Guttalax Express
Guttalax Express: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Guttalax Express
ATX code: A06AB02
Active ingredient: bisacodyl (Bisacodyl)
Manufacturer: Institute De Angeli S.r. L. (Instituto de Angeli, SrL) (Italy)
Description and photo update: 2020-09-07
Prices in pharmacies: from 163 rubles.
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Guttalax Express is a topical laxative drug.
Release form and composition
The drug is produced in the form of rectal suppositories: torpedo-shaped, white or slightly yellow, smooth or slightly oily surface, at the base there is a depression (6 pcs. In strips of aluminum foil, 1 strip in a cardboard box and instructions for using Guttalax Express).
1 suppository contains:
- active substance: bisacodyl - 10 mg;
- auxiliary component: Witepsol W45.
Pharmacological properties
Pharmacodynamics
Guttalax Express is a laxative. Its active substance, bisacodyl, belongs to the group of diphenylmethane derivatives and has a local laxative effect with a slight antiresorptive effect. The mechanism of action is due to direct stimulation of nerve endings in the mucous membrane of the large intestine. Bisacodyl is hydrolyzed in the large intestine, contributing to the stimulation of its peristalsis, the accumulation of water and electrolytes in the lumen of the large intestine, and softening of the stool. This activates the process of emptying the intestines, reducing the time for evacuation of its contents.
The activity of bisacodyl at the level of the colon stimulates the natural evacuation process in the lower gastrointestinal tract (GIT). The drug has no effect on the absorption and digestion of high-calorie foods or essential nutrients in the small intestine.
The laxative effect develops within 10-30 minutes, in some cases a little longer.
Pharmacokinetics
After the administration of the suppository Guttalax Express, the absorption of bisacodyl is insignificant.
It is metabolized by enzymes (esterases) of the mucous membrane of the large intestine with the formation of an active metabolite - bis- (p-hydroxyphenyl) -pyridyl-2-methane. The maximum concentration (C max) of the active metabolite in plasma is achieved in 0.5–3 hours. The laxative effect does not depend on the concentration level of the active metabolite in plasma.
Biotransformation of bisacodyl to inactive glucuronide occurs almost completely in the intestinal wall and liver.
The substance does not pass into breast milk.
The half-life of bisacodyl is approximately 16.5 hours. Most of it is excreted in the form of an active metabolite: almost completely (up to 90% of the total amount) through the intestine; up to 3.1% is excreted in the urine. Unchanged, some bisacodyl is excreted through the intestines.
Indications for use
- constipation due to hypotension of the colon (including chronic constipation);
- regulation of defecation in the postpartum period and in bedridden patients;
- preparation for surgical interventions, postoperative period;
- preparation for instrumental and X-ray examinations.
Contraindications
Absolute:
- acute inflammatory diseases of the intestines and abdominal organs, including appendicitis;
- obstructive bowel pathology;
- intestinal obstruction;
- severe abdominal pain, accompanied by nausea and vomiting;
- severe dehydration;
- age up to 10 years;
- hypersensitivity to drug components.
With caution, only after consulting a specialist, rectal suppositories Guttalax Express should be used for hepatic and / or renal failure, in elderly patients, during pregnancy.
Guttalax Express, instructions for use: method and dosage
Guttalax Express suppositories are used rectally, by introducing into the rectum with the pointed end forward.
Recommended dosage for adults and children over 10 years of age:
- constipation: 1 suppository 1 time per day. Without consulting a doctor and determining the cause of constipation, the drug can be used daily for no more than 10 days;
- preparation for research, pre- and postoperative treatment, conditions that require easier bowel movements: under medical supervision, in combination with a tablet form of bisacodyl, to achieve complete emptying. On the eve of the study or surgery, the attending physician prescribes an individual dose of bisacodyl for rectal administration and oral administration, taking into account the patient's clinical condition and the amount of upcoming manipulation.
