Ibuprom - Instructions For Use, Price, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Ibuprom

Ibuprom: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Ibuprom

ATX code: M01AE01

Active substance: ibuprofen

Producer: US Pharmacia Sp.zo.o (Poland)

Description and photo update: 18.10.2018

Ibuprom is a drug with analgesic and anti-inflammatory effects.

Release form and composition

Dosage forms of release:

• coated tablets 200 mg: biconvex, round, with a white sugar coating (10 pcs. in blisters, in a cardboard box 1 blister; in a sachet, 2 pieces, in a cardboard box, 1 sachet; in a polyvinyl bottle, 50 pcs. in cardboard packaging 1 bottle);
• soft capsules 200 mg (Ibuprom or Ibuprom SPRINT CAPS): oval, size No. 10, blue, transparent, capsules contain an oily transparent liquid from a little blue to colorless (6 or 10 pieces in blisters, 1 blister in a cardboard box);
• coated tablets, 400 mg (Ibuprom MAX): white, oblong, sugar-coated (6 pieces in blisters, in a cardboard box 1, 2 or 4 blisters; in a polyvinyl bottle, 24 pieces, in a cardboard box 1 bottle);
• soft capsules 400 mg (Ibuprom EXTRA): oval, gelatinous, transparent, pale yellow (6 pcs. in blisters, 1 blister in a cardboard box).

Composition of 1 tablet 200 mg:

• active substance: ibuprofen - 200 mg;
• auxiliary components: powdered cellulose, pregelatinized and corn starch, guar gum, talc, crospovidone (type A), aqueous silicon dioxide, hydrogenated vegetable oil;
• shell: hydroxypropyl cellulose, polyethylene glycol (macrogol 400), sucrose, carnauba wax, gelatin, kaolin, calcium carbonate, confectionery sugar, dispersed-dried acacia, titanium dioxide (E 171), Opalux White AS 7000.

Composition of 1 soft capsule 200 mg:

• active substance: ibuprofen - 200 mg;
• auxiliary components: polyethylene glycol 600, potassium hydroxide, purified water, dry substance of anidrisorb 85/70;
• shell: gelatin, patented blue V 85% (E 131).

Composition of 1 tablet 400 mg:

• active substance: ibuprofen - 400 mg;
• auxiliary components: povidone, lactose monohydrate, corn starch, croscarmellose sodium, magnesium stearate, talc, colloidal silicon dioxide;
• shell: sucrose, talc, corn starch, titanium dioxide (E 171), carnauba and white wax.

Composition of 1 soft capsule 400 mg:

• active substance: ibuprofen - 400 mg;
• auxiliary components: polyethylene glycol 600, potassium hydroxide, purified water;
• shell: gelatin, sorbitol (E 420), purified water.

Pharmacological properties

Pharmacodynamics

Ibuprom is an analgesic of the group of non-steroidal anti-inflammatory drugs. It has a pronounced analgesic and anti-inflammatory effect. In addition, it helps to lower body temperature in case of fever and has an anti-exudative effect.

The active substance of Ibuprom is ibuprofen - a synthetic substance derived from propionic acid. The mechanism of its action is associated with the ability to disrupt the metabolism of arachidonic acid, which occurs due to inhibition of the activity of the enzyme cyclooxygenase. In particular, ibuprofen inhibits the synthesis of prostaglandins E and F and thromboxane.

Ibuprofen lowers the number of prostaglandins in the tissues of the central nervous system and the focus of inflammation. Due to a decrease in the amount of prostaglandins in the inflammation focus, the sensitivity of receptors to chemical stimuli decreases. By inhibiting the synthesis of prostaglandins in the tissues of the central nervous system, ibuprofen has a systemic analgesic effect. With fever, inhibition of prostaglandin synthesis in the center of thermoregulation in the hypothalamus contributes to a decrease in body temperature.

Also, ibuprofen has an antiplatelet effect (due to inhibition of the synthesis of thromboxane from arachidonic acid).

Pharmacokinetics

After oral administration, ibuprofen is well absorbed from the gastrointestinal tract, its maximum absorption is noted in the stomach and small intestine.

The bioavailability of ibuprofen reaches 80%, food intake does not significantly affect the degree of absorption of the drug, but it can slightly slow down the absorption of the active substance. Ibuprofen is characterized by a high degree of association with plasma proteins (up to 99%), mainly with albumin.

The maximum plasma concentration of ibuprofen in the blood is reached 45–90 minutes after ingestion, in the synovial fluid - within 2–3 hours. In the synovial fluid, the maximum concentrations of ibuprofen are significantly higher than the maximum plasma concentrations of the drug, which is mainly due to the difference in albumin concentrations in biological fluids.

