Platyphyllina hydrotartrate
Platyphyllina hydrotartrate: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Platyphyllin hydrotartrate
ATX code: A03A
Active ingredient: platyphylline (platyphylline)
Producer: Dalkhimfarm (Russia), Novosibkhimfarm (Russia)
Description and photo update: 2018-23-10
Prices in pharmacies: from 69 rubles.
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Platyphyllina hydrotartrate - M-anticholinergic.
Release form and composition
Solution for subcutaneous administration in the form of a colorless transparent liquid [1 ml in neutral glass ampoules, 10 ampoules in a cardboard box, complete with an ampoule knife or scarifier; 1 ml in ampoules made of neutral glass, 5 or 10 ampoules in blisters, 1–2 packs in a cardboard box complete with an ampoule knife or scarifier (the knife / scarifier is not inserted in ampoule packs with a break point or a break ring)] …
Composition of 1 ml solution:
- active substance: platyphylline hydrotartrate - 2 mg;
- additional component: water for injection - up to 1 ml.
Pharmacological properties
Pharmacodynamics
Platyphylline hydrotartrate is an M-anticholinergic antagonist, which has less effect on peripheral m-cholinergic receptors than atropine (the effect on smooth muscle cells of the gastrointestinal tract and circular muscle of the iris is 5-10 times weaker).
The mechanism of action is due to the ability to block m-cholinergic receptors, due to which the transmission of nerve impulses from postganglionic cholinergic nerves to the effector tissues and organs innervated by them (glands of external secretion, smooth muscle organs, heart) is disrupted.
Platyphylline hydrotartrate also inhibits n-cholinergic receptors, but much weaker.
The anticholinergic effect of the drug is manifested to a greater extent with an increased tone of the parasympathetic part of the autonomic nervous system or with the action of m-anticholinergics. The drug is less likely to cause tachycardia than atropine, especially when used in high doses. Reducing the influence of the vagus nerve (n. Vagus), increases the minute volume of blood, increases the excitability of the myocardium, improves the conductivity of the heart.
Platyphylline hydrotartrate inhibits the activity of the endocrine glands (weaker than atropine), dilates the small vessels of the skin, and helps to relax the smooth muscles of the urinary tract, bladder and uterus. It has a direct myotropic antispasmodic effect, thereby eliminating pain. Reduces the tone of the sphincters and smooth muscles.
Relaxes the smooth muscles of the bronchi during spasm caused by anticholinergics or an increase in the tone of the vagus nerve, inhibits the secretion of the bronchial glands, increases the minute volume of respiration.
In high doses, the drug inhibits the vasomotor center and blocks the sympathetic ganglia, as a result of which the vessels dilate, blood pressure decreases (mainly when administered intravenously).
Platyphyllina hydrotartrate causes a pronounced decrease in the amplitude and frequency of peristaltic contractions of the duodenum, stomach, colon and small intestine. With hyperkinesia of the biliary tract, it reduces the tone of the gallbladder, with hypokinesia, it increases the tone of the gallbladder to a normal state.
The drug stimulates the respiratory center and the brain, to a greater extent - the spinal cord (when used in high doses, it is possible to suppress the central nervous system, respiratory and vasomotor centers, and develop seizures).
Penetrates the blood-brain barrier.
When administered parenterally and instilled into the conjunctival sac of the eye, it relaxes the circular muscle of the iris, thereby causing the pupil to dilate. At the same time, intraocular pressure rises, relaxation of the ciliary muscle of the ciliary body occurs (accommodation paralysis). In comparison with atropine, the effect of platyphylline hydrotartrate on accommodation is less pronounced and shorter.
Pharmacokinetics
The drug easily penetrates through synaptic and cell membranes, as well as histohematogenous barriers, including the blood-brain.
When used in high doses in significant concentrations, it accumulates in the central nervous system. Metabolized in the liver. Does not cumulate. Undergoes hydrolysis with the formation of platinum acid and platinum. It is excreted by the intestines and kidneys.
