Tilaxin
Tilaxin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Tilaxin
ATX code: L.03. AX
Active ingredient: tilorone (tilorone)
Producer: DALKHIMFARM, JSC (Russia)
Description and photo updated: 2018-23-11
Prices in pharmacies: from 427 rubles.
Buy
Tilaxin is an antiviral immunostimulating drug, an inducer of interferon formation.
Release form and composition
Dosage form Tilaxin - coated tablets:
- 60 mg each: biconvex, round, from yellow to light yellow, at the break - orange;
- 125 mg each: biconvex, round, yellow, at the break - orange.
Tablets are produced in blisters of 10 pcs., In polymer cans with opening control, 6 or 10 pcs.; 1 package or 1 can is placed in a cardboard box.
Composition of 1 coated tablet:
- active substance: tilorone (tilaxin) - 60 or 125 mg;
- auxiliary components (core): calcium stearate, basic magnesium carbonate, talc, low molecular weight medical polyvinylpyrrolidone (povidone);
- auxiliary components (shell): basic magnesium carbonate, low molecular weight medical polyvinylpyrrolidone (povidone), talc, beeswax, medical gelatin, tropeolin O dye, titanium dioxide, aerosil (colloidal silicon dioxide), sugar (sucrose); additionally for tablets of 125 mg - liquid paraffin oil (liquid paraffin).
Pharmacological properties
Pharmacodynamics
Tilaxin is a low-molecular-weight synthetic interferon inducer that stimulates the formation of interferons α, β and γ in the body. In response to the introduction of tilorone, the main producers of interferon are granulocytes, neutrophils, T-lymphocytes, hepatocytes, and intestinal epithelial cells.
After oral administration, the maximum production of interferon is determined in the intestine-liver-blood sequence after 4-24 hours. The drug has an antiviral and immunomodulatory effect.
In leukocytes, it induces the synthesis of interferon. Stimulates bone marrow stem cells, depending on the dose, enhances antibody production, reduces the degree of immunosuppression, restores the ratio of T-helpers and T-suppressors.
Tilaxin is effective against various viral infections, including influenza viruses, hepatitis, herpes viruses, and other acute respiratory viral infections. The mechanism of its antiviral action is associated with inhibition of translation of virus-specific proteins in infected cells, whereby the reproduction of viruses is suppressed.
Pharmacokinetics
Characteristic of Tilorone (Tylaxin):
- absorption: rapidly absorbed from the gastrointestinal tract after oral administration;
- distribution: bioavailability is 60%; about 80% of the substance binds to plasma proteins;
- excretion: it is excreted practically unchanged, through the intestines - 70%, kidneys - 9%; T ½ (half-life) - 48 hours; does not undergo biotransformation and does not accumulate in the body.
Indications for use
- influenza and other acute respiratory viral infections (prevention and treatment in adults, therapy in children);
- viral hepatitis A, B and C (treatment in adults);
- herpes and cytomegalovirus infection (treatment in adults);
- pulmonary tuberculosis, infectious-allergic and viral encephalomyelitis (multiple sclerosis, leukoencephalitis, uveoencephalitis and others), urogenital and respiratory chlamydia (as part of complex treatment in adults).
Contraindications
- age under 7;
- pregnancy;
- period of breastfeeding;
- individual intolerance to the components contained in Tilaxin.
Instructions for the use of Tilaxin: method and dosage
Tilaxin tablets are taken orally, after meals.
