Dermazole

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Dermazole: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. For violations of liver function
12. Drug interactions
13. Analogs
14. Terms and conditions of storage
15. Terms of dispensing from pharmacies
16. Reviews
17. Price in pharmacies

Latin name: Dermazol

ATX code: D01AC08

Active ingredient: ketoconazole (Ketoconazole)

Manufacturer: Kusum Helthker Pvt. Ltd. (Kusum Healthcare Pvt. Ltd.) (India)

Description and photo updated: 2018-26-11

Dermazole is an antifungal drug.

Release form and composition

tablets: biconvex, round, white (10 pcs. in a strip; 1 or 3 strips in a cardboard box);
vaginal suppositories: torpedo-shaped, from pale yellow to white (5 pcs. in a strip; 1 or 2 strips in a cardboard box);
cream for external use: homogeneous white (15 or 30 g in an aluminum tube; 1 tube in a cardboard box);
shampoo: viscous transparent liquid from pink to red with a characteristic odor (8 ml in a sachet, 20 sachets in a cardboard box; 50 or 100 ml in a bottle, packed in PVC shrink film, 1 bottle in a cardboard box).

1 tablet contains:

active substance: ketoconazole - 200 mg;
additional components: colloidal silicon dioxide, microcrystalline cellulose PH 102, magnesium stearate, croscarmellose sodium, butylated hydroxytoluene.

1 suppository contains:

active substance: ketoconazole - 400 mg;
additional components: butylhydroxyanisole (E 320), solid fat.

1 g of cream contains:

active substance: ketoconazole - 20 mg;
additional components: cetostearyl alcohol, propylene glycol, cetomacrogol-1000, light mineral oil, white soft paraffin, disodium edetate, polysorbate-80, sodium sulfite anhydrous, purified water.

1 ml of shampoo contains:

active substance: ketoconazole - 20 mg;
additional components: sodium lauryl ether sulfate, cocodiethanolamide, macrogol 120 methyl glucose dioleate, disodium monolauryl ether sulfosuccinate, concentrated hydrochloric acid, propylene glycol, sodium hydroxide, sodium chloride, butylhydroxytoluene, crimson dye 4R, imidazolidinylated water, imidazolidinylated water.

Pharmacological properties

Pharmacodynamics

Ketoconazole is a synthetic imidazole dioxolane derivative that has antifungal, both fungicidal and fungistatic, action on dermatophytes: Microsporum spp., Epidermophyton spp., Trichophyton spp.; yeast-like fungi: Malassezia spp., Candida spp.; dimorphic fungi, eumycetes (higher fungi), yeast fungi Pityrosporum orbiculare and Pityrosporum ovale, as well as pathogens of systemic mycoses (Cryptococcus). Dermazole also demonstrates activity against gram-positive cocci - Streptococcus spp., Staphylococcus spp.

Ketoconazole inhibits the production of ergosterol, which causes a change in the composition of lipids (phospholipids and triglycerides), which are essential components of the cell membrane, providing a fungicidal effect. It causes the loss of the ability of fungi to form filaments and colonies, showing fungistatic effect. The drug is also characterized by activity against pathogens resistant to antifungal antibacterial drugs (levorin, nystatin), and to clotrimazole.

Pharmacokinetics

When taken orally, there is a good absorption of the drug, especially in the acidic environment of the stomach. The bioavailability of ketoconazole is directly proportional to the dose taken. The maximum concentration (C _max) can be reached 2 hours after ingestion. In vitro, the connection of the active substance with blood plasma proteins, mainly with the albumin fraction, is 99%. The drug has high tissue permeability, but only a small part of it passes into the cerebrospinal fluid.

After absorption from the gastrointestinal tract, the metabolic transformation of ketoconazole proceeds in the liver and ends with the formation of a significant amount of inactive metabolites. According to in vitro studies, the main enzyme involved in drug metabolism is CYP3A4. Ketoconazole is metabolized by oxidation and cleavage of the imidazole and hyperazine rings, oxidative O-dealkylation and aromatic hydroxylation. It does not belong to the inducers of its own metabolism. The elimination of a substance from blood plasma is carried out in two stages: during the first 10 hours, the half-life is 2 hours, and subsequently - 8 hours.