Side effects
- from the gastrointestinal tract: discomfort in the abdomen and / or rectum, spastic abdominal pain, nausea, vomiting, diarrhea (accompanied by dehydration, muscle weakness, cramps, low blood pressure), blood in the stool, colitis (including ischemic colitis), pain and local irritation, especially with ulcerative proctitis or the presence of an anal fissure;
- from the nervous system: dizziness and / or fainting caused by a vasovagal reaction (intestinal spasm, tension during bowel movements);
- from the immune system: hypersensitivity reaction, anaphylactic reactions, angioedema.
Overdose
Symptoms of bisacodyl overdose: abdominal cramps, diarrhea, dehydration, hypokalemia, imbalance in water and electrolyte balance. Long-term use of Guttalax Express can cause abdominal pain, chronic diarrhea, hypokalemia, urolithiasis, secondary hyperaldosteronism. Chronic abuse of laxatives contributes to damage to the renal tubules, the development of metabolic alkalosis, muscle weakness due to hypokalemia.
Treatment: symptomatic therapy due to the lack of a specific antidote. It may be necessary to prescribe antispasmodics, take measures aimed at replenishing fluid in the body, and correcting the electrolyte balance.
special instructions
If you need regular or prolonged stimulation of bowel movements, the cause of the constipation should be determined. Long-term use of a laxative can cause dehydration. Against the background of fluid loss, electrolyte imbalance and the development of hypokalemia are likely. Symptoms of dehydration include thirst, a decrease in the volume of urine excreted by the kidneys. Particular care should be taken in the elderly and patients with renal impairment. If symptoms of dehydration appear, they are advised to stop using suppositories. The use of laxatives can be resumed only after consulting a doctor.
The undesirable phenomenon in the form of blood in the feces is usually mild and goes away on its own.
Guttalax Express helps to stimulate bowel movements, does not cause weight loss.
Influence on the ability to drive vehicles and complex mechanisms
In connection with the possible development of undesirable effects on the part of the nervous system (dizziness, fainting), patients are advised to be careful when engaging in potentially hazardous activities that require quick psychomotor reactions and increased concentration of attention, including driving and complex mechanisms.
Application during pregnancy and lactation
During pregnancy, the use of Guttalax Express is indicated only as directed by a specialist, if the expected clinical effect for the mother outweighs the potential threat to the fetus.
The drug can be used during lactation.
Pediatric use
The use of Guttalax Express in children under the age of 10 is contraindicated.
If it is necessary to use the drug in children over the age of 10 years, prior consultation with a doctor is required.
With impaired renal function
Guttalax Express should be used with caution in patients with renal insufficiency.
For violations of liver function
Guttalax Express should be used with caution in patients with hepatic impairment.
Use in the elderly
Guttalax Express should be used with caution in elderly patients.
Drug interactions
The simultaneous use of high doses of Guttalax Express with diuretics or glucocorticosteroids increases the risk of electrolyte imbalance and may lead to the development of hypokalemia. It should be borne in mind that hypokalemia increases sensitivity to the action of cardiac glycosides.
The combination of the drug with other laxatives increases the risk of increased side effects from the gastrointestinal tract.
Analogs
Analogues of Guttalax Express are Guttalax, Bisacodyl, Bisacodyl Grindeks, Bisacodyl-OBL, Bisacodyl-Akrihin, Bisacodyl-Altpharm, Bisacodyl-Hemofarm, Dulcolax, Laxbene, Laxatin, Casalwood ecolactic oil, Gypsum extract, Dewacolac oil, dry oil, Portalak, Senade, Regulax, Mukofalk, Slabilen, etc.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C, protected from moisture.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Guttalax Express
The few reviews about Guttalax Express are positive. Patients confirm the rapid laxative effect of the drug. It is advised, after the introduction of the suppository, to be near the toilet room.
Price for Guttalax Express in pharmacies
The price of Guttalax Express, rectal suppositories, 10 mg, for a package containing 6 pcs., Can range from 219 rubles.
Guttalax Express: prices in online pharmacies
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Drug name Price Pharmacy |
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Guttalax Express 10 mg rectal suppositories 6 pcs. 163 r Buy |
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Guttalax express supp. rekt. 10 mg 6 pcs. 183 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
