Antigrippin Express
Antigrippin-Express: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Antigrippin-Express
ATX code: N02BE51
Active ingredient: paracetamol (Paracetamol), ascorbic acid (vitamin C) [Ascorbic acid (Vitamin C)], pheniramine (Pheniramine)
Producer: JSC "Pharmaceutical Factory of St. Petersburg" (Russia), NPO "PharmVILAR" (Russia)
Description and photo update: 2019-10-07
Antigrippin-Express is a combined drug for eliminating the symptoms of acute respiratory diseases, has anti-cold, antipyretic, antihistamine, analgesic effects.
Release form and composition
The drug is available in the form of a powder for preparation of a solution for oral administration (lemon, raspberry or black currant): a powdery mass from white to white with a yellow tinge color with a lemon scent, or from white with a pink tint to pink with a raspberry smell, or from white to white with a pink tinge of color with the smell of black currant, the presence of lumps of a loose structure is possible; after mixing with water, an opalescent solution is formed from colorless to yellowish with a lemon odor (powder with lemon flavor), or from red-pink to light pink with a raspberry smell (powder with raspberry flavor), or from violet to lilac-red in color with the smell of black currant (powder with black currant flavor) (13.1 g each in heat-sealable sachets, in a cardboard box 6,9 or 12 sachets and instructions for the use of Antigrippin-Express).
1 sachet contains:
- active ingredients: paracetamol - 0.5 g; ascorbic acid - 0.2 g; pheniramine maleate - 0.025 g;
- excipients: soluble saccharin (sodium saccharinate dihydrate), sugar (sucrose), citric acid (citric acid monohydrate), natural lemon flavor; additionally in bags with raspberry flavor - flavoring agent identical to natural raspberry, food coloring raspberry; in bags with black currant flavor - flavoring agent identical to natural black currant, food coloring carmoisin, food black shiny dye.
Pharmacological properties
Pharmacodynamics
Antigrippin-Express is a combined drug that has anti-cold, antipyretic, analgesic and antihistamine effects.
The effect of the drug is due to the following properties of the active ingredients:
- paracetamol is an analgesic non-narcotic drug. Its pronounced analgesic and antipyretic effect is a consequence of the inhibition of COX (cyclooxygenase) in the central nervous system, the effect on the centers of pain and thermoregulation;
- ascorbic acid (vitamin C) - reduces vascular permeability, is an active participant in the regulation of redox processes, blood clotting, carbohydrate metabolism, tissue regeneration, synthesis of steroid hormones. Strengthens immunity, increasing the body's resistance to the influence of adverse environmental factors;
- pheniramine maleate - a blocker of H 1 -histamine receptors, has antiallergic effect. Eliminates sneezing, helps to reduce nasal discharge, nasal congestion, watery eyes.
Pharmacokinetics
After taking Antigrippin-Express inside, paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract (GIT), mainly from the upper intestine. Its maximum concentration (C max) in plasma is reached in 0.5-1 hour.
The binding of paracetamol to blood plasma proteins is 15-25%.
In tissues it is distributed quickly, crosses the placental barrier, a small part (less than 1% of the dose taken) is excreted in breast milk.
The half-life (T 1/2) is from 1 to 4 hours.
Paracetamol is metabolized in the liver, as a result of the conjugation reaction with sulfates and glucuronic acid, inactive metabolites are formed. With the participation of cytochrome P 450, less than 4% of the dose taken is converted into metabolites, which are inactivated by glutathione. In cases of a lack of glutathione, these metabolites are capable of causing necrosis of the enzymatic systems of hepatocytes as a result of their blockage. Both biotransformation products and unchanged drug in an amount of about 5% of the administered dose are excreted through the kidneys.
After oral administration, ascorbic acid is actively absorbed in the small intestine, its bioavailability is approximately 70%. Plasma protein binding is negligible. It accumulates in cells and blood plasma, C max is formed in glandular tissues. Excreted in breast milk.
Ascorbic acid is excreted unchanged and in the form of metabolites mainly through the kidneys, a small part through the intestines.
After oral administration, absorption of almost the entire dose of pheniramine maleate occurs in the gastrointestinal tract. Its C max in blood plasma is reached after 1–2.5 hours. Pheniramine maleate has a high tissue affinity. Biotransformed in the liver by oxidation by enzymes of the cytochrome P 450 system. It is excreted mainly through the kidneys in the form of metabolites and unchanged.
Indications for use
- symptomatic therapy of colds - flu conditions, acute respiratory viral infections, which are accompanied by fever and runny nose;
- rhinopharyngitis, allergic rhinitis.
Contraindications
Absolute:
- liver failure;
- acute erosive and ulcerative lesions of the gastrointestinal tract;
- urinary retention due to prostatic hyperplasia;
- kidney stone disease;
- blood diseases (including sideroblastic anemia, thrombocytopenia, thalassemia, leukopenia);
- angle-closure glaucoma;
- portal hypertension;
- deficiency of glucose-6-phosphate dehydrogenase;
- diabetes;
- hyperoxaluria;
- syndrome of glucose-galactose malabsorption, fructose intolerance, sucrase or isomaltase deficiency;
- period of pregnancy;
- breast-feeding;
- age up to 18 years;
- hypersensitivity to the components of Antigrippin-Express powder.
