Doxibene
Doxibene: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Doxybene
ATX code: J01AA02
Active ingredient: Doxycycline (Doxycycline)
Manufacturer: Merkle GmbH, Germany
Description and photo update: 18.10.2018
Doxibene is a systemic drug with antibacterial effect.
Release form and composition
- capsules 100 mg: gelatinous, soft, dark green; contents - yellow oily paste (10 pcs. in blisters, in a cardboard box 1 blister);
- capsules 200 mg: gelatinous, hard, consist of 2 parts - transparent and dark green opaque, both parts are embossed in white "dox 200"; contents - yellow balls (5 pcs. in blisters, 1 blister in a cardboard box).
Composition of 1 capsule 100 mg:
- active substance: doxycycline - 100 mg (in the form of doxycycline hyclate in the amount of 115.4 mg);
- auxiliary ingredients: beeswax, hydrogenated soybean oil, partially hydrogenated soybean oil, triglycerides of capric and caprylic acids, ethyl vanillin, lecithin E 322, 4-methoxyacetophenone;
- shell: glycerin, gelatin, dry matter of carion, titanium dioxide E171, copper complexes of chlorophylls and chlorophyllins (aqueous solution) E 141.
Composition of 1 capsule 200 mg:
- active substance: doxycycline - 200 mg (in the form of doxycycline hyclate in the amount of 230.8 mg);
- auxiliary ingredients: corn starch, sucrose, shellac, oydragit L-100, oydragit E-100, talc, povidone K30;
- shell: indigo carmine blue E132, titanium dioxide E171, iron oxide black E172, iron oxide yellow E172, gelatin.
Pharmacological properties
Pharmacodynamics
Doxycycline has a bacteriostatic effect. The drug is active against gram-positive bacteria: staphylococci, streptococci, pneumococci, clostridia, listeria monocytogenes and gram-negative microorganisms: aerobic bacteria, aerobic cocci, Escherchia coli, various types of Shigella, Klebsiella, Salmonella. The drug is also active against other microorganisms, such as rickettsia, chlamydia (Chlamydia trachomatis, Chlamydia psittaci,), treponema (Treponema pertenue, Treponema pallidum), ureplasma (Ureaplasma urealyticum). The sensitivity of Staphylococcus aureus to doxycycline in vivo is higher than to other tetracyclines.
Pharmacokinetics
Doxycycline is almost completely absorbed in the digestive tract, the process slightly depends on the availability of food. The concentration of the substance in the blood plasma reaches its maximum values 2 hours after ingestion. Doxycycline, due to its high lipophilicity, penetrates the tissues of the body better than other antibiotics of the tetracycline series. Up to 80–90% of doxycycline binds to plasma proteins; its half-life is ~ 12-18 hours with a single use and ~ 22-24 hours if the drug is taken regularly.
Doxycycline in high concentration is recorded in the parenchyma of the kidneys, bile (5-10 times higher than in the blood plasma); in clinically effective doses, the antibiotic accumulates in the duodenum, muscles, appendix, glomeruli, lungs, uterus, ovaries, thyroid and prostate glands, paranasal sinuses, and lymph nodes.
Indications for use
Doxibene is used to treat diseases caused by bacteria sensitive to doxycycline: pneumonia, bronchitis, tonsillitis, inflammation of the paranasal sinuses, otitis media, cholera, cholecystitis / cholangitis, diarrhea with dysbiosis, gonorrhea, syphilis, pyelonephritis, cystitis, urethitis, urethitis adnexitis, infectious diseases of soft tissues and skin, inflammation of the joints, eye infections (trachoma), specific infections (tularemia, plague, brucellosis, gas gangrene, anthrax), etc.
Contraindications
Absolute:
- severe liver / kidney dysfunction;
- pregnancy and lactation;
- children under 8 years old;
- increased individual sensitivity to doxycycline, other tetracyclines, as well as auxiliary components of the drug.
