Dalatsin

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Instructions for use:

1. Release form and composition
2. Indications for use
3. Contraindications
4. Method of application and dosage
5. Side effects
6. Special instructions
7. Drug interactions
8. Analogs
9. Terms and conditions of storage
10. Terms of dispensing from pharmacies

Prices in online pharmacies:

from 450 rubles.

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Dalacin is an antibiotic drug from the lincosamide group.

Release form and composition

Dalacin is available in the following dosage forms:

Gel for external use 1%: transparent, colorless, viscous (30 g in tubes, 1 tube in a cardboard box);
Vaginal cream 2%: white (20 or 40 g in tubes of polyethylene or aluminum foil, complete with 3 or 7 applicators (respectively), 1 set in a cardboard box);
Capsules: gelatinous, solid, with a white body and lid, with the inscription “P&U 225” (150 mg each) or “P&U 395” (300 mg each); the contents of the capsules are white powder (8 or 10 pcs. in blisters, 2 or 10 blisters in a cardboard box);
Vaginal suppositories: torpedo-shaped, solid, with a smooth surface, almost white or white (3 pcs. In strips made of laminated foil with or without an applicator, 1 strip in a cardboard box).

Composition of 1000 mg gel for external use:

Active ingredient: clindamycin (in the form of phosphate) - 10 mg;
Auxiliary components: methylparaben - 3 mg; allantoin - 2 mg; polyethylene glycol - 100 mg; propylene glycol - 50 mg; carbomer 934R - 7.5 mg; 40% sodium hydroxide solution - in sufficient quantity; purified water - in an amount sufficient up to 1000 mg.

Composition of 1000 mg vaginal cream:

Active ingredient: clindamycin (in the form of phosphate) - 20 mg;
Auxiliary components: cetyl palmitate - 32.1 mg; stearic acid - 21.4 mg; polysorbate 60-50 mg; sorbitan monostearate - 20 mg; propylene glycol - 50 mg; benzyl alcohol - 10 mg; cetostearyl alcohol - 32.1 mg; mineral oil - 64.2 mg; purified water - in sufficient quantity.

Composition of 1 capsule:

Active ingredient: clindamycin (in the form of hydrochloride) - 150 or 300 mg;
Auxiliary components: talc, lactose, corn starch, magnesium stearate, gelatin, titanium dioxide.

Composition of 1 vaginal suppository:

Active ingredient: clindamycin (in the form of phosphate) - 100 mg;
Auxiliary components: solid fat (Witepsol H-32, a mixture of monoglycerides, diglycerides and triglycerides) - about 2400 mg.

Indications for use

Dalacin in the form of capsules is prescribed for the treatment of the following infectious and inflammatory diseases caused by anaerobic bacteria sensitive to the action of the active substance or strains of gram-positive aerobic bacteria (Streptococcus spp., Pneumococcus spp. And Staphylococcus spp.), As well as Chyndamycin serovars sensitive to clindamycin:

Scarlet fever, inflammation of the middle ear;
Upper respiratory tract infections, including pharyngitis, tonsillitis, sinusitis;
Infectious diseases of soft tissues and skin, including furunculosis, impetigo, acne, infections of subcutaneous fatty tissue, infected wounds, abscesses, specific infectious processes in soft tissues and skin caused by pathogens sensitive to the action of Dalacin (erysipelas and panaritium (paronychia));
Lower respiratory tract infections, including pneumonia, bronchitis, lung abscess and pleural empyema;
Gynecological infectious diseases, including endometritis, infections of the tissues surrounding the vagina (abscesses of the fallopian ovaries and tubes, subcutaneous fatty tissue), inflammatory diseases of the pelvic organs and salpingitis (simultaneously with antibacterial drugs that are active against gram-negative aerobic pathogens, such as gentamicin);
Infectious diseases of the joints and bones, including septic arthritis and osteomyelitis;
Infectious diseases of the abdominal cavity, including abscesses of the abdominal cavity and peritonitis (simultaneously with other antibacterial drugs that affect gram-negative aerobic bacteria);
Infectious diseases of the cervix caused by Chlamydia trachomatis (as monotherapy);
Oral infections (periodontitis and periodontal abscess);
Endocarditis and septicemia;
Malaria, incl. caused by multidrug-resistant Plasmodium falciparum (as monotherapy or simultaneously with chloroquine or quinine);
Toxoplasmotic encephalitis in AIDS patients (simultaneously with pyrimethamine in case of intolerance to standard therapy);
Pneumocystis pneumonia in AIDS patients (simultaneously with primaquine in case of intolerance to standard therapy).

Also, the drug is used to prevent endocarditis in patients with hypersensitivity to penicillins.

Dalacin in the form of vaginal cream and suppositories is prescribed for the treatment of bacterial vaginosis.

Dalacin in the form of a gel for external use is prescribed for the treatment of acne vulgaris.

Contraindications

Dalacin is contraindicated for use in the presence of hypersensitivity to clindamycin, lincomycin or auxiliary components of the drug.

The drug in the form of capsules should be taken with caution in patients with gastrointestinal diseases (in history), especially with ulcerative colitis, myasthenia gravis (possibly impaired neuromuscular transmission), severe liver failure.