Approximately 13% of the dose taken is excreted in the urine, with 2–4% being the unchanged active substance. For the most part, the agent is excreted in the bile into the intestines, while about 57% is excreted in the feces.

With intravaginal use, there is a very weak absorption of ketoconazole, less than 1% enters the systemic circulation. After administration of 400 mg of the drug (1 suppository), C _max in plasma varies from 0 to 10.7 ng / ml, this concentration is considered trace and does not demonstrate systemic action.

Due to external use, absorption of the active substance through the skin is negligible. After applying the cream and shampoo to the skin, the plasma concentration of ketoconazole in the blood is not determined. Long-term use of the shampoo causes its moderate accumulation in the keratin of the hair.

Indications for use

Pills

According to the instructions, Dermazole tablets are recommended for use for the treatment of the following diseases, which are not subject to local treatment due to localization, coverage of the lesion or deep infection of the skin, in patients who are resistant or hypersensitive to fluconazole and itraconazole:

dermatomycosis;
Malassezia (formerly called versicolor)
folliculitis;
cutaneous candidiasis;
oropharyngeal candidiasis;
chronic mucocutaneous candidiasis.

Suppositories

acute and chronic recurrent vulvovaginal candidiasis (therapy);
fungal infections of the vagina, against the background of a reduced resistance of the body during the period of treatment with drugs, leading to a violation of the normal microflora of the vagina (prevention).

Cream

Dermazole cream is used to treat fungal infections of the skin, including epidermophytosis groin, athlete's foot, candidiasis of skin folds (diaper dermatitis, candidal intertrigo).

Shampoo

Dermazole shampoo is used to prevent / treat the following scalp and hair lesions caused by the yeast Malassezia (formerly known as Pityrosporum): dandruff, pityriasis versicolor (localized), seborrheic dermatitis.

Contraindications

A general contraindication for all forms of Dermazole release is hypersensitivity to its components or to any antifungal agent that contains imidazole.

Additional contraindications for oral administration of Dermazole are:

congenital or acquired (confirmed by diagnostic methods) lengthening of the QT interval;
acute / chronic liver damage and / or the level of activity of liver enzymes exceeding the upper permissible limit of the norm by 2 times;
pregnancy and lactation;
children under 3 years old;
child's weight up to 15 kg.

Also, the combined systemic use of Dermazole with any of the following substances is contraindicated, due to a possible increase in plasma concentrations of these drugs, an increase / lengthening of the therapeutic effect and the development of life-threatening adverse reactions (the list does not include all drugs that, when interacting with ketoconazole, can lead to extremely serious conditions):

atorvastatin, simvastatin, lovastatin (CYP3A4 metabolized HMG-CoA reductase inhibitors): the threat of toxic effects on skeletal muscle tissue, including rhabdomyolysis, is aggravated;
dronedarone, quinidine, disopyramide, methadone, sertindole, pimozide, saquinavir (saquinavir / ritonavir at a dose of 1000/100 mg 2 times a day), mizolastine, ranolazine, halofantrine: an increase in the concentration of these drugs in plasma, leading to a risk of prolongation of the QT interval;
eplerenone: increased risk of hypotension and hyperkalemia;
oral alprazolam and midazolam, triazolam: possible prolonged or increased sedation and respiratory depression;
ergot alkaloids such as lurasidone, ergometrine (ergonovine), dihydroergotamine, methylergometrine (methylergonovine), ergotamine: the threat of ergotism and other pronounced vasospastic undesirable effects increases significantly;
vardenafil (in men after 75 years), paritaprevir / ombitasvir: the risk of adverse reactions increases;
nisoldipine, felodipine: the risk of congestive heart failure and edema is aggravated;
dabigatran: increased risk of bleeding;
clarithromycin, telithromycin: the risk of hepatotoxicity and prolongation of the QT interval increases in the presence of severe renal dysfunction;
quetiapine: increased toxicity threat;
irinotecan: the metabolism of this drug changes significantly;
colchicine: an increased risk of serious adverse reactions in patients with renal impairment;
sirolimus (rapamycin), everolimus, tolvaptan: plasma concentrations of these substances increase significantly;
fesoterodine, solifenacin: the combination is contraindicated in the presence of impaired renal function.

Instructions for the use of Dermazole: method and dosage

Pills

Dermazole tablets are used orally, once a day, to ensure maximum absorption, the drug must be taken with meals.