Indications for use
- biliary, intestinal and renal colic;
- peptic ulcer of the stomach and duodenum;
- pylorospasm;
- cholecystitis;
- cholelithiasis;
- bronchial asthma (to prevent laryngo- and bronchospasm);
- bronchorrhea;
- eye injury;
- acute inflammatory diseases of the eyes (including keratitis, iritis, iridocyclitis);
- dilation of the pupil for diagnostic purposes (for example, when examining the fundus or determining the true refraction of the eye);
- angina pectoris (as part of combination therapy);
- arterial hypertension;
- angiotrophoneurosis;
- spasm of the cerebral arteries;
- algodismenorrhea.
Contraindications
- pregnancy;
- lactation period;
- hypersensitivity to the drug.
Platyphylline hydrotartrate should be used with caution in the following cases because of the risk of complications:
- increased body temperature;
- hyperthyroidism;
- dryness of the oral mucosa;
- hepatic / renal failure;
- paralytic intestinal obstruction;
- intestinal atony in the elderly and debilitated patients;
- diseases of the gastrointestinal tract, accompanied by obstruction (pyloric stenosis, achalasia);
- reflux esophagitis;
- hernia of the esophageal opening of the diaphragm, combined with reflux esophagitis;
- nonspecific ulcerative colitis;
- chronic lung disease, especially in debilitated patients and young children;
- diseases / conditions with increased intraocular pressure (open-angle and closed-angle glaucoma);
- age over 40 years (due to the risk of having undiagnosed glaucoma);
- myasthenia gravis;
- diseases in which an increase in heart rate may be undesirable: arterial hypertension, chronic heart failure, atrial fibrillation, mitral stenosis, ischemic heart disease, tachycardia, acute bleeding;
- autonomic (autonomic) neuropathy;
- diseases accompanied by obstruction of the urinary tract;
- urinary retention or predisposition to it;
- hyperplasia of the prostate gland without obstruction of the urinary tract;
- brain damage in children;
- central paralysis in children;
- Down's disease;
- gestosis.
Instructions for the use of Platyphyllin hydrotartrate: method and dosage
The solution is injected subcutaneously.
Adults for the relief of renal / hepatic / intestinal colic, acute pain in gastric ulcer or duodenal ulcer, peripheral and cerebral angiospasm, prolonged attack of bronchial asthma are administered 1-2 ml 1-2 times a day.
For a course of treatment appoint 1-2 ml 2-3 times a day for 10-20 days.
The maximum single dose for adults is 5 ml (10 mg of platifillin hydrotartrate), the daily dose is 15 ml (30 mg).
For children, a single dose of Platyphyllin hydrotartrate is determined depending on age:
- newborns and children under 1 year of age: 0.0175 ml / kg (0.035 mg / kg);
- 1–5 years: 0.015 ml / kg (0.03 mg / kg);
- 6-10 years: 0.0125 ml / kg (0.025 mg / kg);
- 11-14 years: 0.01 ml / kg (0.02 mg / kg).
Side effects
Taking Platyphylline hydrotartrate may be accompanied by the following side effects:
- dry mouth, thirst, intestinal atony;
- lowering blood pressure, tachycardia;
- accommodation paralysis, mydriasis;
- atelectasis of the lung;
- retention of urine;
- headache, dizziness, convulsions, photophobia;
- acute psychosis (when used in high doses).
Overdose
Symptoms: increased intraocular pressure, accommodation paralysis, mydriasis, dryness of the mucous membrane of the mouth, nose, throat, tremor, agitation, difficulty in swallowing and speaking, hyperthermia, paralytic intestinal obstruction, depression of the central nervous system, acute urinary retention (in patients with prostatic hyperplasia glands), convulsions, suppression of the activity of the vasomotor and respiratory centers.
