Solpadein Fast
Solpadein Fast: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Solpadeine Fast
ATX code: N02BE71
Active ingredient: caffeine + paracetamol (Caffeine + Paracetamol)
Manufacturer: GlaxoSmithKline Dungarvan, Ltd. (GlaxoSmithKline Dungarvan, Ltd.) (Ireland); Famar S. A. (Famar, SA) (Greece)
Description and photo update: 2019-30-12
Prices in pharmacies: from 79 rubles.
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Solpadein Fast is an analgesic drug (psychostimulant + analgesic non-narcotic drug).
Release form and composition
Solpadein Fast dosage form:
- film-coated tablets: capsule-shaped, white, with a flat edge; on one of the sides there is an embossing in the form of a “+” sign and a triangle (in a pack of cardboard 1 or 2 blisters containing 12 tablets each);
- soluble tablets: white, flat, with a line on one side and a cut-off edge around the circumference (4 or 6 blisters in a cardboard box containing 2 tablets each).
Each pack also contains instructions for the use of Solpadein Fast.
The composition of 1 tablet, film-coated, contains:
- active substances: paracetamol - 500 mg; caffeine - 65 mg;
- auxiliary components: croscarmellose sodium - 10 mg; stearic acid - 5 mg; talc - 15 mg; potassium sorbate - 0.6 mg; povidone (K 22.5–27) - 2 mg; corn starch - 41.4 mg; pregelatinized starch - 50 mg;
- film shell: triacetin - 1 mg; hypromellose - 5 mg.
The composition of 1 soluble tablet contains:
- active substances: paracetamol - 500 mg; caffeine - 65 mg;
- auxiliary components: sodium carbonate - 134.2 mg; citric acid - 925 mg; dimethicone - 1 mg; sodium lauryl sulfate - 0.1 mg; povidone - 1 mg; sodium bicarbonate - 1342 mg; sodium saccharinate - 10 mg; sorbitol - 50 mg; water - qs (evaporates during production).
Pharmacological properties
Pharmacodynamics
Solpadein Fast has antipyretic and analgesic properties.
Pharmacological actions of the medicinal product due to its constituent active components:
- paracetamol: blocks cyclooxygenase in the cells of the central nervous system by acting on the centers of thermoregulation and pain (cellular peroxidases in inflamed tissues neutralize the effect of the substance on cyclooxygenase). This explains the almost complete absence of anti-inflammatory action. It has no negative effect on the gastrointestinal mucosa and water-salt balance in the form of water and sodium retention, which is due to the lack of its effect on the synthesis of prostaglandins in peripheral tissues;
- caffeine: provides an increase in mental and physical performance, eliminating the feeling of fatigue and drowsiness, enhancing the effect of analgesics, stimulating the psychomotor centers of the brain. Caffeine has analeptic properties.
Pharmacokinetics
The main pharmacokinetic characteristics of paracetamol:
- absorption: getting into the gastrointestinal tract is absorbed quickly and almost completely;
- distribution: its distribution in body fluids is relatively even. Plasma protein binding at therapeutic concentrations is minimal;
- metabolism: the substance is metabolized in the liver;
- excretion: through the kidneys it is excreted in the form of sulfate and glucuronide metabolites. Paracetamol is excreted unchanged by less than 5%. When taking a therapeutic dose, the average half-life is 2 to 3 hours.
The main pharmacokinetic characteristics of caffeine are:
- absorption and distribution: from the gastrointestinal tract is absorbed completely and quickly, distributed throughout the body;
- metabolism: almost completely metabolized in the liver through demethylation and further oxidation in the form of metabolites;
- excretion: excreted by the kidneys in the form of metabolites. When taken in therapeutic doses, the average elimination half-life varies from 4 to 9 hours.
Indications for use
- mild to moderate pain syndrome: as a pain reliever for dysmenorrhea (painful menstruation), osteoarthritis, neuralgia, joint / muscle / lower back / throat pain, migraine or headache, toothache, including the period after dental procedures and during tooth extraction;
- acute respiratory and acute respiratory viral pathologies, including influenza, as well as the period after vaccination: in order to reduce elevated body temperature as a means of symptomatic therapy.
Contraindications
Absolute:
- severe renal and / or liver dysfunction;
- sleep disorders;
- glaucoma;
- epilepsy;
- arterial hypertension;
- combined treatment with other drugs, which include paracetamol;
- glucose-galactose malabsorption, fructose intolerance, sucrase / isomaltase deficiency (for soluble tablets, since they contain sorbitol);
- pregnancy;
- period of breastfeeding;
- children under 12 years of age;
- individual intolerance to the components of the drug.
