Bitsillin-3
Bitsillin-3: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Bicillin-3
ATX code: J01CE30
Active ingredient: Benzathine benzylpenicillin + Benzylpenicillin procaine + Benzylpenicillin (Benzathine benzylpenicillin + Benzylpenicillin procaine + Benzylpenicillin)
Producer: Biopreparation RAO (Russia), Sintez JSC (Russia)
Description and photo update: 19.10.2018
Prices in pharmacies: from 51 rubles.
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Bicillin-3 is a drug with antibacterial, bactericidal action.
Release form and composition
The dosage form is a powder for preparing a suspension for intramuscular administration: white with a slightly yellowish tinge or white, prone to clumping, when water is added, forms a stable suspension (in 10 ml vials, in a cardboard box of 1, 10 or 50 vials).
Active substances in 1 bottle of 600 or 1200 thousand units:
- benzathine benzylpenicillin - 200 or 400 thousand units (units of action);
- benzylpenicillin sodium salt or benzylpenicillin potassium salt (benzylpenicillin sodium or benzylpenicillin potassium) - 200 or 400 thousand units;
- novocaine benzylpenicillin salt (procaine benzylpenicillin) - 200 or 400 thousand units.
Pharmacological properties
Pharmacodynamics
Bicillin-3 is one of the combined antibacterial drugs of the long-acting penicillin group, which are destroyed by penicillinase. The mechanism of action is based on a violation of the synthesis of peptidoglycan - a mucopeptide of the cell wall, which causes inhibition of the synthesis of the cell wall of microorganisms, suppression of the reproduction and growth of bacteria.
According to the instructions, Bicillin-3 is active against gram-positive and gram-negative bacteria: Staphylococcus spp. (not producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Neisseria gonorrhoeae, Actinomyces israelii, Neisseria meningitidis, Corynebacterium diphtheriae, Bacillus anthracis as well as Treponema spp., Leishmania, anaerobic spore-forming rods.
Penicillinase-producing Staphylococcus spp. Are resistant to the action of the drug.
Pharmacokinetics
Absorption: after a single application, the active substances remain at an average therapeutic concentration for 6-7 days. The maximum plasma concentration is reached 12-24 hours after administration. Concentration in blood serum on the 14th day after administration of 2400 thousand units is 0.12 μg / ml; after a dose of 1200 thousand units on the 21st day, the serum concentration in the blood is 0.06 μg / ml.
Distribution and metabolism: after intramuscular administration, Bicillin-3 is slowly hydrolyzed with the release of benzylpenicillin. Biotransformation is insignificant. Plasma protein binding is in the range from 40 to 60%. Penetrates into breast milk, passes through the placental barrier. It has a low tissue distribution, while being well distributed in liquids.
Excretion: mainly excreted by the kidneys.
Indications for use
- infectious diseases caused by pathogens sensitive to the action of penicillin (especially in cases where it is necessary to create a long-term therapeutic concentration in the blood);
- streptococcal infections, including acute tonsillitis, wound infections, scarlet fever, erysipelas, except for infections caused by group B streptococci;
- syphilis;
- leishmaniasis;
- yaws;
- rheumatism (prophylactic).
Contraindications
Contraindication to use is individual intolerance to the components of the drug, including procaine (novocaine).
Bitsillin-3 is used with caution in renal failure, diseases of allergic etiology, including bronchial asthma, hay fever (including a history), pseudomembranous colitis.
Instructions for the use of Bitsillin-3: method and dosage
The drug should be injected deep into the upper outer quadrant of the buttock. Intravenous administration is prohibited.
The maximum dose is 1200 thousand units. If two injections are necessary, injections should be made in different buttocks. The drug can be re-administered after 4 days.
Bicillin-3 at a dose of 600 thousand units is administered 1 time in 6 days.
The use of the drug in the treatment of syphilis:
- primary and secondary: single dose - 1800 thousand units; the full course includes 7 injections: the first - 300 thousand units, the second is injected after 24 hours (the full dose is 1800 thousand units), then the drug is used 2 times a week;
- secondary recurrent and latent early: the full course includes 14 injections: the first - 300 thousand units, then the drug is used 2 times a week at a full dose of 1800 thousand units.
