Trental 400
Trental 400: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Trental 400
ATX code: C04AD03
Active ingredient: Pentoxifylline
Producer: Aventis Pharma (India)
Description and photo update: 2018-22-10
Prices in pharmacies: from 557 rubles.
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Trental 400 is a vasodilating drug.
Release form and composition
Dosage form Trental 400 - tablets of prolonged action, film-coated: oblong biconvex, white, engraved on one side "ATA" (10 pcs. In a blister, in a cardboard box 2 or 6 blisters).
1 tablet contains:
- active substance: pentoxifylline - 0.4 g;
- auxiliary components: povidone, talc, hyetellose, magnesium stearate;
- shell composition: macrogol 8000, hypromellose, talc, titanium dioxide (E171).
Pharmacological properties
Pharmacodynamics
Trental 400 is an angioprotective agent that improves microcirculation in the area of impaired blood circulation. The improvement of the rheological properties of blood occurs due to the effect on the pathologically altered deformability of erythrocytes, inhibition of the process of platelet aggregation and a decrease in the increased viscosity of blood.
Pentoxifylline is a xanthine derivative, its mechanism of action is associated with inhibition of phosphodiesterase and the accumulation of cyclic adenosine monophosphate (cAMP) in the blood cells and vascular smooth muscle cells. It has a weak myotropic vasodilator effect, has a slight effect on the expansion of the coronary vessels and a decrease in the total peripheral vascular resistance.
According to the instructions, Trental 400 improves the symptoms of cerebrovascular accidents.
With intermittent claudication and other occlusive lesions of the peripheral arteries, the properties of the drug are manifested in the elimination of night cramps in the calf muscles, the disappearance of pain at rest, and the lengthening of the walking distance.
Pharmacokinetics
Pentoxifylline after oral administration is absorbed from the gastrointestinal tract (GIT) almost completely.
Bioavailability averages 19 ± 13%.
The main pharmacologically active metabolite is 1- (5-hydroxyhexyl) -3,7-dimethylxanthine, its concentration in blood plasma is 2 times higher than the concentration of pentoxifylline.
The process of biotransformation of the active substance in the body occurs completely.
T 1/2 (half-life) of pentoxifylline - 1.6 hours.
More than 90% is excreted through the kidneys in the form of unconjugated water-soluble metabolites.
In severe renal impairment, the excretion of metabolites slows down.
In case of impaired liver function, there is an increase in the bioavailability of pentoxifylline and an increase in its T 1/2.
Indications for use
- intermittent claudication and other disorders of the peripheral circulation of atherosclerotic genesis;
- leg ulcers, gangrene and other trophic disorders associated with diabetic angiopathy;
- cerebral circulation disorders (consequences of cerebral atherosclerosis, including dizziness, deterioration in concentration, memory impairment), post-stroke and ischemic conditions;
- circulatory disorders in the choroid and retina;
- otosclerosis, degenerative changes caused by hearing loss and vascular pathology of the inner ear.
Contraindications
- acute myocardial infarction;
- cerebral hemorrhage;
- massive bleeding;
- massive hemorrhage in the retina;
- period of pregnancy;
- breast-feeding;
- age up to 18 years;
- hypersensitivity to methylxanthine derivatives and drug components.
Care should be taken when prescribing Trental 400 for arterial hypotension, chronic heart failure, severe arrhythmia, gastric ulcer and duodenal ulcer, severe liver dysfunction, renal impairment with creatinine clearance (CC) less than 30 ml / min, a tendency to bleeding (including the use of anticoagulants or a violation of the blood coagulation system), patients after a recent surgery.
Instructions for use of Trental 400: method and dosage
Trental 400 tablets are taken orally, with food or immediately after a meal, swallowing whole (without chewing) and drinking plenty of water.
The dose is determined individually, taking into account the clinical indications.
Recommended dosage: an average of 0.4 g (1 tablet) 2-3 times a day, the daily dose should not exceed 1.2 g, or 3 tablets.
In case of severe renal dysfunction (CC less than 30 ml / min), the daily dose should be reduced, if necessary, to 0.4-0.8 g.
In hepatic insufficiency, the dose of Trental 400 is adjusted taking into account individual tolerance.
In view of a possible decrease in blood pressure (BP), treatment in patients at risk (in patients with arterial hypotension, severe coronary heart disease, hemodynamically significant cerebral vascular stenosis) should be started with low doses, gradually increasing them.