Relative (Solpadein Fast tablets are used under medical supervision):
- dysfunction of the kidneys and liver of mild / moderate severity;
- deficiency of glucose-6-phosphate dehydrogenase;
- chronic alcoholism;
- alcoholic liver disease;
- viral hepatitis;
- benign hyperbilirubinemia, including Gilbert's syndrome.
Solpadein Fast, instructions for use: method and dosage
Solpadein Fast tablets are soluble and film-coated tablets are taken orally. Dissolve tablets immediately before administration in ½ glass of water (not less than 100 ml).
It is recommended to take Solpadein Fast in the lowest effective dose. The minimum interval between taking pills should be 4 hours.
Children over 12 years old, as well as adults, including elderly patients, take 1-2 tablets up to 4 times a day (as needed), observing the interval between doses of 4 hours (minimum). No more than 2 tablets can be taken at a time. The maximum dose is 8 tablets per day. The recommended dosage cannot be exceeded.
Drug therapy without prescribing and observing a doctor should not exceed 3 days when used as an antipyretic drug and 5 days as an anesthetic. An increase in the duration of treatment is possible only under medical supervision.
In cases of exceeding the recommended dose of Solpadein Fast, the patient should immediately seek medical help, even if he feels well. It is required to take into account that an overdose of paracetamol can lead to the development of liver failure.
For patients with impaired renal / liver function, it is important to consult a doctor before starting drug therapy. Restrictions associated with the use of drugs, which include a combination of paracetamol and caffeine, in case of impaired renal / liver function are mainly associated with the presence of paracetamol in these drugs.
Side effects
The use of Solpadein Fast in the recommended dosages is well tolerated in most cases.
During the post-registration use of the medicinal product, side effects were spontaneously detected, occurring with different frequencies (> 10% - very often;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01 %, including individual messages - very rare).
The undesirable effects associated with paracetamol included:
- blood and lymphatic system: very rarely - hemolytic anemia, agranulocytosis, methemoglobinemia, pancytopenia, leukopenia, thrombocytopenia;
- immune system: very rarely - Stevens-Johnson syndrome, anaphylaxis, Quincke's edema (angioedema), skin hypersensitivity reactions, including skin rash, pruritus and hives;
- respiratory system, organs of the chest and mediastinum: very rarely - bronchospasm against the background of increased sensitivity to acetylsalicylic acid and intolerance to other non-steroidal anti-inflammatory drugs;
- liver and biliary tract: very rarely - liver dysfunction.
Long-term use of high doses of the drug increases the risk of developing pancytopenia, nephrotoxic and hepatotoxic effects. In such cases, it is important to monitor the blood picture.
Side effects associated with caffeine include:
- nervous system: the frequency is unknown - headache, dizziness, insomnia, sleep disturbances, increased excitability;
- vessels: frequency unknown - tachycardia;
- gastrointestinal tract: frequency unknown - dyspeptic disorders, including pain in the epigastric region, nausea.
It is not recommended to use caffeine-containing products against the background of Solpadein Fast therapy, since this increases the likelihood of such side effects as cardiac arrhythmia, tachycardia, gastrointestinal disorders, headache, anxiety, irritability and insomnia.
In cases of the appearance of any undesirable phenomena, they immediately stop therapy and immediately consult a doctor.
Overdose
Paracetamol
The main symptoms of paracetamol overdose: there is a high likelihood of developing liver failure, which can be fatal or lead to the need for organ transplantation. The use of paracetamol in adults at a dose of 10 g or more leads to a hepatotoxic effect. The presence of factors affecting the toxicity of paracetamol to the liver contributes to organ damage after taking the drug at a dose of 5 g or more. Prolonged use of the drug in higher doses can lead to nephrotoxic effects (papillary necrosis, interstitial nephritis, nonspecific bacteriuria, renal colic).
During the first 24 hours after taking high doses, metabolic acidosis, anorexia, pallor of the skin, nausea, stomach pain and vomiting may occur. After 1-2 days, there are manifestations of liver damage (increased activity of liver enzymes, pain in the liver), there is also a chance of metabolic acidosis and disorders of carbohydrate metabolism.
In severe cases, as a result of liver failure, hypoglycemia, bleeding, impaired brain function (encephalopathy), cerebral edema, up to death, the need for liver transplantation, and death can occur. It is also likely to develop acute renal failure with acute tubular necrosis, the characteristic manifestations of which include proteinuria (increased protein content in the urine), hematuria (impurity in the urine of red blood cells or blood), pain in the lumbar region, while the patient does not necessarily have severe liver damage … There are reports of the development of pancreatitis and cardiac arrhythmias.