It is necessary to prepare the suspension immediately before use. 2-3 ml of isotonic sodium chloride solution or sterile water for injection should be injected into the vial with the drug. Within 30 seconds the mixture is shaken (in the direction of the longitudinal axis of the vial) until a homogeneous suspension / slurry is formed. It is not recommended to rub the injection site after injection.
Side effects
- blood coagulation system: anemia, leukopenia, thrombocytopenia, hypocoagulation;
- digestive system: glossitis, stomatitis;
- allergic reactions: urticaria, erythema multiforme, angioedema, exfoliative edema, anaphylactic shock, fever, arthralgia;
- others: with a long course - mycoses, superinfection.
Overdose
To date, there are no reports of overdose.
special instructions
In cases of allergic reactions, therapy is immediately canceled.
When anaphylactic shock occurs, anti-shock therapy is prescribed (norepinephrine, glucocorticosteroids, artificial ventilation).
Endolumbar / intravenous administration is not permissible, since this can lead to the development of Wanier's syndrome (manifested in the form of depression, paresthesia, anxiety, visual impairment).
In the treatment of sexually transmitted diseases, in cases of suspicion of syphilis, serological / microscopic examinations must be performed before starting treatment and then for 4 months.
It should be borne in mind that the use of insufficient doses of Bicillin-3 or early termination of therapy can lead to the emergence of resistant strains of pathogens.
Due to the likelihood of developing fungal infections, it is advisable to use antifungal drugs (nystatin, levorin), as well as B vitamins and ascorbic acid.
Application during pregnancy and lactation
There is no information on the use of Bitsillin-3 during pregnancy / lactation.
Drug interactions
With the combined use of certain drugs / substances, the following effects may develop:
- allopurinol, diuretics, phenylbutazone, nonsteroidal anti-inflammatory drugs: decreased tubular secretion and increased concentration of penicillin;
- bacteriostatic antibiotics (including tetracyclines, macrolides, lincosamides, chloramphenicol): antagonism of action;
- bactericidal antibiotics (including rifampicin, cephalosporins, vancomycin, cycloserine, aminoglycosides): synergistic action;
- oral contraceptives and ethinyl estradiol: decrease in their effectiveness and increase the likelihood of breakthrough bleeding;
- allopurinol: an increase in the likelihood of the risk of allergic reactions.
Analogs
Bitsillin-3 analogs are: Extensillin, Benzatin benzylpenicillin, Moldamin, Retarpen, Benzicillin.
Terms and conditions of storage
Store in a place protected from moisture at a temperature of 8-15 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Bitsillin-3
According to reviews, Bitsillin-3 in most cases is prescribed for the treatment of various ENT infections, while its high efficiency is noted.
There are reviews indicating the development of allergic reactions, which in some cases requires discontinuation of therapy.
The price of Bitsillin-3 in pharmacies
The approximate price for Bitsillin-3 is (600 or 1200 thousand units):
- 1 bottle per package - 10 or 17 rubles;
- 50 bottles per package - 470 or 620 rubles.
Bitsillin-3: prices in online pharmacies
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Drug name Price Pharmacy |
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Bicillin-3 600000 IU powder for preparation of suspension for intramuscular injection 10 ml 1 pc. RUB 51 Buy |
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Bicillin-3 1200000 IU powder for preparation of suspension for intramuscular injection 10 ml 1 pc. 52 RUB Buy |
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Bitsillin-3 6000ED powder for prigot. suspension d / v / m enter RUB 81 Buy |
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Bitsillin-3 1200000ED powder for prigot. suspension for intramuscular injection RUB 90 Buy |
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Bicillin-3 400 + 400 + 400 powder for preparation of suspension for intramuscular injection 10 ml 50 pcs. RUB 105 Buy |
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Bicillin-3 200 + 200 + 200 powder for preparation of suspension for intramuscular injection 10 ml 50 pcs. 3254 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
