Sulfadimezin - Instructions For Use, Indications, Doses

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Sulfadimezin

Instructions for use:

1. 1. Release form and composition
2. 2. Indications for use
3. 3. Contraindications
4. 4. Method of application and dosage
5. 5. Side effects
6. 6. Special instructions
7. 7. Drug interactions
8. 8. Terms and conditions of storage

Prices in online pharmacies:

from 24 rubles.

Buy

Sulfadimezin is an antibacterial drug from the group of sulfonamides.

Release form and composition

Sulfadimezin is produced in the form of tablets: flat-cylindrical, white or white with a slight yellowish tinge, with a line and a chamfer (10 pcs. In blisters, two packs in a cardboard box; 10 pcs. In blister-free contour packs, 500 packs in a cardboard box)).

Composition for 1 tablet:

• active substance: sulfadimidine - 500 mg;
• auxiliary components: potato starch, stearic acid, polysorbate 80, talc.

Indications for use

Sulfadimezin is used for infectious and inflammatory diseases caused by microorganisms sensitive to sulfadimidine:

• otitis media;
• inflammation of the tonsils (tonsillitis);
• pneumonia;
• sinusitis;
• chronic bronchitis in the acute stage;
• erysipelas;
• shigellosis;
• wound infections;
• diseases of the urinary and biliary tract.

Contraindications

Absolute:

• chronic kidney failure;
• porphyria;
• oppression of hematopoiesis in the bone marrow;
• hyperbilirubinemia in children (due to an increased risk of developing bilirubin encephalopathy);
• congenital deficiency of the enzyme glucose-6-phosphate dehydrogenase;
• increased content in the blood of nitrogenous metabolic products, excreted by the kidneys;
• children under 3 years old;
• increased individual sensitivity to the drug or other sulfonamides.

Relative (Sulfadimezin is used with caution):

• liver failure;
• a history of allergies.

Method of administration and dosage

Sulfadimezin tablets are intended for oral administration. Recommended doses and duration of treatment:

• otitis media: adults - 2 tablets of the drug twice a day; children over 3 years old - 50–75 mg / kg of body weight per day in two doses; the course of treatment is 7-10 days;
• tonsillitis: adults - 2 tablets two or three times a day; children over 3 years old - 50–75 mg / kg of body weight per day in two or three doses; the course of treatment is 5-7 days;
• pneumonia: adults - 4 tablets of Sulfadimezin for the first dose, then 2 tablets 4-6 times a day; children over 3 years old - 100 mg / kg of body weight for the first dose, then 100-150 mg / kg of body weight per day in 4-6 doses; treatment is continued for another 2-3 days after the disappearance of the symptoms of pneumonia;
• sinusitis, erysipelas: adults - 2 tablets of the drug 4-6 times a day; children over 3 years old - 100–150 mg / kg of body weight per day in 4–6 doses; the course of treatment is 7-10 days;
• exacerbation of chronic bronchitis: adults - 2 tablets of Sulfadimezin 4–6 times a day; children over 3 years old - 100–150 mg / kg of body weight per day in 4–6 doses; the course of treatment is 10-14 days;
• shigellosis: therapy is carried out in two courses; first course: 2 tablets every 4 hours on the first and second days of treatment, 2 tablets every 6 hours on the third and fourth days of treatment, 2 tablets every 8 hours on the fifth and sixth days of treatment; the second course (carried out 5-6 days after the end of the first course): 2 tablets every 4 hours on the first and second days of treatment (at night, the interval between doses should be 8 hours, that is, the daily dose in the first two days of therapy is 5000 mg), 2 tablets every 4 hours on the third and fourth days of treatment (except for night hours, that is, the daily dose is 4000 mg), 6 tablets per day on the fifth day of treatment;
• wound infections: for adults - 4 tablets of the drug for the first dose, then 2 tablets 4-6 times a day; children over 3 years old - 50–75 mg / kg of body weight per day in 4–6 doses; the course of treatment for a mild form of the disease is 5-7 days, for a severe one - about 10 days;
• inflammatory diseases of the urinary and biliary tract: for adults - 1 tablet 4-6 times a day; children over 3 years old - 50–75 mg / kg of body weight per day in 4–6 doses; the course of treatment is 7-10 days.

The maximum single dose of Sulfadimezin for adults is 2000 mg, the maximum daily dose for adults is 7000 mg, the maximum daily dose for children over 3 years is 100-150 mg / kg of body weight.

Side effects

During treatment with Sulfadimezin, the following side effects may occur: vomiting and nausea, hematopoiesis disorders (agranulocytosis, leukopenia), crystalluria and allergic reactions.

special instructions

During the period of therapy, the patient should consume a sufficient amount of fluid to reduce the likelihood of developing salt diathesis (crystalluria).

With prolonged treatment with Sulfadimezin, it is necessary to regularly monitor hematological parameters.

The drug does not affect the patient's ability to drive vehicles and engage in potentially hazardous activities that require a quick reaction and concentration.

Drug interactions

When used simultaneously with bactericidal antibiotics acting only on fissile microorganisms (including cephalosporins and penicillins), Sulfadimezin reduces their effectiveness.

When taken together with thiamazole and chloramphenicol, there is a mutual increase in the hematotoxicity of these substances and sulfadimidine.

Procaine and benzocaine reduce the antimicrobial effect of the drug.

The risk of developing crystalluria increases with simultaneous use with methenamine and ascorbic acid.

Myelotoxic drugs increase the manifestation of the hematotoxicity of Sulfadimezin.

When taken simultaneously with antacids, the absorption of sulfadimidine in the intestine decreases.

With toxoplasmosis, the drug can be taken together with pyrimethamine.

Hypoglycemic drugs (sulfonylurea derivatives), coumarin anticoagulants, nonsteroidal anti-inflammatory drugs and phenytoin increase the severity of unwanted side effects of sulfadimidine (agranulocytosis, leukopenia).

Terms and conditions of storage

Store in a dark, protected from moisture place at a temperature not exceeding 25 ° C. Keep out of the reach of children.

The shelf life of the drug is 5 years.

Sulfadimezin: prices in online pharmacies

Drug name Price Pharmacy

Sulfadimezin 500 mg tablets 10 pcs. RUB 24 Buy

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!