Adults and children weighing more than 30 kg are prescribed a daily dose of 200 mg (1 tablet), in the absence of the expected therapeutic effect, the dose is increased to 400 mg (2 tablets). Children with a body weight of 15-30 kg are recommended to take the drug in a daily dose of 100 mg (½ tablet).

The course of therapy for all indications should be continuous, treatment is completed after the removal of all the symptoms of mycosis and negative results of microbiological studies confirming the elimination of the fungal infection.

In the case of an inadequate treatment period, a relapse of active infection is possible. However, it should be borne in mind that the threat of severe toxic liver damage is exacerbated by prolonged use of Dermazole. Therapy lasting more than 10 days can only be carried out when the expected positive therapeutic effect outweighs the possible risk, and liver activity is carefully controlled.

When treating malassezia, Dermazole should be used no longer than 4 weeks.

Suppositories

The tool is used intravaginally.

After removing the suppository from the strip, it is injected in a supine position with knees bent and legs pulled up to the chest, or squatting deep into the vagina. The daily dose is 1 suppository administered at night (before bedtime). The course is 3-5 days, if necessary, it is possible to carry out a second course to achieve a complete recovery, confirmed by the results of laboratory tests.

In the treatment of chronic candidiasis, Dermazole is used for 10 days.

Suppositories cannot be cut into parts, since such a change in storage conditions may cause a violation of the distribution of the active substance.

Cream

Dermazole cream is applied externally, applying a thin layer to the affected area of the skin and adjacent areas, 2 times a day.

With epidermophytosis of the feet, as a rule, the course is 7 days. With a more severe degree of damage, after the removal of all symptoms of the disease, therapy is extended for another 2-3 days in order to prevent relapse.

With candidiasis of skin folds (intertrigo) and inguinal epidermophytosis, treatment should last for a sufficient time, and in order to avoid the recurrence of the disease, at least 2-3 days after the disappearance of all signs of damage.

If necessary, the course of therapy can be 6 weeks. If, 4 weeks after the start of the use of Dermazole, the symptoms of the disease do not go away, you need to consult a specialist.

Shampoo

Dermazole shampoo is applied together with warm water to the affected areas of the scalp and then left for 3-5 minutes, after which it is washed off with water.

Recommended dosage regimen of Dermazole:

dandruff and seborrheic dermatitis (seborrheic eczema): treatment - 2 times a week, course - 2-4 weeks; prevention - once a week or once every 2 weeks;
pityriasis versicolor: treatment - daily, course - 5 days; prevention - before the start of the summer season, every day for 3 days (one-time course).

Side effects

Pills

blood and lymphatic system: infrequently - thrombocytopenia;
endocrine system: often - adrenal insufficiency;
nervous system: infrequently - dizziness, headache, drowsiness; with an unknown frequency - paresthesia, increased intracranial pressure (bulging fontanelle, edema of the optic nerve head);
mental disorders: with an unknown frequency - increased excitability, insomnia;
immune system: infrequently - allergic reactions, including anaphylactoid and anaphylactic reactions, anaphylactic shock, Quincke's edema;
metabolism and nutritional disorders: with an unknown frequency - increased appetite or loss of appetite, alcohol intolerance;
digestive tract: often - vomiting, abdominal pain, nausea, diarrhea; with an unknown frequency - dry mouth, discoloration of the tongue, dysgeusia, flatulence, indigestion;
liver and biliary tract: very often - abnormal liver function tests; rarely - severe hepatotoxicity, including jaundice, cirrhosis of the liver, hepatitis, necrotizing hepatitis; liver failure, including cases of liver transplantation or death;
respiratory, chest and mediastinal organs: with an unknown frequency - epistaxis;
musculoskeletal system: with unknown frequency - arthralgia, myalgia;
skin and subcutaneous tissue: often - rash, itching; infrequently - alopecia, urticaria; with an unknown frequency - xeroderma, photosensitivity, dermatitis, erythema, erythema multiforme;
organ of vision: with an unknown frequency - photophobia;
genitals and mammary gland: with an unknown frequency - menstrual irregularities, erectile dysfunction, azoospermia, gynecomastia;
general disorders: infrequently - asthenia; extremely rarely - hyperthermia; with an unknown frequency - general malaise, peripheral edema, hot flashes;
laboratory tests: infrequently - a lowered platelet count; with an unknown frequency - a temporary decrease in testosterone levels.