Relative contraindications: Doxibene is taken with caution in case of arrhythmia, simultaneously with digitalis preparations and in case of excessive exposure to ultraviolet radiation (prolonged exposure to sunlight, visiting a solarium) due to the risk of photosensitization reactions.
Instructions for use Doxibene: method and dosage
Doxibene capsules are taken orally during meals, whole with plenty of water or other neutral liquid.
Recommended daily doses:
- adult patients weighing> 70 kg: from the first day of treatment, 200 mg (2 capsules of 100 mg for 2 doses with an interval of 12 hours or 1 capsule of 200 mg);
- adolescents and adult patients weighing 50–70 kg: on the first day - 200 mg (2 capsules of 100 mg for 2 doses with an interval of 12 hours or 1 capsule of 200 mg); from the second day until the end of therapy, 100 mg;
- children aged 8 years and older with a body weight <50 kg: oral dosage forms are not used due to the content of high doses of doxycycline.
The duration of therapy is determined taking into account the type of disease, the severity of clinical symptoms and the nature of the course.
Doxibene special dosage:
- tick-borne encephalitis: 200 mg / day for 10–20 days;
- gonorrhea in women in acute form: 200 mg / day, for at least 7 days;
- acute gonorrheal (gonococcal) urethritis in men: 200 mg / day for 7 days;
- infections of the male genital organs with a violation of the fertilizing ability of sperm, of an undetected nature: 200 mg / day for 28 days, subject to treatment of both sexual partners;
- acute diseases of the appendages caused by chlamydia / gonococci: 200 mg / day for 10 days;
- syphilis: 300 mg / day for at least 10 days; the daily dose is allowed to be taken at a time;
- skin infections (severe forms of acne, erysipelas): 100 mg / day for 7 to 21 days;
- nonspecific diseases of female genital organs in acute form: 200 mg / day for 10-14 days, as part of complex therapy.
Treatment should be continued for another 1–3 days after the symptoms of the disease disappear.
Infections caused by β-hemolytic streptococci are treated for at least 10 days to avoid possible negative effects such as rheumatic fever or glomerulonephritis.
Side effects
- cardiovascular and hematopoietic systems: tachycardia, lymphadenopathy, leukocytosis, leukopenia, thrombocytopenia, anemia, coagulation disorders; in isolated cases - the appearance of atypical lymphocytes and toxic granularity in neutrophilic granulocytes;
- central nervous system: increased intracranial pressure, decreased visual acuity, excessive excitability, paresthesia, generalized convulsions;
- gastrointestinal tract (GIT) and liver: nausea / vomiting, heartburn, flatulence, stool disorders, glossitis, stomatitis, discoloration of tooth enamel; possible development of pseudomembranous enterocolitis, requiring discontinuation of the drug;
- urinary system: impaired renal function, anuria, hematuria, interstitial nephritis;
- hypersensitivity reactions: urticaria, pruritus, bronchospasm, erythema, photosensitization, Stevens-Johnson syndrome, Lyell's syndrome, Quincke's edema, anaphylactic shock; possible development of an allergic reaction, accompanied by headache, hyperthermia, arthralgia;
- other reactions: impaired sense of smell and taste, pain in muscles and joints, candidiasis (vaginal / oral), anal itching, hypertrichosis; possibly an increase in the level of residual nitrogen in the blood plasma.
In case of development of undesirable side effects, you should stop taking the drug and consult a specialist as soon as possible. After the examination, the doctor will decide whether to continue using doxycycline or prescribe an alternative treatment.
Overdose
Signs of Doxibene overdose are the manifestation of more pronounced side effects from the gastrointestinal tract; the risk of liver damage increases.
To relieve intoxication, standard symptomatic therapy is mainly used, including gastric lavage, intake of activated charcoal and treatment aimed at maintaining vital functions. As a counteraction to intoxication, it is possible to take calcium salts, since they are able to form chelate complexes with tetracycline.
special instructions
Taking Doxibene capsules simultaneously with food reduces the risk of abnormalities in the digestive tract.
It is not recommended to take the drug at night, just before going to bed.
