Selank - Instructions For The Use Of Drops, Reviews, Price, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Selank

Selank: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Selang

ATX code: N05BX

Active ingredient: threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline diacetate (threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline diacetate)

Producer: JSC "Innovative Research and Production Center" Peptogen "(Russia)

Description and photo update: 2018-21-11

Prices in pharmacies: from 430 rubles.

Buy

Selank is an anxiolytic drug (tranquilizer).

Release form and composition

The dosage form of Selanka is nasal drops 0.15%: transparent, colorless (3 ml each in glass bottles with a pipette stopper or bottles equipped with a pipette with a lid, in a cardboard box 1 bottle or 1 set).

Composition of 1 ml drops:

• active substance: threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline diacetate (in terms of 100% substance) - 0.001 5 g;
• auxiliary substances: purified water - up to 1 ml; nipagin (methyl parahydroxybenzoate) - 0.001 g.

Pharmacological properties

Pharmacodynamics

Selank is a synthetic analogue of taftcin (endogenous peptide), has an original mechanism of neurospecific action on the central nervous system (CNS), binds to specific receptors on the membranes of nerve cells.

The drug affects the activity of the brain enzymes tyrosine and tryptophan hydroxylase, the exchange of monoamines in the emotiogenic structures of the brain (cerebral cortex, diencephalon, hypothalamus).

By normalizing the level of serotonin in the brain under conditions of an experimentally induced decrease, it exhibits tropism to the serotonergic system.

Increases the resistance of cerebral cortex neurons to high-intensity functional loads, stabilizes the processes of inhibition and excitation in the brain.

In the spectrum of its pharmacological action, anxiolytic effect with an activating (stimulating) component prevails. It does not have a hypnosedative and muscle relaxant effect. It has a positive effect on the cognitive and mnestic functions of the brain, including when they are impaired. Improves the parameters of attention and short-term memory, activates the processes of reproduction and analysis of information, memory and learning.

Increases motivational stability and the adequacy of adaptive behavior. It has a vegetative effect, improves the vegetative support of activity during emotional stress, and has an optimizing effect on the body's adaptive reserve.

In comparison with ED50, the drug does not reveal any undesirable side and toxic effects at 200-300 fold increase in the dose. Selank has no undesirable long-term effects, does not have a local irritating, allergenic, teratogenic and embryotoxic effect, does not have mutagenic properties, does not cause drug dependence.

Pharmacokinetics

With intranasal administration, the absolute bioavailability of the drug is 92.8%. It is rapidly absorbed from the nasal mucosa into the bloodstream and is found in it half a minute after injection. A progressive decrease in its concentration in blood plasma is observed for 5–5.5 minutes.

With intranasal administration, drug metabolites are not detected. Selank penetrates into the brain tissue, quickly spreads to tissues and organs, and is found in well-vascularized organs (such as the heart, kidneys and liver) unchanged.

Due to the rapid degradation under the influence of tissue peptidases, neither metabolites nor unchanged drug is detected in daily urine.

Indications for use

According to the instructions, Selank is recommended for the treatment of the following anxiety conditions:

• anxiety, unmotivated anxiety;
• asthenia;
• neurasthenia;
• panic attacks;
• emotional instability;
• sleep disorders;
• indecision, self-doubt, reduced will and initiative, difficulty in making decisions;
• lack of confidence in communication;
• adjustment disorder.

The drug is also prescribed for the prevention and treatment of stress disorders.

Contraindications

• pregnancy;
• period of breastfeeding;
• individual intolerance to the components contained in Selank drops.

Instructions for the use of Selank: method and dosage

Drops are applied intranasally, in a sitting position with the head slightly thrown back. After instillation, each nostril is clamped with a finger for a short time.

Before use, the tip of the pipette on the dropper bottle is carefully cut along the cut line. Then a cap is put on the pipette (it must close it tightly). The bottle is turned over and lightly tapped on the bottom with a finger so that the liquid moves to the pipette and fills its entire space. After that, the cap is removed and, by slightly pressing on the wide part of the pipette, the required number of drops are squeezed into the nasal passage.

With increased secretion of the secretion of the mucous membrane of the nasal cavity, the effectiveness of absorption of the drug may decrease, and therefore, the nasal passages should be cleaned before instillation.

Recommended dosing regimen: 2 drops of Selanka three times a day in each nasal passage. The duration of the course is 2 weeks. If necessary, in agreement with the attending physician, the treatment can be repeated, but not earlier than after 1–3 weeks.

The drug should be used according to the method indicated in the instructions, without violating the recommended dosage.

Side effects

Against the background of hypersensitivity to the perception of taste and smell, unpleasant taste sensations can be observed when the drug gets from the nasal cavity onto the pharyngeal mucosa. With individual intolerance to the components of the drug, allergic reactions may develop.

Cases of other side effects not indicated in the instructions, or in case of aggravation of the reactions listed above, should be immediately reported to the attending physician.

Overdose

There are no data on an overdose of Selank drops.

special instructions

Before using Selank, it is recommended to consult with your doctor.

Selank's use does not cause drug dependence / addiction.

Influence on the ability to drive vehicles and complex mechanisms

Selank does not affect the ability to perform potentially hazardous types of work, including driving.

Application during pregnancy and lactation

Selank should not be administered to pregnant women due to the lack of data from controlled studies of its use during this period.

It is necessary to stop breastfeeding if it is necessary to use the drug during lactation.

Pediatric use

Studies of the efficacy and safety of Selank's use in pediatrics have not been conducted; its appointment to children and adolescents under 18 years of age is contraindicated.

Drug interactions

Selank does not affect the effectiveness of drugs that depress / stimulate the central nervous system (haloperidol, pentobarbital, hexobarbital, analeptics).

A combination of Selank with any type of psycho- and neuroactive therapy is allowed.

It is safe to use drops together with ethanol-containing drugs.

Before starting therapy, you must inform your doctor about taking other drugs (including over-the-counter).

Analogs

Selank's analogues are: Strezam, Noofen, Fenazepam, Mebikar, Phenibut, Adaptol.

Terms and conditions of storage

Store in a place protected from light and moisture, at temperatures up to 10 ° C, do not freeze. Keep out of the reach of children.

Shelf life is 2 years.

After opening the bottle should be stored at temperatures up to 25 ° C for no more than 15 days.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Selank

According to reviews, Selank is an affordable and effective drug that helps to quickly cope with stress. Especially often they note the absence of pronounced side effects of the drug and the withdrawal syndrome characteristic of most similar drugs.

Selank price in pharmacies

The approximate price of Selanka nasal drops (3 ml in a bottle) is 551 rubles.

Selank: prices in online pharmacies

Drug name Price Pharmacy

Selank 0.15% nasal drops 3 ml 1 pc. 430 RUB Buy

Selank gave the drops. 0.15% 3ml RUB 510 Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!