Suppositories

digestive tract: abdominal pain, nausea;
skin and subcutaneous tissue: rash, itching, hyperemia;
immune system: hypersensitivity reactions, including urticaria, anaphylactic and anaphylactoid reactions, angioedema;
nervous system: dizziness;
local reactions: irritation of the vaginal mucosa, accompanied by hyperemia, burning sensation, itching.

The listed violations are rare and quickly disappear after the termination of the use of Dermazole.

Cream

skin and subcutaneous tissue: peeling / stickiness of the skin, burning sensation, urticaria, contact dermatitis, bullous rash;
reactions at the site of application: discomfort, inflammation, dryness, itching, irritation, bleeding, erythema, paresthesia;
immune system: hypersensitivity reactions.

Shampoo

nervous system: violation of taste sensitivity (dysgeusia);
immune system: hypersensitivity reactions, including angioedema;
organ of vision: eye irritation, increased lacrimation;
infections and invasions: folliculitis;
reactions at the site of application: itching, irritation, discomfort, hypersensitivity, erythema, pustular rash in the area of application;
skin and subcutaneous tissue: dry / flaky skin, rash, alopecia, hives, burning sensation of the skin, contact dermatitis, acne, changes in the normal structure of the hair, changes in hair color (in the presence of gray or chemically damaged hair), excessive oily or dry hair.

Overdose

Pills

In the treatment of Itsenko-Cushing's disease, the maximum daily dose was 1600 mg. If an overdose is suspected, supportive symptomatic therapy is prescribed. During the first hour after oral administration, gastric lavage is performed and, if necessary, activated charcoal is taken. If signs of adrenal insufficiency occur, in addition to general measures, hydrocortisone at a dose of 100 mg, and an infusion of saline and glucose solution are recommended. Over the next few days, you need to monitor blood pressure, electrolyte balance and fluid balance.

The antidote for ketoconazole is unknown.

Suppositories

Against the background of an overdose, itching, burning, irritation, hyperemia of the vaginal mucosa may occur, with these violations it is recommended to douche with water.

Cream

With frequent use of the cream in excessively high doses, skin edema, erythema, burning sensation at the application site may occur, which self-pass after stopping treatment. If Dermazole is accidentally taken orally, symptomatic and supportive therapy is prescribed.

Shampoo

Due to the fact that the shampoo is intended exclusively for external use and with this method of application, ketoconazole is not absorbed into the systemic circulation, the occurrence of overdose symptoms is unlikely. In case of unintentional swallowing, supportive and symptomatic measures are used. Gastric lavage or vomiting should not be performed to prevent aspiration.

special instructions

Pills

Due to the potential threat of severe hepatotoxicity, during the period of therapy, it is required to monitor liver function tests during the first month of treatment once a week, and then once a month for six months.

While taking Dermazole tablets, it is necessary to regularly monitor the function of the adrenal glands due to the possible risk of developing adrenal cortex insufficiency in conditions of a lack of cortisol, due to the increased need of the body for glucocorticoids (during the development of infection, during stress, surgery) or in case of an overdose of ketoconazole. Patients should be informed about the symptoms and signs of Addison's disease, which include: hypotension, loss of appetite, fatigue, weakness, vomiting, nausea, weight loss, hypoglycemia, hyperkalemia, and hyponatremia. In the event of clinical symptoms of adrenal insufficiency, it is required to establish the level of cortisol, temporarily stop the use of Dermazole or reduce its dose and, if necessary, start appropriate therapy.

Before the start of the course and during the first week of treatment with Dermazole, as well as with concomitant therapy with drugs that lengthen the QT interval, it is recommended to monitor the electrocardiogram (ECG).

Suppositories

In order to reduce the threat of recurrence of the lesion, simultaneous therapy of the sexual partner is recommended.

When using suppositories in some cases, the sexual partner may develop local allergic reactions.

It is necessary to beware of contact of the drug with latex drugs (diaphragm contraceptive condoms), since this reduces the reliability of mechanical contraception, as a result of which pregnancy or infection with sexually transmitted diseases may occur. During the period of therapy, it is required to refuse sexual intercourse.

Since Dermazole has an osmotic and drainage effect that increases vaginal discharge, it is recommended to inject it at night using sanitary napkins.

