Tachocomb
Tachocomb: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Tachocomb
ATX code: B02BC30
Active ingredient: fibrinogen (Fibrinogen), thrombin (Thrombin)
Manufacturer: Takeda Austria, GmbH (Takeda Austria, GmbH) (Austria)
Description and photo update: 2020-23-01
Prices in pharmacies: from 3280 rubles.
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Tachocomb is a combined hemostatic drug for local use, has an adsorbing effect.
Release form and composition
The drug is produced in the form of a hemostatic sponge: a twisted porous plate with an almost white embossed surface, a yellow coating is applied on one side with active substances (1 pc. In foil containers, in contour packs of laminated aluminum foil 1 container complete with 1 drying agent agent: sponge 2.5 × 3 × 0.5 cm, in a cardboard box 1 or 3 packages, a sponge 4.8 × 4.8 × 0.5 cm, in a cardboard box 2 packages, sponge 9.5 × 4.8 x 0.5 cm, in a carton box of 1, 5 or 10. Each box also contains instructions for the use of Tachocomb).
1 cm 2 sponge contains:
- active ingredients: fibrinogen - 5.5 mg; thrombin - 2 ME (international unit);
- auxiliary components: albumin, riboflavin, L-arginine hydrochloride, sodium citrate, sodium chloride, collagen.
Pharmacological properties
Pharmacodynamics
Tachocomb is a hemostatic drug for local use. The mechanism of action of the drug is due to the properties of active components - fibrinogen and thrombin, which are located in the form of a dry coating on the surface of the collagen sponge.
After contact with blood, lymph or electrolyte solutions, the components of the sponge coating dissolve and partially penetrate into the tissues of the wound surface. The reaction arising in the process of diffusion of fibrinogen and thrombin initiates the last phase of physiological blood coagulation.
The transformation of fibrinogen into fibrin monomer and its subsequent polymerization with the formation of a fibrin clot (thrombus) promotes tight fixation of the collagen of the sponge on the surface of the wound. With the help of blood coagulation factor XIII, fibrin polymers are crosslinked and a mechanically strong solid network structure is formed. Its good adhesive properties ensure reliable wound closure.
Pharmacokinetics
After entering the body, the active components undergo progressive biodegradation. The metabolism of the fibrin clot occurs by fibrinolysis and phagocytosis, similar to endogenous fibrin. Under the influence of the resorptive granulation tissue of the collagen of the sponge, it breaks down.
Indications for use
The use of the Tachocomb sponge is indicated during surgical operations in adults as an aid to ensure tissue connection and improve hemostasis.
In vascular surgery, a collagen sponge is used to strengthen sutures when standard vascular connection methods are not effective enough.
In addition, for surgical interventions on the lungs, Tachocomb is used to ensure complete tightness.
Contraindications
Absolute:
- children / adolescents under 18 years of age;
- hypersensitivity to the active and auxiliary components of the hemostatic sponge.
With caution, only in cases of extreme necessity, it is recommended to resort to the use of Tachocomb during pregnancy and breastfeeding.
Tachocomb, instructions for use: method and dosage
Tachocomb is not intended for intravascular (intravascular) use.
The sponge is applied topically, by applying directly to surgical wound surfaces.
The drug can only be used under sterile conditions and from undamaged packaging, it cannot be re-sterilized.
The outer aluminum foil packaging bag can be opened in the non-sterile operating area, and the sterile inner blister can only be opened in the sterile area.
To use Tachocomb, the wound surface must be prepared in advance by thoroughly cleaning it from blood, disinfectants (solution of ethanol, iodine or heavy metals) and other liquids.
After opening the inner blister, the sponge is removed, moistened in 0.9% sodium chloride solution, immediately applied to the prepared area with the yellow side covered with active substances, and lightly pressed with moistened gloves or a moistened pad for 3-5 minutes.
To avoid adhesion of the sponge to blood-stained gloves or instruments, they should be pre-moistened with 0.9% sodium chloride solution.
Then the pad or glove is carefully removed, for a more reliable and tight hold of the sponge in the right place, you can use a pair of clips at one of its ends.
In case of severe bleeding, the Tachocomb sponge can be applied to the wound surface without preliminary moistening and slightly fixed for 3-5 minutes.
The size of the sponge used depends on the size of the wound surface, if necessary, it can be cut to obtain the required size, and unused fragments disposed of.
The sponge should overlap the wound edges by 1–2 cm.
If the area of the wound surface exceeds the size of one sponge, then the required number of pieces should be used, applying to the wound so that their edges overlap each other.
