Methyluracil

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Instructions for use:

1. Release form and composition
2. Indications for use
3. Contraindications
4. Method of application and dosage
5. Side effects
6. Special instructions
7. Drug interactions
8. Analogs
9. Terms and conditions of storage
10. Terms of dispensing from pharmacies

Prices in online pharmacies:

from 25 rubles.

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Methyluracil is a drug that activates metabolism in tissues and stimulates the regeneration process.

Release form and composition

Methyluracil is available in three dosage forms:

Tablets: white, flat-cylindrical, round, scored and chamfered (in contoured non-cell and cell packs of 10 pcs., 5 packs in a cardboard box);
Ointment for local and external use 10% (25, 30 g in aluminum tubes, 1 tube in a cardboard box; 15, 25, 30, 50, 75 g in cans, 1 can in a cardboard box);
Suppositories for rectal use (5 pcs. In blisters, 1 or 2 packages in a cardboard box).

The composition of 1 tablet includes:

Active ingredient: methyluracil (in the form of dioxomethyltetrahydropyrimidine) - 500 mg;
Auxiliary components: potato starch - 130 mg, povidone K30 - 49 mg, calcium stearate - 7 mg, talc - 14 mg.

The composition of 100 mg ointment for local and external use includes:

Active ingredient: methyluracil - 10 mg;
Auxiliary component: ointment base (water lanolin, medical petroleum jelly) - up to 100 mg.

The composition of 1 rectal suppository includes:

Active ingredient: methyluracil - 500 mg;
Auxiliary component: base for suppositories - an amount sufficient to obtain a suppository weighing 2190-2410 mg.

Indications for use

Tablets:

Leukopenia (with a mild course, including cases when the disease has developed due to chemotherapy of malignant neoplasms, X-ray and radiation therapy);
Radiation sickness;
Peptic ulcer and duodenal ulcer (along with other drugs);
Agranulocytic angina;
Alimentary-toxic aleukia;
Thrombocytopenia;
Anemia;
Intoxication with benzene;
Pancreatitis;
Hepatitis;
Bone fractures;
Burns, sluggish wounds;
Reconvalescence (after severe infections).

Ointment for local and external use:

Methyluracil is prescribed as an epithelizing agent in the treatment of wounds, burns, photodermatosis, dermatitis, bedsores, diaper rash, abscesses, boils.

Suppositories for rectal administration:

Proctosigmoiditis, ulcerative colitis, anal fissures;
Local injuries of female genital organs, as well as radiation damage to the colon and sigmoid colon, radiation cystitis and colpitis (treatment and prevention).

Contraindications

Tablets:

Malignant neoplasms of the bone marrow;
Leukemia (leukemic forms, especially myeloid);
Hemoblastosis;
Lymphogranulomatosis;
Age up to 3 years;
Hypersensitivity to drug components.

Pregnant and lactating women should take Methyluracil only after the doctor has assessed the balance of benefits for the health of the mother with the possible risk to the fetus and the baby.

Ointment for local and external use: A

contraindication to the use of Methyluracil is hypersensitivity to the components of the drug.

Suppositories for rectal administration:

Leukemic forms of leukemia (acute and chronic);
Malignant neoplasms of the gastrointestinal tract;
Lymphogranulomatosis;
Hypersensitivity to drug components.

Method of administration and dosage

Tablets:

Methyluracil is taken orally, preferably during or after a meal.

The drug is prescribed depending on age:

Adults: 4 times a day, 500 mg (it is possible to increase the frequency of use up to 6 times a day), the maximum dose is 3000 mg per day;
Children 8-14 years old: 3 times a day, 250-500 mg, the maximum dose is 1500 mg per day;
Children 3-8 years old: 250 mg 3 times a day, the maximum dose is 750 mg per day.

The duration of the course in the treatment of diseases of the gastrointestinal tract is from 30 to 40 days, with other indications, shorter therapy is possible.

Ointment for local and external use:

Methyluracil is applied to damaged areas in a thin layer, a single dose - 5-20 g. The drug is used daily for 15-30 days. In loose tampons, the drug is used for radioepitheliitis and late radiation damage to the vagina.

In the treatment of acute bullous radiation dermatitis, burns, ulcers and wounds, Methyluracil is used topically, simultaneous use with external applications of sulfonamides, antibiotic and antiseptic drugs is possible.

Suppositories for rectal administration:

The drug is prescribed depending on age:

Adults: 1-2 suppositories 1-4 times a day;
Children 8-15 years old: 1 suppository per day;
Children 3-8 years old: 1/2 suppository per day.

Depending on the indications, the duration of the drug use can vary from 1 week to 4 months.

Side effects

When taking Methyluracil inside, you may experience: headache, allergic reactions, heartburn, dizziness.

With local and external use of the drug in extremely rare cases, the development of hyperemia and itching is possible.

Possible side effects with rectal administration of Methyluracil are not described in the instructions.

special instructions

Methyluracil is generally effective in treating only mild leukopenia.

Drug interactions

When used simultaneously with cystamine, Methyluracil enhances its antiradiation effect.

Analogs

Analogues of Methyluracil are: Methyluracil-Akos, Methyluracil ointment 10%, Stizamet, Anaferon, Wobenzym, Immunorm, Imudon, Engistol, Florexil, Immuneks, Uro-Vaxom, Galavit, Glutoxim, Cycloferon.

Terms and conditions of storage

Store in a dark, dry place out of reach of children.

Shelf life:

Tablets - 5 years at temperatures up to 25 ° C;
Ointment for local and external use - 3 years and 6 months at temperatures up to 20 ° C;
Suppositories for rectal use - 2 years at temperatures up to 25 ° C.

Terms of dispensing from pharmacies

Dispensed by prescription.