Gynoflor E
Ginoflor E: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Instructions for the use of E: method and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price of E in pharmacies
Latin name: Gynoflor E
ATX code: G02CX
Active ingredient: acidophilic lactobacillus (lyophilisate) and estriol
Manufacturer: Medinova Ltd. Switzerland for LLC "Invar", Russia
Description and photo update: 2018-22-10
Gynoflor E is a combined drug for regulating the balance of vaginal microflora.
Release form and composition
Dosage form of the drug - vaginal tablets: oval, biconvex, from light beige to white, inclusions are allowed (6 pcs. In blisters; 1 or 2 packs in a cardboard box).
Composition for 1 tablet:
- active ingredients: acidophilic lactobacilli (in the form of lyophilisate) ≥ 100 million viable bacteria - 50,000 μg; estriol - 30 mcg;
- auxiliary ingredients: lactose monohydrate, sodium carboxymethyl starch, magnesium stearate, microcrystalline cellulose, sodium dihydrogen phosphate.
Pharmacological properties
Pharmacodynamics
The composition of Gynoflor E contains as active ingredients: a short-acting female sex hormone of the estrogen class - estriol; live bacteria that dominate the vagina of a healthy woman, possessing antagonistic activity against a wide range of pathogenic and opportunistic microflora, supporting and normalizing the vaginal biocenosis - lactobacillus acidophilus.
Estriol has a protective trophic effect on the vaginal epithelium and does not affect the woman's body systemically. The mature proliferating epithelial layer of the vagina accumulates glycogen, which is necessary for the functioning of lactobacilli, which produce lactic acid to maintain the acidic environment of the vagina (pH 3.8-4.5), as well as create unfavorable conditions for the development and colonization of pathogenic microflora. Together with lactic acid, acidophilic lactobacilli produce bacteriocins and hydrogen peroxide, which also act depressingly on the development of pathogenic and conditionally pathogenic microflora.
Modification of the normal physiological environment of the vagina can occur due to the use of antibacterial agents of local or systemic action for the treatment of vaginal infections or systemic diseases, as well as if personal hygiene is not followed. In such cases, a significant decrease in the number of natural lactobacilli is likely. With intravaginal application, Gynoflor E normalizes the state of the vaginal epithelium and restores its natural microflora. Contained as a filler in vaginal tablets, lactose can be fermented by lactobacilli into lactic acid.
In case of hormonal disorders, the epithelial layer of the vagina can become thinner and damaged, therefore Gynoflor E is also recommended for use in postmenopausal women to relieve its local symptoms: itching, burning, dryness in the vagina, pain during intercourse. The drug helps to normalize the state of the epithelium of the vagina and urethra, reduces the frequency of degenerative inflammatory processes.
In vitro studies have shown that acidophilic lactobacilli reduce the pH to normal within a few hours. Estriol, when treated with a course of 6–12 days, provides a proliferative trophic effect on the epithelial layer of the vagina.
Pharmacokinetics
When the Gynoflor E tablet is introduced into the vagina, lyophilized acidophilic lactobacilli and estriol are released.
The study of the absorption of estriol from Gynoflor E was carried out with the use of the drug by women in the postmenopausal period. The plasma concentration of estriol after repeated use corresponds to the level of endogenous unbound estriol. After 12 days of treatment with vaginal tablets Gynoflor E, provided that they are used once a day, the maximum concentration (Cmax) in the blood plasma of unbound estriol does not differ from the initial one, which is an indicator of the absence of systemic absorption.
The use of the drug does not affect the plasma concentration of the sex hormones present in the woman's body - estrone and estradiol, since estriol is the end product of their metabolism.
Indications for use
According to the instructions, Gynoflor E is recommended for use to restore normal vaginal microflora after the use of antibiotics and other antimicrobial drugs for local / systemic treatment of vaginal infections (bacterial vaginosis, non-specific vulvovaginitis), urogenital infections and sexually transmitted diseases. In the postmenopausal period, the drug is used in combination with hormone replacement therapy (HRT) for estrogen-dependent atrophic vaginitis.
Contraindications
- vaginal bleeding of unknown etiology;
- malignant estrogen-dependent tumors, including neoplasms of the mammary gland, ovaries, uterus or vagina (in history, diagnosed, as well as if they are suspected);
- endometriosis (suspected / diagnosed);
- untreated endometrial hyperplasia;
- increased individual sensitivity to any component of the drug.
Gynoflor E is contraindicated for use before the onset of sexual activity.
Instructions for the use of Gynoflor E: method and dosage
The tablets are intended for intravaginal (deep) administration. The procedure is recommended to be carried out in the evening, before going to bed, preferably in the supine position, with the legs slightly bent at the knees.
Dosing regimen according to indications:
- restoration of the normal microflora of the vagina: inject 1-2 tablets daily, the course is 6-12 days;
- treatment of estrogen-dependent atrophic vaginitis in the postmenopausal period: inject 1 tablet daily, course 6-12 days; maintenance dose - 1 tablet 1-2 times a week.
Side effects
When using Gynoflora E in the vagina, a burning sensation is possible, in rare cases - redness of the vulva and vagina and vulvovaginal itching.
Overdose
There is no data.
special instructions
The composition of the Gynoflor E preparation contains components that cannot dissolve without a trace, therefore, sometimes you can find the remnants of a vaginal tablet on your underwear. This fact does not affect the effectiveness of the drug.
In exceptional cases, with excessive vaginal dryness, the tablet may not dissolve. To prevent such a situation, it can be moistened with a small amount of plain water before introduction - this will facilitate faster dissolution. During therapy, patients are advised to use sanitary pads.
Influence on the ability to drive vehicles and complex mechanisms
The use of Gynoflora E does not affect the ability to drive vehicles and complex mechanisms.
Application during pregnancy and lactation
No undesirable effects of lactobacilli and estriol on the course of pregnancy and the condition of the fetus / newborn were found. But long-term clinical studies on the effect of estriol on the fetus have not been conducted.
It is undesirable to use Gynoflor E in the first trimester of pregnancy. Allowed therapy with the drug in the II-III trimesters of pregnancy and during breastfeeding, after consultation with a specialist.
Drug interactions
The simultaneous use of Gynoflora E with antibacterial drugs is not recommended, since acidophilic lactobacilli are sensitive to most antibacterial drugs for local or systemic therapy. Their simultaneous use can significantly reduce the effectiveness of treatment.
It is also not recommended to use Gynoflor E simultaneously with spermicidal agents.
Analogs
The analogues of Ginoflor E are: Vagisan, Vagilak, Vaginorm-S, Laktogin, Laktovag, Ekofemin, etc.
Terms and conditions of storage
Store at 2–8 ° С. Do not freeze. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Gynoflor E
Women who used pills, reviews of Gynoflor E leave quite contradictory. For some of them, the drug helped to effectively restore the microflora and consolidate the results of previous therapy. They describe the tablets as compact, easy to use, and non-allergenic, and emphasize the benefits of breastfeeding.
Patients for whom the drug did not fit report unpleasant side effects such as itching and burning sensation, swelling of the vulva and vagina, as well as relapses of thrush. And almost everyone agrees that the cost of the pills is relatively high.
Price for Gynoflor E in pharmacies
Approximate price of Gynoflor E vaginal tablets for 6 pcs. in the package - 825–990 rubles; for 12 pcs. in the package - 1120-1375 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
