Flemoxin Solutab
Flemoxin Solutab: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Flemoxin Solutab
ATX code: J01CA04
Active ingredient: amoxicillin (amoxicillin)
Producer: Astellas Pharma Europe BV (Netherlands)
Description and photo update: 2019-20-08
Prices in pharmacies: from 180 rubles.
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Flemoxin Solutab is an antibiotic drug of the penicillin group with a wide spectrum of action.
Release form and composition
Dosage form Flemoxin Solutaba - dispersible tablets: color - from white to light yellow, shape - oval, on one side - dividing the tablet in half, on the other - the manufacturer's logo and the digital designation of the dosage - "231", "232", "234" or "236", which corresponds to 125, 250, 500 or 1000 mg (in blisters of 5 or 7 pieces, in a cardboard box of 2, 4, 6, 8 or 10 blisters).
Composition of 1 tablet:
- active substance: amoxicillin - 125, 250, 500 or 1000 mg (in the form of amoxicillin trihydrate - 145.7 / 291.4 / 582.8 / 1165.5 mg);
- additional components (according to the content of the active substance): saccharin - 1.6 / 3.3 / 6.6 / 13.1 mg; vanillin - 0.13 / 0.26 / 0.5 / 1 mg; microcrystalline cellulose - 6.3 / 12.6 / 25.2 / 50.5 mg; dispersible cellulose - 4.3 / 8.7 / 17.4 / 34.8 mg; crospovidone - 6.3 / 12.6 / 25.2 / 50.4 mg; magnesium stearate - 0.76 / 1.5 / 3/6 mg; tangerine flavor - 1.1 / 2.3 / 4.5 / 9.1 mg; lemon flavor - 1.4 / 2.8 / 5.6 / 11.1 mg.
Pharmacological properties
Pharmacodynamics
Flemoxin Solutab is one of the bactericidal antibiotics of a wide spectrum of action (a group of semi-synthetic penicillins). The mechanism of action is based on disruption of the synthesis of peptidoglycan (a supporting polymer of the cell wall) during growth and division, which leads to lysis of bacteria.
Shows activity against the following gram-positive / gram-negative microorganisms: Helicobacter pylori, Staphylococcus aureus (non-beta-lactamase-producing), Streptococcus pneumoniae, Streptococcus pyogenes, Clostridium welchii, Clostridium meteranis, Listeria monocytogenis, Nerachehitis antaer.
To a lesser extent, it affects Escherichia coli, Vibrio cholera, Enterococcus faecalis, Proteus mirabilis, Shigella sonnei, Salmonella typhi.
Does not show activity against Pseudomonas spp., Serratia spp., Indole-positive Proteus spp., Enterobacter spp., Beta-lactamase-producing microorganisms.
Penicillinase-producing strains are resistant to the action of amoxicillin.
Pharmacokinetics
Amoxicillin after oral administration at a high rate and almost in full (approximately 93%) is absorbed without being destroyed in the acidic environment of the stomach. Food intake has practically no effect on the absorption of the drug. Achievement of C max (maximum concentration of a substance) in plasma occurs within 1–2 hours. After oral administration of 500 mg of amoxicillin C max (5 μg / ml) in blood plasma is observed after 2 hours. When the dose of Flemoxin Solutab is changed (increased or decreased) by 2 times, C max in blood plasma is proportionally increased or decreased.
Amoxicillin binds to plasma proteins by 17%. In therapeutically effective concentrations, it penetrates well into bone tissue, mucous membranes, intraocular fluid and sputum. The concentration of the substance in bile is 2–4 times higher than its plasma concentration. In the umbilical cord vessels and amniotic fluid, the concentration of amoxicillin is 25 to 30% of its level in the blood plasma of a pregnant woman.
It penetrates the blood-brain barrier poorly; however, in patients with inflammation of the meninges, the concentration in the cerebrospinal fluid is approximately 20% of the plasma concentration. Amoxicillin undergoes partial metabolism in the liver to form metabolites, most of which have no microbiological activity.
Excretion by 50–70% occurs unchanged by the kidneys (80% - by tubular secretion, 20% - by glomerular filtration). From 10 to 20% of the substance is excreted through the liver. Excreted in breast milk in small amounts.
With normal renal function, T 1/2 (half-life) of amoxicillin is in the range of 1-1.5 hours. In premature babies, newborns and children under 6 months, this figure is 3-4 hours.
