Bitsillin-5
Bitsillin-5: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Bicillin-5
ATX code: J01CE30
Active ingredient: Benzathine benzylpenicillin + Benzylpenicillin procaine (Benzathine benzylpenicillin + Benzylpenicillin procaine)
Manufacturer: SINTEZ, JSC (Russia)
Description and photo update: 19.10.2018
Prices in pharmacies: from 84 rubles.
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Bicillin-5 is an antibiotic (biosynthetic penicillin).
Release form and composition
The drug is produced in the form of a powder for preparing a suspension for intramuscular administration: a white or white with a yellowish tinge, a powdery mass prone to clumping; when water is added, it forms a stable suspension (10 ml in vials; in a carton of 1, 5, 10 or 50 vials) …
Powder composition (for 1 bottle):
- benzylpenicillin procaine (benzylpenicillin novocaine salt) - 300,000 units;
- benzathine benzylpenicillin - 1 200 000 units.
Pharmacological properties
Pharmacodynamics
Bicillin-5 is a bactericidal combined antibiotic containing two long-acting benzylpenicillin salts. Inhibits the synthesis of the cell wall of pathogenic microorganisms.
Active against the following microbes:
- gram-positive: Streptococcus spp. (including Streptococcus pneumoniae), Staphylococcus spp. (non-penicillinase-forming), Bacillus anthracis, Clostridium spp., Corynebacterium diphtheriae, anaerobic spore-forming rods, Actinomyces israelii;
- gram negative: Treponema spp., Neisseria gonorrhoeae, Neisseria meningitidis.
Strains of Staphylococcus spp. That produce penicillinase are resistant to the drug.
Pharmacokinetics
Bicillin-5 is an antibiotic with a prolonged action, its high concentration in the blood lasts for 4 weeks.
Benzathine benzylpenicillin is very slowly hydrolyzed after intramuscular injection, releasing benzylpenicillin. The maximum concentration (Cmax) in the blood serum is reached after 12-24 hours after administration. The long half-life provides a long and stable drug concentration in the blood: on the 14th day after injection of 2,400,000 IU, the serum drug concentration is 0.12 μg / ml; on the 21st day after administration - 1,200,000 IU, the concentration is 0.06 μg / ml (1 IU = 0.6 μg). Diffusion of matter in tissue is very weak, in liquid it is complete. The connection with plasma proteins is 40-60%. Benzathine benzylpenicillin passes in small volumes through the placental barrier and also enters breast milk. Biotransformation is insignificant, mainly excreted by the kidneys unchanged,up to 33% of the administered dose is released in 8 days.
Benzylpenicillin reaches its maximum concentration in blood plasma after intramuscular injection after 20-30 minutes. The half-life is 0.5–1 hour, in the presence of renal failure, this figure increases to 4–10 hours or more. Communication with plasma proteins ~ 60%. The substance penetrates into tissues, organs and biological fluids, except for the tissues of the eye, cerebrospinal fluid and prostate gland. Passes through the blood-brain barrier with inflammation of the meningeal membranes. It crosses the placenta and passes into breast milk. It is excreted by the kidneys unchanged.
Indications for use
Bicillin-5 is used to treat the following infectious and inflammatory diseases / conditions provoked by pathogens sensitive to the drug:
- rheumatism - for year-round long-term prevention of relapse;
- syphilis;
- yaws;
- streptococcal infections (with the exception of infections caused by group B streptococci) - scarlet fever, acute tonsillitis, erysipelas, wound infections.
Contraindications
Absolute:
- period of breastfeeding;
- hypersensitivity to any component of the drug and other beta-lactam antibiotics.
Relative:
- bronchial asthma;
- burdened allergic anamnesis;
- pregnancy;
- renal failure;
- pseudomembranous colitis.
Instructions for the use of Bitsillin-5: method and dosage
A suspension prepared from a powder is injected intramuscularly (i.m.).
Recommended dosages of Bicillin-5:
- children under 8 years old: 480,000 U + 120,000 U once every 3 weeks;
- children from 8 years old: 960,000 units + 240,000 units once every 4 weeks;
- adults: 1 200 000 IU + 300 000 IU 1 time in 4 weeks.
When preparing a suspension, it is recommended to use a 0.25–0.5% solution of novocaine (procaine), isotonic sodium chloride solution, or sterile water for injection.