Therapy: if you suspect an overdose of Solpadein Fast, even in the absence of pronounced first manifestations, it is important to stop taking the drug and immediately seek medical help. During the first 60 minutes after poisoning, but no later than 4 hours, gastric lavage and the use of enterosorbents (polyphepan, activated carbon) are recommended. Determine the content of paracetamol in blood plasma, however, not earlier than 4 hours after its use in a high dose, since earlier results may be unreliable.
Acetylcysteine is administered within 24 hours after intoxication. The maximum protective effect is provided during the first 8 hours after intoxication; over time, its effectiveness drops sharply. In cases of need, acetylcysteine is recommended to be administered intravenously. If the patient does not vomit before admission to the hospital, methionine can be used. Depending on the concentration of paracetamol in the blood plasma and the time elapsed after its use, the importance of additional therapeutic measures is determined (intravenous administration of acetylcysteine, methionine intake). Therapy of patients with serious liver dysfunctions 24 hours after the use of paracetamol should be carried out together with specialists from a specialized department of liver pathologies or a toxicological center.
Caffeine
The main symptoms of caffeine intoxication: arrhythmia, vomiting, tachycardia, frequent urination, pain in the epigastric region, stimulation of the central nervous system (convulsions, tremors, excitability, increased neuro-reflexive, anxiety, agitation, anxiety, insomnia). It is important to take into account that the appearance of clinically significant signs of high-dose caffeine intake during drug use is always associated with severe liver damage from paracetamol overdose.
Treatment: no specific antidote. Therapy includes supportive measures such as monitoring vital signs and drinking plenty of fluids. During the period from 1 to 4 hours after taking the drug in high doses, you should take activated charcoal. In order to reduce the effect of caffeine on the functions of the central nervous system, intravenous administration of sedative drugs is recommended, and to reduce the cardiotoxic effect, beta-adrenoreceptor antagonists.
special instructions
There is no data on the effect of Solpadein Fast on fertility.
It is recommended to consult a doctor in cases where there is no improvement in the patient's condition against the background of therapy, or the headache becomes constant.
The drug cannot be used in combination with other paracetamol-containing drugs, since their combined use can lead to an overdose of paracetamol.
It should be borne in mind that hepatic impairment that occurs when taking paracetamol in high doses may lead to the need for liver transplantation or death.
Solpadein Fast should not be used in conjunction with caffeine-containing foods (coffee, tea, and others), as this provokes the development of cardiac arrhythmias, tachycardia, gastrointestinal disorders, headache, insomnia, irritability, anxiety and anxiety.
Patients with glutathione deficiency due to an eating disorder, dietary fibrosis, HIV infection, fasting, or wasting are more prone to drug toxicity. In this regard, it is recommended to observe precautions and consult a doctor before taking it.
Cases of liver failure and liver dysfunction have been reported against the background of a small overdose of paracetamol (at a dose of 5 g or more) in patients with low glutathione levels, including extremely malnourished patients with anorexia, chronic alcoholism, or patients with low weight.
The use of Solpadein Fast in patients with low levels of glutathione, for example, with sepsis, may increase the risk of developing metabolic acidosis, accompanied by rapid breathing difficulties (feeling short of breath, shortness of breath), nausea, vomiting, and loss of appetite. With the simultaneous manifestation of these symptoms, you should immediately consult a doctor.
To avoid toxic damage to the liver, it is important to avoid taking paracetamol with alcohol and not to prescribe its therapy in persons prone to chronic consumption of alcoholic beverages. The likelihood of further liver damage during drug therapy increases in the presence of concomitant pathologies. Prescribing the drug to patients with non-alcoholic cirrhosis of the liver is accompanied by a high risk of overdose. With pollinosis, atopic bronchial asthma, there is an increased likelihood of allergic reactions.
Before conducting an analysis to determine the content of glucose and uric acid in the blood, the doctor should be warned about the use of the drug.
Combinations of paracetamol and caffeine can alter the results of doping control tests in athletes.
Deficiency of glutathione due to malnutrition, starvation, HIV infection, dietary fibrosis, or an eating disorder can lead to severe liver damage with small overdose of paracetamol in a dose of 5 g or more.
Influence on the ability to drive vehicles and complex mechanisms
The influence of Solpadein Fast on the reaction rate, concentration of attention and other psychophysical qualities of the patient is unlikely, including the ability to control complex mechanisms and vehicles.
