Wagiferon
Vagiferon: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Vagiferon
ATX code: G01AF20
Active ingredient: Metronidazole (Metronidazole), Fluconazole (Fluconazole), Interferon alfa-2b (Interferon alfa-2b)
Manufacturer: FIRN M CJSC (Russia)
Description and photo update: 19.10.2018
Prices in pharmacies: from 352 rubles.
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Vagiferon is a local combined preparation with antibacterial, antifungal and antiprotozoal action, used in gynecology.
Release form and composition
Dosage form - vaginal suppositories: white with a yellowish tinge or white, torpedo-shaped (5 pcs. In blisters, 1 or 2 packs in a cardboard box).
Active substances in the composition of Vagiferon (in 1 suppository):
- recombinant human alpha-2b interferon - not less than 50,000 IU (international units);
- fluconazole - 200 mg;
- metronidazole - 150 mg.
Auxiliary components in the composition of Vagiferon: edetate disodium - 2 mg; boric acid - 400 mg; base (macrogol 400 - 8%; macrogol 1500 - 92%) - up to 2000 mg.
Pharmacological properties
Pharmacodynamics
Vagiferon is one of the combined drugs for intravaginal use. It has antiviral, immunomodulatory, anti-inflammatory, antifungal, antimicrobial and antiprotozoal (trichomonacid) effect.
Properties of active ingredients:
- metronidazole: is a 5-nitroimidazole derivative; has an antiprotozoal and antibacterial effect. The mechanism of action lies in the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of protozoa and anaerobic microorganisms. Shows activity against Gardnerella vaginalis, Trichomonas vaginalis, as well as gram-negative anaerobes Bacteroides spp., Fusobacterium spp. and some gram-positive anaerobes (sensitive strains - Peptococcus niger, Eubacterium spp., Peptostreptococcus spp., Clostridium spp., Mobiluncus spp.). Facultative anaerobes and aerobic microorganisms are not sensitive to metronidazole;
- fluconazole: has a highly specific fungicidal (antifungal) effect. Shows activity in mycoses, including Candida spp. (including generalized forms of candidiasis against the background of immunosuppression), Coccidioides immitis and Cryptococcus neoformans, Blastoyces dermatitidis, Microsporum spp. With intravaginal administration, it is more active against Candida albicans, to a lesser extent - Candida glabrata;
- interferon alpha-2b: has a pronounced immunomodulatory and antiviral effect.
Pharmacokinetics
Bioavailability of metronidazole after intravaginal administration is 20% higher in comparison with oral administration. After intravaginal administration, it undergoes systemic absorption (approximately 56%). It is metabolized in the liver by hydroxylation, oxidation and glucuronidation. The activity of the main metabolite (2-oxymetronidazole) is 30% of the activity of the parent compound. It is excreted by 40–70% through the kidneys (in unchanged form - about 20%). The half-life ranges from 6 to 12 hours.
The pharmacokinetics of fluconazole and interferon with intravaginal administration has not been studied.
Indications for use
- vaginitis caused by mixed infection, including yeast-like fungi, gardenrella, Trichomonas, herpes simplex virus types 1 and 2, ureaplasma, mycoplasma (in combination with other drugs);
- bacterial vaginosis;
- nonspecific (bacterial) vaginitis.
Contraindications
- pregnancy and lactation;
- age up to 18 years;
- individual intolerance to the components of the drug, as well as nitroimidazole derivatives.
Instructions for the use of Vagiferon: method and dosage
The drug is used intravaginally.
Recommended regimen: 1 suppository in the evening (before bedtime) for 10 days.
Side effects
Vagiferon, as a rule, does not lead to the appearance of side effects. In some cases, the development of allergic and local reactions can be observed.
Disturbances characteristic of metronidazole (its systemic absorption is 56%): ataxia, convulsions, leukopenia, mental changes (in the form of anxiety, mood lability); rarely - dizziness, allergic reactions, loss of appetite, nausea, vomiting, abdominal cramps / pains, diarrhea, constipation, headache, unpleasant or metallic taste, change in taste, dry mouth, increased fatigue.
Overdose
There is no evidence of an overdose.
Possible symptoms of an overdose of metronidazole: dizziness, dark urine staining, convulsions, nausea, abdominal pain, vomiting, diarrhea, itching, metallic taste in the mouth, leukopenia, ataxia, paresthesia.
special instructions
It is recommended to refrain from sexual intercourse during treatment.
In cases of using the drug in combination with oral administration of metronidazole, especially during a repeated course, it is necessary to control the picture of peripheral blood (associated with the risk of developing leukopenia).
It is impossible to consume alcohol during therapy (due to the likelihood of disulfiram-like reactions manifested in the form of abdominal pain of a spastic nature, nausea, vomiting, headache, sudden flushes of blood to the face). Patients who have taken disulfiram within the past 14 days should not be prescribed metronidazole.
Application during pregnancy and lactation
It is contraindicated to use the drug during pregnancy and lactation.
Breastfeeding can be resumed no earlier than 48 hours after the end of therapy.
Pediatric use
The drug is not prescribed for children under 18 years old, which is due to the lack of data confirming its safety / efficacy in this group of patients.
Drug interactions
According to the instructions, Vagiferon can be used simultaneously with a macrolide antibiotic (josamycin) of systemic action.
Combined use with non-depolarizing muscle relaxants (vecuronium bromide) is not recommended.
Analogs
Analogs of Vagiferon are: Vagisept, Gainomax, Ginokaps, Klomegel, Metromikon-Neo, Klion-D 100, Neo-Penotran Forte.
Terms and conditions of storage
Store at 2-8 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Vagiferon
According to a few reviews, Vagiferon is a fairly effective drug that practically does not cause side effects.
The price of Vagiferon in pharmacies
The approximate price for Vagiferon (10 suppositories per pack) is 260–550 rubles.
Vagiferon: prices in online pharmacies
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Drug name Price Pharmacy |
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Vagiferon vaginal suppositories 10 pcs. 352 r Buy |
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Vagiferon vaginal suppositories 10 pcs. 423 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
