Benalgin - Instructions For Use, Price, Analogues, Composition, Reviews

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Benalgin

Benalgin: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Benalgin

ATX code: N02BB52

Active ingredient: caffeine (caffeine), metamizole sodium (metamizole sodium), thiamine (thiamine)

Manufacturer: BALKANPHARMA-DUPNITSA, AD (Bulgaria)

Description and photo update: 2019-26-08

Benalgin is a combined drug that has antipyretic, analgesic and anti-inflammatory effects.

Release form and composition

The drug is produced in the form of flat white tablets, round in shape, with a dividing line on one of the sides (10 pcs. In a blister, 2 blisters in a cardboard box and instructions for use of Benalgin).

Composition of 1 tablet:

• Metamizole sodium - 500 mg;
• Caffeine - 50 mg
• Thiamine hydrochloride - 38.75 mg.

Excipients: gelatin, microcrystalline cellulose, talc, wheat starch, magnesium stearate and colloidal silicon dioxide.

Pharmacological properties

Pharmacodynamics

Benalgin is a combined analgesic-antipyretic, the action of which is due to the properties of the active ingredients.

Metamizole sodium is a pyrazole derivative with pronounced analgesic and antipyretic effects. Peripheral analgesia of the substance is explained by its ability to disrupt the synthesis of COX-1 and COX-2, as a result of which the production of prostaglandins is suppressed. The central action of metamizole is due to the suppression of the neuronal activity of the posterior sensory roots of the spinal cord. The drug does not depress breathing, does not have hypnotic activity, does not cause addiction and the development of withdrawal syndrome.

Caffeine binds and energizes purine receptors in the brain, thereby stimulating the central nervous system (CNS). Inhibits the enzyme phosphodiesterase, thereby increasing the concentration of cyclic adenosine monophosphate in cells. As a result, stimulation of glycogenolysis in the central nervous system and muscle tissue is noted. It has a pronounced vasoconstrictor effect. It potentiates the effects of metamizole sodium, thereby enhancing the clinical efficacy of Benalgin. Facilitates the penetration of drug substances through the blood-brain barrier.

Thiamine hydrochloride (vitamin B ₁), being a direct participant in the decarboxylation of pyruvate, reduces the severity of the inflammatory response in the central nervous system. The substance is part of the structure of cocarboxylase - a molecule that triggers the burning of pyruvate and the metabolism of carbohydrates. During phosphorylation, thiamine is converted into an active metabolite, thiamine pyrophosphate. Participates in the decarboxylation of keto acids and the synthesis of acetyl coenzyme A of the Krebs cycle as a coenzyme. By suppressing the activity of cholinesterase and facilitating the synthesis of acetylcholine, vitamin B ₁ facilitates the conduction of nerve impulses through the fibers. In high doses, thiamine exhibits a pronounced analgesic effect.

Benalgin improves blood circulation and reparative processes in the nervous system.

Pharmacokinetics

No data provided.

Indications for use

• Joint pain;
• Radicular syndrome;
• Neuralgia;
• Algodismenorrhea;
• Renal, bilious and intestinal colic;
• Headache, toothache;
• Migraine;
• Myalgia;
• Elevated body temperature with diagnosed colds or infectious and inflammatory diseases.

Contraindications

• Bronchospasm;
• Severe hepatic and renal impairment;
• Insomnia;
• Uncontrolled arterial hypertension;
• Increased intraocular pressure;
• Deficiency of glucose-6-phosphate dehydrogenase;
• Oppression of bone marrow hematopoiesis;
• Severe atherosclerosis;
• Leukopenia, agranulocytosis, hemolytic anemia;
• Pregnancy and breastfeeding period;
• Hypersensitivity to the components in Benalgin.

The drug is not used in children under 12 years of age.

Benalgin should be used with caution in the following cases: stomach diseases (pylorus stenosis, achalasia, gastroesophageal reflux disease), exacerbation of peptic ulcer disease, decompensated liver and / or kidney function, a history of acute cardiovascular crises, congestive chronic heart failure, bronchial conduction disorders history (especially in combination with hyperthyroidism), benign prostatic hyperplasia.

Benalgin, instructions for use: method and dosage

Benalgin is taken 1 tablet 2-3 times a day, with severe pain syndrome - 2 tablets with the same frequency of administration. The drug is recommended to be taken in the morning.

Children 12-16 years old are prescribed ½-1 tablet 2-3 times a day.

Do not exceed the maximum daily dose: children - 4 tablets, adults - 6 tablets.

As an antipyretic agent, Benalgin is taken no longer than 3 days, as an anesthetic - no longer than 5 days.

