Skincleer
Skinclair: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Skinoclear
ATX code: D10AX03
Active ingredient: Azelaic acid (Azelaic acid)
Manufacturer: Ozone, LLC (Russia)
Description and photo update: 2018-26-10
Prices in pharmacies: from 483 rubles.
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Skinoclear is a drug with antibacterial and antiproliferative effects, used in the treatment of hyperpigmentation and acne.
Release form and composition
Dosage forms of Skinoclera release:
- gel for external use 15%: from yellowish-white to white, homogeneous, opaque (5, 10, 15, 30 or 50 g in aluminum tubes, in a cardboard box 1 tube);
- cream for external use 20%: white (10 or 30 g in aluminum tubes, in a cardboard box 1 tube; 10, 15, 20, 25, 30 or 50 g in dark glass jars, in a cardboard box 1 can).
Composition of 100 mg Skinocleer gel:
- active substance: azelaic acid - 15 mg;
- auxiliary components: ceramides LS - 0.1 mg; carbomer 980 - 1 mg; disodium edetate dihydrate - 0.1 mg; benzoic acid - 0.1 mg; sodium hydroxide - 0.2 mg; isopropyl myristate - 1 mg; polysorbate 20 - 1.5 mg; propylene glycol - 12 mg; water - up to 100 mg.
Composition of 100 mg Skinoclear cream:
- active substance: azelaic acid - 20 mg;
- auxiliary components: glyceryl stearate and macrogol-30 stearate - 5 mg; benzoic acid - 0.2 mg; glyceryl stearate, cetostearyl alcohol, cetyl palmitate and coconut oil fatty acid glycerides - 7 mg; glycerol - 1.5 mg; cetearyl ethylhexanoate - 3 mg; propylene glycol - 12.5 mg; purified water - up to 100 mg.
Pharmacological properties
Pharmacodynamics
Due to the inhibition of the synthesis of cellular proteins, azelaic acid causes a moderate cytostatic effect, which manifests itself as the normalization of keratinization processes in the walls of the follicles of the sebaceous glands.
The drug has the following effect (on the skin surface and in the sebaceous glands):
- anti-inflammatory - reduces the metabolism of neutrophilic granulocytes and their production of free radical oxygen species, which are important factors in maintaining the inflammatory process;
- antimicrobial - mainly against Staphylococcus epidermidis and Propionibacterium acnes.
During a long course, the resistance of microorganisms is not formed.
Inhibition of the growth and viability of abnormal melanocytes is dose-dependent.
In hyperpigmentation, the therapeutic effect is due to suppression of cellular respiration of abnormal melanocytes and / or inhibition of DNA synthesis.
Pharmacokinetics
Azelaic acid, after being applied to the skin, penetrates into the dermis and epidermis. Approximately 4% of the dose is absorbed into the systemic circulation after 1 g of azelaic acid.
Part of the absorbed substance is excreted unchanged by the kidneys, the remaining dose is in the form of dicarboxylic acids (C5, C7), which are formed as a result of beta-oxidation.
Indications for use
- acne vulgaris (acne vulgaris);
- hyperpigmentation such as melasma, such as chloasma.
Contraindications
Absolute:
- age up to 12 years;
- individual intolerance to any component of the drug.
Relative (Skinoclear is prescribed under medical supervision):
- pregnancy;
- feeding period.
Instructions for the use of Skinoklera: method and dosage
Skinoclear cream and gel are applied externally.
The maximum duration of the course is determined by the individual picture of the disease and the severity of symptoms.
The drug should be applied 2 times a day (morning and evening) evenly in a thin layer on previously cleaned (with water and mild cleansers) and dried areas of the skin. A 2.5 cm column of cream / gel is sufficient for the entire face. Also, if necessary, Skinoclear is applied to the neck and upper chest affected by acne.
The drug should be used regularly throughout the course of treatment.
The minimum duration of melasma therapy is 3 months. During this period, in order to prevent exacerbation of the disease and / or re-pigmentation of the skin under the influence of the sun, sunscreens (UV A and B) must be used.
A marked improvement in patients with acne vulgaris is usually observed after 4 weeks. In order to obtain the best results, the use of Skinoclear should be continued for several months.
Side effects
Possible adverse reactions (> 10% - very common;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01%, including isolated messages - very rare):
- skin and subcutaneous fat: infrequently - skin depigmentation, acne, seborrhea; rarely - cheilitis;
- immune system: rarely - worsening of the course of bronchial asthma, drug hypersensitivity;
- general disorders (at the site of application): very often - burning, itching, erythema; often - pain, peeling, dryness, discoloration, irritation; infrequently - paresthesia, discomfort, dermatitis, edema; rarely - a feeling of warmth, eczema, vesicular eruptions, rash.
Local skin irritations usually resolve on their own during treatment.
Overdose
There are no reports of overdose cases.
special instructions
Skinoclear gel and cream are intended for external use only.
Its contact with the mucous membranes of the eyes, mouth and nose should be avoided as it can lead to irritation. In case of accidental contact with eyes, they should be immediately rinsed with running water.
In the first weeks of treatment with severe skin irritation, the frequency of application of the drug can be reduced to 1 time per day, or the amount of gel / cream applied to the skin can be reduced. A short-term cancellation of therapy is also allowed. After the symptoms disappear, therapy should be resumed at the recommended dose.
Dermal melasma is insensitive to the action of the drug. A Wood lamp is used for differential diagnosis.
Application during pregnancy and lactation
According to the instructions, Skinoclear is prescribed for women during pregnancy / lactation after assessing the benefit / risk ratio.
Do not apply the cream to the breast area before feeding.
Pediatric use
For patients under 12 years of age, the drug is not prescribed.
Drug interactions
The interaction of Skinocler with other drugs is unknown.
Skinoclear can be used in combination with other acne therapies. In this case, it may be necessary to correct the dosage regimen of concurrently used drugs.
Analogs
Skinoclear's analogs are: Aziks-Derm, Azelik, Skinoren.
Terms and conditions of storage
Store in a place protected from light at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Skinclair
Reviews of Skinoclear are mostly positive. They note its high efficiency, fast action, economical consumption. The drug dries acne well, relieves the inflammatory process. Side effects develop in rare cases.
The price of Skinclear in pharmacies
The approximate price for Skinoclear (gel or cream, 30 g in a package) is 528 or 570-615 rubles.
Skinclear: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Skin clear gel for outdoor use approx. 15% tube 30g 483 r Buy |
|
Skinoklyr 15% gel for external use 30 g 1 pc. 483 r Buy |
|
Skinoclear 20% cream for external use 30 g 1 pc. 497 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