Additionally, Dalacin in other dosage forms is contraindicated for the following diseases / conditions:

A history of antibiotic-associated colitis;
Age: up to 18 years old - for vaginal cream and suppositories; up to 12 years - for a gel for external use (there are no data on the efficacy and safety of using Dalacin in this group of patients);
History of hypersensitivity to lincomycin or clindamycin (for topical gel).

Method of administration and dosage

Dalacin capsules are taken orally. To avoid complications, it is recommended to use it strictly according to the doctor's prescription.

To avoid irritation of the esophageal mucosa, capsules should be taken with a full glass of water.

The drug is usually taken:

Adults: 600-1800 mg per day, the frequency of administration is 2-4 times (in equal doses);
Children: 8-25 mg / kg of body weight per day, the frequency of administration is 3-4 times (in equal doses).

In the treatment of infections caused by beta-hemolytic streptococcus, Dalacin is used in the doses described above. The duration of the therapeutic course is at least 10 days.

Treatment of pelvic inflammatory disease begins with intravenous clindamycin, 900 mg every 8 hours, along with a suitable antibacterial agent for at least 4 days. After improving the patient's condition, therapy is continued for at least 2 more days, after which Dalacin is prescribed in the form of capsules in a single dose of 450-600 mg. The drug is taken every 6 hours daily. The full course of treatment is 10-14 days.

Depending on the indications, Dalatsin is prescribed:

Toxoplasmotic encephalitis in AIDS patients: in case of intolerance to standard therapy, the drug is taken simultaneously with pyrimethamine according to the following scheme: Dalacin - 600-1200 mg every 6 hours for 14 days, then 300-600 mg with the same frequency of use; pyrimethamine - 25-75 mg daily. Typically, the treatment course is 8-10 weeks. When using pyrimethamine in higher doses, 10-20 mg of folic acid should be prescribed per day;
Infections of the cervix caused by Chlamydia trachomatis: daily at 450-600 mg, frequency of administration - 4 times a day, duration of therapy - 10-14 days;
Acute streptococcal pharyngitis / tonsillitis: within 10 days, 300 mg 2 times a day;
Pneumocystis pneumonia in AIDS patients: within 21 days, 300-450 mg every 6 hours, simultaneously with primaquine, 15-30 mg once a day;
Malaria: adults - 10-20 mg / kg per day; children - 10 mg / kg per day. The drug is taken in equal doses every 12 hours, the duration of the course is 7 days. It is also possible to use Dalacin simultaneously with quinine (every 12 hours at 12 mg / kg) or chloroquine (every 24 hours at 15-25 mg), the course duration is 3-5 days.

For the prevention of endocarditis in patients with hypersensitivity to penicillins, Dalacin is prescribed: adults - 600 mg; children - 20 mg / kg. The drug should be taken 1 hour before minor dental or surgical interventions, or any other procedure in which there is a risk of endocarditis.

Elderly patients with normal kidney and liver function for a given age, as well as patients with functional disorders of the liver and kidneys, should not adjust the dose.

When treating bacterial vaginosis, the following are usually prescribed:

Vaginal cream: 5000 mg of cream (1 full applicator, approximately 100 mg of clindamycin) should be inserted into the vagina. The procedure is best done before bedtime. Course duration - 3 or 7 days;
Vaginal suppositories: 1 suppository is administered intravaginally 1 time a day, preferably at bedtime. The duration of the course is 3 days.

Dalacin in the form of a gel is used externally in the treatment of acne vulgaris. The drug is applied in a thin layer to the affected area (dry, clean skin). Frequency rate of application - 2 times a day. The recommended course duration is 6-8 weeks. According to indications, it is possible to use Dalacin for 6 months. If, after applying the gel for several months, the effectiveness of the treatment decreases, you need to take a break for 4 weeks.

Side effects

When using Dalatsin inside, the following side effects may develop:

Digestive system: nausea, abdominal pain, esophagitis, diarrhea and vomiting, pseudomembranous colitis, esophageal ulcer, jaundice, dysbiosis, liver dysfunction, including hyperbilirubinemia;
Hematopoiesis (hematopoietic system): cases of transient eosinophilia and leukopenia (neutropenia), as well as cases of thrombocytopenia and agranulocytosis, have been reported, however, the relationship between taking Dalacin and these phenomena has not been established;
Allergic reactions: itching, urticaria, maculopapular rash; most often - a measles-like generalized rash of moderate to mild severity; rarely - vesiculobullous and exfoliative dermatitis, toxic epidermal necrolysis, erythema multiforme, anaphylactoid reactions;
Others: vaginitis.

Also, during therapy, the following side effects may occur: the development of superinfection, impaired neuromuscular transmission.

