SolkoTrichovak
SolkoTrikhovak: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacodynamics and pharmacokinetics
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Solcotrichovac
ATX code: J07AX
Active ingredient: L. rhamnosus (3 strains), L. vaginalis (3 strains), L. fermentum (1 strain), L. salivarius (1 strain)
Producer: IDT Biologika GmbH (Germany)
Description and photo updated: 15.08.2018
SolcoTrichovak is a vaccine that has an immunostimulating and antibacterial effect, normalizing the vaginal microflora.
Release form and composition
Dosage form - lyophilisate for preparation of suspension for injection, which is a porous tablet of a lyophilized white substance; when dissolved in injection water, a translucent opaque suspension is formed [1 vaccination dose in vials, in a box of 1 or 3 vials complete, respectively, with one or three ampoules with a solvent (0.5 ml of water for injection)].
Active substance: inactivated lyophilized microorganisms of the strain of acidophilic lactobacilli (Lactobacillus acidophilus), in 1 dose - at least 7x10 9.
Auxiliary components: phenol (preservative), sodium chloride and repolymerized gelatin (hemacel).
Pharmacodynamics and pharmacokinetics
The SolcoTrichovac vaccine activates nonspecific and specific immunity, has a positive effect on the vaginal microflora and prevents the risk of re-infection with vaginal infections prone to recurrence.
The drug increases the number of specific sIgA antibodies in the vaginal secretion, and also increases the amount of humoral IgG antibodies to atypical lactobacilli. After some time, the level of specific antibodies decreases, but the protective effect of the drug remains, which significantly reduces the likelihood of reinfection. SolcoTrichovak also activates polyclonal B-lymphocytes and enhances the phagocytic activity of T-lymphocytes and macrophages.
As a result of the activation of the body's defenses, the growth of Doderlein sticks is observed, the normal microflora of the vagina and the pH level of the mucous membrane are restored.
The pharmacokinetics of the vaccine have not been studied.
Indications for use
Treatment and prevention in women:
- recurrent nonspecific bacterial vaginosis;
- recurrent trichomoniasis.
Contraindications
- diseases of the heart and kidneys with symptoms of decompensation;
- active tuberculosis;
- diseases of the immune system (including human immunodeficiency virus);
- acute infectious diseases;
- diseases of the hematopoietic system (for example, acute leukemia);
- hypersensitivity to drug components.
Instructions for the use of SolcoTrichovak: method and dosage
The vaccine is administered intramuscularly.
A single dose is 0.5 ml (contents of 1 bottle). The vaccination course includes 3 injections at intervals of 2 weeks. The time of administration of the drug should be calculated so that it does not coincide with the patient's menstruation.
After 1 year, a single revaccination is carried out at a dose of 0.5 ml.
In the future, revaccination is carried out every 2 years.
To prepare the solution, the supplied solvent must be injected into the vial with the lyophilisate using a sterile syringe. Dissolution of a porous tablet occurs within 30 seconds, the finished suspension must have a homogeneous structure.
The solution for injection should be prepared immediately before administration. Before taking the drug into the syringe, shake the bottle.
Side effects
The vaccine is generally well tolerated.
Rarely, there are local reactions in the form of pain, swelling and redness at the injection site.
In some cases, general reactions are possible: increased fatigue, chills, increased body temperature (up to 40 ºС), headache.
Overdose
Overdose data have been reported.
special instructions
Clinical trials regarding the safety of the vaccine during pregnancy and lactation have not been conducted, therefore, during these periods, the drug can be used only in cases where the expected benefit outweighs the potential risks.
Vaccination should not be carried out for sexually transmitted diseases. In the case of acute trichomoniasis, the drug can be administered only after preliminary etiotropic treatment.
For girls under 15 years of age, SolcoTrichovac can be prescribed only in cases of extreme necessity, if the intended therapeutic effect is higher than the risk of developing possible side effects.
SolcoTrichovac should not be administered if: there are cracks on the vial with the lyophilisate or ampoule with a solvent, the drug is unclear, the physical properties of the dissolved lyophilisate are impaired.
When conducting radiation therapy and / or the simultaneous use of immunosuppressants, partial or complete loss of the effectiveness of the vaccine is possible.
The drug does not affect the speed of reactions and the ability to concentrate.
Application during pregnancy and lactation
There are no clinical data on the use of the vaccine during pregnancy and breastfeeding, therefore, it is not recommended to prescribe the drug to pregnant and lactating women.
Pediatric use
According to the instructions, SolcoTrichovac is not used in children and adolescents under 15 years old, since there is no data on the safety and effectiveness of the vaccine in children.
With impaired renal function
In case of insufficient renal function, the use of the vaccine is contraindicated.
Drug interactions
SolcoTrichovac should not be mixed in the same syringe with other vaccines or parenteral agents.
Analogs
There is no information on analogues of the SolcoTrichovac vaccine.
Terms and conditions of storage
Store dry, out of the reach of children, at a temperature of 15 to 25 ºС.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about SolkoTrikhovak
The vaccine has proven to be effective in the treatment of bacterial vaginosis and trichomoniasis. After using SolcoTrichovak, the number of relapses is significantly reduced.
Immunization has a number of advantages over taking antimicrobial agents: you can reduce the dose of drugs used and the duration of the course of therapy, which in turn reduces the incidence of side effects.
The price of SolkoTrichovak in pharmacies
The vaccine is not registered in Russia, so it is currently impossible to buy it in pharmacies.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
