Table of contents:
- Release form and composition
- Pharmacological properties
- Indications for use
- Instructions for using Intetrix: method and dosage
- Side effects
- special instructions
- Application during pregnancy and lactation
- Pediatric use
- For violations of liver function
- Drug interactions
- Terms and conditions of storage
- Terms of dispensing from pharmacies
- Reviews about Intetrix
- Price for Intetrix in pharmacies
Video: Intetrix - Instructions For Use, Reviews, Price, Analogues
2023 Author: Rachel Wainwright | [email protected]. Last modified: 2023-08-25 01:36
Intetrix: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. For violations of liver function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Intetrix
ATX code: P01A
Active ingredient: trichinol (trikhinol) + tilbroquinol (tilbrokhinol) + tilikhinol N-dodecyl sulfate (tilikhinol N-dodecilsulfate)
Producer: Beaufour Ipsen International (France)
Description and photo updated: 2018-27-02
Intetrix is a drug used in the treatment of intestinal amebiasis.
Release form and composition
Dosage form - capsules of 420 mg: size No. 1, body - white opaque, lid - dark red opaque, contents of capsules - grayish-yellow microcrystalline powder (10 or 20 capsules in blisters made of aluminum foil and PVC film, 1 or 2 blisters in a cardboard box).
1 capsule contains active substances:
- Tilichinol - 50 mg;
- Tiliquinol N-dodecyl sulfate (N-dodecyl sulfate = lauryl sulfate) - 50 mg (in total, 1 capsule contains 68.7 mg ± 5% of tiliquinol);
- Tilbroquinol 200 mg
Auxiliary components: lactose monohydrate - 90 mg, corn starch - 30 mg.
The composition of the capsule (body and cap): indigotine (E132), gelatin, titanium dioxide (E171), azorubin (E122).
In chronic amoebiasis, the pharmacological effect is achieved due to the synergism of the amoebicidal action of three active ingredients, which are antiseptic substances.
Intetrix acts in the intestinal lumen and is used in the treatment of intestinal amebiasis. Effective against vegetative forms of amoebas. Has a wide antimicrobial (bacteriostatic and bactericidal) spectrum of action against Vibrio cholerae Ogawa, S. Faecalis, E. coli 111. B4, Vibrio cholerae Inaba, S. enteritidis Danysz, S. Paratyphi B, Proteus vulgaris, Serratia marcescens, Pseudomonas aerug others, as well as antifungal action against C. albicans.
It does not lead to an imbalance in the normal intestinal microflora and does not cause plasmid resistance.
When administered orally, the drug has a low degree of absorption in the gastrointestinal tract, due to which an effective concentration is maintained in the intestinal lumen.
The maximum plasma concentration in the blood after oral administration is reached in 3-4 hours. The half-life is approximately 10 hours. The maximum excretion is determined after 12-24 hours. The entire dose is removed in full within 48 hours.
Drug metabolism occurs in several ways:
- entry into the systemic circulation after absorption from the intestine;
- entering the intestine without absorption, excretion is carried out along with the intestinal contents;
- transformation in the intestine after partial absorption.
Indications for use
According to the instructions, Intetrix is prescribed for the treatment of intestinal amebiasis in adults:
- Asymptomatic cases of diagnosed amebiasis (monotherapy);
- Intestinal amoebiasis with tissue amoebicides (along with other drugs).
- lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
- combined use with drugs containing hydroxyquinoline derivatives;
- age up to 18 years;
- pregnancy and lactation;
- individual hypersensitivity to the components of the drug.
For patients with hepatic insufficiency, Intetrix is prescribed under medical supervision.
Instructions for using Intetrix: method and dosage
Intetrix is taken orally with a sufficient amount of water, preferably at the beginning of a meal. The capsules should be swallowed whole.
Single dose - 2 capsules, frequency of administration - 2 times a day (in the morning and evening).
The duration of therapy is 10 days.
In rare cases, during therapy, it is possible to develop skin reactions such as urticaria, persistent pigmented erythema and Quincke's edema.
It is extremely rare, with prolonged use of the drug, transient disorders of the optic nerve and peripheral neuropathy can be observed.
It is also possible to increase the content of transaminases.
Overdose increases the likelihood of hepatotoxicity.
Therapy: abolition of Intetrix, symptomatic treatment. It is required to control the activity of hepatic transaminases and prothrombin, as well as the concentration of prothrombin.
With an increase in the level of transaminases, especially in patients with hepatic insufficiency, the intake of Intetrix should be discontinued.
Long-term therapy is impractical because of the risk of peripheral neuropathy.
The use of Intetrix by nursing and pregnant women is not recommended (due to the lack of necessary data on the safety and effectiveness of the drug for this group of patients). Also, taking the drug is undesirable in the presence of habitual miscarriages, since these conditions require careful observation and well-planned antenatal monitoring.
Application during pregnancy and lactation
Intetrix is not prescribed during pregnancy / lactation.
Drug therapy for patients under 18 years of age is contraindicated.
For violations of liver function
The drug for liver failure is prescribed under medical supervision.
Intetrix should not be used simultaneously with drugs containing hydroxyquinolines.
There is no information about the analogues of Intetrix.
Terms and conditions of storage
Keep out of reach of children at temperatures up to 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Intetrix
Reviews about Intetrix are mostly positive. Its high efficiency is also noted in the treatment of intestinal infections that cause diarrhea. Some users report that the drug has a negative effect on the liver. In addition, they indicate the return of diarrhea symptoms after the end of the course of therapy.
Price for Intetrix in pharmacies
The approximate price for Intetrix (20 capsules) is 412–478 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
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