Recommended dosage regimen:
- viral hepatitis A (tablets of 125 mg): on the first day - 1 pc. 2 times a day, then - 1 pc. after 48 hours; course dose - 10 pcs.;
- acute hepatitis B (tablets of 125 mg): the initial phase of therapy - in the first 2 days, take 1 pc., then - 1 pc. after 48 hours; course dose - 16 pcs. In cases of a protracted course of the disease, on the first day, take 2 pcs., Divided into 2 doses; further - 1 pc. after 48 hours; course dose - 20 pcs.;
- chronic hepatitis B (tablets of 125 mg): the initial phase of therapy - 1 pc. 2 times a day in the first 2 days, then - 1 pc. after 48 hours; total dose - 20 pcs. Continuation phase - 1 pc. in 7 days; total dose - from 10 to 20 pcs. Heading dose varies within 30-40 pcs., Duration of therapy - from 3.5 to 6 months, depending on the results of morphological, immunological and biochemical studies, reflecting the degree of activity of the process;
- acute hepatitis C (tablets of 125 mg): 1 pc. per day in the first 2 days of therapy, then - 1 pc. after 48 hours; course dose - 20 pcs.;
- chronic hepatitis C (tablets of 125 mg): initial phase of treatment - 1 pc. 2 times a day in the first 2 days, then - 1 pc. after 48 hours; total dose - 20 pcs. Continuation phase - 1 pc. in 7 days; total dose - 20 pcs. Heading dose - 40 pcs., Duration of treatment - 6 months, depending on the results of morphological, immunological and biochemical markers of the process activity;
- neuroviral infections, complex treatment (tablets of 125 mg): 1-2 pcs. per day in the first 2 days, then - 1 pc. after 48 hours; the dose of Tilaxin is selected individually, the duration of therapy varies within 21–28 days;
- flu and other acute respiratory viral infections, treatment (125 mg tablets): 1 pc. per day in the first 2 days, then - 1 pc. after 48 hours; course dose - 6 pcs.;
- influenza and other acute respiratory viral infections, prevention (125 mg tablets): 1 pc. 1 time in 7 days for 42 days; course dose - 6 pcs.;
- herpes, cytomegalovirus infection (tablets of 125 mg): 1 pc. in the first 2 days, then - 1 pc. after 48 hours; course dose - from 10 to 20 pcs.;
- urogenital and respiratory chlamydia (125 mg tablets): 1 pc. in the first 2 days, then - 1 pc. after 48 hours; course dose - 10 pcs.;
- pulmonary tuberculosis, complex treatment (tablets of 125 mg): 2 pcs. per day in the first 2 days of therapy, then - 1 pc. after 48 hours; course dose should not exceed 20 pcs.;
- uncomplicated forms of influenza and other acute respiratory viral infections in children over 7 years old (60 mg tablets): 1 pc. per day on the 1st, 2nd and 4th days from the start of treatment; course dose - 3 pcs. In cases of complications of diseases - 1 pc. per day on the 1st, 2nd, 4th and 6th days from the start of therapy; course dose - 4 pcs.
Side effects
During the period of therapy with Tilaxin, the development of short-term chills, dyspeptic symptoms, and allergic reactions is possible.
Overdose
There are no data on Tilaxin overdose.
special instructions
Before using the medicinal product, it is recommended to consult a doctor.
Application during pregnancy and lactation
Tilaxin is contraindicated for use during pregnancy and lactation.
Pediatric use
Tilaxin is contraindicated in children under the age of 7.
Drug interactions
According to the instructions, Tilaxin is compatible with antibacterial agents and drugs for traditional therapy of bacterial and viral pathologies. Its clinically significant interaction with these drugs has not been identified.
Analogs
Tilaxin's analogs are: Tiloram, Lavomax, Amiksin, Actaviron.
Terms and conditions of storage
Store in a place protected from light and moisture at a temperature of 5-30 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
60 mg tablets are available by prescription, 125 mg tablets are available without a prescription.
Reviews about Tilaxin
According to reviews, Tilaxin is a fast-acting and effective drug. Among the shortcomings, the rare presence of the drug in the pharmacy network is noted.
The price of Tilaxin in pharmacies
The approximate price of Tilaxin (in a package of 10 coated tablets, 125 mg each) is 222 rubles.
Tilaxin: prices in online pharmacies
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Drug name Price Pharmacy |
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Tilaxin 125 mg film-coated tablets 10 pcs. 427 r Buy |
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Tilaxin tablets p.p. 125mg 10 pcs. 652 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
