Idebenone
Idebenone: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Use in the elderly
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Idebenone
ATX code: N06BX13
Active ingredient: idebenone (idebenone)
Manufacturer: Kanonpharma production CJSC (Russia)
Description and photo update: 18.10.2018
Idebenone is a nootropic drug.
Release form and composition
Dosage form - capsules: size No. 1 (30 mg) or No. 0 (45 mg), hard gelatinous, with a yellow body and a brown lid; contents - a mixture of powder and granules of yellow or yellowish-orange color, there may be lumps (10 pcs. in blisters, 1, 2, 3, 6 or 12 packs are packed in a cardboard box; 15 pcs. in blisters, 1, 2, 4 or 8 packs are packed in a cardboard box).
Composition of 1 capsule:
- active substance: idebenone - 30 or 45 mg;
- auxiliary components: microcrystalline cellulose, pregelatinized starch, calcium hydrogen phosphate dihydrate, magnesium stearate, macrogol (polyethylene glycol).
Composition of the gelatin capsule:
- body: titanium dioxide, gelatin, dye iron oxide yellow;
- cap: gelatin, titanium dioxide, iron dye red oxide, iron dye black oxide, iron dye yellow oxide.
Pharmacological properties
Pharmacodynamics
Idebenone is a nootropic agent with trophic and metabolic effects. Improves oxygenation, blood supply to brain tissue and metabolic processes in the brain, increases the speed and intensity of neurophysiological reactions of brain structures, promotes the elimination of lactate. Protects membranes of neurons and mitochondria from damage by slowing down lipid peroxidation.
The antidepressant effect occurs at least 14 days after starting the drug.
Pharmacokinetics
Idebenone is rapidly and completely absorbed. The maximum plasma concentration is observed after 4 hours. In significant quantities, it penetrates the blood-brain barrier and is distributed in the brain tissues. Does not cumulate. It is excreted by the kidneys.
Indications for use
- manifestations of vestibular insufficiency (dizziness, tinnitus);
- asthenic and asthenic-depressive syndrome;
- psychoorganic syndrome due to impaired cerebral circulation and age-related involutional changes in the brain;
- moderately severe depressive syndrome;
- cerebroasthenic disorders of psychogenic (neurasthenia), vascular and traumatic etiology: decreased intellectual productivity and general activity, impaired memory and / or attention, emotional instability.
Contraindications
Absolute:
- chronic renal failure;
- hypersensitivity to the drug;
- age up to 18 years.
With care: during pregnancy and lactation.
Instructions for the use of Idebenone: method and dosage
The tablets should be taken orally after meals. The last appointment must be no later than 17 hours.
Adults are usually prescribed 30 mg 2-3 times a day. Increase the dose if necessary.
The duration of therapy, depending on the clinical situation, is 1.5–2 months. Repeated courses are possible, only 2-3 courses per year are allowed.
Side effects
The drug is generally well tolerated. In rare cases, the following side effects are possible:
- from the gastrointestinal tract: dyspeptic disorders;
- from the central nervous system: headache, mental agitation, sleep disturbance;
- allergic reactions: skin rash.
Overdose
In case of an overdose, an increase in the severity of adverse reactions is possible. If you accidentally take a high dose of the drug, the patient should take activated charcoal. Further treatment is symptomatic.
special instructions
Influence on the ability to drive vehicles and complex mechanisms
According to the instructions, Idebenone has an effect on the central nervous system, so it should not be prescribed to vehicle drivers and persons employed in potentially hazardous industries that require speed of psychophysical reactions and concentration of attention.
Application during pregnancy and lactation
During pregnancy and lactation, the product should be used with caution, under the supervision of a physician.
Pediatric use
The drug is contraindicated in children and adolescents under 18 years of age.
With impaired renal function
The drug is contraindicated in chronic renal failure.
Use in the elderly
The drug is used for psychoorganic syndrome due to age-related involutional changes in the brain.
Drug interactions
No information available.
Analogs
Idebenone's analogues are: Noben, Celestab, Neuromet.
Terms and conditions of storage
Store in a dry, dark place, out of reach of children, at a temperature not exceeding 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Idebenone
Reviews about Idebenone are mostly good. Elderly people use the drug to improve memory and treat Alzheimer's disease, middle-aged people - to improve brain function and overall activity. In both cases, Idebenone has established itself as an effective remedy that practically does not cause side reactions.
Patients note that an increase in motivation and a rise in vitality appears within 2 hours after taking the drug. However, to achieve a pronounced nootropic effect, at least 3 weeks are required.
A good effect can be achieved by combining the drug with a complex of B vitamins.
Price for Idebenone in pharmacies
The price for Idebenone is approximately 500-800 rubles per pack of 60 capsules at a dose of 45 mg.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
