Espa Lipon
Instructions for use:
- 1. Pharmacological action
- 2. Indications for use
- 3. Contraindications
- 4. Side effects
- 5. Drug interaction
- 6. Method of application
Prices in online pharmacies:
from 529 rub.
Buy
Espa-Lipon is a hepatoprotector, a drug that increases the liver's resistance to adverse factors. In addition, the action of Espa-Lipon extends to the regulation of lipid and carbohydrate metabolism in the body.
Dosage forms of the product - yellow biconvex round tablets, coated and transparent solution for injections of a greenish-yellow hue.
The active ingredient of Espa-Lipon in tablets is thioctic acid (200 and 600 mg). Auxiliary components: povidone, lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, sodium carboxymethyl starch, silicon dioxide, magnesium stearate. One ampoule of Espa-Lipona injection solution contains 300 and 600 mg of active ingredient.
Pharmacological action of Espa-Lipon
According to the instructions for Espa-Lipon, the drug has detoxification, hypoglycemic, hypocholesterolemic and hepatoprotective activity, taking part in the regulation of metabolism. Thioctic acid, which is part of Espa-Lipon, participates in the oxidative reactions of alpha-keto acids and pyruvic acid, improves liver function, and stimulates cholesterol metabolism.
By the nature of the action, thioctic acid is similar to vitamins of group B. Espa-Lipon promotes an increase in glycogen in liver cells, a decrease in the concentration of glucose in the blood, and overcoming the violation of the susceptibility of cells to the action of insulin. The drug helps to remove toxins from the body, protects liver cells from the effects of toxic substances, protects the organ in case of poisoning with heavy metal salts.
The neuroprotective effect of Espa-Lipon consists in inhibiting lipid peroxidation in the nervous tissue, activating endoneural blood flow, and facilitating the process of conducting nerve impulses through the cells.
Taking the drug by patients suffering from motor neuropathy, according to reviews to Espa-Lipon, provokes the appearance of a large number of high-energy compounds in the muscles.
When taken orally, Espa-Lipon is well and quickly absorbed from the gastrointestinal tract, and the simultaneous use of the drug with food reduces the rate and quality of absorption of the drug.
Metabolization of thioctic acid is carried out by conjugation and oxidation of side chains. The active substance of Espa-Lipon is excreted in the urine in the form of metabolites. The half-life of the drug from blood plasma is 10-20 minutes.
Espa-Lipon has a "first pass" effect through the liver - that is, the active properties of the drug are partially reduced under the influence of a natural protector against foreign substances entering the body.
Indications for use of Espa-Lipon
According to the instructions, Espa-Lipon is prescribed for the following conditions of patients:
- Polyneuropathy (including diabetic and alcoholic etiology);
- Liver diseases (including liver cirrhosis and chronic hepatitis);
- Chronic or acute intoxications associated with poisoning with salts of heavy metals, fungi, etc.
Also, the drug is effective against atherosclerosis, used to treat and prevent arterial disease.
Contraindications
Espa-Lipon is not prescribed for patients suffering from chronic alcohol dependence, glucose-galactose malabsorption syndrome, as well as persons with a lactase deficiency in the body.
With caution, taking Espa-Lipon is recommended for patients with diabetes mellitus - with the obligatory adjustment of the dose of hypoglycemic agents. You should not carry out treatment with Espa-Lipon for children under 18 years of age - due to the lack of data on the safety of the drug for this category of patients. In the case of important indications, the administration of the drug by persons of this age group can be carried out strictly on the recommendation of a doctor, taking into account the individual dosage.
The complete safety of Espa-Lipon for fetal health has not also been proven when taking the drug during pregnancy. If it is necessary to treat a woman with Espa-Lipon during lactation, it is necessary to resolve the issue of temporary weaning of the baby from the breast.
Side effects of Espa-Lipona
According to reviews, Espa-Lipon is well tolerated by the body, however, in isolated cases, the following side effects may appear:
- Nausea, vomiting, headache, shortness of breath;
- Increased sweating, cramps;
- Allergic reactions in the form of eczema, urticaria, hemorrhagic rash and anaphylactic shock.
Patients with peripheral polyneuropathy may feel creeping on the skin at the beginning of therapy. With rapid intravenous administration of the drug, an increase in intracranial pressure, punctate hemorrhages in the skin and mucous membranes, and visual impairment are possible.
Drug interactions
The simultaneous intake of Espa-Lipon with oral hypoglycemic drugs and insulin can provoke an increase in the hypoglycemic effect - an increase in the sensitivity of the body's peripheral tissues to insulin.
The use of Espa-Lipon according to the instructions together with ethyl alcohol reduces the activity of thioctic acid. During the period of drug treatment, it is recommended to refrain from taking products containing ethanol and alcoholic beverages.
In addition, the activity of thioctic acid in relation to the binding of metals was revealed, therefore, taking Espa-Lipon simultaneously with drugs containing iron, calcium, magnesium ions is possible with a two-hour interval between taking drugs.
Reception of Espa-Lipon with cisplatin reduces the effectiveness of the latter.
Mode of application
The coated tablet is taken orally, orally, without chewing or crushing. For ease of use, you can drink the medicine with plain water.
A solution for intravenous administration is prepared from a concentrate diluted in isotonic sodium chloride solution.
In diabetic polyneuropathy, 600 mg of the drug is prescribed once a day or 200 mg of the drug 2-3 times a day.
In severe diabetic polyneuropathy, a dosage of 600 mg of the drug is used 3 times a day.
The dose of Espa-Lipon and the duration of the course of treatment depend on the nature and course of the disease, as well as the personal characteristics of the patient's body. The optimal dosage of the drug is selected exclusively by the doctor.
Reviews to Espa-Lipon about drug overdose have been reported. When the drug is taken in quantities significantly exceeding the recommended dose, nausea, headache and vomiting may occur. Since there is no specific antidote for Espa-Lipon, the treatment of this condition is symptomatic.
Attention! This instruction for Espa-Lipon is presented for informational purposes only. Before using the drug, consult your doctor!
Espa Lipon: prices in online pharmacies
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Drug name Price Pharmacy |
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Espa-Lipon 600 mg film-coated tablets 30 pcs. 529 r Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