With caution and only as directed by a doctor, the drug should be taken in case of renal failure, congenital hyperbilirubinemia (Dubin-Johnson, Gilbert and Rotor syndromes), alcoholic hepatitis, viral hepatitis, hemochromatosis, in an elderly patient.
Antigrippin-Express, instructions for use: method and dosage
Antigrippin-Express solution prepared from powder should be taken orally warm. To do this, pour the contents of the sachet into a vessel, pour 200 ml of warm water and stir until the powder is completely dissolved.
Recommended dosage: 1 pc. 2-3 times a day with an interval between doses of at least 4 hours.
The duration of the course of treatment as an antipyretic agent without consulting a doctor should not exceed 3 days, as an anesthetic - 5 days.
In severe renal failure with creatinine clearance less than 10 ml / min, the second dose of Antigrippin-Express should be taken no earlier than 8 hours later.
Side effects
- from the central nervous system: a decrease in the speed of psychomotor reactions, drowsiness; in elderly patients - confusion, agitation; with prolonged use in a daily dose of more than 5 sachets - insomnia, headache, increased excitability;
- from the digestive system: dry mouth, nausea, irritation of the gastrointestinal mucosa, pain in the stomach; against the background of long-term use of high doses - vomiting, diarrhea, hyperacid gastritis, erosive and ulcerative lesions of the gastrointestinal tract, bleeding in the gastrointestinal tract, liver dysfunction;
- from the senses: violation of accommodation, increased intraocular pressure;
- on the part of the cardiovascular system: tachycardia (increased heart rate); against the background of long-term intake of high doses - a decrease in capillary permeability, which may result in a deterioration in tissue trophism, an increase in blood clotting and blood pressure (BP), the development of microangiopathy;
- from the urinary system: urinary disorder; against the background of long-term intake of high doses, it is possible to develop such functional disorders of the kidneys as hyperoxaluria (excessive excretion of oxalic acid salts with urine), urolithiasis (nephrolithiasis), papillary necrosis, damage to the glomerular apparatus;
- on the part of the hematopoietic system: against the background of long-term use of high doses - anemia, methemoglobinemia (weakness, headache, palpitations, shortness of breath during exertion, dizziness), thrombocytopenia (may be accompanied by nosebleeds, bleeding gums);
- allergic reactions: skin redness, itching, rash, dermatitis, urticaria, angioedema;
- laboratory parameters: erythropenia, hyperprothrombinemia, hypokalemia, neutrophilic leukocytosis, glucosuria;
- others: dysfunction of the pancreas (inhibition of the function of the insular apparatus) - glucosuria, hyperglycemia (excessive thirst, increased fatigue, frequent urination, weight loss).
Overdose
In case of an overdose of Antigrippin-Express, the negative effect of all its active components should be taken into account.
Symptoms caused by paracetamol: nausea, vomiting, pallor of the skin, decreased appetite, hepatonecrosis. The severity of liver necrosis due to intoxication is in direct proportion to the degree of overdose; in adults, toxic effects may develop after the simultaneous intake of more than 10-15 g of paracetamol, or 20 or more sachets. Usually, a detailed clinical picture of liver damage appears in 1-6 days. In rare cases, there may be an instantaneous development of liver failure, including those complicated by renal failure (tubular necrosis).
Treatment: if no more than 6 hours have passed since the overdose, gastric lavage should be performed, after which the intake of activated charcoal or other enterosorbents should be prescribed. After 8-9 hours from the moment of overdose, the introduction of methionine is shown, and after 12 hours - N-acetylcysteine. The need for additional administration of SH-group donors and glutathione synthesis precursors is determined based on the level of paracetamol concentration in the blood and the time elapsed after its administration.
Symptoms due to pheniramine maleate: impaired consciousness, convulsions, coma.
Symptoms due to ascorbic acid: insomnia, stomach pain, irritability, flatulence, increased urination, diarrhea, nausea, urolithiasis, low blood glucose (hypoglycemia), which is accompanied by sweating, pallor, agitation, vomiting, muscle tremors, enlargement pupils, increased blood pressure, tachycardia.
Treatment: carrying out forced diuresis. Appointment of symptomatic therapy.
special instructions
If, after three days of using Antigrippin-Express, symptoms of fever persist, or after five days of therapy, pain continues, you should consult a doctor for advice.
During the treatment period, it is required to monitor blood pressure indicators, peripheral blood patterns, the functional state of the liver, adrenal glands, and the insular apparatus of the pancreas.
It should be borne in mind that Antigrippin-Express distorts the results of laboratory tests to determine the amount of glucose in blood and urine, uric acid in plasma, bilirubin, lactate dehydrogenase activity and hepatic transaminases.
Do not exceed the recommended dosage, take Antigrippin-Express without consulting a doctor in combination with other drugs (including sedatives) or with impaired renal function.
Patients with diabetes mellitus or following a diet with a reduced sugar content should take into account that in one sachet with lemon flavor, the sucrose content corresponds to 1.16 XE (bread unit), with raspberry / black currant flavor - 1.18 XE.