Side effects
Like any protein product, the Tachocomb sponge, when used in patients with hypersensitivity, can provoke the development of allergic reactions such as urticaria (including in generalized forms), lowering blood pressure, airway obstruction, anaphylactic shock. With the development of such symptoms, the use of a hemostatic sponge should be discontinued immediately.
Other side effects from systems and organs when using Tachocomb collagen sponge:
- from the immune system: infrequently - hypersensitivity reactions; extremely rare - anaphylactic shock;
- from the side of the vessels: extremely rarely - thromboembolism against the background of intravascular use of a sponge;
- general disorders and disorders at the site of application: often - hyperthermia; rarely - the formation of antibodies to fibrin or hemostatic products.
Overdose
Overdose symptoms have not been established.
special instructions
Intravascular use of Tachocomb is inadmissible. Accidental ingestion of the sponge inside the vessel can lead to life-threatening thromboembolic complications.
If patients develop symptoms of allergic reactions, airway obstruction, low blood pressure or anaphylactic shock, the drug should be discontinued immediately and standard emergency therapy should be started.
When using Tachocomb, the possibility of introducing viral agents cannot be excluded, despite the standard measures for preventing infections in the manufacture of drugs from human blood or plasma. In this connection, it is recommended to record the name and batch number of the drug so that, if necessary, an appropriate analysis can be made. There is a risk of transmission of previously identified or previously unknown viruses and other pathogens, even with careful selection of donors, screening of material from donors for specific markers of infections and special procedures for inactivating or eliminating viruses during the technological process.
Prevention measures are considered effective for enveloped viruses (hepatitis B and C virus, human immunodeficiency virus) and non-enveloped viruses (including hepatitis A virus).
The effectiveness of preventive measures is limited in relation to the non-enveloped parvovirus B19, infection with which is dangerous in immunodeficiency, hemolytic anemia and other conditions characterized by an increase in erythropoiesis, as well as during pregnancy, since the fetus may become infected.
Application during pregnancy and lactation
It is recommended to use Tachocomb during pregnancy or breastfeeding only in cases where the expected effect of therapy for the mother outweighs the potential threat to the fetus or child.
Pediatric use
The use of Tachocomb in children under the age of 18 is contraindicated due to the lack of sufficient data confirming the safety and efficacy of the drug in this category of patients.
Drug interactions
When Tachocomb comes into contact with solutions of ethanol, iodine or heavy metals (including antiseptic solutions), the properties of its components may be disturbed. As a consequence, careful removal of such products from the areas of the intended application of the sponge is required.
Analogs
Tachocomb's analogues are hemostatic collagen sponge, antiseptic sponge with kanamycin, Zhelplastan, Ivisel, Polyhemostat, Polikapran, Thrombin, etc.
Terms and conditions of storage
Keep out of the reach of children. Store at temperatures up to 25 ° C.
The shelf life is 3 years.
After depressurization of the inner sterile packaging, the sponge is used immediately.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Tachocombe
In reviews of Tachocombe, patients describe the effective use of a hemostatic collagen sponge for a wide variety of indications. From stopping bleeding in the oral cavity during the installation of dental implants to its application after massive cavity operations. The drug has proven itself well for stopping bleeding from tissue injury during active games and walks in nature. The sponge adheres tightly to the wound surface, stops bleeding, reduces blood loss, improves tissue connection and regeneration.
Disadvantages and side reactions were not described. Patients justify the high cost of Tachocomb by its sterility and excellent clinical effect.
Price for Tachocomb in pharmacies
The price for a Tachocomb for a package containing two sponges measuring 4.8 × 4.8 × 0.5 cm can be from 13 474 rubles, one sponge measuring 9.5 × 4.8 × 0.5 cm - from 14 883 rub., one sponge measuring 2.5 × 3 × 0.5 cm - from 3400 rubles.
Tachocomb: prices in online pharmacies
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Drug name Price Pharmacy |
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Tachocomb 2.5x3.0x0.5 cm sponge 1 pc. 3280 RUB Buy |
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Tachocomb sponge 2.5x3x0.5 cm 3529 RUB Buy |
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Tachocomb 2.5x3.0x0.5 cm sponge 1 pc. 3529 RUB Buy |
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Tachocomb sponge 4.8x4.8x0.5 cm container RUB 6702 Buy |
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Tachocomb 9.5x4.8x0.5cm sponge 1 pc. 13919 RUB Buy |
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Tachocomb sponge 4.8x4.8x0.5 cm 2 pcs. 14046 RUB Buy |
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Tachocomb 4.8x4.8x0.5 cm sponge 2 pcs. 14046 RUB Buy |
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Tachocomb sponge 9.5x4.8x0.5cm n1 RUB 14883 Buy |
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Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