When treating bacterial vaginosis with Dalacin in the form of a vaginal cream and suppositories, disorders may develop from some body systems:

Reproductive system: vulvovaginitis, vaginal candidiasis, uterine bleeding, irritation of the mucous membrane of the vagina and vulva, vaginal infections, Trichomonas vaginitis, vaginal pain, abnormal labor, menstrual irregularities, vaginal discharge, endometriosis;
Urinary system: urinary tract infections, dysuria, proteinuria;
Digestive system: taste perversion, flatulence, nausea, diarrhea, vomiting, dyspepsia, constipation, bad breath, gastrointestinal disturbances;
Skin: erythema, itching, rash, candidiasis of the skin, maculopapular rash, urticaria;
Central nervous system: dizziness, headache, vertigo;
Endocrine system: hyperthyroidism, glucosuria;
Respiratory system: upper respiratory tract infections, epistaxis;
The body as a whole: fungal infections, bacterial infections, bloating, localized and / or generalized abdominal pain, lower abdominal pain, abdominal cramps, deviation of microbiological test results from the norm, back pain, allergic reactions;
Local reactions: inflammatory edema and itching at the injection site.

When using the gel for external use, the following side effects may occur:

Digestive system: colitis, abdominal pain, pseudomembranous colitis, dyspeptic disorders (nausea, diarrhea, vomiting);
Organ of vision: burning sensation in the eyes;
Skin: most often dry skin; increased production of sebaceous glands, skin irritation, urticaria, contact dermatitis;
Others: folliculitis caused by gram-negative flora.

special instructions

With the development of diarrhea after the use of Dalacin orally or intravaginally, the possibility of developing pseudomembranous colitis should be considered. The disease can also appear 2-3 weeks after stopping therapy. Its main symptoms include: diarrhea, leukocytosis, fever, abdominal pain (sometimes accompanied by mucus and blood with feces). If necessary, diagnostic and therapeutic measures should be taken. With external use of the drug, cases of colitis are rare, however, care must be taken and, in case of prolonged or severe diarrhea, the use of the gel should be canceled.

For Chlamydia trachomatis cervical infections, Dalacin capsule monotherapy is effective for complete cure.

When Dalacin is taken inside, excessive growth of microorganisms insensitive to the drug is possible, especially yeast-like fungi. In case of development of superinfection, depending on the clinical situation, it is necessary to take appropriate measures.

Clindamycin should not be used to treat meningitis.

When prescribing Dalacin in high doses, it is necessary to control the concentration of clindamycin in plasma. With prolonged therapy, kidney and liver function tests should be carried out regularly.

Before prescribing Dalacin for the treatment of vulvovaginitis, the following possible causative agents should be excluded: Chlamydia trachomatis, Trichomonas vaginalis, Candida albicans, Neisseria gonorrhoeae, and the Herpes simplex virus.

It should be borne in mind that intravaginal use of the drug can cause increased growth of microorganisms insensitive to its action, especially yeast-like fungi.

With intravaginal use of the drug, sexual intercourse should be avoided, as well as the use of other types of products administered intravaginally (for example, syringes, tampons).

The use of Dalacin in the form of a cream or suppository during menstruation is not recommended. The beginning of therapy in this case should be postponed until the end of menstruation.

Dalacin contains components that affect the strength of rubber or latex products (contraceptive vaginal diaphragms, condoms). The use of such products during therapy and within 3 days after using the drug is not recommended.

It is necessary to avoid getting the gel for external use on the mucous membranes of the oral cavity and eyes. Wash your hands thoroughly after applying the drug. In case of accidental contact with sensitive surfaces (abrasions on the skin, eyes, mucous membranes), rinse them abundantly with cool water.

Drug interactions

Clindamycin should not be taken by mouth at the same time as erythromycin and chloramphenicol.

There is cross-resistance of microorganisms to lincomycin and clindamycin.

Clindamycin should be used with caution in patients receiving other peripheral muscle relaxants.

With the simultaneous use of Dalacin orally with opioid (narcotic) analgesics, which have a central inhibitory effect on respiratory function, the development of more pronounced respiratory depression up to apnea is possible.

The risk of developing pseudomembranous colitis increases with the simultaneous use of Dalacin with antidiarrheal drugs that reduce the motility of the gastrointestinal tract.

The spectrum of antimicrobial action of clindamycin is expanded by aminoglycosides.

The simultaneous use of vaginal cream and suppositories with other drugs for intravaginal administration is not recommended.

Analogs

Dalacin analogues are: Clindacin, Klindes, Clindamycin, Klindovit, Klindatop.

Terms and conditions of storage

Keep out of reach of children at temperatures up to 25 ° C. Do not freeze.

Shelf life:

Capsules - 5 years;
Vaginal cream, gel for external use - 2 years;
Vaginal suppositories - 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Dalatsin: prices in online pharmacies

Drug name

Price

Pharmacy

Dalacin 100 mg vaginal suppositories 3 pcs.

450 RUB

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Dalacin (gel) 1% gel for external use 30 g 1 pc.

490 rbl.

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Dalacin 2% vaginal cream with applicator 20 g 1 pc.

RUB 624

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Dalacin vaginal suppositories 100mg 3 pcs.

641 r

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Dalacin 2% vaginal cream with applicator 40 g 1 pc.

728 RUB

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Dalacin cream vaginal. 2% 40g

739 RUB

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Dalacin cream vaginal. 2% 20g

822 RUB

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Dalacin gel 1% 30g

854 r

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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!