Side effects
- from the central nervous system: sleep disturbances, headache, anxiety, convulsions, dizziness; very rarely - aseptic meningitis;
- from the digestive system: nausea, vomiting, anorexia, intestinal atony, diarrhea, xerostomia, feeling of fullness and pressure in the stomach; very rarely - increased activity of alkaline phosphatase and hepatic transaminases, intrahepatic cholestasis;
- on the part of the blood coagulation system: bleeding from mucous membranes, vessels of the skin, stomach and / or intestines, hypofibrinogenemia;
- on the part of the cardiovascular system: cardialgia, tachycardia, arrhythmia, lowering blood pressure, progression of angina pectoris;
- from the hematopoietic system: thrombocytopenia, pancytopenia, leukopenia;
- from the senses: scotoma, visual impairment;
- dermatological reactions: flushing of the skin of the face and upper chest, flushing of the skin of the face, edema, significant fragility of the nails;
- allergic reactions: pruritus, hyperemia, urticaria, anaphylactic shock, angioedema.
Overdose
Symptoms: nausea, chills, dizziness, lowering blood pressure, tachycardia, arrhythmia, hyperemia of the skin, areflexia, tonic-clonic seizures, loss of consciousness.
Treatment: the patient is placed on his back, his legs should be raised; then symptomatic therapy is prescribed, which ensures the maintenance of normal blood pressure and respiratory function. It is necessary to monitor the free airway. In case of seizures, diazepam is administered. The drug should be canceled.
special instructions
During the period of use of Trental 400, blood pressure should be monitored regularly.
Since high doses of the drug while taking hypoglycemic agents can cause severe hypoglycemia, patients with diabetes mellitus require a dose adjustment of the drug taken.
There is a risk of worsening the patient's condition with severe arrhythmia and arterial hypotension.
With concomitant anticoagulant therapy, careful monitoring of the parameters of the blood coagulation system is required in order to prevent the development of severe bleeding.
Patients who have recently undergone surgery should be systematically monitored for the level of hemoglobin and hematocrit in the blood.
At low or unstable blood pressure in a patient, it is recommended to reduce the dose of Trental 400.
Adverse events develop when taking the highest doses of pentoxifylline.
The therapeutic efficacy of the drug for smoking may decrease.
Application during pregnancy and lactation
The use of Trental 400 is contraindicated during gestation and lactation.
If necessary, the appointment of the drug during lactation, breastfeeding should be discontinued.
Pediatric use
Insufficient data base on safety and effectiveness does not allow the use of Trental 400 for the treatment of children and adolescents under the age of 18 years.
With impaired renal function
In case of severe renal dysfunction (CC less than 30 ml / min), the patient should be prescribed a daily dose reduced to 0.4-0.8 g.
Treatment with Trental 400 should be accompanied by careful monitoring of the patient's condition, since the risk of side effects and the risk of cumulation in this category of patients is high.
For violations of liver function
Due to the increased risk of undesirable effects and cumulation, patients with severe hepatic impairment require careful monitoring of their condition during the period of treatment with Trental 400.
Use in the elderly
Elderly patients may need to lower the standard dose of the drug (decrease the rate of elimination and increase the bioavailability of pentoxifylline).
Drug interactions
With the simultaneous use of Trental 400:
- other xanthines can cause excessive nervous excitement;
- angiotensin-converting enzyme inhibitors, nitrates enhance their effect;
- cimetidine increases the level of concentration of pentoxifylline in the blood plasma and the risk of side effects;
- thrombolytics, indirect and direct anticoagulants (drugs affecting the blood coagulation system), antibiotics (including cephalosporins) can enhance their effect;
- insulin, oral hypoglycemic agents increase their clinical effect and the risk of hypoglycemia;
- theophylline can increase its plasma level and increase the side effects characteristic of theophylline.
Analogs
Analogs of Trental 400 are: tablets - Agapurin, Vazonit, Pentilin, Pentoxifylline; solutions - Agapurin, Latren, Pentilin.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C, protected from moisture.
Shelf life is 4 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Trental 400 reviews
Reviews of Trental 400 by both patients and doctors are positive, they indicate the effectiveness of the drug. At the same time, there is a fairly frequent manifestation of undesirable phenomena (nausea, dizziness, insomnia, headache). Also, doctors warn about the possibility of bleeding in the eyes, therefore, before starting therapy with Trental 400, it is recommended to consult an ophthalmologist.
Price for Trental 400 in pharmacies
The price of Trental 400 for a pack containing 20 tablets is approximately 620 rubles, 60 tablets - 1519 rubles.
Trental 400: prices in online pharmacies
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Drug name Price Pharmacy |
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Trental 400 400 mg film-coated tablets of prolonged action 20 pcs. 557 r Buy |
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Trental 400 400 mg film-coated tablets of prolonged action 60 pcs. 1281 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
