Finoptin
Instructions for use:
- 1. Pharmacological action
- 2. Pharmacokinetics
- 3. Indications for use
- 4. Dosage and instructions for use
- 5. Side effects
- 6. Contraindications to use
- 7. Reception during pregnancy and lactation
- 8. Special instructions
- 9. Influence on the ability to work requiring concentration
- 10. Drug interactions
pharmachologic effect
The active ingredient is verapamil hydrochloride. The drug is a derivative of diphenylalkylamine, belongs to the selective calcium channel blockers of the 1st class. It has antihypertensive, antiarrhythmic and antianginal effects.
The antianginal effect is caused both by a direct effect on the myocardium and by an effect on peripheral geodynamics. By blocking the flow of calcium into the cell, Finoptin leads to a decrease in the transformation of the energy contained in it into mechanical action, thus reducing myocardial contractility.
Finoptin significantly reduces atrioventricular conductance and increases the refractory period. With supraventricular arrhythmias, it has an antiarrhythmic effect.
Pharmacokinetics
When taken orally, Finoptin, getting inside the body, is absorbed by 90%. Metabolism occurs in the liver during the "first pass". The main metabolite is norverapamil. The half-life, with a single dose, is 2.5-7.5 hours, with further doses, 4.5-12 hours. The drug is excreted mainly by the kidneys and from 9 to 16% through the intestines. After intravenous administration, the half-life is 2-5 hours.
Indications for the use of Finoptin
- angina pectoris (stable without angiospasm, vasospastic);
- sinus tachycardia;
- supraventricular tachycardia;
- hypertensive crisis;
- atrial fibrillation;
- primary hypertension;
- atrial premature beats;
- atrial flutter;
- arterial hypertension;
- hypertrophic obstructive cardiomyopathy.
Finoptin dosage and instructions for use
Internal intake - an initial dose of 40-80 mg, 3 times a day. For prolonged forms of Finoptin, a single dose should be increased, and the frequency of administration should be reduced.
Intravenous administration of Finoptin (jet) is possible - slowly, controlling the patient's blood pressure and pulse. For patients with severe liver dysfunction, the daily dose of Finoptin should not exceed 120 mg. The maximum permissible oral dose for adult patients is 480 mg per day.
Finoptin side effects
From the side of the cardiovascular system: a pronounced decrease in blood pressure, tachycardia, bradycardia, worsening of heart failure; rarely - myocardial infarction, angina pectoris, arrhythmia; with rapid intravenous administration - collapse, atrioventricular block of the III degree, asystole.
From the central nervous system and peripheral nervous system: depression, increased fatigue, dizziness, asthenia, anxiety, fainting, lethargy, drowsiness, headache, extrapyramidal disorders (trembling of the hands, mask-like face, ataxia, shuffling gait, difficulty swallowing, stiffness of the limbs).
On the part of the digestive system: increased appetite, constipation (rarely diarrhea), nausea, gingival hyperplasia.
Other possible side effects of Finoptin: weight gain, extremely rarely - gynecomastia, agranulocytosis, galactorrhea, hyperprolactinemia, arthritis, pulmonary edema, peripheral edema, asymptomatic thrombocytopenia.
Contraindications for use
- pregnancy;
- sinoatrial blockade;
- lactation period;
- atrioventricular block II and III degree;
- severe arterial hypotension;
- hypersensitivity to Finoptin.
Taking Finoptin during pregnancy and lactation
During lactation and pregnancy, Finoptin is contraindicated for use.
special instructions
According to the instructions, Finoptin should be used with caution:
- with myocardial infarction with left ventricular failure;
- with heart failure in chronic form;
- with bradycardia;
- with AV blockade - I degree;
- with liver failure;
- with severe aortic stenosis;
- with renal failure;
- with mild or moderate arterial hypotension;
- elderly patients;
- children and adolescents under 18 years of age.
Impact on the ability to work requiring concentration
After taking Finoptin, manifestations of drowsiness and dizziness are possible, which can negatively affect concentration.
Finoptin drug interactions
The combination of Finoptinas with antihypertensive drugs such as: vasodilators, ACE inhibitors, thiazide diuretics, leads to a mutual strengthening of the antihypertensive effect.
Simultaneous use with beta-blockers, means for inhalation anesthesia, antiarrhythmic drugs, increases the risk of bradycardia, heart failure, arterial hypotension. With parenteral administration of Finoptin to patients receiving beta-blockers, there is a risk of asystole and arterial hypotension.
When Finoptinas is combined with acetylsalicylic acid, there are cases of increased bleeding time. Simultaneous administration with digoxin leads to an increase in the concentration of digoxin in the blood plasma.
The combination with disopyramide can cause severe arterial hypotension and collapse. Concomitant use with diclofenac reduces the plasma concentration of verapamil.
When taking Finoptin with clonidine in patients with arterial hypertension, cases of cardiac arrest were recorded.
Concomitant use with phenobarbital or phenytoin may cause a decrease in the concentration of verapamil in the blood.
The combination of Finoptin with enflurane or etomidate may cause an increase in the duration of anesthesia.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
