Tiloron-NW
Tiloron-SZ: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Tiloron-SZ
ATX code: J05AX; L03AX
Active ingredient: tilorone (Tilorone)
Manufacturer: North Star, NAO (Russia)
Description and photo update: 2020-11-02
Prices in pharmacies: from 437 rubles.
Buy
Tiloron-SZ is an antiviral immunostimulating agent.
Release form and composition
The drug is produced in the form of film-coated tablets: biconvex, round; the film shell is orange, the core in the cross section is orange with small white blotches (6 or 10 pieces in a blister, 20 pieces in a polymer can / bottle; in a cardboard box 1 blister or 1 can / bottle and instructions for use of Tilorona-SZ).
1 film-coated tablet contains:
- active substance: tilorone (in the form of dihydrochloride) - 125 mg;
- additional components (core): hypromellose (hydroxypropyl methylcellulose), microcrystalline cellulose, hyprolose (hydroxypropyl cellulose), potato starch, magnesium stearate;
- additional components (shell): Opadray II 85F220184 - titanium dioxide (E171), macrogol (polyethylene glycol), aluminum varnish based on sunset yellow dye (E110), indigo carmine dye (E132), iron oxide yellow dye (E172), talc.
Pharmacological properties
Pharmacodynamics
Tilorone is a low molecular weight synthetic interferon inducer (IFN) that stimulates the body to produce all types of IFNs - α, β, γ, λ. As a result of the action of the active substance, hepatocytes, intestinal epithelial cells, T-lymphocytes, granulocytes and neutrophils become the main producers of IFN. After oral administration, the peak of IFN formation is recorded 4–24 hours later in the intestine-liver-blood sequence.
Tilorone exhibits immunomodulatory and antiviral effects. After a single oral administration of the active substance at a dose equal to the maximum human dose per day, the highest content of IFN-λ in the lung tissue was detected after 24 hours, and IFN-α - after 48 hours. Induction of IFN-λ in the lung tissue contributes to the enhancement of antiviral protection the respiratory tract for influenza and other respiratory infections caused by viruses.
In human leukocytes, tilorone induces IFN production. It stimulates stem cells in the bone marrow, in accordance with the dose, increases antibody production, reduces the degree of immunosuppression, restores the ratio of two subtypes of T cells - T-suppressors and T-helpers. Tiloron-SZ demonstrates effectiveness against various viral infections, including acute respiratory viral infections (ARVI), including influenza, as well as herpesvirus infections and viral hepatitis. The mechanism of antiviral action is based on the suppression of translation of virus-specific proteins in infected cells, which leads to inhibition of viral reproduction.
Pharmacokinetics
After oral administration, the agent is rapidly absorbed from the gastrointestinal tract (GIT), bioavailability is 60%. The drug binds to plasma proteins by about 80%. Almost unchanged, it is excreted through the intestines and kidneys - 70 and 9%, respectively. The half-life (T 1/2) is 48 hours, the agent does not undergo biotransformation and does not accumulate in the body.
Indications for use
- flu and other acute respiratory viral infections (treatment and prevention);
- herpes infection (treatment).
Contraindications
- age up to 18 years;
- pregnancy and lactation;
- hypersensitivity to any component of Tiloron-SZ tablets.
Tiloron-SZ, instructions for use: method and dosage
Tiloron-SZ tablets should be taken orally after meals.
Recommended dosage regimen:
- influenza and other acute respiratory viral infections: for medicinal purposes - the first 2 days of therapy at 125 mg / day, then after 48 hours at 125 mg, course dose - 750 mg (6 tablets); for prophylaxis - 125 mg once a week, duration of admission - 6 weeks, course dose - 750 mg (6 tablets);
- herpes infection (treatment): the first 2 days at 125 mg, then 48 hours later in the same dose, course dose - 1250-2500 mg (10-20 tablets).
When treating ARVI, including influenza, if signs of the disease persist for more than 4 days, you should consult a doctor.
Side effects
Undesirable reactions noted during the period of use of Tilorona-SZ may include short-term chills, dyspeptic symptoms, and allergic reactions.
In case of aggravation of the severity of any of the above side effects or the development of other negative effects, it is required to consult a specialist.
Overdose
Overdose cases of Tilorona-SZ have not been recorded.
special instructions
Data not specified.
Influence on the ability to drive vehicles and complex mechanisms
Tiloron-SZ does not show a negative impact on the ability to drive vehicles and control other complex mechanisms.
Application during pregnancy and lactation
During pregnancy, taking the drug is contraindicated.
If it is necessary to use Tilorona-SZ during lactation, it is required to stop breastfeeding.
Pediatric use
The use of the drug is contraindicated for persons under 18 years of age.
Drug interactions
Therapy with tilorone dihydrochloride is compatible with the use of antibiotics and drugs for traditional treatment of bacterial and viral lesions. No clinically significant interaction between the active substance and these agents has been identified.
Analogs
Tiloron-SZ analogs are Tiloron, Tiloron-FPO, Tilaxin, Amiksin, Lavomax, Aktaviron, Tiloron-VERTEX, Tiloram, Flogardin, Orvis Immuno, etc.
Terms and conditions of storage
Store in a place protected from light, out of reach of children, at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Tilorone-SZ
According to the few reviews of Tilorone-SZ, it is an effective antiviral agent used for the prevention and treatment of ARVI (including influenza). Due to the action of the drug during ARVI therapy, the severity of the symptoms of infection is weakened and the duration of the disease decreases. After a course of prophylactic intake of the drug, immunity is strengthened and the risk of developing influenza and other ARVI decreases.
There are no complaints about adverse reactions.
Price for Tiloron-SZ in pharmacies
The price of Tiloron-SZ in the form of film-coated tablets (125 mg) can be 570 rubles. (6 pcs in the package) or 870 rubles. (10 pcs in the package).
Tiloron-SZ: prices in online pharmacies
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Drug name Price Pharmacy |
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Tiloron-sz tablets p.p. 125mg 6 pcs 437 r Buy |
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Tiloron-sz tablets p.p. 125mg 10 pcs 647 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
