Crynon
Krynon: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. In case of impaired renal function
- 11. For violations of liver function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Krinon
ATX code: G03DA04
Active substance: progesterone
Manufacturer: Fleet Laboratories (Great Britain)
Description and photo update: 2019-07-08
Prices in pharmacies: from 2216 rubles.
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Crainon is a gestagenic drug that causes the transition of the uterine mucosa into the secretory phase from the proliferation phase caused by the action of follicle-stimulating hormone (FSH), reducing the excitability and contractility of the fallopian tubes and uterine muscles.
Release form and composition
Dosage form - vaginal gel: soft consistency, homogeneous, white or almost white, has a specific odor (1 dose in disposable polyethylene vaginal applicators, 6 or 15 applicators in a cardboard box).
Active ingredient: progesterone, 1 applicator (1.125 g) contains 90 mg.
Additional substances: purified water, hydrogenated palm oil glyceride, light liquid paraffin, carbomer 974R, polycarbophil, sorbic acid, sodium hydroxide, glycerol.
Pharmacological properties
Pharmacodynamics
The active component of Crynon is synthetic progesterone, which is completely identical to natural progesterone - the corpus luteum hormone. Under its influence, the mucous membrane of the uterus passes from the proliferative phase, for which the follicle-stimulating hormone (FSH) is responsible, to the secretory phase. The substance reduces the contractility and excitability of the muscles of the uterus and fallopian tubes.
Progesterone inhibits the work of the hypothalamic release factors of FSH and LH (luteinizing hormone), suppresses ovulation and interferes with the synthesis of gonadotropic hormones in the pituitary gland.
In Crynon, progesterone is contained in the form of a vaginal gel placed in a polymeric delivery system that binds to the vaginal mucosa and provides a constant release of the drug for at least 3 days.
Pharmacokinetics
When using Krynon at a dose of 90 mg, the maximum concentration of progesterone in the blood (11 ng / ml) is reached after about 6 hours. The half-life is 34–48 hours.
Most of the progesterone is metabolized in the liver. Vaginal administration significantly reduces the "first pass" effect through the liver. The main metabolite is 3-α, 5-β-pregnanediol, excreted in the urine.
Indications for use
- Hormone replacement therapy in the postmenopausal period (in combination with estrogens);
- Dysfunctional uterine bleeding and secondary amenorrhea due to progesterone deficiency.
Also, the drug is used to maintain the luteal phase when using assisted reproduction methods.
Contraindications
Absolute:
- Malignant tumors of the genital organs or mammary glands, or suspicion of their presence;
- Vaginal bleeding of unknown etiology;
- Incomplete abortion;
- Acute porphyria;
- Acute violation of cerebral circulation at the present time or in history;
- Thromboembolic diseases, acute thrombophlebitis and thrombosis;
- Lactation;
- Hypersensitivity to drug components.
Relative (for the following diseases / conditions, Crainon should be used with extreme caution due to the risk of complications):
- Arterial hypertension;
- Cardiovascular insufficiency;
- Chronic renal failure
- Bronchial asthma;
- Migraine;
- Epilepsy;
- Hyperlipoproteinemia;
- Depression;
- Diabetes.
Instructions for use of Krainon: method and dosage
Gel Crainon is applied intravaginally.
Recommended dosage regimens:
- Hormone replacement therapy in postmenopausal women: 1 applicator (90 mg of progesterone) 2 times a week;
- Dysfunctional uterine bleeding and secondary amenorrhea due to progesterone deficiency: 1 applicator every other day from the 15th to the 25th day of the cycle. Increase or decrease the dose if necessary;
- Maintenance of the luteal phase when using assisted reproduction methods: 1 applicator daily from the day of embryo transfer for 10-12 weeks from the moment of pregnancy confirmation or until 12 weeks.
Rules for using the drug:
- Hold the applicator firmly in the upper part of the palm, between the thumb and forefinger, shake it like a medical thermometer so that the gel moves to the lower end of the applicator;
- Holding the applicator by the upper flat end of the air container, by turning, carefully, without pressing on the container, remove the break-off cap from the opposite end;
- Take a comfortable position (lying with legs slightly bent at the knees or sitting) and gently insert the lower end of the applicator deep into the vagina;
- Squeeze the air container firmly to allow the drug to enter the vagina. A certain amount of gel will remain in the applicator, however, the dose will be injected completely;
- Throw away the used applicator with the remaining gel.