Application during pregnancy and lactation
Solpadein Fast is not prescribed during pregnancy / lactation.
No risk associated with the use of paracetamol during pregnancy or its negative effect on the intrauterine development of the fetus in animal and human studies has not been identified. However, taking caffeine can increase the likelihood of miscarriage or low birth weight, and therefore the use of Solpadein Fast during pregnancy is not recommended.
Paracetamol passes into breast milk and through the placental barrier. No negative effects on the body of an infant during breastfeeding have been identified in human studies. Caffeine also passes into breast milk, but unlike paracetamol, it can have a stimulating effect on a breastfed baby. In this regard, the drug is not used during lactation.
Pediatric use
Solpadein Fast is not prescribed to patients under 12 years of age.
With impaired renal function
- use is contraindicated: severe renal dysfunction;
- application requires medical supervision: impaired renal function of mild and moderate severity.
For violations of liver function
- use is contraindicated: severe liver dysfunction;
- use requires medical supervision: liver dysfunction of mild and moderate severity.
Drug interactions
Possible interactions of Solpadein Fast with other drugs / substances:
- indirect anticoagulants (warfarin and other coumarins): with regular use over a long period, their effect is enhanced, which increases the likelihood of bleeding;
- monoamine oxidase inhibitors: Solpadein Fast enhances their effect;
- preparations containing St. John's wort, other inducers of microsomal oxidation, butadione, phenylbutazone, flumecinol, zidovudine, rifampicin, ethanol, diphenin, phenytoin, carbamazepine, barbiturates, primidone and other anticonvulsant drugs: increase the production of hydroxycetylated active metabolites liver against the background of small overdose of paracetamol (5 g or more);
- cimetidine (inhibitors of liver microsomal enzymes): reduces the likelihood of the hepatotoxic effect of paracetamol;
- chloramphenicol (chloramphenicol): under the action of paracetamol, its elimination time increases by 5 times, which increases the risk of intoxication with chloramphenicol (chloramphenicol);
- domperidone, metoclopramide: increases the rate of absorption of paracetamol;
- cholestyramine: reduces the rate of absorption of paracetamol;
- uricosuric drugs: probably a decrease in their effectiveness;
- non-steroidal anti-inflammatory drugs: long-term combined use with paracetamol increases the risk of end-stage renal failure, renal papillary necrosis and analgesic nephropathy;
- salicylates: with prolonged treatment with paracetamol in high doses, the likelihood of malignant neoplasms of the bladder and kidneys increases;
- flucloxacillin: combined administration with paracetamol may cause metabolic acidosis, especially in patients with risk factors for glutathione depletion (chronic alcoholism, malnutrition, or sepsis);
- alcoholic beverages: simultaneous administration with paracetamol increases the likelihood of acute pancreatitis and liver damage;
- ergotamine: Caffeine speeds up its absorption. Combined use with caffeine-containing products is not recommended.
The combined episodic administration of a single dose of the drug with indirect anticoagulants does not significantly affect their effect.
In cases of therapy with other drugs, before using Solpadein Fast, you should consult a doctor for advice.
Analogs
Solpadein Fast analogs are: Analgin, Children's Panadol, Ifimol, Panadol extra, Ksumapar, Migrenol, Migrenium, FluZiOZ, Efferalgan, etc.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 4 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Solpadein Fast
According to reviews, Solpadein Fast is a safe, fast-acting and effective drug used to relieve pain of various etiologies.
Among the disadvantages, the high cost of the drug, the short-term effect of its use, the development of side effects, and the unpleasant taste of effervescent tablets are mainly noted.
The price of Solpadein Fast in pharmacies
The approximate price for Solpadein Fast is: film-coated tablets (12 pcs per pack) - 94 rubles; soluble tablets (8 pcs. in a package) - 148 rubles., soluble tablets (12 pcs. in a package) - 237 rubles.
Solpadein Fast: prices in online pharmacies
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Drug name Price Pharmacy |
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Solpadein Fast 65 mg + 500 mg film-coated tablets 12 pcs. 79 RUB Buy |
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Solpadein Fast Solpadeine Fast pain reliever, tablets, 12 pcs. 117 RUB Buy |
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Solpadein Fast 65 mg + 500 mg soluble tablets 8 pcs. 122 RUB Buy |
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Solpadein Fast 65 mg + 500 mg film-coated tablets 24 pcs. 131 r Buy |
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Solpadein Fast 65 mg + 500 mg soluble tablets 12 pcs. 183 r Buy |
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Solpadein Fast Solpadeine Fast anesthetic, soluble tablets, 12 pcs. RUB 218 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