T 1/2 with creatinine clearance <15 ml / min can increase and reach 8.5 hours with anuria. Amoxicillin is removed by hemodialysis.
Indications for use
According to the instructions, Flemoxin Solutab is prescribed for the treatment of the following infectious and inflammatory diseases caused by microorganisms sensitive to the action of amoxicillin:
- infections of the skin and soft tissues;
- infections of the digestive, respiratory and genitourinary systems.
Contraindications
An absolute contraindication to the appointment of Flemoxin Solutaba is an individual intolerance to the components of the drug, as well as other beta-lactam antibiotics, including other penicillins, carbapenems and cephalosporins.
Relative contraindications (Flemoxin Solutab should be used with caution in the presence of the following diseases / conditions):
- renal failure;
- polyvalent hypersensitivity to xenobiotics;
- lymphocytic leukemia;
- Infectious mononucleosis;
- a history of diseases of the digestive system, in particular colitis associated with the use of drugs with antibacterial action;
- pregnancy and the period of breastfeeding (before prescribing Flemoxin Solutaba, the doctor must assess the ratio of the expected benefit to the possible risk).
Instructions for the use of Flemoxin Solutab: method and dosage
The drug should be taken orally before, simultaneously or after a meal.
Flemoxin Solutab can be swallowed whole, chewed or divided into parts and washed down with a glass of water, or diluted in 20 or 100 ml water until a syrup or suspension is formed that has a pleasant fruity taste.
The regimen for taking the drug is established by the doctor on an individual basis. When determining it, he takes into account the severity of the condition, the age of the patient and the sensitivity of the infectious agent to the action of amoxicillin.
The recommended dosage regimen for the treatment of moderate / mild diseases:
- children 1-3 years old: 2 times a day, 250 mg, or 3 times a day, 125 mg;
- children 3-10 years old: 2 times a day, 375 mg, or 3 times a day, 250 mg;
- children from 10 years old and adults: 2 times a day, 500-750 mg, or 3 times a day, 375-500 mg.
The dose of Flemoxin Solut for children (including under the age of 1 year) depends on weight and is 30-60 mg / kg per day, divided into 2-3 doses.
In cases of a severe course of infections, as well as in the treatment of hard-to-reach foci of infection (for example, otitis media in acute course), it is recommended to divide the daily dose of Flemoxin Solutaba into 3 doses.
In high doses, the drug is used for recurrent infections, chronic diseases and infections in severe course: children - 60 mg / kg per day, divided into 3 doses, adults - 3 times a day, 750-1000 mg.
In acute uncomplicated gonorrhea, a combination therapy is performed: Flemoxin Solutab - 3000 mg and probenecid - 1000 mg (once).
With functional impairment of the kidneys (in patients with creatinine clearance ≤ 10 ml per minute), a dose reduction of 15-50% is shown.
Course duration:
- moderate / mild infections: 5-7 days; longer use (at least 10 days) is indicated in cases of treatment of infections caused by Streptococcus pyogenes;
- severe infections, chronic diseases: the duration is determined by the clinical picture; after the disappearance of the symptoms of the disease, therapy is continued for another 48 hours.
Side effects
- allergic reactions: rhinitis, allergic vasculitis, urticaria, skin flushing, erythematous rash, conjunctivitis, Stevens-Johnson syndrome, exfoliative dermatitis, fever, arthralgia, eosinophilia, acute generalized exanthematous pustulosis, toxic epidermal necrolysis usually manifest as a specific maculopapular rash); in some cases - angioedema, anaphylactic shock;
- urinary system: interstitial nephritis, crystalluria;
- nervous system: epileptic seizures, behavioral changes, peripheral neuropathy, anxiety, insomnia, agitation, confusion, ataxia, depression, headache, dizziness;
- hematopoietic system: thrombocytopenic purpura, neutropenia, hemolytic anemia, leukopenia, agranulocytosis, eosinophilia, thrombocytopenia;
- digestive system: rarely - stomatitis, dysbiosis, change in taste, nausea, diarrhea, vomiting, glossitis; in some cases - a moderately pronounced increase in the activity of hepatic transaminases, cholestatic jaundice, hepatic cholestasis, acute cytolytic hepatitis, hemorrhagic / pseudomembranous colitis;
- others: shortness of breath, vaginal candidiasis, superinfection (especially against the background of diseases with a chronic course or reduced body resistance).
