Selamerex
Selamerex: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Selamerex
ATX code: V03AE02
Active ingredient: sevelamer (Sevelamer)
Producer: Polpharma S. A., Poland Pharmaceutical Works Polpharma, SA (Poland); CJSC "PharmFirma" Sotex "(Russia)
Description and photo update: 2019-20-12
Prices in pharmacies: from 3490 rubles.
Buy
Selamerex is a drug for the treatment of hyperphosphatemia.
Release form and composition
The drug is produced in the form of tablets coated with a film coating: biconvex, oval, a core on a cross section and a film shell - from white to white with a yellow tint, SVL engraving on one side (30, 60, 90 or 180 pcs. In polymer bottle with a screwed polymer cap with child protection and first opening control, or without them; in a cardboard box 1 bottle and instructions for the use of Selamerex).
1 tablet contains:
- active substance: sevelamer carbonate - 800 mg (in terms of dry matter);
- additional components: colloidal silicon dioxide, zinc stearate, lactose monohydrate;
- film shell: polyvinyl alcohol and macrogol copolymer, talc.
Pharmacological properties
Pharmacodynamics
Sevelamer is a drug used for the treatment of hyperphosphatemia and is a polymer of allylamine hydrochloride. By binding phosphates in the gastrointestinal tract (GIT), it reduces their serum levels in the blood. Selamerex does not contain ionized calcium (Ca 2+), as a result of which it does not contribute to the development of hypercalcemia, which is observed when using phosphate-excreting agents that contain calcium ions. The effect on the content of phosphorus in the blood is preserved while taking the drug for one year.
Pharmacokinetics
The active substance is not absorbed in the gastrointestinal tract. With a long course of therapy, the likelihood of systemic absorption and cumulation of sevelamer cannot be completely excluded.
Indications for use
Selamerex is used for hyperphosphatemia in the following cases:
- against the background of chronic renal failure (CRF) in patients receiving treatment with hemodialysis or peritoneal dialysis, as part of a combination therapy including Ca 2+ preparations, colecalciferol or its analogs;
- in patients on hemodialysis.
In addition, the drug is recommended to be used as a component of complex therapy aimed at preventing bone damage associated with kidney disease, and including calcium supplements, 1,25-hydroxyvitamin D 3 or one of its analogues.
Contraindications
Absolute:
- intestinal obstruction;
- hypophosphatemia;
- age up to 18 years;
- hypersensitivity to any component of Selamerex tablets.
Relative (taking the drug requires caution):
- violation of gastrointestinal motility, including constipation;
- diseases of the gastrointestinal tract, of an inflammatory nature;
- surgical operations on the gastrointestinal tract (in history);
- difficulty swallowing;
- dysphagia;
- pregnancy and lactation;
- combined use with antiepileptic and antiarrhythmic drugs (specialist advice is required).
Selamerex, instructions for use: method and dosage
Selamerex tablets are taken orally with meals. They are swallowed whole, without crushing or chewing. During the period of therapy, it is required to adhere to the established diet.
If patients have not received phosphate binders, then the dose of the drug should be set individually, depending on the level of phosphoric acid salts in serum. In this case, at a phosphate concentration of 1.76-2.42 mmol / l (5.5-7.5 mg / ml), an initial dose of Selamerex 800 mg 3 times a day is recommended, at a concentration of> 2.42 mmol / l (> 7.5 mg / ml) - 1600 mg with the same frequency of administration.
If patients have taken phosphate-binding agents (Ca 2+ preparations), then sevelamer is used in equivalent doses in terms of 1 mg of these preparations, including Ca 2+ (by base).
The dose can vary from 800 to 4000 mg, while the maximum amount of sevelamer taken per day should not exceed 7000 mg. The dose is set taking into account the serum phosphate content in the blood; it is recommended to reduce its concentration to 1.76 mmol / l (5.5 mg / dl) and below.
Phosphate levels are measured every 2-3 weeks until stabilization is achieved.
Side effects
Possible side reactions when taking sevelamer:
- cardiovascular system: very often - increase / decrease in blood pressure;
- digestive system: very often - abdominal pain, nausea, vomiting, dyspepsia, constipation, diarrhea; often - flatulence;
- nervous system: very often - headache;
- skin: very often - itching; often a rash;
- others: very often - pain of various localization; often - pharyngitis.
Intestinal obstruction has been noted extremely rarely in clinical practice. The most common adverse reactions were observed in patients in the terminal stage of chronic renal failure.
Overdose
Overdose cases of sevelamer have not been recorded.
If you suspect an overdose, you should immediately consult a doctor.
special instructions
During treatment with Selamerex, a deficiency of vitamins A, D, E, K and B 9 (folic acid) in the blood may occur, as a result of which the latter can be prescribed additionally.
If 1 dose is missed, the next dose must be taken at the usual time. In this case, doubling the dose in order to make up for the missed dose should not be.
It is necessary to inform the attending physician about taking medications for the treatment of arrhythmias or epilepsy, and get advice about taking Selamerex.
Influence on the ability to drive vehicles and complex mechanisms
The effect of the drug on the ability to drive motor vehicles and control complex equipment was not found.
Application during pregnancy and lactation
The safety of using sevelamer during pregnancy and lactation has not been established. In the process of preclinical studies in animals, no evidence was found that this substance has an embryotoxic effect.
For pregnant and lactating women, Selamerex can be used only when there is a clear need, and a careful assessment of the risk-benefit ratio for the mother and the fetus / child has been made.
Pediatric use
Persons under 18 years of age are contraindicated to use Selamerex, since there are no data confirming the safety and efficacy of its administration in patients of this age category.
With impaired renal function
Patients with impaired renal function use Selamerex according to indications, according to the recommended dosing regimen.
Drug interactions
- mycophenolate mofetil, cyclosporine, tacrolimus: sevelamer weakens the effect of these substances;
- ciprofloxacin: its bioavailability decreases by 50%;
- drugs for which a decrease in bioavailability may have a certain clinical significance: it is recommended to use these drugs 1 hour before or 3 hours after taking sevelamer;
- levothyroxine: in rare cases, there may be a deficiency of thyroid hormones.
Analogs
Selamereks analogs are Velforo, Renvella, Osvaren, Renagel Fosrenol.
Terms and conditions of storage
Store out of the reach of children, protected from moisture, at a temperature not exceeding 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Selamerex
Currently, on specialized sites there are no reviews of Selamerex from patients or specialists, on the basis of which it would be possible to objectively assess its shortcomings and effectiveness. In the discussion of the drug on the medical forum devoted to the treatment of hyperphosphatemia, it is assumed that Selamerex, the active component of which is sevelamer carbonate, is less likely to cause heartburn than the drug containing sevelamer hydrochloride. Although the therapeutic effect of the latter is more pronounced.
The price of Selamerex in pharmacies
The approximate price for Selamerex 800 mg is 11450-11600 rubles. per package containing 180 film-coated tablets.
Selamerex: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Selamerex 800 mg film-coated tablets 180 pcs. 3490 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
