Dimetinden-Akrikhin
Dimetinden-Akrikhin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Dimetindene-Akrihin
ATX code: D04AA13
Active ingredient: dimetindene (Dimetindene)
Manufacturer: AKRIKHIN KhFK, JSC (Russia); Medana Pharma, SA (Poland)
Description and photo update: 2020-22-07
Prices in pharmacies: from 232 rubles.
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Dimetinden-Akrikhin is a drug for external use with antiallergic action. Refers to blockers of H1-histamine receptors.
Release form and composition
The drug is produced in the form of a gel for external use 0.1%, which is a transparent, colorless homogeneous mass (5, 30 or 50 g in aluminum tubes, 1 tube in a cardboard box and instructions for use of Dimetinden-Akrihin).
Composition for 1 g of gel:
- active substance: dimethindene maleate - 1 mg;
- auxiliary components: disodium edetate, benzalkonium chloride, carbomer, propylene glycol, sodium hydroxide, purified water.
Pharmacological properties
Pharmacodynamics
Dimetindene-Akrikhin has antiallergic, antipruritic and antihistamine effects. It belongs to the blockers of H 1 -histamine receptors and is a competitive antagonist of one of the inflammatory mediators - histamine. Dimetindene reduces the increased capillary permeability caused by allergic reactions.
When applying the drug to the skin, irritation and itching caused by skin-allergic reactions are reduced.
The gel also has a pronounced local anesthetic effect. In addition, it has a weak anticholinergic and antikinin activity.
The gel base of the preparation provides a light cooling effect and a quick onset of action (within a few minutes after application). The maximum effectiveness appears after 1-4 hours.
Pharmacokinetics
The gel penetrates well into the skin. Its systemic bioavailability is about 10%.
Indications for use
Dimetinden-Akrikhin is used for pruritus of various origins: itching with eczema, insect bites, urticaria; itchy dermatoses (with the exception of pruritus associated with cholestasis).
Also, the use of the cream is recommended for household, sun and industrial light burns.
Contraindications
Absolute:
- hyperplasia of the prostate;
- angle-closure glaucoma;
- children under one month old (especially premature babies);
- hypersensitivity to the main or additional components of the gel.
Relative (Dimetinden-Akrikhin is used with caution): the first trimester of pregnancy, the period of breastfeeding.
Dimetinden-Akrikhin, instructions for use: method and dosage
Dimetinden-Akrikhin gel is intended for external use.
The drug is applied to the affected skin 2 to 4 times a day. In case of severe itching or extensive skin lesions, it is recommended to use oral forms of dimetindene simultaneously with the gel.
Side effects
During the use of Dimetinden-Akrikhin gel, adverse reactions from the skin and subcutaneous fat may occur. Burning and dryness of the skin is infrequently noted, in very rare cases, allergic dermatitis (including itchy skin and rash).
Overdose
With the correct use of the drug in the recommended doses, an overdose is unlikely.
Symptoms of intoxication can occur if a large amount of gel is accidentally swallowed. The patient has drowsiness (mainly in adults), depression or stimulation of the functions of the central nervous system. Antimuscarinic effects appear (especially common in children), which include ataxia, mydriasis, hyperexcitability, dry mouth, tonic-clonic seizures, flushing, fever, hallucinations, ataxia, and urinary retention. Finally, a strong drop in blood pressure is possible.
There is no specific antidote. The usual measures of emergency medical care are taken: saline laxatives and activated charcoal by mouth, as well as measures aimed at maintaining the functions of the respiratory and cardiovascular systems. With arterial hypotension, vasoconstrictors are used.
special instructions
In children aged 1 month to 2 years, Dimetinden-Akrikhin can be used only as directed by a doctor.
For infants and young children, the gel should not be applied to large areas of the skin, especially if there is bleeding or inflammation.
In patients with extensive skin lesions or in the presence of severe itching, Dimetindene-Akrikhin should be used after consultation with a specialist.
If the gel is applied to large areas of skin, exposure of the skin to direct sunlight should be avoided.
In the absence of improvement or worsening of symptoms of the disease during the period of use of the drug, you should consult a doctor.
Dimetindene-Akrikhin is ineffective for pruritus caused by cholestasis.
The gel contains benzalkonium chloride and propylene glycol, which can cause local allergic reactions.
Influence on the ability to drive vehicles and complex mechanisms
Does not affect.
Application during pregnancy and lactation
In the first trimester of pregnancy, the drug is used with caution and only after consultation with a specialist.
In the second and third trimesters of pregnancy, as well as during breastfeeding, Dimetindene-Akrikhin can be used only on limited areas of the skin, especially with signs of bleeding or the presence of inflammation. During breastfeeding, the gel should not be applied to the nipples of the mammary glands.
Pediatric use
The drug is contraindicated in infants under 1 month old, especially premature babies.
Drug interactions
There is no data on any types of pharmacological interaction of Dimetindene-Akrikhin gel with medicinal substances / preparations used simultaneously.
Analogs
Analogs of Dimetinden-Akrikhin are Akriderm, Akriderm Genta, Afloderm, Belogent, Betaderm, Gistan, Dimetinden (gel), Diprosalik ointment, Kutiveit, Psilo-Balsam, Fenistil (gel and emulsion), etc.
Terms and conditions of storage
Keep out of reach of children at a temperature not exceeding 25 ° C.
The shelf life of the gel is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Dimetinden-Akrikhin
According to reviews, Dimetinden-Akrikhin quickly and effectively eliminates itching of various origins, helps with household and sunburn. The gel cools the skin well. It is safe and allowed for children from 1 month old. Adverse reactions are very rare. The drug is cheaper than analogues.
The price of Dimetinden-Akrikhin in pharmacies
The price of Dimetinden-Akrikhin in the form of a gel for external use 0.1% in tubes of 30 g is 230–260 rubles, in tubes of 50 g - 260–280 rubles.
Dimetinden-Akrikhin: prices in online pharmacies
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Drug name Price Pharmacy |
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Dimetindene-Akrikhin 0.1% gel for external use 30 g 1 pc. 232 RUB Buy |
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Dimetindene-Akrikhin 0.1% gel for external use 50 g 1 pc. 295 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
