Aspeckard
Pharmacological actions
Aspecard is an antiaggregatory (preventing platelet adhesion) agent. By group, this drug belongs to non-narcotic analgesics. In addition to antithrombotic action, Aspecard also has antipyretic, anti-inflammatory and analgesic properties.
The main active ingredient of the drug is acetylsacilic acid, the properties of which determine the ability of Aspecard. The mechanism of action of acetylsalicylic acid is based on a violation of the synthesis of prostacyclins, prostaglandins and thromboxane. A decrease in the production of prostaglandins leads to a decrease in their pyrogenic effect (increase in temperature) on the centers of thermoregulation. As a result of the use of Aspecard, there is a decrease in the effect of prostaglandins on the sensitivity of nerve endings to pain mediators. The antiplatelet effect of the drug is due to the participation of acetylsalicylic acid in the irreversible disruption of the synthesis of thromboxane A 2 in platelets.
Aspecard in the digestive tract is absorbed completely and quickly. The maximum concentration in blood plasma is observed 10-20 minutes after ingestion. Aspecard binding to plasma proteins is 49-70% (depending on concentration). The drug is excreted in the urine in the form of metabolites. Penetrates into breast milk, synovial fluid (located in the joint cavity), cerebrospinal fluid through the blood-brain barrier.
Indications for use of Aspeckard
The drug is prescribed in the following cases:
- febrile syndrome accompanying infectious and inflammatory diseases;
- pain syndrome: migraine, toothache and headache, lumbago, neuralgia, myalgia, algodismenorrhea, chest radicular syndrome;
- ischemic heart disease or the presence of several risk factors;
- painless myocardial ischemia, myocardial infarction, unstable angina pectoris, ischemic stroke and repeated transient cerebral ischemia, heart valve replacement, non-atherosclerotic coronary artery disease, aortoarteritis, mitral valvular heart disease, atrial fibrillation, recurrent pulmonary artery disease, pulmonary embolism syndrome Dressler, acute thrombophlebitis.
According to the instructions to Aspecard, the drug in increasing doses is prescribed in order to reduce the body's sensitivity to the effects of acetylsalicylic acid by re-using it in the form of Aspecard, starting with the lowest doses.
Also, this drug is prescribed to patients with "aspirin triad" and "aspirin" asthma to develop tolerance to non-steroidal anti-inflammatory drugs.
Instructions for the use of Aspeckard
The dosage regimen of this drug is determined by the doctor individually for each patient. The instructions for Aspeckard include the following recommendations:
- Active rheumatism. The daily dose for adults is 5-8 g, which is divided into 4-5 doses. The children's dose is calculated by multiplying 100-125 mg of the drug by the child's weight, after 7-14 days of treatment, the daily dose is 60-70 mg / kg, with the same frequency of use as in adults. The duration of treatment is up to 6 weeks with gradual withdrawal of Aspecard within 7-14 days.
- Fever and pain. A single dose should not exceed 1 g, taken up to 6 times a day. The children's dose is 10-15 mg, multiplied by the child's weight (no more than 5 times a day). The duration of treatment should not exceed 14 days.
- Prevention of thrombosis and embolism. Aspecard is taken 2-3 times a day for 0.5 g.
- Improving the rheological properties of blood. The drug is taken for several months at 0.15-0.25 g per day.
The use of Aspecard in the form of effervescent tablets occurs by their preliminary dissolution in 100-200 ml of water and oral administration after meals. The recommended dose (0.25-1 g) should be taken 3-4 times a day.
Side effects
According to the instructions, Aspecard can cause the following negative reactions of the body:
- nausea, diarrhea, abdominal pain, vomiting, microhemorrhage, erosive and ulcerative lesions of the stomach, discomfort in the epigastric region, gastric bleeding;
- dysfunction of the liver and kidneys;
- anemia, thrombocytopenia;
- hypoglycemia;
- itching, skin rash, urticaria.
With prolonged use of Aspecard, nephrotic syndrome, interstitial nephritis, papillary neurosis, blood diseases, edema, aseptic meningitis are possible.
Contraindications
Refuse to use Aspecard should be when:
- hemorrhagic diathesis;
- dissecting aortic aneurysm;
- heart failure;
- erosive and ulcerative diseases of the gastrointestinal tract;
- acute renal or hepatic failure;
- severe violations of liver and kidney function;
- hyperuricemia;
- initial hypoprothrombinemia;
- nephrolithiasis;
- vitamin K deficiency;
- thrombotic thrombocytopenic purpura;
- thrombocytopenia.
According to the instructions, Aspecard is not prescribed in the first trimester of pregnancy, breastfeeding mothers, children under 14 years of age and persons with hypersensitivity to salicylates.
Additional Information
Store Aspeckard in a dark and dry place at room temperature. After three years from the date of manufacture, the drug is considered unfit for use.
Aspeckard 100
Aspeckard 100 is one of the analogues of Aspeckard. The pharmacological properties of this drug are due to the action of acetylsalicylic acid (100 mg per tablet).
Indications for use, method of administration, side effects and contraindications of Aspekard 100 correspond to the same characteristics of Aspekard.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
