Sustagard Artro - Instructions For Use, Powder, Solution In Ampoules

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Sustagard Artro

Sustagard Artro: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Use in the elderly
14. 14. Drug interactions
15. 15. Analogs
16. 16. Terms and conditions of storage
17. 17. Terms of dispensing from pharmacies
18. 18. Reviews
19. 19. Price in pharmacies

Latin name: Sustaguard artro

ATX code: M01AX05

Active ingredient: Glucosamine (Glucosamine)

Producer: PharmFirma SOTEX CJSC (Russia)

Description and photo update: 19.10.2018

Prices in pharmacies: from 500 rubles.

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Sustagard Artro is a drug with anti-inflammatory, chondroprotective action.

Release form and composition

Dosage forms:

• solution for intramuscular injection: ampoule A - transparent, light yellow or colorless; ampoule B (solvent) - colorless, transparent; the prepared solution is transparent, light yellow or colorless, does not have suspended particles (ampoule A dark glass, 2 ml of concentrate complete with a solvent in ampoules B of 1 ml, 5 sets in blisters, in a cardboard box 1 or 2 packaging);
• powder for preparation of solution for oral administration: granular, white or white with a slightly creamy shade (in heat-sealable bags made of a combined material of 3.95 g, in a cardboard box 5, 10, 20 or 30 bags).

Composition of 2 ml of Sustagard Artro solution (ampoule A):

• active substance: sodium chloride glucosamine sulfate (in terms of dry matter) - 502.5 mg (glucosamine sulfate - 400 mg; sodium chloride - 102.5 mg);
• auxiliary components: lidocaine hydrochloride - 10 mg; sodium disulfite - 2 mg; concentrated hydrochloric acid - up to pH 2-3; water for injection - up to 2 ml.

Composition of 1 ml of solvent (ampoule B):

• diethanolamine - 24 mg;
• water for injection - up to 1 ml.

Composition of 4 g powder (1 sachet):

• active substance: sodium chloride glucosamine sulfate - 1884 mg (glucosamine sulfate - 1500 mg);
• auxiliary components: aspartame - 2.5 mg; sorbitol - 2028.5 mg; macrogol 4000 - 10 mg; citric acid monohydrate - 25 mg.

Pharmacological properties

Pharmacodynamics

Sustagard Artro is one of the stimulants of tissue regeneration. It has anti-inflammatory, chondroprotective, stimulating regeneration of cartilage tissue, anti-catabolic, analgesic and anabolic effects.

The active component of the drug - glucosamine sulfate, is a salt of natural amino-monosaccharide glucosamine, physiologically contained in the body. Glucosamine stimulates the synthesis of proteoglycans (hyaluronic acid and glucosaminoglycans) of the synovial fluid by chondrocytes; inhibits enzymes (including phospholipase A2, collagenase), leading to the destruction of cartilage tissue; inhibits the activity of lysosomal enzymes, prevents the formation of superoxide radicals; promotes normal calcium deposition in bone tissue and initiates the process of sulfur fixation in the synthesis of chondroitinsulfuric acid; prevents the disruption of the synthesis of glycosaminoglycans, induced by non-steroidal anti-inflammatory drugs, and the damaging effect on chondrocytes of corticosteroids.

Also sulfo groups are involved in the metabolism of cartilage tissue and the synthesis of glycosaminoglycans; sulfoesters of side chains in proteoglycans are necessary for water retention, which helps to maintain the elasticity of the cartilage matrix.

In osteoarthritis, glucosamine sulfate stops the destruction of cartilage and reduces the severity of symptoms (usually 2 weeks after the start of therapy, while maintaining the clinical effect for 8 weeks after discontinuation of the drug).

Pharmacokinetics

Glucosamine sulfate quickly passes through biological barriers with subsequent penetration into tissues, mainly articular cartilage.

The half-life of the substance is approximately 60 hours. Excretion occurs mainly by the kidneys.

Indications for use

• osteoarthritis (primary and secondary);
• spondyloarthrosis;
• osteochondrosis.

Contraindications

Injection solution in ampoules Sustagard Artro

Absolute:

• impaired renal / hepatic function in severe course, impaired cardiac conduction, acute heart failure, aggravated history of epileptiform seizures (associated with lidocaine, which is part of the drug);
• pregnancy and the period of breastfeeding;
• age up to 18 years;
• individual intolerance to the components of the drug.

Relative (diseases / conditions that require caution):

• chronic heart failure;
• arterial hypotension;
• intolerance to seafood (associated with an increase in the likelihood of developing allergic reactions);
• insufficiency of blood circulation;
• tendency to malignant hyperthermia;
• impaired renal / hepatic function;
• arterial hypotension;
• epilepsy;
• respiratory failure;
• heart conduction disorders;
• elderly age.

Powder

• phenylketonuria;
• pregnancy and lactation;
• age up to 12 years;
• individual intolerance to the components of the drug.

Instructions for the use of Sustagard Artro: method and dosage

Combined therapy (intramuscular and oral administration) is possible.