Side effects

The drug can cause allergic reactions such as anaphylactic shock, itching, skin rash, Quincke's edema, bronchospasm.

Long-term use of the drug can cause thrombocytopenia, palpitations, leukopenia, heart rhythm disturbances, agranulocytosis, and sleep disturbances.

Overdose

In case of an overdose of the drug, vomiting, mental and motor agitation, nausea, epigastric pain, tachycardia, decreased urine output, heart rhythm disturbances and epileptiform seizures may appear.

If you take a dose of Benalgin that is significantly higher than the recommended dose, you should immediately seek medical help. Shows gastric lavage, the appointment of adsorbents and laxatives, symptomatic therapy, if necessary - infusion therapy. There is no specific antidote.

special instructions

In order to avoid mutual reinforcement of toxic effects, caution should be exercised while using Benalgin with the following drugs:

• Other non-narcotic analgesics;
• Oral contraceptives;
• Allopurinol;
• Non-steroidal anti-inflammatory drugs;
• Tricyclic antidepressants.

During the period of treatment, the consumption of products containing caffeine (including coffee and tea) should be limited, since an overdose of this substance is possible.

Alcoholic drinks are not recommended for patients taking Benalgin.

Patients with pollinosis and atopic bronchial asthma have an increased risk of developing hypersensitivity reactions.

The composition of Benalgin contains wheat starch as an auxiliary component, which is dangerous for patients with gluten enteropathy.

Metamizole sodium metabolites can change the color of urine, but this fact has no clinical significance.

Benalgin should not be used during treatment with non-steroidal anti-inflammatory drugs and other drugs containing metamizole sodium, since the risk of accumulation of the substance is high.

If it is necessary to conduct a diagnostic test using adenosine phosphate or dipyridamole, the drug should be discontinued at least 12 hours before the study.

Athletes should be aware that Benalgin may alter the results of doping control tests.

With long-term treatment, it is necessary to regularly monitor the blood picture.

Influence on the ability to drive vehicles and complex mechanisms

While taking Benalgin, you should refrain from driving and performing work that requires quick reactions and increased concentration of attention.

Application during pregnancy and lactation

Benalgin is contraindicated for pregnant and breastfeeding women.

Pediatric use

Benalgin is prohibited for children under 12 years of age. Teenagers 12-16 years old should not exceed the daily dose of 4 tablets.

With impaired renal function

Severe renal failure is a contraindication to taking the drug.

In case of impaired renal function, the drug should be used with caution, under medical supervision.

For violations of liver function

Severe hepatic impairment is a contraindication to taking the drug.

In case of impaired liver function, the drug should be used with caution, under medical supervision.

Drug interactions

With the simultaneous use of Benalgin (due to metamizole sodium in the composition) and other non-narcotic analgesics or non-steroidal anti-inflammatory drugs, mutual enhancement of toxic effects is possible.

Allopurinol, oral contraceptives and tricyclic antidepressants interfere with the metabolism of metamizole sodium in the liver and increase its toxicity.

Metamizole sodium reduces the level of cyclosporine in the blood.

Tranquilizers and sedatives enhance the analgesic effect of metamizole sodium.

Barbiturates, phenylbutazone and other inducers of liver microsomal enzymes weaken the effect of metamizole sodium.

Benalgin reduces the effectiveness of coumarin anticoagulants.

With the simultaneous use of sympathomimetics, the excitability of the central nervous system increases, chlorpromazine - there is a risk of hypothermia.

Tempidone enhances the effect of Benalgin and lengthens its duration.

Analogs

Benalgin's analogs are: Aquacitramon, Analgin-Quinine, Askofen-P, Brustan, Ibuklin, Kaffetin, Codelmikst, Kofitsil-Plus, Migrenol Extra, Nurofen Long, Nurofen MultiSymptom, Padeviks, Paralen, Pentalagin-Plulant, Pentaloperalit, Safiston, Sedal-M, Sedalgin Plus, Solpadein, Tempalgin, Citramon P, Excedrin, etc.

Terms and conditions of storage

The drug should be stored at a temperature of 15-25 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Benalgin

Reviews about Benalgin are mostly positive. According to patients, it is an inexpensive, but effective pain reliever that helps with pain syndrome of various etiologies.

Price for Benalgin in pharmacies

The drug is currently not on sale, so the price of Benalgin is unknown. The cost of some popular analogs: Askofen-P, 10 tablets per pack - 22–58 rubles; Kofitsil-Plus, 10 tablets per pack - 8–20 rubles; Sedal-M, 20 tablets per pack - 199–269 rubles, Citramon P, 10 pcs. in a blister - 8-18 rubles.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!