Overdose
The main symptoms: imbalance in water and electrolyte balance, nausea, diarrhea, vomiting.
Therapy: gastric lavage, intake of saline laxatives, activated carbon. The measures aimed at normalizing the water-electrolyte balance are shown.
special instructions
Due to the high likelihood of developing exanthema with non-allergic etiology, with infectious mononucleosis, lymphocytic leukemia, Flemoxin Solutab is prescribed with caution.
With mild diarrhea that appears during the period of taking the drug, antidiarrheal drugs that lower intestinal motility should not be used. It is recommended to use preparations containing attapulgite or kaolin. After the symptoms disappear, treatment should be continued for another 48–72 hours.
In cases of severe diarrhea, which is characteristic of pseudomembranous colitis, Flemoxin Solutab is canceled.
The presence of erythroderma in the anamnestic data is not a contraindication for the appointment of therapy.
During the course of therapy, it is necessary to monitor the functional state of the hematopoietic organs, liver and kidneys.
Due to the growth of microflora insensitive to the action of Flemoxin Solutab, superinfection may develop (it will be necessary to make appropriate changes to antibiotic therapy).
The development of cross-resistance with drugs of the penicillin series and cephalosporins is possible.
Application during pregnancy and lactation
Flemoxin Solutab during pregnancy / lactation should be used under medical supervision and only on condition that the expected positive effect for the mother outweighs the risks of side effects in the fetus / child.
Amoxicillin in small quantities is excreted in breast milk, which can cause the development of sensitization phenomena in a child.
Pediatric use
Perhaps the appointment of Flemoxin Solutab for children according to the dosage regimen.
With impaired renal function
Drug therapy for renal failure is prescribed with caution.
Drug interactions
With the combined use of Flemoxin Solutab tablets with some drugs / substances, the following undesirable effects may develop:
- bactericidal antibacterial drugs (including rifampicin, cephalosporins, vancomycin, aminoglycosides): manifestation of synergy;
- oxyphenbutazone, diuretics, non-steroidal anti-inflammatory drugs, probenecid, allopurinol, phenylbutazone, to a lesser extent acetylsalicylic acid, sulfinpyrazone: an increase in the half-life (T1 / 2) and plasma concentration of amoxicillin in the blood;
- allopurinol: increased likelihood of skin rash;
- digoxin: increasing its absorption;
- estrogen-containing oral contraceptives: an increase in the likelihood of acyclic bleeding and a decrease in their effectiveness (the use of other or additional methods of contraception is recommended);
- some bacteriostatic drugs (sulfonamides, chloramphenicol): antagonism is possible;
- indirect anticoagulants: increasing their effectiveness (due to the suppression of intestinal microflora by amoxicillin);
- ascorbic acid: increased absorption of amoxicillin;
- aminoglycosides, glucosamine, antacids, drugs with a laxative effect, food: reduced absorption of amoxicillin.
Analogs
Analogues of Flemoxin Solutab are: Ospamox, Hikontsil, Amoxicillin, Amoxicillin DS, Ekobol, Amosin.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Flemoxin Solutab
According to reviews, Flemoxin Solutab is an effective drug used in the treatment of a wide range of infectious and inflammatory diseases. In some cases, good tolerance is noted, other users indicate the development of side effects. The main disadvantage is the high cost.
The price of Flemoxin Solutab in pharmacies
The approximate price for Flemoxin Solutab (20 tablets) is: 125 mg - 214-278 rubles, 250 mg - 240-271 rubles, 500 mg - 330-350 rubles, 1000 mg - 454-471 rubles.
Flemoxin Solutab: prices in online pharmacies
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Drug name Price Pharmacy |
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Flemoxin Solutab 125 mg dispersible tablets 20 pcs. RUB 180 Buy |
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Flemoxin Solutab 250 mg dispersible tablets 20 pcs. 210 RUB Buy |
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Flemoxin Solutab tablets dispersion 125mg 20 pcs. 241 RUB Buy |
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Flemoxin Solutab tablets dispersion 250mg 20 pcs. 295 RUB Buy |
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Flemoxin Solutab 500 mg dispersible tablets 20 pcs. RUB 314 Buy |
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Flemoxin Solutab dispersion tablets 500mg 20 pcs. 364 RUB Buy |
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Flemoxin Solutab 1000 mg dispersible tablets 20 pcs. 384 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