Metabolism occurs in the liver by carboxylation and hydroxylation. As a result, 4 metabolites are formed, which do not have pharmacological activity.

After a single use of 200 mg ibuprofen, the half-life is 2 hours, with an increase in the dose, the half-life increases. With repeated use of Ibuprom, the half-life is in the range of 2 to 2.5 hours.

Excretion occurs mainly by the kidneys in the form of metabolites, no more than 1% of the drug is excreted unchanged. A small amount of the drug is excreted with bile in the form of metabolites.

Indications for use

Ibuprom is prescribed as an anti-inflammatory and analgesic agent for pain of various etiologies, including the following diseases / conditions:

• pain syndrome of moderate / low intensity caused by inflammatory-degenerative diseases of the musculoskeletal system, including osteoarthritis, ankylosing spondylitis, rheumatoid arthritis;
• diseases of the musculoskeletal system of a different etiology, occurring with pain syndrome, including psoriatic arthritis and articular syndrome against a background of exacerbation of gout;
• diseases of soft tissues of inflammatory etiology, which occur with pain syndrome of moderate / low intensity, including tendovaginitis, bursitis;
• joint / muscle pain that has developed as a result of injury;
• fever against the background of infectious and inflammatory diseases (to lower the temperature);
• pain syndrome of moderate / weak intensity of unexplained etiology, including neuralgia, algomenorrhea, muscle pain, headache and toothache, adnexitis;
• infectious and inflammatory diseases of the upper respiratory tract, occurring with severe pain syndrome (simultaneously with other drugs).

Contraindications

Absolute:

• a tendency to develop gastrointestinal bleeding;
• aspirin triad: urticaria, allergic rhinitis and bronchospasm, including a burdened history;
• nonspecific ulcerative colitis and ulcerative lesions of the stomach and duodenum, including a burdened history;
• pathology of the optic nerve;
• severe hepatic / renal failure;
• deficiency of sugar-isomaltose, impaired absorption of glucose-galactose;
• disorders of the hematopoietic system;
• III trimester of pregnancy;
• age up to 12 years;
• individual intolerance to the components of the drug, including the presence of hypersensitivity to other non-steroidal anti-inflammatory drugs.

Relative (diseases / conditions in the presence of which caution is required):

• heart failure;
• bronchial asthma;
• connective tissue diseases;
• systemic lupus erythematosus;
• arterial hypertension;
• functional disorders of renal / hepatic function;
• I – II trimesters of pregnancy (only if the benefit to the mother outweighs the potential harm to the fetus / child);
• period of breastfeeding.

In cases of prolonged use of Ibuprom, it is recommended to monitor the blood picture, as well as the functional state of the kidneys and liver.

Instructions for the use of Ibuprom: method and dosage

Tablets and capsules are taken orally.

The dosage regimen is determined individually.

As a rule, the drug is prescribed up to 3 times a day (with a 4–6 hour break) at 200–400 mg. In renal / hepatic impairment, the dose should be reduced.

Ibuprom in capsule form is recommended to be taken whole, without chewing and drinking plenty of water, preferably with / after meals.

Ibuprom Max can be taken with or without food. Sharing a pill is not recommended. The maximum daily dose is 3 tablets.

In the presence of diseases of the gastrointestinal tract, as well as with a burdened history of gastritis or ulcerative erosive lesions of the stomach and duodenum, Ibuprom, regardless of the form of release, is recommended to be taken with meals.

If a headache appears during the use of the drug (as a side effect), it is contraindicated to increase the dose of Ibuprom in order to stop the attack.

Side effects

• cardiovascular system: tachycardia; in isolated cases (usually in the presence of hypersensitivity or with simultaneous use with other non-steroidal anti-inflammatory drugs) - hypertension, heart failure, an increase in the likelihood of arterial thrombotic events, including stroke and myocardial infarction;
• central nervous system: drowsiness, headache, dizziness;
• digestive system: stool disorders, vomiting, nausea, pain in the epigastric region, digestive disorders, heartburn, flatulence; extremely rarely - gastrointestinal bleeding, erosive and ulcerative lesions of the stomach and duodenum, ulcerative colitis, pancreatitis; in isolated cases - a change in taste;
• hematopoietic system: leukopenia, anemia, pancytopenia, thrombocytopenia; with prolonged use - agranulocytosis, proceeding with ulcerative lesions of the oral mucosa, sore throat, fever and an increase in the likelihood of bleeding;
• urinary system: edema, a decrease in the daily volume of urine, an increase in the level of urea in the blood; in isolated cases - papillary necrosis;
• liver: increased activity of liver enzymes, hepatitis, liver failure;
• allergic reactions: erythema multiforme, skin rash, pruritus, bronchospasm, urticaria, epidermal necrosis, anaphylactoid reactions, including Quincke's edema and anaphylactic shock;
• others: against the background of autoimmune diseases - aseptic meningitis (manifested in the form of fever, headache, vomiting, nausea, disorientation in space and stiff neck muscles).