As a therapeutic measure in case of an overdose, forced diuresis is performed, anticholinergic stimulants and anticholinesterase agents are administered parenterally. With hyperthermia, wet rubdowns and taking antipyretic drugs are indicated. When excited, sodium thiopental is administered intravenously. If mydriasis develops, eye drops with pilocarpine are prescribed. Patients who develop an attack of glaucoma are shown immediate instillation of 2 drops of 1% pilocarpine solution into the conjunctival sac, followed by instillation every hour, subcutaneously 3–4 times a day, 1 ml of 0.05% solution of neostigmine methyl sulfate (Proserin) is injected.
special instructions
During therapy, regular monitoring of pulse and blood pressure is indicated.
Patients receiving Platyphyllina hydrotartrate should refrain from drinking alcoholic beverages.
Influence on the ability to drive vehicles and complex mechanisms
During the period of treatment, it is worth avoiding activities that require speed of reactions and increased attention, since they are potentially dangerous due to the risk of side effects such as dizziness.
Application during pregnancy and lactation
The use of Platyphyllin hydrotartrate during pregnancy and lactation is contraindicated. Lactating women for the period of therapy, if required, should stop breastfeeding.
Pediatric use
There are no age restrictions for prescribing the drug. However, the product should be used with caution in children with the following diseases:
- chronic lung diseases (under the action of Platyphyllin hydrotartrate, bronchial secretion decreases, which can lead to thickening of the secretion and the formation of plugs in the bronchi);
- cerebral palsy (a more pronounced reaction to anticholinergics is possible);
- Down's disease (heart rate may rise, possibly unusual pupil dilation);
- brain damage (there is a risk of increased effects from the central nervous system).
With impaired renal function
In the presence of renal failure, the drug must be used with caution.
For violations of liver function
In the presence of liver failure, the drug must be used with caution.
Use in the elderly
Because of the likelihood of undiagnosed glaucoma in elderly patients, Platyphyllina hydrotartrate should be used with caution.
Drug interactions
According to the instructions, Platyphyllina hydrotartrate enhances the effect of magnesium sulfate, the sedative and hypnotic effects of phenobarbital.
Antagonism with anticholinesterase drugs is noted.
With the simultaneous use of other m-anticholinergics, tricyclic antidepressants, monoamine oxidase inhibitors, phenothiazine, haloperidol, amantadine, some antihistamines, the risk of side effects increases.
With vascular spasms, the effect of platyphylline hydrotartrate is enhanced by sedatives and antihypertensive drugs, and for pain associated with spasms of smooth muscles, sedatives, analgesics and tranquilizers.
Procainamide and quinidine enhance the anticholinergic effect of platyphylline hydrotartrate, morphine - a depressant effect on the cardiovascular system, cardiac glycosides - a positive batmotropic effect, monoamine oxidase inhibitors - positive chrono- and batmotropic effects.
Analogs
An analogue of Platyphyllin hydrotartrate is Platyphyllin.
Terms and conditions of storage
Keep out of reach of children, protected from light at temperatures up to 25 ° C.
The shelf life is 2–5 years, depending on the manufacturer.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Platyphyllina hydrotartrate
According to numerous reviews, Platyphyllina hydrotartrate, despite its relatively low cost, is an effective remedy that, in particular, quickly relieves pain.
The disadvantages include a large list of diseases and conditions in which the drug should be used with extreme caution. In this regard, treatment should be prescribed by a doctor and carried out under his supervision.
Price for Platyphyllina hydrotartrate in pharmacies
In the pharmacy network, the price of Platyphyllin hydrotartrate varies in the range from 50 to 69 rubles per pack of 10 ampoules of 1 ml.
Platyphyllina hydrotartrate: prices in online pharmacies
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Drug name Price Pharmacy |
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Platyphyllina hydrotartrate 2 mg / ml solution for subcutaneous administration 1 ml 10 pcs. RUB 69 Buy |
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Platyphyllina hydrotartrate 2 mg / ml solution for subcutaneous administration 1 ml 10 pcs. RUB 69 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
