Estrofem
Instructions for use:
- 1. Pharmacological action
- 2. Release form
- 3. Indications for use
- 4. Contraindications
- 5. Instructions for use
- 6. Side effects
- 7. Special instructions
- 8. Storage conditions
Estrofem is a drug belonging to the estrogen group.
Pharmacological action Estrofem
The therapeutic effect of Estrofem is to replenish the deficiency of endogenous estrogen in the body. It contains 17-beta-estradiol, which is identical to the estrogen produced in the female body and produced by the ovaries. Together with specific receptors in the vagina, uterus, mammary glands, pituitary gland and other organs, which are targeted by the action of estrogen, the hormone forms a receptor-liganide complex. This complex, when interacting with specific elements of the genome and some intracellular proteins, promotes the synthesis of proteins, i-RNA, and determines the growth factor.
Estrofem has a stimulating effect on the development of the fallopian tubes, uterus, vagina, ducts of the mammary glands, stroma, and also causes pigmentation in the areola and genital area. Also, the drug promotes the formation of female secondary sexual characteristics, regulates monthly bleeding, suppresses lactation, stimulates the synthesis of certain transport proteins, etc.
In addition, the drug Estrofem is able to regulate the metabolism of carbohydrates, fats and proteins, reduce blood cholesterol levels, increase libido and improve the emotional background.
Release form
Estrofem comes in the form of film-coated tablets. The color of the tablets is blue. The estradiol content reaches 2 mg. The tablets are packed in a plastic calendar disk in the amount of 28 pieces. One box contains one disc.
Indications for use of Estrofem
According to the instructions for Estrofem, the drug is recommended for use in the following cases:
- with estrogen deficiency during menopause and with surgical menopause caused by non-malignant neoplasms, following radiation castration;
- with amenorrhea of the primary and secondary type;
- with hypomenorrhea, dysmenorrhea, oligomenorrhea and secondary estrogen deficiency;
- with hirsutism against the background of the formation of multiple ovarian cysts;
- with vaginitis (in young and old age);
- with hypogenitalism;
- with infertility;
- with weak labor;
- in case of post-term pregnancy;
- with viril hypertrichosis in women;
- to suppress lactation;
- with postmenopausal osteoporosis;
- with breast or prostate cancer;
- with urogenital disorders (including atrophic vulvovaginitis, trigonitis, dyspareunia (painful intercourse), urethritis);
- with alopecia on the background of hyperandrogenism;
- as a means capable of stimulating hematopoiesis in men who have undergone acute radiation damage.
Contraindications
According to medical reviews about Estrofem, the drug has many contraindications. Therefore, before starting the application, it is important to exclude the patient's presence of this or that disease and condition that could interfere with taking the medicine. Contraindications include:
- pregnancy;
- hypersensitivity to the components of the composition;
- malignant neoplasms dependent on estrogen, as well as suspicion of them;
- uterine or genital bleeding of an unusual nature;
- active phase of thromboembolic diseases or thrombophlebitis (excluding cases of treatment of breast or prostate cancer).
With caution, Estrofem should be prescribed in the following cases:
- with thrombosis, thrombophlebitis, thromboembolism (occurring while taking estrogen-containing drugs);
- with familial hyperlipoproteinemia;
- with endometriosis;
- with pancreatitis;
- with diseases of the gallbladder (especially cholelithiasis);
- with severe liver failure;
- with jaundice (including during pregnancy);
- with hepatic porphyria;
- with leiomyoma;
- with hypercalcemia.
Instructions for the use of Estrofem
The instruction to Estrofem prescribes taking the drug in the amount of one tablet daily. It is imperative to avoid interruptions in taking the medication. Tablets from one disc of Estrofem are taken within 21 days, after which it is necessary to take a break in taking for 7 days, then resume treatment.
The course of treatment is usually 6 months. After the expiration of the period, you should consult a doctor about the advisability of further taking Estrofem.
Side effects of Estrofem
The use of Estrofem can cause the appearance of a whole spectrum of undesirable reactions. In women, adverse reactions most often manifest themselves in the form of:
- the occurrence of sensitivity and soreness in the mammary glands, an increase in their size;
- amenorrhea;
- menorrhagia;
- the appearance of “smearing” discharge between periods;
- increase libido;
- tumors of the mammary glands;
- edema;
- flatulence, anorexia, nausea and diarrhea.
Men, while taking Estrofem, sometimes develop sensitivity and soreness in the chest area, a decrease in libido and the appearance of gynecomastia are possible.
special instructions
Estrofem has no contraceptive effect and is unable to protect against pregnancy.
Medical reviews about Estrofem note the ability of the drug to have a protective effect on the endometrium when taken together with progestogens for at least 10 days during each cycle.
The appearance of unusual or irregular menstrual flow during the use of Estrofem requires diagnostic curettage, which would exclude the presence of malignant neoplasms in the uterus.
In the case of prolonged use of Estrofem, it is recommended to undergo preventive examinations at least once a year.
It is important to keep in mind that long-term use of Estrofem alone (monotherapy) increases the risk of developing endometrial cancer if the uterus is not removed.
Patients suffering from migraines, epilepsy, bronchial asthma and diabetes mellitus, as well as those taking antihypertensive drugs, are recommended to be monitored by a doctor throughout the entire course of taking Estrofem.
It is recommended to discontinue treatment in the event of deep vein thrombosis, jaundice, thromboembolic disorders, sudden visual impairment, pronounced increase in blood pressure, as well as before elective surgery (4-6 weeks before).
Storage conditions
Estrofem can be stored for 4 years without losing its therapeutic effects. Store the drug at a temperature not exceeding 25 ° C. Freezing the drug is not allowed.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
