Domstal - Instructions For The Use Of Tablets, Price, Analogs, Reviews

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Domstal

Domstal: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Domstal

ATX code: A03FA03

Active ingredient: Domperidone (Domperidone)

Manufacturer: TORRENT PHARMACEUTICALS Ltd. (India)

Description and photo update: 18.10.2018

Prices in pharmacies: from 262 rubles.

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Domstal is an antiemetic drug, a central blocker of dopamine receptors.

Release form and composition

Dosage form - tablets: flat, round, almost white or white, with a chamfer and a notch on one side, (10 pcs. In a blister of aluminum foil and PVC film, in a cardboard box 1 or 3 blisters).

1 tablet contains:

• active substance: domperidone - 10 mg;
• excipients: lactose - 114 g, starch - 38 mg, potassium hydrogen phosphate - 29.5 mg, gelatin - 3.5 mg, talc - 3 mg, magnesium stearate - 2 mg.

Pharmacological properties

Pharmacodynamics

Domperidone is a dopamine antagonist and, like metoclopramide and a few antipsychotics, has antiemetic properties. But in comparison with them, domperidone does not pass well through the blood-brain barrier. Its use rarely causes extrapyramidal side effects, especially in adult patients, but the use of domperidone stimulates the release of prolactin by the pituitary gland. The antiemetic effect of Domstal is possibly due to a combination of gastrokinetic (peripheral) action with antagonism to dopamine receptors in the trigger zone of the brain.

The use of domperidone inside increases the duration of duodenal and antral contractions, accelerates gastric emptying - the release of solid fractions in patients (in whom this process was slowed down), liquid and semi-solid fractions in healthy people, and also increases the pressure of the sphincter of the lower esophagus in healthy people. Domperidone has no effect on gastric secretion.

Pharmacokinetics

The bioavailability of the drug after oral administration (inside) reaches 13-17% (the effect of the first passage through the liver). The half-life is 7.5 hours, with renal failure it can increase to 20.8 hours. Domperidone is subject to extensive and rapid metabolism. It is excreted through the intestines - 66%, by the kidneys - 33%, including in unchanged form - 10 and 1%, respectively.

Indications for use

• a set of dyspeptic symptoms, often associated with delayed gastric emptying, gastroesophageal reflux, esophagitis (feeling of fullness in the epigastrium, pain in the upper part and a feeling of bloating; flatulence, belching; nausea / vomiting; heartburn);
• nausea and vomiting of functional, infectious, organic, origin, caused by drug therapy, radiation therapy or diet disturbance, as well as dopamine agonists when used in Parkinson's disease (for example, levodopa and bromocriptine).

Contraindications

• prolactinoma (prolactin-secreting pituitary tumor);
• mechanical intestinal obstruction, perforation of the stomach or intestines, in which stimulation of the motor function of the stomach can be dangerous;
• gastrointestinal bleeding;
• glucose-galactose malabsorption or lactase deficiency, hereditary lactose intolerance;
• age up to 5 years and the weight of the child is less than 20 kg;
• high sensitivity to drug components.

Instructions for use of Domstal: method and dosage

The tablets are taken orally 15-30 minutes before meals.

Recommended dosage for children over 5 years of age and adult patients: 3 times a day, 10 mg, if necessary, an additional 10 mg at bedtime. In cases of severe vomiting / nausea or severe dyspepsia - 3-4 times a day, 20 mg.

Patients with renal insufficiency should reduce the frequency of taking the drug.

Side effects

• digestive system: transient intestinal spasms (completely disappear after stopping treatment);
• central nervous system: extrapyramidal disorders in patients with increased permeability of the blood-brain barrier and in children (they are transient and pass on their own upon completion of therapy); it is impossible to completely eliminate the likelihood of such side effects in case of underdevelopment of the blood-brain barrier (for example, in children) or its high permeability;
• hypersensitivity reactions: urticaria and rash;
• other reactions: hyperprolactinemia (galactorrhea, gynecomastia).

Overdose

In case of an overdose, the following symptoms may occur (especially in children): disorientation, extrapyramidal disorders, drowsiness.

For therapy, it is recommended to take activated carbon and careful monitoring of the patient's condition. In the event of extrapyramidal reactions, anticholinergic drugs, drugs used for parkinsonism, or antihistamines with an anticholinergic effect may be effective.

special instructions

In the case of complex use of the drug Domstal with antisecretory or antacid agents, the latter must be taken after meals. At the same time, Domstal is taken before meals, since the absorption of domperidone is slightly slowed down by the presence of food in the stomach.

Application during pregnancy and lactation

There is not enough information on the use of the drug during pregnancy.

There is currently no evidence of an increased risk of malformations in humans. Domstal should be prescribed only if the expected benefit to the mother outweighs the potential risk to the child.

The concentration of domperidone in breast milk is 4 times lower than in plasma. Whether this level contributes to adverse effects in newborns is unknown. When using the drug, breastfeeding should be discontinued.

Pediatric use

The use of the drug is contraindicated in children under 5 years of age.

With impaired renal function

In case of renal failure, it is recommended to reduce the frequency of taking the drug.

For violations of liver function

With severe liver failure, Domstal should be used with caution.

Drug interactions

• antifungal drugs of the azole series, HIV protease inhibitors, antibiotics from the macrolide group, nefazodone (antidepressant): increasing the concentration of domperidone in plasma;
• anticholinergic drugs: it is possible to neutralize the action of Domstal;
• cimetidine, sodium bicarbonate: their bioavailability decreases;
• antipsychotics: domperidone does not enhance their effect;
• dopaminergic receptor agonists (bromocriptine, levodopa): suppression of undesirable peripheral effects, such as nausea, vomiting, digestive disorders, without neutralizing their main properties;
• paracetamol and digoxin: the concentration of these drugs in the blood does not change.

Analogs

Domstal's analogues are: Domet, Domperidon, Domperidon-Teva, Motijekt, Motilak, Motilium, Motilium Express, Motorinorm, Passages.

Terms and conditions of storage

Store out of the reach of light and moisture, at a temperature not exceeding 30 ° C. Keep out of the reach of children.

Shelf life is 4 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Domstal

The few reviews left by patients about Domstal are mostly positive. The action of the drug corresponds to that described in the instructions, taking the pills significantly improves health.

The price of Domstal in pharmacies

Today, the price of Domstal in online pharmacies ranges from 270–300 rubles. But it should be borne in mind that the drug is included in the list of medicines, the delivery of which from online pharmacies to home is prohibited in accordance with the law. The order is delivered to the pharmacy nearest to the house.

An analogue of Domstal Passages can be purchased in pharmacies for about 250 rubles per pack containing 30 tablets.

Domstal: prices in online pharmacies

Drug name Price Pharmacy

Domstal 10 mg tablets 30 pcs. 262 RUB Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!