If during the period of treatment the appearance of undesirable reactions is observed, you should stop using suppositories and consult a specialist. Dermazole contains butylhydroxyanisole (E 320), which can provoke irritation of the mucous membranes or the appearance of local skin reactions, including contact dermatitis.

Cream, shampoo

Dermazole cream is not intended for use in ophthalmic practice.

When applying the cream to the affected skin immediately after prolonged therapy with ointments containing corticosteroids (CS), irritation may develop. In such cases, it is recommended to treat the problem area with Dermazole in the evening, and local KS in the morning, for 2-3 weeks, until the use of the latter is gradually stopped. Also, within 2-3 weeks, the use of CS should be combined (until they are completely canceled) and shampoo, if it is used after long-term local treatment of CS.

It is required to avoid getting shampoo in the eyes, but if it does happen, you should rinse your eyes with water.

Propylene glycol included in the cream can cause itching of the skin, and cetostearyl alcohol can cause local skin reactions (contact dermatitis).

Influence on the ability to drive vehicles and complex mechanisms

There is no information on the negative effect of Dermazole on the ability to drive vehicles and other complex and potentially dangerous equipment. However, with oral and intravaginal use of the drug, the likelihood of dizziness and drowsiness (for tablets) during the period of therapy should be taken into account.

Application during pregnancy and lactation

Appropriate and well-controlled clinical studies of the effect of ketoconazole on pregnant and breastfeeding women have not been conducted.

Pills

According to preclinical studies, when taken orally, ketoconazole crosses the placenta and has a teratogenic effect. As a result, the use of Dermazole tablets during pregnancy, as well as women of reproductive age who do not use reliable contraceptives, are contraindicated.

Ketoconazole passes into breast milk; during the period of drug therapy, breastfeeding should be stopped.

Suppositories

Despite the fact that with intravaginal use of ketoconazole, its systemic absorption is absent or extremely low, Dermazole suppositories should not be used in the first trimester of pregnancy. In the II and III trimesters of pregnancy, as well as during breastfeeding, suppositories are prescribed only if the intended benefit to the mother significantly exceeds the possible threat to the health of the fetus / child.

Cream, shampoo

The risk factors for external use of Dermazole during pregnancy and lactation are unknown. As a result, there are no contraindications to the use of cream and shampoo for pregnant and breastfeeding women.

Pediatric use

There is no data on the safety and efficacy of oral administration of ketoconazole in children under 3 years of age, and therefore Dermazole should not be prescribed to this category of patients. For children over 3 years old with a weight of 15 to 30 kg, the drug is prescribed with caution, in a dose equal to half an adult. With a child's body weight of more than 30 kg, the same doses are prescribed as for adult patients.

Suppositories are not prescribed for children, since there is no experience with this form of Dermazole in patients of this age group.

There is no experience of using cream and shampoo in children.

For violations of liver function

The tablets are contraindicated in the presence of acute and chronic liver damage and / or the level of activity of liver enzymes exceeding the upper permissible limit of the norm by 2 times.

Drug interactions

Pills

Strong inhibitors of cytochrome CYP3A4 (antiviral drugs and others) can increase the bioavailability of ketoconazole. Drugs included in this group should be combined with Dermazole with extreme caution, monitoring the patient's condition to identify possible signs and symptoms of adrenal insufficiency, and the dose of ketoconazole may also need to be changed.

Agents affecting gastric acidity impair the absorption of Dermazole.

Being a potent inhibitor of CYP3A4, ketoconazole is able to suppress the biochemical transformation of drugs metabolized by this enzyme, which can provoke an increase and / or prolongation of their action, including negative effects.

Ketoconazole has the ability to inhibit the breast cancer resistance protein (BCRP) in the intestine at a clinically relevant concentration. Since Dermazole is rapidly absorbed, BCRP substrates must be taken 2 hours after administration.