Overdose

The main symptoms are: nausea, vomiting, gastralgia, headache, dizziness, drowsiness and lethargy; with a further increase in the dose, hypotension may appear, an increase in the amount of potassium in the blood, accompanied by loss of consciousness, fever, arrhythmia, coma, metabolic acidosis, impaired respiratory and renal function; in chronic poisoning caused by prolonged inconsistent use of high doses of Ibuprom - granulocytopenia, thrombocytopenia and hemolytic anemia.

Therapy: there is no specific antidote, hemodialysis is ineffective, since the drug has a high degree of connection with plasma proteins. In case of acute overdose, enterosorbents are prescribed, gastric lavage and symptomatic treatment. Also, until all symptoms disappear, it is required to monitor the vital functions of the body, in particular - blood pressure, electrocardiogram. In case of acute poisoning, it is recommended to exclude the likelihood of disturbances from the central nervous system and gastrointestinal bleeding. In patients with acute poisoning, metabolic acidosis can be observed, therefore, when the first symptoms appear, it is necessary to carefully monitor the patient's condition and take measures to restore the acid-base balance and maintain the pH in the range of 7.0–7.5.

special instructions

Ibuprom should not be used in combination with other non-steroidal anti-inflammatory drugs.

The use of the drug for bronchial asthma requires special care (due to the likelihood of an attack). If a peptic ulcer of the stomach / duodenum is suspected, the likelihood of gastrointestinal bleeding increases.

In cases of need for long-term therapy, regular monitoring of liver and kidney function indicators, as well as hemogram is required. It is imperative to monitor blood pressure.

If visual disturbances appear, it is necessary to reduce the dose / cancel the drug.

Application during pregnancy and lactation

III trimester of pregnancy is a contraindication to the use of Ibuprom. In the I-II trimesters, it is not recommended to take the drug (except in cases where the benefits to the mother outweigh the potential harm to the fetus).

Ibuprofen and its metabolites are excreted in breast milk. There is no need to interrupt breastfeeding with a single dose in a daily dose of up to 1200 mg. In cases of prolonged use of Ibuprom in high doses, breastfeeding should be interrupted.

Pediatric use

According to the instructions, Ibuprom is not prescribed for children under 12 years old.

With impaired renal function

Severe renal impairment is a contraindication to taking the drug.

For violations of liver function

Severe violations of hepatic function are a contraindication to taking the drug.

Drug interactions

With the combined use of Ibuprom with certain drugs / substances, the following effects may develop:

• other non-steroidal anti-inflammatory drugs: the likelihood of adverse reactions from the gastrointestinal tract and the blood system increases (due to the low degree of systemic action, the use with local anti-inflammatory drugs is permissible);
• antihypertensive drugs, including angiotensin-converting enzyme inhibitors and beta-blockers: their effectiveness decreases;
• anticoagulants: platelet aggregation decreases, and therefore requires regular monitoring of blood clotting;
• diuretics (loop / thiazide diuretics): their effectiveness decreases;
• zidovudine: the combination is contraindicated;
• lithium preparations: the concentration of lithium in the blood increases, if combined use is necessary, the level of lithium in the blood should be regularly monitored;
• methotrexate: its toxicity is increasing.

Analogs

Ibuprom analogs are: Solpaflex, Ibuprofen, MIG 400, Nurofen, Faspik, Advil.

Terms and conditions of storage

Store at temperatures up to 25 or 30 ° C (capsules / tablets). Keep out of the reach of children.

Shelf life:

• 200 mg tablets / capsules - 2 years;
• 400 mg tablets / capsules - 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Ibuprom

According to reviews, Ibuprom is quite effective even with severe pain, while its rapid action is noted. Of the shortcomings, the development of adverse reactions is most often indicated.

Price for Ibuprom in pharmacies

The price of Ibuprom is unknown because it is not available in pharmacies. Group analogues are available (approximate price):

• Nurofen Express Neo (pack of 12 tablets of 200 mg): 110–160 rubles;
• Nurofen Express capsules (in a package of 16 capsules, 200 mg each): 300–320 rubles;
• MIG 400 (in a package of 20 tablets of 400 mg): 90–150 rubles.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!