Side effects
- From the reproductive system: intermenstrual bleeding, breast tenderness, irritation of the vaginal mucosa and other moderate reactions in the area of application;
- From the central nervous system: drowsiness and headache;
- From the digestive system: abdominal pain;
- Allergic reactions: hypersensitivity reactions (usually a skin rash).
Overdose
Overdose cases have not been registered.
special instructions
Before prescribing Crainon, the patient should undergo an examination by a doctor, including an analysis of a cervical smear (Pap test), an assessment of the development and condition of the pelvic organs and mammary glands.
The drug can be used in the first trimester of pregnancy with insufficient function of the corpus luteum. At a later date, the appointment of the drug is not recommended.
Patients with any risk factors for the development of thrombotic disorders (pulmonary embolism, cerebral circulation disorders, thrombophlebitis, retinal thrombosis) should be closely monitored.
During treatment, special attention should be paid to possible early signs of thrombotic disorders. In case of the appearance of any symptom that allows one to suspect the presence of such a violation, it is necessary to immediately cancel Crainon.
With long-term treatment, regular gynecological examinations are shown to exclude the likelihood of developing endometrial hyperplasia.
To avoid the risk of incomplete abortion when using the drug, ultrasound examination should be performed regularly or the level of chorionic gonadotropin should be determined.
In cases of irregular vaginal bleeding, including breakthrough bleeding, organic pathology must be excluded.
In case of vaginal bleeding of unknown origin, an appropriate examination should be carried out.
Special monitoring during treatment is required in patients with a history of depression. If depressive symptoms appear, the use of Crainon should be discontinued.
In some cases, etrogen-progestogen drugs can reduce glucose tolerance, so patients with diabetes should be under close medical supervision.
Sorbic acid, which is part of the Crainon gel, can cause contact dermatitis.
The drug can cause drowsiness and fatigue, so care should be taken when driving and performing potentially hazardous work (alcohol can increase this effect).
Application during pregnancy and lactation
It is allowed to use Crainon in the first trimester of pregnancy with insufficient function of the corpus luteum. Prescribing the drug later in pregnancy is not recommended.
With impaired renal function
In patients with renal dysfunction, the drug is used with extreme caution and under medical supervision due to the risk of fluid retention in the body.
For violations of liver function
According to the instructions, Crainon is prescribed with caution in case of liver dysfunctions.
Drug interactions
It is not recommended to use Crainon simultaneously with other intravaginal agents.
Analogs
The analogues of Krainon are: Progesterone, Progestozhel, Prajisan, Utrozhestan.
Terms and conditions of storage
Keep out of the reach of children. Do not exceed a temperature of 25 ° C. Do not freeze.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Crynon
According to reviews, Crynon is necessary when planning pregnancy, since progesterone is responsible for preparing the endometrium for implantation of the ovum. Most of the patients claim that the vaginal gel is very convenient and easy to use and prefer this method of administration to intramuscular. Women also note that the bioadhesive gel is practically not subject to leakage, which minimizes the loss of the active substance compared to conventional progesterone suppositories.
Reviews of the drug as an element of assisted reproductive technologies that provide progesterone support for pregnancy up to 8–12 weeks are very common. At a period of 14 weeks, the placenta is already fully formed, therefore, it is inappropriate to use Krynon. A blood test for hCG is performed starting from the 12th day after the embryo is transplanted into the uterus.
The appointment of Krynon can lead to an increase in body temperature up to 37.5 ° C, which is considered normal. During therapy, some women experience pinkish, beige, or brown discharge. White discharge can be considered as a variant of the norm, however, their staining indicates the need to increase hormonal support for pregnancy and requires immediate medical attention.
With prolonged use, the gel base accumulates in the body. Therefore, experts recommend that 1 time in 2 days to carry out mechanical cleansing of the vaginal mucosa using a sterile gauze swab. This must be done before the next introduction of Krynon. Some patients complain of side effects such as constipation, drowsiness and headache, as well as the high cost of the drug.
Price for Krynon in pharmacies
The price of Krynon in the form of a gel for vaginal use in most pharmacies varies from 2,600 to 3,000 rubles (the package includes 15 applicators).
Krynon: prices in online pharmacies
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Drug name Price Pharmacy |
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Krynon 90 mg / dose vaginal gel 1.125 g 15 pcs. 2216 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