Injection solution

The drug should be administered only intramuscularly (the drug is not intended for intravenous administration).

The contents of ampoules A and B must be mixed in one syringe immediately before administration. The prepared solution of 3 ml is injected 3 times a week for a course of 4-6 weeks.

Powder

Sustagard Artro powder is taken orally, after dissolving the contents of 1 sachet (1.5 g) in 200 ml of water.

The drug is taken once a day for a course of 6 weeks. After 2 months, a second course of treatment can be prescribed.

Side effects

• digestive system: diarrhea, flatulence, constipation;
• allergic reactions: itching, urticaria.

Additionally for solution for injection (including disorders associated with exposure to lidocaine):

• nervous system: headache, disorientation, dizziness, euphoria, tremors, drowsiness, numbness of the tongue and oral mucosa, diplopia;
• cardiovascular system: impaired cardiac conduction;
• digestive system: vomiting, nausea;
• allergic reactions: anaphylactic shock, edema;
• local reactions: thrombophlebitis, a slight burning sensation (disappears within 1 minute after the development of the anesthetic effect);
• others: bronchospasm and severe hypersensitivity reactions (associated with sodium disulfite included in the solution).

Overdose

Overdose cases have not been identified.

The main symptoms (lidocaine hydrochloride reactions): dizziness, tremors, drowsiness, numbness of the lips and tongue, depression, blurred vision, agitation, tinnitus, anxiety.

The therapy is carried out under the control of the function of the respiratory and cardiovascular systems, a change in the corresponding parameters may be a symptom of an overdose, therefore, the patient must immediately provide access to oxygen. According to the indications, symptomatic treatment is carried out.

special instructions

In patients with impaired glucose tolerance and bronchial asthma, the injection solution should be administered with caution.

If you follow a strict salt-free diet, it should be borne in mind that 1 dose of the solution contains 40.8 mg of sodium.

Before the administration of the drug, it is necessary to conduct a skin test for individual sensitivity to lidocaine (reactions are manifested in the form of edema and redness of the injection site).

Influence on the ability to drive vehicles and complex mechanisms

When using Sustagard Artro solution, care must be taken when driving motor vehicles, since lidocaine can have a short-term effect on coordination and motor ability.

Application during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation.

Pediatric use

Sustagard Artro powder is not prescribed for children under 12 years old; injection solution - for children and adolescents under 18 years of age.

With impaired renal function

Injection solution Sustagard Artro is not prescribed for disorders of renal function in severe cases, for disorders in milder forms, the drug should be used with caution.

For violations of liver function

The injection solution is not prescribed for violations of hepatic function in severe course, for violations in milder forms, the drug should be used with caution.

Use in the elderly

Care must be taken when using the solution in elderly patients.

Drug interactions

Glucosamine sulfate is compatible with non-steroidal anti-inflammatory drugs, paracetamol and glucocorticosteroids. Reduces the absorption of chloramphenicol and penicillins, increases tetracyclines.

Possible interactions of lidocaine, which is part of the Sustagard Artro solution:

• class IA antiarrhythmic drugs, including quinidine, procainamide, disopyramide: prolongation of the QT interval, in very rare cases - the occurrence of ventricular fibrillation or AV (atrioventricular) blockade;
• chlorpromazine, nortriptyline, cimetidine, bupivacaine, peptidin, quinidine, propranolol, amitriptyline, disopyramide, imipramine: an increase in the plasma concentration of lidocaine in the blood, a decrease in its hepatic metabolism;
• drugs with a sedative effect: strengthening the sedative effect;
• phenytoin: an increase in the cardiodepressant effect of lidocaine;
• procainamide: development of hallucinations, delirium;
• ethanol: increasing the inhibitory effect of lidocaine on respiration;
• drugs that predetermine the blockade of neuromuscular transmission: enhancing their action.

Analogs

The analogues of Sustagard Artro are: DONA, Chondroxide Maximum, Elbona, Artrakam, Glucosamine, Glucosamine sulfate 750, Sustilak.

Terms and conditions of storage

Store in a place protected from light and moisture at temperatures up to 25/30 ° C (solution / powder). Keep out of the reach of children.

Shelf life: solution - 2 years; powder - 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Sustagard Artro

According to a few reviews, Sustagard Artro is an effective drug. There is no information on the development of side effects.

Price for Sustagard Artro in pharmacies

The approximate price for Sustagard Artro is:

• solution for intramuscular injection (5 ampoules with solvent in a package): 710–850 rubles;
• powder for preparation of oral solution (20 sachets per pack): 730-810 rubles.

Sustagard Artro: prices in online pharmacies

Drug name Price Pharmacy

Sustagard Artro 200 mg / ml concentrate for solution for injection complete with solvent 2 ml 5 pcs. RUB 500 Buy

Sustagard Artro 1.5 g powder for oral solution 20 pcs. RUB 520 Buy

Sustagard Artro solution for intramuscular injection 200mg / ml 2ml 5 pcs. 754 RUB Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!