The simultaneous use of ketoconazole with the following agents / substances is not recommended (a significant break between their use is desirable):

apixaban, rivaroxaban: the area under the concentration-time curve (AUC) and C _{max of} these agents increases, which increases the threat of bleeding;
phenytoin, carbamazepine, isoniazid, rifampicin, rifabutin: the plasma concentration of these drugs increases and ketoconazole decreases;
telithromycin: its plasma level increases;
eletriptan, sildenafil, vardenafil, tadalafil, reboxetine: their AUC and C _max significantly increase;
erlotinib, nilotinib, lapatinib, dasatinib, sunitinib, cabozantinib, dabrafenib, crizotinib, haloperidol, domperidone, ebastin, fesoterodine, solifenacin, salmeterol: the effect of these agents is increased and aggravated during the development of Q. T.
nevirapine: its plasma level increases and ketoconazole AUC and C _max decrease;
Ibrutinib: Possible increased toxicity associated with this substance;
bosentan: its AUC and C _max doubles, the threat of liver damage is aggravated;
pasireotide: in the presence of cardiac arrhythmias, prolongation of the QT interval is possible.

Ketoconazole must be combined with caution (carefully monitoring possible side effects and, if necessary, adjusting the dosage) with the following drugs / substances:

midazolam, when administered intravenously (i.v.), buprenorphine (sublingual or i.v.), aripiprazole, risperidone, repaglinide, saxagliptin, tolbutamide, maraviroc, aprepitant, cinacalcet: the AUC and C _{max of} these substances increase; the need for dose adjustment is possible;
fentanyl, alfentanil, oxycodone, digoxin, praziquantel, imatinib, busulfan, docetaxel, bortezomib, cabazitaxel, vinblastine (vinca alkaloid), vincristine, buspirone verapamil, and other dihydropyridines, nadolazironusironus, aexilustidin, budesonide, cyclosporine: an increase in the plasma concentration of these substances is possible, which may lead to an increase in side effects and require a decrease in their dose;
cilostazol: its activity increases, it is recommended to use it in a dose of 50 mg 2 times a day;
drugs from the coumarin group (including warfarin): the plasma concentration of these drugs increases, the international normalized ratio (INR) should be monitored;
paclitaxel: dose adjustment may be required;
indinavir: its C _min increases, it is recommended to reduce the dose to 600 mg every 8 hours;
ritonavir: the AUC and C _{max of} ketoconazole increase, which requires a decrease in its dose.

With the combined use of Dermazole with ethanol, a disulfiram-like reaction may occur, the manifestations of which are rash, redness, peripheral edema, headache and nausea; within a few hours, these symptoms completely disappear.

Suppositories

rifampicin, isoniazid: the plasma concentration of ketoconazole decreases;
methylprednisolone, indirect anticoagulants, cyclosporine: the concentration of these drugs in plasma increases.

When using Dermazole in the form of vaginal suppositories, the practical significance of these interactions has not been established.

Cream, shampoo

When Dermazole is used externally, data on its interaction with other drugs are not indicated.

Analogs

Dermazole analogues are: Ketoconazole, Ketoconazole-Altpharm, Livarol, Mikanisal, Mycozoral, Mikoket, Nizoral, Perhotal, Sebozol, Fungavis, etc.

Terms and conditions of storage

Store in a place protected from moisture and light, out of reach of children, at a temperature not exceeding 25 ° C.

Shelf life of tablets - 4 years, cream and shampoo - 3 years, suppositories - 2 years.

Terms of dispensing from pharmacies

Suppositories, cream and shampoo are available without a prescription, tablets are available with a prescription.

Reviews of Dermazole

Reviews of Dermazole are mostly positive. Especially often patients praise the shampoo, indicating its high effectiveness in treating dandruff. This form of the drug helped most of them get rid of dandruff immediately after the first use. As a disadvantage, it is noted that the shampoo cannot be used regularly, some believe that Dermazole does not cure dandruff, but only temporarily eliminates it.

The disadvantages of the cream include the need for its long-term use and, in some cases, a weak therapeutic effect. There are very few reviews of tablets and suppositories. Patients recommend taking pills very carefully and in strict accordance with the prescription of the attending physician. Many people complain about the high cost of all forms of Dermazole.

Dermazole price in pharmacies

The price of Dermazole depends on the form of release and volume, and can be:

a bottle of shampoo: 50 ml - 200-400 rubles, 100 ml - 350-600 rubles; 20 sachets, 8 ml each - 500-900 rubles;
tube of cream: 15 g - 150-250 rubles; 30 g - 200-350 rubles.

The reliable price for suppositories and tablets is unknown, since these forms of Dermazole are currently not available in pharmacies.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!