The suspension is prepared under aseptic conditions, immediately before use (ex tempore): 5-6 ml of solvent is slowly introduced into a bottle with Bitsillin-5 under pressure (at a rate of 5 ml in 20-25 seconds). The contents are mixed and shaken along the longitudinal axis of the vial until a homogeneous suspension is formed. There may be bubbles near the walls of the bottle on the surface of the suspension.
The finished preparation must be injected deeply intramuscularly into the upper outer quadrant of the gluteal muscle immediately after preparation. It is not recommended to rub the gluteus muscle after injection. With a delay in administration after preparation, the colloidal and physical properties of the suspension change, as a result of which its movement through the syringe needle may be difficult.
Side effects
- allergic reactions: anaphylactoid reactions, fever, urticaria, angioneurotic edema, arthralgia, exfoliative dermatitis, exudative erythema multiforme, anaphylactic shock;
- laboratory parameters: leukopenia, thrombocytopenia, anemia, hypocoagulation;
- others: glossitis, stomatitis.
Overdose
There is no information on overdose.
special instructions
Intravenous, endolumbar and subcutaneous administration of the suspension, as well as injections into the body cavity are not allowed. Inadvertent intravascular administration may cause transient feelings of anxiety, depression, and visual impairment (Wanier syndrome). In order to avoid unintentional intravascular injection of the drug, aspiration should be performed before intramuscular injection in order to identify possible needle penetration into the vessel.
When treating syphilis, serological and microscopic studies should be performed before starting treatment and for 4 months. Due to the development of fungal infections, it is advisable to prescribe vitamin C and B vitamins at a time, and, if necessary, prescribe antifungal agents for systemic use. It is important to take into account that too early termination of therapy or the use of an insufficient dosage of Bicillin-5 can lead to the emergence of resistant strains of pathogens.
Application during pregnancy and lactation
According to the instructions, Bicillin-5 in small quantities penetrates into the mother's milk and through the placental barrier. Its use during pregnancy is allowed only when the expected benefit to the mother outweighs the potential risk to the fetus.
If necessary, the appointment of the drug during lactation, breastfeeding should be discontinued.
Drug interactions
- bactericidal antimicrobials, including vancomycin, cephalosporins, aminoglycosides, rifampicin: synergistic;
- bacteriostatic antimicrobials, including chloramphenicol, macrolides, tetracyclines, lincosamides: have an antagonistic effect;
- indirect anticoagulants: their effectiveness increases due to the suppression of intestinal microflora and a decrease in the prothrombin index;
- oral contraceptives, drugs whose metabolism occurs with the formation of para-aminobenzoic acid, ethinyl estradiol: an antibiotic reduces their effectiveness, increasing the risk of breakthrough bleeding;
- tubular secretion blockers, diuretics, allopurinol, nonsteroidal anti-inflammatory drugs, phenylbutazone: reduce tubular secretion, increase the concentration of benzylpenicillin in tissues and in the blood;
- allopurinol: Increases the risk of developing allergic reactions such as skin rashes.
Analogs
Analogues of Bicillin-5 are: Benzylpenicillin, Benzylpenicillin sodium salt, Benzylpenicillin sodium salt-Vial, Benzylpenicillin novocaine salt.
Terms and conditions of storage
Store at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Bitsillin-5
Positive reviews about Bitsillin-5 most often talk about its high efficiency at a relatively low cost. The antibiotic is characterized as low-toxic, with an ultra-long-term effect. Those who received Bicillin-5 injections warn that the procedure must be carried out with caution, having certain skills. Sometimes, such negative effects as painful injections and the depressing effect of therapy on the intestinal microflora are noted.
The price of Bitsillin-5 in pharmacies
The price for Bitsillin-5 is approximately 730 rubles.
Bitsillin-5: prices in online pharmacies
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Drug name Price Pharmacy |
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Bicillin-5 1.2 million IU + 300 powder for preparation of suspension for intramuscular injection 1 pc. 84 rbl. Buy |
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Bitsillin-5 powder for prig suspension. for i / m int. 1.5 million units 10ml 125 RUB Buy |
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Bicillin-5 1.2 million IU + 300 powder for preparation of suspension for intramuscular injection 10 ml 50 pcs. RUB 1100 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