The use of alcoholic beverages is contraindicated during the entire period of treatment due to the possible development of hepatotoxic effects.
Influence on the ability to drive vehicles and complex mechanisms
While taking Antigrippin-Express, drowsiness may appear, therefore, during the period of treatment, it is recommended to avoid performing potentially hazardous types of work that require speed of psychomotor reactions and increased concentration of attention, including driving.
Application during pregnancy and lactation
The use of Antigrippin-Express is contraindicated during the period of gestation and breastfeeding.
Pediatric use
The use of Antigrippin-Express for the treatment of patients under the age of 18 is contraindicated. This is due to the fact that in the daily dose of the drug, the content of ascorbic acid is 400-600 mg, and the maximum daily dose for children should not exceed 300 mg.
With impaired renal function
Patients with renal insufficiency can take Antigrippin-Express only as directed by a doctor who will determine the individual dosage regimen.
For violations of liver function
The use of Antigrippin-Express is contraindicated for the treatment of patients with hepatic insufficiency.
Caution should be exercised in patients with congenital hyperbilirubinemia (Dubin-Johnson, Gilbert and Rotor syndromes), alcoholic or viral hepatitis. For this category of patients, the drug should be used only as directed and under the supervision of a physician.
Use in the elderly
It is recommended to take Antigrippin-Express with caution in elderly patients.
Drug interactions
- ethanol: enhances the sedative effect, the development of acute pancreatitis;
- antiparkinsonian drugs, antidepressants, antipsychotics (phenothiazine derivatives): increase the likelihood of developing undesirable phenomena such as dry mouth, urinary retention, constipation;
- glucocorticosteroids (GCS): increase the risk of glaucoma; with long-term treatment with GCS, the supply of ascorbic acid decreases;
- inducers of liver microsomal enzymes - phenylbutazone, rifampicin, barbiturates, phenytoin, carbamazepine, zidovudine, tricyclic antidepressants, hepatotoxic drugs, ethanol: increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication with minor overdoses;
- barbiturates, primidone: promote enhanced excretion of ascorbic acid in the urine;
- cimetidine and other inhibitors of microsomal oxidation: reduce the risk of hepatotoxic effect;
- nonsteroidal anti-inflammatory drugs (NSAIDs): against the background of long-term concomitant NSAID therapy, analgesic nephropathy may develop, the risk of renal papillary necrosis and end-stage renal failure increases;
- Diflunisal: helps to increase the plasma concentration of paracetamol by 50%, increasing hepatotoxicity. Long-term use of high doses of salicylates can lead to the development of cancer of the bladder or kidney;
- acetylsalicylic acid: combined administration of drugs causes a decrease in absorption (by 30%) and an increase in urinary excretion of ascorbic acid, while the excretion of acetylsalicylic acid decreases in parallel;
- myelotoxic drugs: increase the hematotoxic manifestations of Antigrippin-Express;
- quinolone drugs, calcium chloride: with prolonged concomitant therapy, the reserves of ascorbic acid in the body are depleted;
- oral contraceptives, alkaline drinks, fresh juices: help to reduce the absorption and assimilation of ascorbic acid;
- uricosuric drugs: when interacting with paracetamol, their effectiveness decreases;
- anticoagulants: high doses of paracetamol increase the effect of anticoagulants.
In addition, it is necessary to take into account the effect of ascorbic acid when combined with the following drugs:
- benzylpenicillin, tetracyclines: the level of their concentration in the blood increases;
- ethinyl estradiol: its bioavailability increases with the intake of ascorbic acid at a dose of 1 g per day (5 sachets);
- iron supplements: their absorption in the intestine improves;
- heparin, indirect anticoagulants: reduce their therapeutic effect;
- salicylates, short-acting sulfonamides: increase the risk of crystalluria;
- alkaloids and other drugs with an alkaline reaction: their excretion from the body increases;
- oral contraceptives: reduce their concentration in the blood;
- ethanol: its total clearance increases, the content of ascorbic acid in the body decreases;
- antipsychotics - phenothiazine derivatives: reduce their therapeutic effect;
- amphetamines, tricyclic antidepressants: their tubular reabsorption decreases;
- isoprenaline: its chronotropic effect decreases;
- mexiletine: at high doses of ascorbic acid, its renal excretion increases.
Analogs
Analogs of Antigrippin-Express are: Fervex, ORVIS Fly, Fastorik, Febricet, RINZASIP for children, Fervex for children, etc.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews of Antigrippin-Express
Reviews about Antigrippin-Express are positive. Users point to the high effectiveness of the drug. Taking it relieves the symptoms of flu and colds, nasal congestion, prevents the development of the disease, makes breathing easier. A rapid decrease in body temperature and an improvement in general condition have been reported. In addition, the advantages of Antigrippin-Express include good tolerance, affordable price and pleasant taste of the drug.
The price of Antigrippin Express in pharmacies
The price of Antigrippin-Express for a package containing 6 sachets of powder for preparing a solution for oral administration can be from 189 rubles, 9 sachets - from 249 rubles, 12 sachets - from 289 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
