anticoagulants, antiplatelet agents, fibrinolytics: their effect is enhanced;
- estrogens, mineralocorticosteroids (MCS) and glucocorticosteroids (GCS): negative side reactions of these groups of drugs may be more pronounced;
- antihypertensive drugs and diuretics: their effectiveness decreases;
- sulfonylurea derivatives: their hypoglycemic effect is enhanced;
- lithium preparations, methotrexate: an increase in their concentration in the blood is possible;
- barbiturates, phenylbutazone, rifampicin, tricyclic antidepressants, phenytoin, ethanol, as well as other inducers of microsomal oxidation in the liver: the production of their active metabolites, formed by hydroxylation, increases;
- antacids and cholestyramine: inhibit the absorption of tenoxicam;
- other NSAIDs: the risk of developing negative side effects, especially from the gastrointestinal tract, increases;
- myelotoxic drugs: intensify the manifestations of Texared's hematotoxicity.
Analogs
The analogues of Texared are Artoxan, Actasulid, Betaren, Butadion-OBL, Voltaren, Diclofenac, Oxyten, Oxiliten, Revmonn, Tilcotil, Texamen-L, Indomethacin-Biosynthesis, Diclobene, Diclonat P, Naklofen, Ortofen and dr.
Terms and conditions of storage
Store at temperatures up to 25 ° C in a dry and dark place. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Texared
In the few, but very detailed reviews about Texared, patients give the drug a rather high rating as a means to get rid of back pain (for example, with lumbar osteochondrosis). With an exacerbation of the condition, as part of a comprehensive course of therapy, Texared is first used for 5 days parenterally, intramuscularly or intravenously, and then in the form of tablets. Both forms are easy to use, since they only need to be used once a day (pills or injection). The cumulative effect of the drug is noted, in which in the first week the therapeutic effect is insignificant, and already in the second week of use, there is a strong relief of the condition and the elimination of pain. This ensures tolerable well-being and an acceptable quality of life until the underlying disease is cured.
During therapy, side effects such as digestive disorders, weight gain, brittle nails, and hair loss are observed. Despite this, the analgesic effect that Texared has for patients taking therapy makes it the drug of choice, as the most tangible in terms of results. The cost of tablets and lyophilisate is called high.
Price for Texared in pharmacies
The approximate price of Texared, depending on the form of release:
- film-coated tablets, 20 mg, 10 pcs. in the package - 306–450 rubles;
- lyophilisate for preparation of solution for injection, 20 mg, 1 bottle complete with an ampoule of solvent in a package - 147–214 rubles.
Texared: prices in online pharmacies
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Drug name Price Pharmacy |
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Texared 20 mg lyophilisate for the preparation of a solution for intravenous and intramuscular administration complete with a solvent 1 pc. RUB 150 Buy |
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Texared lyoph. for prig of solution for in. 20mg fl. + r-l water for in. amp. 2ml 156 r Buy |
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Texared tablets p.p. 20mg 10 pcs. RUB 300 Buy |
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Texared 20 mg film-coated tablets 10 pcs. RUB 300 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
