Doxy-Hem
Doxy-Hem: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Doxi-Chem
ATX code: C05BX01
Active ingredient: Calcium dobesilate
Manufacturer: Hemofarm (Serbia)
Description and photo update: 2018-13-05
Prices in pharmacies: from 243 rubles.
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Doxy-Hem is an angioprotective agent.
Release form and composition
Dosage form - capsules: size No. 0, hard, gelatinous, with an opaque light yellow body and an opaque dark green lid; content - powder from white to white with a yellow tinge, may contain conglomerates, which, when lightly pressed with a glass rod, turn into a free-flowing powder (10 pcs. in blisters, in a cardboard box 3 blisters).
Composition of 1 capsule:
- active substance: calcium dobesilate (in the form of monohydrate) - 500 mg;
- excipients: magnesium stearate, corn starch;
- capsule body: titanium dioxide E171, iron dye yellow oxide E172;
- capsule cap: titanium dioxide E171, gelatin, indigo carmine dye E132, iron dye black oxide E 172, iron dye yellow oxide E172.
Pharmacological properties
Pharmacodynamics
Doxy-Hem is an angioprotective agent that:
- increases the resistance of the capillary walls;
- reduces increased vascular permeability;
- increases the elasticity of the erythrocyte membrane;
- moderately reduces platelet aggregation and blood viscosity;
- improves microcirculation and drainage function of lymphatic vessels.
The effect of the drug is to some extent associated with an increase in the activity of plasma kinins.
Pharmacokinetics
Calcium dobesylate is rapidly absorbed in the gastrointestinal tract. The maximum concentration in blood plasma reaches 6 hours after oral administration.
Plasma protein binding is about 20-25%.
Practically does not penetrate the blood-brain barrier. In very small amounts (0.0004 mg / ml after taking 1500 mg of the drug) is excreted in breast milk.
The half-life is 5 hours. It is excreted mainly unchanged in approximately equal amounts (50% each) through the intestines and kidneys. In the form of metabolites, 10% of the substance is excreted. The time for complete elimination from the body is 24 hours.
Indications for use
- vascular lesions accompanied by increased capillary permeability and fragility (nephropathy and diabetic retinopathy) and other microangiopathies associated with various diseases of the cardiovascular system and metabolism;
- venous insufficiency of varying severity and its complications: pre-varicose condition with pain, symptoms of tissue edema, congestive dermatosis and paresthesias, varicose veins, superficial phlebitis, trophic ulcers.
Contraindications
- hemorrhages caused by anticoagulants;
- bleeding from the gastrointestinal tract;
- period of exacerbation of gastric ulcer and 12 duodenal ulcer;
- kidney and liver diseases;
- age up to 13 years;
- I trimester of pregnancy;
- hypersensitivity to any component of the drug.
Instructions for the use of Doxy-Hem: method and dosage
Doxy-Hem should be taken with food, swallowing the capsules whole.
During the first 2-3 weeks, 1 capsule is prescribed 3 times a day, then the frequency of administration is reduced to 1 time per day.
In case of retinopathy and microangiopathy, 1 capsule 3 times a day is recommended to be taken for 4–6 months and only then to reduce the frequency of administration to 1 time per day.
Depending on the indications and the therapeutic effect, the course of treatment can last from 3 weeks to several months.
Side effects
Doxy-Chem is generally well tolerated, in rare cases (0.01-0.1%), the following adverse reactions are possible:
- from the skin and subcutaneous tissues: allergic reactions (itching, rash);
- from the musculoskeletal and connective tissue: arthralgia;
- from the gastrointestinal tract: nausea, vomiting, diarrhea;
- others: fever, chills.
In some cases (0.01-0.1%), reversible agranulocytosis occurs (disappears after drug withdrawal).
Overdose
Overdose cases are unknown.
special instructions
According to the instructions, Doxy-Hem can be used for the prevention of diseases and conditions indicated in the indications.
In very rare cases, calcium dobesylate causes agranulocytosis, its first signs: inflammation of the oral mucosa, pain when swallowing, headache, weakness, chills, fever. If these symptoms appear, you should immediately consult a doctor and conduct a clinical blood test.
The drug can interfere with the results of laboratory tests to determine the level of creatinine.
Influence on the ability to drive vehicles and complex mechanisms
Calcium dobesylate does not negatively affect the speed of mental and physical reactions, as well as the ability to concentrate.
Application during pregnancy and lactation
Adequate and well-controlled studies on the safety of the use of calcium dobesilate in pregnant and lactating women have not been conducted. In this regard, in the first trimester of pregnancy, Doxy-Chem is contraindicated, in the second and third trimesters it can be used only for health reasons and provided that the expected therapeutic effect exceeds the potential risks.
If necessary, treatment during lactation should consider stopping breastfeeding.
Pediatric use
In pediatric practice, the use of the drug is contraindicated for the treatment of children under the age of 13.
With impaired renal function
Doxy-Hem is contraindicated in kidney disease.
For violations of liver function
In liver diseases, the use of the drug is contraindicated.
Drug interactions
There have been no reports of adverse drug interactions between calcium dobesilate and other drugs.
Analogs
Doxy-Hem's analogues are: Doxilek, Calcium Dobesylate, Doxium and Doxium 500.
Terms and conditions of storage
Store in a dry place out of the reach of children, observing the temperature regime from 15 to 25 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Doxy-Hem
Unlike etamsylate, which is widely used for similar indications, calcium dobesilate has a more pronounced effect on vascular permeability, therefore it is the drug of choice for diabetic retinopathy, including as an effective prophylactic agent. Patients report a decrease in edema and an improved prognosis in general.
In addition, calcium dobesilate is a highly effective angioprotector used in diabetes mellitus.
According to reviews, Doxy-Hem practically does not cause side effects, has a convenient dosage form, and is affordable.
The price of Doxy-Hem in pharmacies
The price of Doxy-Hem in pharmacies varies from 186 to 349 rubles for a pack of 30 capsules.
Doxy-Hem: prices in online pharmacies
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Drug name Price Pharmacy |
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Doxy-Hem 500 mg capsules 30 pcs. 243 r Buy |
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Doxy-Hem capsules 500mg 30 pcs. 299 r Buy |
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Doxy-Hem 500 mg capsules 90 pcs. RUB 540 Buy |
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Doxy-Hem capsules 500mg 90 pcs. RUB 672 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
