Melarhythm
Melarhythm: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. In case of impaired renal function
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Melaritm
ATX code: N05CH01
Active ingredient: melatonin (melatonin)
Producer: CJSC Pharmaceutical Enterprise Obolenskoe (Russia)
Description and photo update: 2018-21-11
Prices in pharmacies: from 308 rubles.
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Melarhythm is an adaptogenic drug that normalizes physiological sleep and biological rhythms.
Release form and composition
Dosage form - tablets, film-coated: biconvex, round, almost white or white (in a blister contour package 6 pcs., In a cardboard box 1, 2 or 4 packs; in a blister contour packaging 10 or 12 pcs., In a cardboard pack of 1 or 2 packs; in a blister contour pack 20 or 24 pcs., in a cardboard pack 1 pack).
Composition of one tablet:
- active substance: melatonin - 1.5 or 3 mg;
- auxiliary components (core): microcrystalline cellulose, sodium starch glycolate (sodium carboxymethyl starch), calcium hydrogen phosphate dihydrate, mannitol, polyethylene glycol 6000 (macrogol 6000), magnesium stearate;
- shell: opadry II (polyvinyl alcohol, titanium dioxide, macrogol, talc).
Pharmacological properties
Pharmacodynamics
The active substance of Melarithm is melatonin, a synthetic analogue of the hormone of the pineal gland (pineal gland of internal secretion), which helps to normalize circadian rhythms. By regulating the cycle of alternation of sleep and wakefulness, daily changes in body temperature and locomotor activity, the drug improves the parameters of night sleep. It promotes faster falling asleep, improves sleep quality, reduces the number and severity of nocturnal awakenings, promotes well-being after waking up in the morning (does not cause feelings of fatigue, weakness and lethargy), and also affects the quality of dreams, making them more emotionally rich and vivid.
Melatonin helps to reduce the intensity of stress reactions and adapt the body with a rapid change of time zones.
The drug has the property of reducing the secretion of gonadotropic hormones and, to a lesser extent, other hormones of the anterior pituitary gland - somatotropin, thyrotropin, corticotropin.
Melarhythm has a pronounced antioxidant and immunostimulating effect.
The drug does not cause addiction and dependence.
Pharmacokinetics
When taken orally, melatonin is absorbed quickly and completely in the gastrointestinal tract. The substance easily penetrates the histohematogenous barriers, including the blood-brain barrier. The half-life is relatively short.
Indications for use
According to the instructions, Melarithm is recommended for use to improve night sleep, normalize biological rhythms and adapt the body in case of a rapid change of time zones.
Contraindications
- severe and chronic renal dysfunction;
- leukemia;
- autoimmune diseases;
- lymphoma and malignant granuloma;
- epilepsy;
- multiple myeloma;
- diabetes;
- allergic reactions;
- pregnancy and lactation period;
- increased individual sensitivity to melatonin or auxiliary components of the drug.
Instructions for the use of Melarithm: method and dosage
Melarithm tablets are taken orally, 30-40 minutes before bedtime.
Recommended dosing regimen as a sleeping pill: for adults, 1.5–3 mg once a day before bedtime.
For adaptation when changing time zones, Melarithm is taken 1 day before the flight and in the next 2-5 days, 1 tablet 3 mg before bedtime.
The maximum permissible daily dose of melatonin is up to 6 mg.
Side effects
- from the central nervous system: morning sleepiness, headache;
- from the immune system: allergic reactions;
- from the gastrointestinal tract: nausea, vomiting, diarrhea;
- other: swelling in the first 7 days of use.
Overdose
In case of an overdose of Melarithm, an increase in the severity of adverse reactions is possible.
In such cases, gastric lavage and symptomatic treatment are recommended.
special instructions
During the use of Melarithm, exposure to bright light should be avoided.
The fact that the drug has a weak contraceptive effect must be notified to women planning to become pregnant.
Influence on the ability to drive vehicles and complex mechanisms
During the period of therapy with Melarithm, one should refrain from driving vehicles and performing all types of activities that require a quick motor / mental response and high concentration of attention.
Application during pregnancy and lactation
The use of Melarithm is contraindicated in pregnant and breastfeeding women.
With impaired renal function
The drug is not recommended for patients with severe renal impairment and chronic renal failure.
Drug interactions
When used together, melatonin can enhance the effect of beta-blockers and drugs that act depressingly on the central nervous system.
Melatonin is incompatible with cyclosporine, glucocorticosteroids and MAO (monoamine oxidase) inhibitors.
It is not recommended to take Melarithm simultaneously with hormonal drugs.
Analogs
Analogues of Melarithm are: Kakspal Neo, Melaxen, Melarena, Sonnovan, Circadin and others.
Terms and conditions of storage
Store in a dry place protected from light, at a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Melarithm
Reviews about Melarithm are mostly positive. Users report that the pharmacological properties declared in the annotation to the drug are fully consistent with reality. The drug promotes faster falling asleep, restful and full sleep, and also helps to adapt and restore biological rhythms when changing time and climatic zones. It is often used by athletes to normalize work and rest. Unlike other sedative medicines, Melarithm is sold over the counter without a prescription.
The cost of the drug is quite high, but the tablets are enough for a long period of time.
The price of Melarithm in pharmacies
The average price for Melarithm per pack is: 12 tablets - 305 rubles, 24 tablets - 425 rubles.
Melarithm: prices in online pharmacies
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Drug name Price Pharmacy |
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Melarithm 3 mg film-coated tablets 12 pcs. 308 RUB Buy |
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Melarithm 3 mg film-coated tablets 24 pcs. 430 RUB Buy |
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Melarithm tablets p.p. 3mg 24 pcs. 432 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
