Enam - Instructions For Use, Indications, Reviews

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Enam

Instructions for use:

1. 1. Composition and form of release
2. 2. Pharmacological action
3. 3. Indications for use
4. 4. Method of application and dosage regimen
5. 5. Contraindications
6. 6. Side effects
7. 7. Use of the drug during pregnancy and breastfeeding
8. 8. Overdose
9. 9. Storage conditions

Prices in online pharmacies:

from 20 rubles.

Buy

Enam is an antihypertensive drug.

Composition and form of release of Enam

The drug is available in the form of tablets at a dosage of 2.5 mg, 5 mg and 10 mg. The active substance of the drug is enalapril maleate.

In blister strip packs of 10 tablets. 20 tablets in a cardboard box (two packs each).

pharmachologic effect

According to the instructions, Enam is an antihypertensive drug. The active ingredient is rapidly absorbed into the body, forming a pharmacologically active substance - enalaprilat. The use of Enam inhibits the angiotensin-converting enzyme in the body, preventing the conversion of angiotensin I to angiotensin II, which helps to reduce the total peripheral vascular resistance, reduces the level of aldosterone and increases the level of bradykinin, activates depressive systems and inhibits pressor systems.

Reception of Enam according to indications leads to a decrease in diastolic and systolic pressure, without developing reflex tachycardia.

According to reviews, Enam reduces left ventricular hypertrophy and reduces myocardial oxygen demand. In conditions of hypoxia, it improves the condition of the heart muscle. The drug prevents the development of diabetic nephropathy, increases renal blood flow, which leads to a decrease in cardiac mortality. Enam has no effect on carbohydrate and lipid metabolism.

Indications for Enam's use

According to the instructions, Enam is prescribed for the treatment of patients suffering from arterial hypertension in various forms, including essential arterial and renovascular hypertension.

In addition, the indication for Enam is chronic heart failure (as part of a combination therapy).

The drug is used to prevent coronary ischemia and severe heart failure in patients with reduced left ventricular function.

Method of application of Enam and dosage regimen

According to the instructions, Enam is intended for oral administration. The drug is taken regardless of food intake, as a rule, once a day at approximately the same time. The dosage of the drug depends on the age of the patient and the indication for Enam.

With essential hypertension in adults, as a rule, the dosage is 2.5-5 mg per day. The maximum dosage of the drug is 40 mg per day.

Before taking enalapril, it is recommended that patients taking diuretics stop taking them at least three days in advance. Enam therapy is started with a minimum dosage, gradually increasing it to the optimal one.

With heart failure in adults, the initial dosage is 2.5 mg per day, with a gradual increase to 20 mg.

With reduced renal function, the dosage of enalapril needs constant correction. The maximum daily dosage for people with reduced creatinine clearance from 30 to 80 ml / min is 10 mg, and with creatinine clearance from 10 to 30 ml / min - 5 mg. For patients on hemodialysis, the maximum daily dosage is 2.5 mg.

The intervals between dosage increases should be at least two weeks.

For children over six years of age with arterial hypertension, the initial dosage of Enam is 2.5 mg per day. The maximum daily dosage for children is calculated on the basis of 0.58 mg per kg of body weight.

Contraindications

The instructions for Enam contain the following contraindications:

• hypersensitivity to enalapril and other components of the drug;
• aortic and mitral stenosis;
• the period of pregnancy and breastfeeding;
• reduced renal function (creatinine clearance less than 30 ml / min);
• idiopathic or hereditary angioedema;

According to reviews, Enam is not recommended for patients with glucose-galactose malabsorption syndrome, galactosemia and lactase deficiency, since the drug contains lactose.

Enam is prescribed with caution when:

• hypovolemia;
• violation of cerebral blood flow;
• ischemic heart disease;
• violation of the water-salt balance;
• heart failure;
• decreased kidney function;
• renal artery stenosis.

Side effects of Enam

According to reviews, Enam is mostly well tolerated by patients. At the very beginning of treatment, a slight decrease in blood pressure, increased fatigue and dizziness are possible. In addition, the drug can cause the following side effects:

• Respiratory system: rhinorrhea, pharyngitis, glossitis, shortness of breath, unproductive cough. If a cough occurs, it is recommended to stop taking enalapril and prescribe an alternative therapy.
• Cardiovascular system: bradycardia, myocardial infarction, angina pectoris, tachycardia.
• Gastrointestinal tract: indigestion and stool, nausea, dryness of the oral mucosa, pancreatitis, pain in the epigastric region, increased activity of hepatic transaminases, decreased liver function. In addition, according to reviews, Enam can cause stomatitis, intestinal obstruction, decreased appetite and a change in taste.
• Central nervous system: depression, headache, convulsions, insomnia, impaired coordination of movements, tinnitus, paresthesia.
• Hematopoietic system: hypoglycemia, neutropenia, a decrease in the level of leukocytes, hematocrit and hemoglobin, proteinuria, an increase in the concentration of bilirubin and potassium in the blood plasma.
• Allergies: bronchospasm, urticaria, pruritus. Rarely, angioedema of the face, lips and tongue, larynx may occur. In this case, urgent help is required.
• Other side effects: agranulocytosis, erectile dysfunction, alopecia, Raynaud's syndrome, hot flashes, renal failure, excessive sweating.

In addition to the above symptoms, the use of Enam can cause the development of a sympathocomplex, which includes: vasculitis, hyperemia, pain in joints and muscles, eosinophilia, leukocytosis, an increase in the erythrocyte sedimentation rate and the presence of antinuclear bodies in the body.

The use of the drug Enam during pregnancy and breastfeeding

Enam is contraindicated during pregnancy. Before starting therapy with enalapril, it is recommended to exclude the likelihood of pregnancy, and while taking it, use reliable contraception. If pregnancy does occur, you must stop taking Enam.

When using the drug during lactation, the issue of stopping breastfeeding should be resolved.

Overdose

According to reviews, Enam in too high dosages leads to arterial hypotension.

In case of overdose, gastric lavage and symptomatic treatment should be performed.

Storage conditions

Enam is stored in a dry place at room temperature for no longer than 36 months.

Enam: prices in online pharmacies

Drug name Price Pharmacy

Enam 2.5 mg tablets 20 pcs. RUB 20 Buy

Enam 10 mg tablets 20 pcs. RUB 33 Buy

Enam 5 mg tablets 20 pcs. 34 rbl. Buy

Enam tablets 5mg 20 pcs. RUB 40 Buy

Enam tablets 10mg 20 pcs. RUB 51 Buy

Enam 20 mg tablets 20 pcs. RUB 68 Buy

Enam tablets 20mg 20 pcs. 112 RUB Buy

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!