With the development of superinfection caused by resistant microorganisms, Doxibene should be discontinued and appropriate treatment initiated.
Pseudomembranous colitis can develop as a result of the use of almost all antibiotics, including doxycycline. Therefore, the presence of this disease should be definitely excluded in patients suffering from diarrhea as a result of taking antibiotics.
The catabolic effect of tetracyclines can provoke an increase in the level of residual nitrogen in the blood.
When using preparations containing doxycycline, ultraviolet radiation (solarium, sunbathing) should be avoided, since antibiotics of the tetracycline group can cause increased photosensitivity with skin rashes and burns.
Influence on the ability to drive vehicles and complex mechanisms
According to the instructions, Doxibene should be used with caution by patients for whom an increased concentration of attention and an increased speed of psychomotor reactions are important for work and life, who control potentially dangerous mechanisms, vehicles, and perform other complex jobs.
Application during pregnancy and lactation
According to the results of clinical studies, it has been proven that tetracyclines penetrate the placental barrier into the fetal tissue and can have a toxic effect on it (up to a delay in skeletal development). Doxycycline can also pass into breast milk.
During pregnancy, lactation, as well as in children under 8 years of age, Doxibene is used as an exception for life-threatening diseases / conditions and the absence of the possibility of using other antibiotics.
Pediatric use
Doxibene is not used to treat children under 8 years of age, since the use of the drug during the development and formation of teeth can have an irreversible effect on the color of the tooth enamel.
With impaired renal function
Doxibene is prohibited for use in case of severe renal dysfunction.
For violations of liver function
Doxibene is prohibited for use in case of severe liver dysfunction.
Drug interactions
- indirect anticoagulants: doxycycline may enhance their effect;
- sulfonylurea derivatives: it is possible to enhance their hypoglycemic action;
- penicillins and cephalosporins: Doxibene exhibits antagonistic properties in relation to their bactericidal properties;
- curariform substances: doxycycline potentiates their effect;
- antacids containing aluminum, calcium and magnesium; preparations containing iron and bismuth salts: disrupt the absorption of doxycycline;
- isotretinoin: in the complex therapy of acne, it is necessary to withstand a break after taking doxycycline, since in some cases the simultaneous administration of drugs can lead to a reversible increase in intracranial pressure;
- theophylline: the risk of negative side effects from the gastrointestinal tract may increase;
- contraceptive hormonal contraceptives: sometimes their effectiveness may decrease, and therefore it is recommended to use non-hormonal contraceptives;
- drugs that negatively affect liver / kidney function (methoxyflurane, etc.): joint use with doxycycline and other tetracyclines is prohibited;
- phenobarbital, carbamazepine, phenytoin, and ethanol (for chronic alcoholism): reduce the half-life of doxycycline.
Analogs
Doxibene's analogs are: Doxycycline, Unidox Solutab, Doxy-M, Olettrin, Chloramphenicol, Vilprafen, Erebra, Tsiprobay, Levoximed, Poteseptil, Respibron, Co-trimoxazole, Imupret, Amosin, etc.
Terms and conditions of storage
Store in a dry place at a temperature not exceeding 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Doxiben
According to a few reviews, Doxibene is well tolerated. The negative side effects associated with taking the drug are practically not described.
According to the patients who took the capsules, the minor disadvantages of Doxibene's effectiveness are offset by its moderate cost.
The price for Doxiben in pharmacies
The drug is not available in pharmacies. Doxibene's price in an online pharmacy for 10 capsules in a dose of 100 mg is 313 rubles.
There are substitutes available, the use of which must be agreed with the attending physician personally:
- Unidox Solutab (100 mg tablets, 10 pcs.) - 385 rubles;
- Vibramycin (dispersible tablets 100 mg, 10 pcs.) - 789 rubles;
- Doxycycline (capsules 100 mg, 10 pcs.) - 42 rubles;
- Doxycycline-Darnitsa (capsules 100 mg, 10 pcs.) - 50 rubles;
- Doxycycline hydrochloride (capsules 100 mg, 10 pcs.) - 39 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
