Hepa-Merz
Hepa-Merz: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Hepa-Merz
ATX code: A05BA
Active ingredient: Ornithine (Ornithine)
Manufacturer: Merz Pharma GmbH & Co. KGaA (Germany)
Description and photo update: 2019-12-08
Prices in pharmacies: from 611 rubles.
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Hepa-Merz is a hypoammonic drug for the treatment of liver and biliary tract diseases.
Release form and composition
Dosage forms of the drug:
- Granules for preparation of oral solution: a mixture of white and orange granules (5 g in sachets, in a cardboard box, 10 or 30 sachets);
- Concentrate for preparation of solution for infusion: transparent liquid of light yellow color (10 ml in dark glass ampoules, in a cardboard box of 10 ampoules).
Active ingredient - L-ornithine L-aspartate:
- 1 sachet - 3 g;
- 1 ampoule - 5 g.
Excipients:
- Granules: orange flavor, anhydrous citric acid, sodium saccharinate (sodium saccharin), lemon flavor, sodium cyclamate, polyvinyl pyrrolidone (povidone), sunset yellow dye, fructose (levulose);
- Concentrate: water for injection.
Pharmacological properties
Pharmacodynamics
Hepa-Merz is characterized by a detoxifying effect, reducing the increased concentration of ammonia in the body. In particular, this condition occurs with liver disease. L-ornithine-L-aspartate is involved in the ornithine cycle of Krebs urea formation (promotes the activation of the cycle by increasing the activity of liver cell enzymes - carbamoyl phosphate synthetase and ornithine carbamoyl transferase).
The drug improves the production of growth hormone and insulin, normalizes protein metabolism in diseases that require parenteral nutrition. The active ingredient Hepa-Merz reduces pain, dyspeptic and asthenic syndromes, and also provides a decrease in increased body weight (with steatohepatitis and steatosis).
Pharmacokinetics
L-Ornithine-L-Aspartate undergoes rapid dissociation into aspartate and ornithine. The drug begins to act within 15-25 minutes after administration and has a short half-life. The active substance is excreted in the urine during the urea cycle.
Indications for use
- Chronic and acute liver diseases, accompanied by hyperammonemia;
- Latent or severe hepatic encephalopathy.
In addition, the use of the concentrate is indicated as part of the complex therapy of severe hepatic encephalopathy in a patient's condition in precoma or coma, and as a corrective additive to parenteral nutrition products in case of protein deficiency.
Contraindications
- Severe renal failure (creatinine level 3 mg / 100 ml);
- Breastfeeding period;
- Hypersensitivity to drug components.
According to the instructions, Hepa-Merz in granules is prescribed with caution during pregnancy.
Instructions for the use of Hepa-Merz: method and dosage
- Granules are taken orally, after meals, dissolved in liquid - 1 sachet per 200 ml, 2-3 times a day;
- The concentrate is administered intravenously drip, dissolved in 500 ml of infusion solution up to 40 ml (4 ampoules) per day. In the case of hepatic encephalopathy (depending on the severity of the condition), up to 80 ml (8 ampoules) per day are administered intravenously. The doctor prescribes the dosage and treatment period on the basis of clinical indications individually. The maximum permissible infusion rate is 5 g per hour. It is recommended to dissolve no more than 60 ml (6 ampoules) of the drug in 500 ml of infusion solution.
Side effects
- Digestive system: in some cases - vomiting, nausea;
- Other: allergic reactions.
Overdose
When taking Hepa-Merz in doses significantly exceeding the therapeutic ones, the severity of the side effects of the drug may increase. In this case, the stomach is immediately washed, and activated charcoal and symptomatic therapy are prescribed.
special instructions
In case of nausea or vomiting, the rate of administration of the drug should be reduced.
Patients with a diagnosis of hepatic encephalopathy need to be careful when engaging in potentially hazardous activities, the performance of which requires concentration of attention and speed of psychomotor reactions, including when driving.
Drug interactions
There are no data on clinically significant drug interactions.
Analogs
Analogs of Hepa-Merz are: Ornilatex, Ornithin, Ornicetil.
Terms and conditions of storage
Keep out of the reach of children. Store at temperatures up to 25 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Granules are dispensed without a prescription, the concentrate is dispensed by prescription.
Reviews about Hepa-Merz
According to reviews, Hepa-Merz is a fairly effective drug that has very few contraindications. People who took it note that side reactions during treatment are extremely rare, which makes the drug suitable for a wide range of patients, including children and elderly patients. However, the cost of Hepa-Merz is quite high.
Price for Hepa-Merz in pharmacies
On average, the price of Hepa-Merz granules ranges from 825 to 920 rubles (for a package containing 10 sachets) or from 1960 to 2180 rubles (for a package containing 30 sachets). You can buy a concentrate for preparing a solution for infusion for 3150–3500 rubles.
Hepa-Merz: prices in online pharmacies
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Drug name Price Pharmacy |
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Hepa-Merz 3 g granules for preparation of oral solution 5 g 10 pcs. RUB 611 Buy |
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Hepa-Merz 3 g granules for preparation of oral solution 5 g 30 pcs. 1414 RUB Buy |
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Hepa-Merz granules for prigot. solution for internal approx. 3g / 5g 30 pcs. 1456 RUB Buy |
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Hepa-Merz 500 mg / ml concentrate for preparation of solution for infusion 10 ml 10 pcs. 2000 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
